Clinical trials: Depressive Disorders
Parenting, Anxiety
Parental Stress After the Covid-19 Pandemic
The aim of this study is to investigate the levels of parental stress 3 months after (T2) the strict physical distancing government initiated physical distancing protocols related to the COVID-19 pandemic (T1).
- Conditions
- Parenting, Anxiety, Depression, Anger
- Trial name
- NCT04442308
- Volunteers
- 1,440 people, healthy volunteers welcome
- Sponsor
- University of Oslo
Mothers, Postpartum Depression
Early Half Swaddling and Kangaroo Care Practices on Maternal Sleep Quality and Postpartum Depression in Term Babies
Aim: In this prospective, randomized controlled study, it was aimed to examine the effects of early half-swaddle and kangaroo care practices in term babies on maternal sleep quality and postpartum depression.
- Trial name
- NCT06348316
- Testing
- Half swaddle, Kangaroo care
- Where
- Turkey (Türkiye)
- Volunteers
- 136 people, healthy volunteers welcome
- Sponsor
- Trakya University
PTSD, Depression
Increasing Psychological Resilience in Combat Soldiers Applying Advanced Eye-Tracking-Based Attention Bias Modification
Military service in combat units entails exposure to traumatic events that require mental adjustment. To develop and efficiently apply attention bias modification interventions aimed at enhancing soldiers' mental resilience, it…
- Conditions
- PTSD, Depression, Anxiety Disorders
- Trial name
- NCT05294848
- Testing
- Gaze-Contingent Feedback Training, Attention Bias Modification, Neutral Control
- Where
- Israel
- Volunteers
- 501 people, healthy volunteers welcome
- Sponsor
- Tel Aviv University
Adolescent Development, Stress
Neurophysiology, Estrogen, and Stress Exposure in the Emergence of Depression in Adolescent Girls
The prevalence of adolescent depression is steadily rising in the U.S., especially among adolescent girls. Currently 20% of adolescent girls experience major depression compared with 6% of boys (National Institute of Mental…
- Conditions
- Adolescent Development, Stress, Emotional Disturbances
- Trial name
- EVOLVE (NCT03450135)
- Testing
- Trier Social Stress Test, Emotional go/no-go task
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Anxiety, Depression
CBT for Young Mothers
Approximately 1 in 4 adolescent mothers will develop depression after delivering a child, though some studies suggest that as many as 53% will develop postpartum depression.
- Conditions
- Anxiety, Depression, Emotion Regulation
- Trial name
- CBTYM (NCT03329144)
- Testing
- Cognitive Behavioural Therapy
- Where
- Canada
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- McMaster University
Major Depressive Disorders, Senile; Depression
Health Care Management for the Elderly in Community Through Screening
Depression in late life has been associated with losses in functioning and quality of life, mortality, and increased health care costs.
- Trial name
- NCT01347138
- Testing
- case management
- Where
- South Korea
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- National Clinical Research Coordination Center, Seoul, Korea
Postoperative Depression
The Impact of Preoperative Chronic Pain on Postoperative Depressive States in Elderly Patients Undergoing Joint Replacement Surgery: A Secondary Analysis Based on Prospective Data
Background: Postoperative depression is a significant complication that hinders recovery in elderly patients undergoing joint replacement surgery.
- Trial name
- NCT07403838
- Where
- China
- Volunteers
- 575 people, healthy volunteers welcome
- Sponsor
- Chinese PLA General Hospital
HIV Infections, HIV/AIDS
Evaluation of a Home-based Community Health Worker Program in Rural Eastern Cape, South Africa
The purpose of this early Phase 2 comparison trial is to evaluate the impact of community health worker (CHW) home visitors on pregnant women and their children in a rural setting in the rural Eastern Cape of South Africa.
- Conditions
- HIV Infections, HIV/AIDS, Depression, Depressive Symptoms
- Trial name
- NCT03517878
- Testing
- Comprehensive CHW Program
- Where
- 2 sites in South Africa
- Volunteers
- 1,490 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Suicide Threat, Burnout, Professional
Modified Interactive Screening Program Plus MINDBODYSTRONG: A Mental Health Resiliency Intervention for Nurses
The overall purpose of this study is to evaluate the efficacy of an intervention designed to prevent nurse suicide. This randomized controlled trial will test the modified Interactive Screening Program (mISP) alone and the mISP…
- Conditions
- Suicide Threat, Burnout, Professional, Depression
- Trial name
- NCT05582343
- Testing
- MINDBODYSTRONG™
- Where
- United States
- Volunteers
- 849 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Depression, Anxiety
Mediterranean-style Dietary Pattern (MDP), Mood and Anxiety
Observational studies and a limited numbers of RCTs have observed that habitual Mediterranean-style dietary pattern (MDP) consumption is associated with improved mental health and cognition.
- Trial name
- MediMood (NCT05927376)
- Testing
- Mediterranean diet, Western diet
- Where
- United Kingdom
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of East Anglia
Mindfulness Based Cognitive Therapy, Depression
MBCT Intervention: Healthy Mind, Healthy Living
Depression among older Korean Americans are rising. Mindfulness-based cognitive therapy (MBCT) is an evidence-based intervention (EBI), effective for preventing depression relapse and reducing depressive symptoms.
- Conditions
- Mindfulness Based Cognitive Therapy, Depression, Sleep, Anxiety Depression
- Trial name
- HMHL (NCT05965349)
- Testing
- Healthy Mind, Healthy Living
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Washington
Depression, Post Traumatic Stress Disorder
Ketamine and Epigenetic Aging
This is a prospective, clinical pilot study (n=20) to evaluate the impact of a ketamine treatment for Major Depressive Disorder (MDD) or Post Traumatic Stress Disorder (PTSD) on epigenetic aging by the TruAge epigenetic age…
- Trial name
- NCT05294835
- Testing
- Ketamine
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- TruDiagnostic
Depression, Anxiety, Self-Injurious Behavior
Brief App-based Mood Monitoring and Mindfulness Intervention for First-year College Students
The investigators examined whether brief, app-based interventions were helpful in alleviating mental health symptoms during the transition to college.
- Trial name
- NCT06348277
- Testing
- Mindfulness plus mood monitoring, Mood monitoring
- Where
- United States
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Lawrence University
Premenstrual Syndromes, Education
Investigation of the Effectiveness of Structured Education According to Premenstrual Syndrome Symptom Map
In this study, it was aimed to evaluate the effectiveness of the training structured according to the PMS symptom map. This experimental (randomised-controlled) study was conducted with women of reproductive age with PMS.
- Conditions
- Premenstrual Syndromes, Education, Menstrual Cycle Disorder
- Trial name
- NCT06585475
- Testing
- Structured training according to premenstrual syndrome symptom map
- Where
- Turkey (Türkiye)
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- Sakarya University
Anxiety, Microbiome
Microbiome, Anxiety and Cognitive Orientation Study
Mounting evidence shows that the gut microbiome plays an important role in communication within the gut-brain axis. However, the relationship between gut microbiota and their influence on anxiety is still not fully understood.
- Conditions
- Anxiety, Microbiome, Mood Disorders, Neurodegeneration
- Trial name
- MACO (NCT05388630)
- Where
- United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Endominance
Depression, Anxiety
Mechanism of Antidepressant-Related Dysfunctional Arousal in High-Risk Youth
A 16-week double blind, placebo-controlled investigation of escitalopram in adolescents with depression and/or anxiety with a family history of Bipolar Disorder.
- Conditions
- Depression, Anxiety, Bipolar Disorder
- Trial name
- NCT02553161
- Testing
- Escitalopram, Cognitive behavioral Psychotherapy
- Where
- 2 sites in United States
- Volunteers
- 214 people, healthy volunteers welcome
- Sponsor
- University of Cincinnati
LPS, Mood Disorders
Resistance Exercise Plus Vinegar Ingestion on Biomarkers in Healthy Adults
Given its capacity to stimulate exercise-induced neuroplasticity at lower doses compared to aerobic exercise, resistance exercise has become the top-recommended rehabilitation approach for individuals with neurocognitive…
- Conditions
- LPS, Mood Disorders, Cognitive Change
- Trial name
- NCT06437405
- Testing
- Vinegar liquid, vinegar pill
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Arizona State University
Depression
Latina Adolescent Depression Treatment Study
Despite experiencing higher rates of depressive symptoms and similar rates of Major Depressive Disorder (MDD), Latina (female) adolescents in the U.S.
- Trial name
- NCT04164537
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Duke University
Depression
A Relative Bioavailability Study of Bupropion HCI 150 mg Sustained-Release Tablets Under Fasting Conditions
The purpose of this study is to demonstrate the relative bioequivalence of Bupropion HCI 150 mg SR Tablets under fasting conditions.
- Trial name
- NCT00864981
- Testing
- Bupropion HCI ER Tablets, 150 mg; EON Labs Inc., WELLBUTRIN SR (Bupropion HCI) Sustained-Release Tablets, 150 mg; GlaxoSmithKline
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Sandoz
Major Depressive Episode (MDE), Beliefs
Belief Update: The Effects of Depression and Antidepressants in Older People
People in good health do not perceive the future in the same way as those suffering from depression. This difference in perception affects behaviour and emotions and warrants further investigation, both before and after treatment…
- Conditions
- Major Depressive Episode (MDE), Beliefs, Beliefs About Future, Depression
- Trial name
- OLDBELIEFS (NCT07681492)
- Testing
- Response to questionnaire
- Where
- 2 sites in France
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Hospital Center Guillaume Régnier
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