Clinical trials: Depressive Disorders
Major Depressive Disorder
Linking Affective Dynamics in Response to Daily Stress to Peripheral Vascular Function in Working Age Adults
The objective of this proposal is to determine whether heightened negative affective responsivity (NA-R) to daily stressors is related to blunted nitric oxide (NO)-mediated endothelium-dependent dilation (EDD) in working age…
- Trial name
- NCT06860724
- Testing
- NG-nitro-L-arginine methyl ester (L-NAME)
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Delaware
Treatment Resistant Depression
Intranasal Esketamine to Maintain the Antidepressant Response to IV Racemic Ketamine
This study aims to assess the efficacy and safety of intranasal esketamine as maintenance antidepressant therapy in patients who have demonstrated clinical improvement with off-label intravenous racemic ketamine for…
- Trial name
- NCT04856124
- Testing
- Intranasal esketamine
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Psych Atlanta
Job Stress, Workplace Stress
Breath Regulation and Yogic Exercise An Online Therapy for Calm and Happiness During the COVID-19 Pandemic
This study will examine the feasibility of conducting an online Randomized Controlled Trial (RCT) in frontline hospital and long term care healthcare staff in managing COVID-19 patients in London, ON.
- Conditions
- Job Stress, Workplace Stress, Compassion Fatigue, Psychological Trauma
- Trial name
- BREATH (NCT04368676)
- Testing
- Sudarshan Kriya Yoga (SKY), Health Enhancement Program
- Where
- Canada
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Depression, Anxiety
Pharmacogenomic Testing to Optimize Antidepressant Drug Therapy
A randomized controlled trial comparing pharmacogenomic guided versus standard pharmacist care to optimize antidepressant drug therapy.
- Conditions
- Depression, Anxiety, Major Depressive Disorder, Generalized Anxiety Disorder
- Trial name
- NCT03591224
- Testing
- Pharmacogenomic Testing, Pharmacist Standard of Care
- Where
- 2 sites in Canada
- Volunteers
- 213 people, healthy volunteers welcome
- Sponsor
- John Papastergiou Pharmacy Ltd
Perinatal Depression
Exposures to Perinatal Adverse Experiences: Multimodal Omics Signature of Stress Vulnerability and Resilience and Preventive Strategies
The study aims at identifying: 1. specific biological and molecular alterations associated with development of depression in pregnancy or risk of it. 2.
- Trial name
- PRESeNT (NCT05951738)
- Testing
- Blood and saliva collection, Psychometric scales, Smartphone app
- Where
- 4 sites in Italy
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- IRCCS Centro San Giovanni di Dio Fatebenefratelli
Depression, Depressive Disorder
Targeting Adolescent Depressive Symptoms Via Brief, Web-Based Interventions
Major depression (MD) in youth is a serious psychiatric illness with extensive morbidity and mortality. The American Academy of Pediatrics recently released practice guidelines promoting primary care (PC)-based youth MD…
- Conditions
- Depression, Depressive Disorder, Behavioral Symptoms, Mood Disorders
- Trial name
- NCT04066985
- Testing
- Growth Mindset Online Single-Session Program, Self-Kindness Online Single-Session Program, Supportive Therapy Online Single-Session Program (Control)
- Where
- United States
- Volunteers
- 501 people, healthy volunteers welcome
- Sponsor
- Child Mind Institute
Health Behavior, Work Related Stress
HRV and Coaching Preparation Phase Study
This pilot study will evaluate possible intervention components to be included in a future stress management and health behaviour change trial and to pilot test their feasibility and acceptability in a small sample.
- Conditions
- Health Behavior, Work Related Stress, Job Stress, Anxiety Depression
- Trial name
- NCT05150574
- Testing
- Core Health Program, Daily resting HRV, Momentary HRV feedback
- Where
- Canada
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Brock University
Resting Metabolic Rate, Bone Mineral Density, Low, Susceptibility to
The Health of Competitive Fitness Athletes
Fitness athletes emphasize the value of staying lean, muscular and defined, and motivates and inspires followers through social media.
- Conditions
- Resting Metabolic Rate, Bone Mineral Density, Low, Susceptibility to, Body Image, Perfectionism
- Trial name
- NCT03007459
- Testing
- Psychological health, Physiological health
- Where
- Norway
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Norwegian School of Sport Sciences
Feasibility Studies, Acceptability
Feasibility and Acceptability of a Single Session of Imagery Rescripting in a Community Sample of Adults
Negative experiences related to eating and appearance (NEREAs), such as critical commentary from parents about food, are common. They are also associated with depression and disordered eating, predictors of early mortality.
- Conditions
- Feasibility Studies, Acceptability, Depressive Symptoms, Disordered Eating Behaviors
- Trial name
- NCT06610318
- Testing
- imagery rescripting, nutrition education
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- University of Oregon
Anxiety
Feasibility Study of a Music and Social Support Intervention for Postnatal Mothers/Infants
This research study aims to assess the feasibility of conducting a full scale trial of Mamas in Harmony, a group music and social support class delivered by a professional musician for mothers and their babies.
- Trial name
- NCT05930990
- Testing
- Mamas in Harmony
- Where
- United Kingdom
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Queen's University, Belfast
Cognition - Other, Depression, Anxiety
Effects of a Black Rice Extract and Anthocyanidin Metabolites on the Synthesis and Release of BDNF in Healthy Subjects
The goal of this clinical trial is to investigate the effect of black rice extract (BRE) supplementation on levels of BDNF, which is a key molecule in cognition in healthy volunteers.
- Trial name
- NCT06594848
- Testing
- Black rice extract
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Depression
Cognitive Correlates of Antidepressant Treatment Response in Elders
Major depression is a very common health problem affecting older persons. The present standard of treatment is with medications called "antidepressants".
- Trial name
- NCT01477268
- Testing
- Zoloft (antidepressant)
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Post Traumatic Stress Disorder, Anxiety
Level and Predictors of Trauma-symptoms Among Health Workers and Public Service Providers During the COVID-19 Outbreak
The aim of this study is to investigate the levels of trauma and mental symptoms (i.e., depression and anxiety) among health workers and public service providers during the strict social distancing government-initiated…
- Conditions
- Post Traumatic Stress Disorder, Anxiety, Depression
- Trial name
- NCT04374097
- Where
- Norway
- Volunteers
- 1,778 people, healthy volunteers welcome
- Sponsor
- University of Oslo
Depression
Assessment of Stress, Depression and Anxiety in Healthcare Caring for Patients With COVID-19
Medical personnel working in the Intensive Care Unit will be examined by means of tests. Their aim is to check how work-related stress in a potentially lethal threat affects the occurrence of depression, stress, anxiety and sleep…
- Trial name
- NCT04631497
- Testing
- test
- Where
- Poland
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Jagiellonian University
Healthy Lifestyle Behaviors, Depressive/Anxiety Symptoms
COPE/Healthy Lifestyles for Teens: A School-Based RCT
The prevention and treatment of obesity and mental health disorders in adolescence are two major public health problems in the United States today.
- Trial name
- NCT01704768
- Testing
- COPE/Healthy Lifestyles TEEN Program., Healthy Teens Attention Control Program
- Where
- United States
- Volunteers
- 1,219 people, healthy volunteers welcome
- Sponsor
- Arizona State University
Depression, Physical Functional Performance
Eccentrically Reinforced Resistance Training vs. Traditional Resistance Training in Sedentary Older Women
There are easily accessible and safe strategies, such as physical exercise, that can contribute to reducing depressive symptoms and to the preservation of physical and executive function in elderly women.
- Conditions
- Depression, Physical Functional Performance, Executive Function
- Trial name
- NCT05910632
- Testing
- Eccentrically strengthened resistance exercise, Traditional resistance training
- Where
- Brazil
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Federal University of Vicosa
Depression, Hypertension
Biological CVD Risk Factors in Older Depressed Patients
The purpose of this study is to determine if improvements in mood will ameliorate autonomic dysregulation, HPA dysfunction and typical (e.g.
- Conditions
- Depression, Hypertension, Hypercholesterolemia
- Trial name
- NCT00318864
- Testing
- Cognitive behavioral therapy
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Stanford University
Pregnancy, Postpartum Depression
Rosie the Chatbot: Leveraging Automated and Personalized Health Information Communication
Rosie the Chatbot is an educational chatbot that moms can have on their computers or cellphones and will work by moms typing in their questions about pregnancy, health, infant milestones, and other variety of health related…
- Conditions
- Pregnancy, Postpartum Depression, Infant Development, Infant Conditions
- Trial name
- NCT06053515
- Testing
- Rosie the Chatbot
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University of Maryland, College Park
Lateral Gluteal Depression
Analyze Previously Collected Biopsy Samples From Participants Who Completed the "SPLASH: Split-Body Randomized Clinical Trial of Poly-L-Lactic Acid for Adipogenesis and Volumization of the Hip Dell" Study
Primary Objective: use immunofluorescence (IF) on previously obtained biopsies to analyze and quantify changes in adipose tissue of subjects injected with poly-L-lactic acid (PLLA) or saline.
- Trial name
- NCT06656923
- Testing
- Biopsies
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Goldman, Butterwick, Fitzpatrick and Groff
Anxiety, Depression
Integrated Maternal Psychosocial Assessment to Care Trial (IMPACT) Full Trial
We hypothesize that the intervention will: (1) offer a feasible approach for providing mental healthcare to pregnant women and have a high level of acceptability by pregnant women and healthcare providers; (2) reduce symptoms of…
- Trial name
- NCT01901796
- Testing
- Cognitive Behavioral Therapy
- Where
- Canada
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- University of Calgary
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