Clinical trials: Depressive Disorder NOS
Major Depressive Disorder
Canadian Biomarker Integration Network for Depression Study
This study is a pilot to assess feasibility of the protocol in patients and controls across six participating sites. The goal is to identify biological markers (biomarkers)that can be measured at baseline or early in treatment to…
- Trial name
- CAN-BIND-1 (NCT01655706)
- Testing
- escitalopram, aripiprazole
- Where
- 6 sites in Canada
- Volunteers
- 211 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Depressive Disorder
A PET Study in Healthy Volunteers
This will be an open label, non-randomised [11C]PHNO PET study using healthy male volunteers. Each volunteer will undergo 4 [11C]PHNO PET scans to allow for further characterisation of this radioligand and examine the effects of…
- Trial name
- NCT01424449
- Testing
- [11C]PHNO, Aripiprazole
- Where
- United Kingdom
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Depression - Major Depressive Disorder
Effectiveness of Health Communication on Depression Elderly in Ho Chi Minh City
The goal of this clinical trial is to learn if a community-based health education and communication program helps prevent and reduce depression in older adults living in Ho Chi Minh City.
- Trial name
- Depression (NCT07877571)
- Testing
- Health Communication
- Where
- Vietnam
- Volunteers
- 550 people, healthy volunteers welcome
- Sponsor
- University of Medicine and Pharmacy at Ho Chi Minh City
Major Depressive Disorder
Validation of the THINC-it Tool for Cognitive Dysfunction in Major Depressive Disorder
Cognitive dysfunction is a highly persistent, pervasive and progressive abnormality in young adults (i.e., 18-65 years) with MDD.
- Trial name
- NCT02508493
- Testing
- THINC-it Tool, Pencil-and-paper Cognitive Tests
- Where
- Canada
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Brain and Cognition Discovery Foundation
Major Depressive Disorder
Study to Assess the Distribution, Metabolism and Excretion of [14C]AZD6765 After a Single-Dose Intravenous Administration
This is a study to assess the distribution, metabolism and excretion of [14C]AZD6765 after a single-dose intravenous administration.
- Trial name
- AZD6765 (NCT01217645)
- Testing
- 150 mg [14C] AZD6765
- Where
- United Kingdom
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Depressive Disorder
Effect of Nicotine on Brain Reward Pathways
The investigators will determine whether an acute dose of nicotine, in the form of the nicotine lozenge, impacts brain and behavioral measures of mood and reward responsiveness in individuals with major depressive disorder.
- Trial name
- NCT02346539
- Testing
- Nicotine polacrilex
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Mclean Hospital
Major Depressive Disorder (MDD)
PET Imaging Using the Tracer [18F]VAT to Assess the Antidepressant Effect of Nicotine.
In the brain, certain nerve cells communicate using a chemical called acetylcholine. Acetylcholine is thought to be important for several functions including mood, memory and wakefulness.
- Trial name
- VATMDDNicotine (NCT07095205)
- Testing
- Nicotine transdermal patch, PET Scan with [18F] VAT
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Stony Brook University
Major Depressive Disorder
Dose Escalation, Double-Blind Treatment With Duloxetine Hydrochloride Once Daily Dosing for Evaluation of Safety in Major Depression
The Purposes of this Study are to determine: The safety of duloxetine and any side effects that might be associated with it. Whether duloxetine can help patients with major depression.
- Trial name
- NCT00042575
- Testing
- Duloxetine
- Where
- 9 sites in United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Major Depressive Disorder, Depression, Unipolar
A Prediction Study of Multiple Indexes of the Effect of Different Mechanisms of Antidepressants Treatment on Depression
Antidepressants is the primary treatment for depression, but only less than 50% of the patients get clinical remission. There is no objective markers to select antidepressants for clinical treatment .
- Trial name
- NCT03623711
- Testing
- Escitalopram, Duloxetine, Bupropion
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Yuqi Cheng
Major Depressive Disorders
The Effects of Transcranial Magnetic Stimulation on Retina and Choroidal Structures
Transcranial Magnetic Stimulation (TMS) therapy is an approved and effective treatment option in treatment-resistant depression.
- Trial name
- TMSEYE (NCT06615804)
- Testing
- Transcranial Magnetic Stimulation
- Where
- Turkey (Türkiye)
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Gulhane Training and Research Hospital
Major Depressive Disorder
Exploring Biomarkers for Depression
The purpose of this research is to explore objective biomarkers in voice, physiological, motor, and brain imaging signals that may one day be used to complement clinical evaluation and treatment of depression.
- Trial name
- NCT01424111
- Testing
- Escitalopram, Healthy Control
- Where
- United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Wyss Institute at Harvard University
Depressive Disorder, Major
A Study of Oral Seltorexant as an add-on Medication to an Antidepressant on On-road Driving Performance in Participants With Major Depressive Disorder
The purpose of the study is to evaluate the effect of seltorexant, compared to placebo, as an add-on medication to an antidepressant, on next-day driving performance as assessed by the mean difference of standard deviation of…
- Trial name
- NCT04451187
- Testing
- Seltorexant Dose 1, Seltorexant Dose 2, Zopiclone
- Where
- 2 sites in Belgium, Germany
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Janssen Research & Development, LLC
Depression, Anxiety
Cognitive Behavioral Therapy Versus Ericksonian Hypnosis Therapy for Depression and Anxiety Symptoms
Title: Comparison of Cognitive Behavioral Therapy and Ericksonian Hypnosis Therapy for Depression and Anxiety Symptoms; A Controlled Randomized Study. Principal Investigator: Dr.
- Trial name
- NCT06484400
- Testing
- Cognitive Behavioral Therapy, Ericksonian Hypnotehrapy
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Istanbul Nisantasi University
Major Depression
Healthy Mood Internet Intervention Research Project
The purpose of the study is: 1. to study whether individuals WHO ARE NOT CURRENTLY SERIOUSLY DEPRESSED will participate in an online study to prevent clinical depression and 2.
- Trial name
- NCT01358487
- Testing
- Online self-help course plus live follow-up if needed, Online + incentives Follow-up Group
- Where
- United States
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Major Depressive Disorder (MDD)
Caregiver Depression in a Low-Resource Setting: Socio-Demographic Predictors of Major Depressive Disorder Among Family Caregivers of Breast Cancer Patients in Pakistan
This cross-sectional study aims to assess the prevalence of depression among primary caregivers of breast cancer patients within low-resource country like Pakistan.
- Trial name
- NCT06992167
- Where
- 4 sites in Pakistan
- Volunteers
- 402 people, healthy volunteers welcome
- Sponsor
- Rahmah Health Foundation
Major Depressive Disorder (MDD)
The Effect of Transcranial Magnetic Stimulation Treatment on Microvasculature Stracture of the Retina and the Choroid
Transcranial Magnetic Stimulation (TMS) therapy is an approved and effective treatment option in treatment-resistant depression.
- Trial name
- TMS_OCT-A (NCT06708013)
- Testing
- Transcranial Magnetic Stimulation
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Gulhane Training and Research Hospital
Major Depressive Disorder
Effect of Food, Gender, and Age on the Pharmacokinetic Profile of SUVN-911 in Healthy Subjects
The purpose of the study is to investigate the effect of Food, Gender, and Age on the Pharmacokinetic Profile of SUVN-911 in Healthy Subjects
- Trial name
- SUVN-911 (NCT03551288)
- Testing
- SUVN-911
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Suven Life Sciences Limited
Postpartum Depression, Anxiety
Yoga in the NICU for Parents Study
The purpose of this proposal is to test the efficacy of yoga as a mind and body intervention to decrease stress, anxiety, and depression in parents of critically ill neonates hospitalized in the Seattle Children's and University…
- Conditions
- Postpartum Depression, Anxiety, Depression, Stress Disorder
- Trial name
- YiN (NCT05322161)
- Testing
- yoga classes
- Where
- 2 sites in United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Seattle Children's Hospital
Social Determinants of Health, Major Depressive Disorder
The Role of Social Determinants in Cardiovascular Health and Vascular Function
This study aims to identify the influence of social determinants of health domains on vascular function in a low income, racial, and ethnic minority population at risk for disparities.
- Conditions
- Social Determinants of Health, Major Depressive Disorder, Cardiovascular Diseases
- Trial name
- CVRRC (NCT05772221)
- Testing
- Screening
- Where
- United States
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Baylor Research Institute
Major Depressive Disorder
A Study of LY2940094 in Major Depressive Disorder
The purpose of this study is to investigate the safety and tolerability of ascending single and multiple oral doses of LY2940094 in healthy male subjects.
- Trial name
- NCT01263236
- Testing
- LY2940094
- Where
- Canada
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- BlackThorn Therapeutics, Inc.
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