Clinical trials: Depressive Disorders
Depression, Anxiety
Mental Health E-screening in Pregnant and Postpartum Women
To compare e-screening versus usual screening on: 1) women's and healthcare providers' views on feasibility and acceptability; 2) rates of detection of prenatal and postpartum depression and anxiety; 3) perceived risk and benefit…
- Trial name
- NCT01899534
- Testing
- E-screening
- Where
- 3 sites in Canada
- Volunteers
- 566 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Major Depressive Disorder
Multimodal MRI Study of Acupuncture's Rapid Antidepressant Mechanisms and Response Prediction in Depression
This study aims to investigate the rapid antidepressant effects of acupuncture and to explore the underlying brain mechanisms using multimodal MRI techniques.
- Trial name
- NCT07611487
- Testing
- Acupuncture
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital of Tsinghua University
Group Meetings
Feasibility of Therapy Integrating Peer-sharing, Technology, Aerobic and Resistance Training (TIPSTART)
The purpose of this randomized controlled clinical trial with first-generation college students with symptoms of mental illness is to test the preliminary feasibility and efficacy of TIPSTART, a multi-faceted, mental health and…
- Trial name
- TIPSTART (NCT04813198)
- Testing
- TIPSTART
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Urbana-Champaign
Multiple Sclerosis
Multidimensional Assessment of Fatigue in Multiple Sclerosis- Observational Study - Ticino
Fatigue is a common symptom in patients with multiple sclerosis, however, its nature is not completely understood. Fatigue overlaps often with other symptoms such as somnolence, depression and cognitive disorders, from which it…
- Trial name
- NCT02082002
- Where
- Switzerland
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- Claudio Gobbi
Sleep Disorder (Disorder), Anxiety Depression Disorder
The Effect of Avnace eZZe on Sleep Improvement
This study aims to examine the effectiveness of Avance eZZe drink with liposomal technology in improving sleep quality. Participants will be randomly assigned to either the placebo group, Avance eZZe drink group, and Avance eZZe…
- Trial name
- NCT07172607
- Testing
- Avance eZZe drink, Avance eZZe drink (without liposomal)
- Where
- Taiwan
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- TCI Co., Ltd.
Stress, Psychological, Depression
Evaluating an Online Acceptance and Commitment Training Program for Individuals with Chronic Health Conditions
Chronic health conditions (CHC) commonly share the challenge of impaired health-related quality of life, negatively impacting the lives of millions of people in the United States.
- Conditions
- Stress, Psychological, Depression, Well-Being, Psychological
- Trial name
- NCT06179264
- Testing
- ACT Guide for Chronic Health Conditions
- Where
- United States
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- Utah State University
Major Depression, Mania
Reliability and Validity of the MINI International Neuropsychiatric Interview for Children and Adolescents (MINI-KID)
The primary aims of this study are to assess: 1. The inter-rater and test-retest reliability of the MINI-KID 2. The validity of the standard MINI-KID interview in relation to the parent rated pencil/paper version (MINI-KID-P) and…
- Conditions
- Major Depression, Mania, Anxiety Disorders, Psychotic Disorder
- Trial name
- NCT00579267
- Testing
- MINI-KID
- Where
- United States
- Volunteers
- 230 people, healthy volunteers welcome
- Sponsor
- University of South Florida
Pregnancy, Pre-eclampsia
Oxfordshire Women and Their Children's Health
The aim of this feasibility study is to test recruitment of participants into Phase 1 of the study and then the re-recruitment and retention of participants in Phase 2 of the study.
- Conditions
- Pregnancy, Pre-eclampsia, Gestational Diabetes, Depression
- Trial name
- OxWATCH (NCT02419898)
- Where
- United Kingdom
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Oxford University Hospitals NHS Trust
Psychosocial Functioning, Mindfulness
Psychosocial Effects of Mindfulness-Based Exercise in Postmenopausal Women
Menopause is a natural biological process characterized by the permanent cessation of the menstrual cycle in women. Hormonal changes associated with menopause commonly lead to mood swings, anxiety, depression, stress, and…
- Conditions
- Psychosocial Functioning, Mindfulness, Postmenopausal Symptoms
- Trial name
- NCT07424521
- Testing
- Mindfulness-Based Stress Reduction Training
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Halic University
Perinatal Depression
Center M Randomized Trial
This is a randomized controlled trial with an intervention of Center M compared to treatment as usual. Center M consists of weekly digital one-hour group sessions led by a trained therapist aligned with mindfulness based…
- Trial name
- NCT07304895
- Testing
- Center M
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
University Students, Psychological Well Being
Development of the Online Mindfulness-based Intervention (Mind Space Application) for Thai-university Students: Phase II
Development of the online mindfulness-based intervention (MFU-mindful Application for Thai university students: Phase II Objectives: Phase I: (October 2025 to September 2026) 1.
- Conditions
- University Students, Psychological Well Being, Mindfulness
- Trial name
- NCT07346612
- Testing
- mind space intervention
- Where
- Thailand
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Mae Fah Luang University
Depression
A Genotype Stratification Study for Pharmacokinetics and Pharmacodynamics of Amitriptyline in Healthy Male Subjects
A total of 24 healthy Korean male subjects will receive a single oral dose of amitriptyline, 25 mg. Subjects will be enrolled in this study based on their cytochrome P450 2D6 and cytochrome P450 2C19 genotypes, and serial blood…
- Trial name
- NCT02519400
- Testing
- Amitriptyline
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Asan Medical Center
Dementia (Diagnosis), Alzheimer Dementia (AD)
Speech-Based Artificial Intelligence for Detection of Dementia in Danish Patients (DetectAI)
The goal of this observational study is to learn if an artificial intelligence (AI)-based speech analysis tool can identify which patients with memory problems need specialist evaluation at a memory clinic.
- Conditions
- Dementia (Diagnosis), Alzheimer Dementia (AD), Vascular Dementia (VaD), Lewy Body Dementia (LBD)
- Trial name
- DetectAI (NCT07200739)
- Testing
- Mini-mental State Examination, Addenbrooke's Cognitive Examination, Speech Task - Picture Description
- Where
- Denmark
- Volunteers
- 440 people, healthy volunteers welcome
- Sponsor
- Zealand University Hospital
Polycystic Ovary Syndrome
The Effect of Escitalopram in PCOS
In a randomized study the investigators aim to characterize the effect of antidepressive medicine on quality of life, body composition, adrenal activity and glucose metabolism in PCOS.
- Trial name
- NCT05840692
- Testing
- Escitalopram 20 mg
- Where
- Denmark
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Odense University Hospital
Depressive Disorder, Major
Alpha-Stim AID and Major Depressive Disorder
The study will be a multi-centre parallel group, double blind, non-commercial, randomised controlled superiority trial. Study participants will be referred from Primary Care GP practices via their GP and randomised into active…
- Trial name
- NCT04963907
- Testing
- Active Alpha-Stim CES
- Where
- United Kingdom
- Volunteers
- 230 people, healthy volunteers welcome
- Sponsor
- Electromedical Products International, Inc.
Major Depressive Disorder (MDD), Healthy Adult Volunteer
Emotional Cognition: Establishing Constructs and Neural-Behavioral Mechanisms in Older Adults With Depression
This is a cross-sectional pilot study designed to establish hot and cold cognitive functions and underlying neurocircuitry in older adults with MDD. The investigators will study 120 participants aged 21-80 years old with MDD.
- Trial name
- ENSURE (NCT05966532)
- Testing
- Hot Cognitive Task, Cold cognitive tasks, Structural magnetic resonance imaging (sMRI)
- Where
- 2 sites in United States
- Volunteers
- 276 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Mild Cognitive Impairment
WAVE: AudioVisual Stimulation Enhances Cognitive, Mental and Physical Health in Elderly
The goal of this randomized controlled trial is to 1) carry out a screening of cognitive function, depressive symptoms, agility and functional balance and chronic inflammatory conditions in older adults; 2) analyze the influence…
- Trial name
- NCT06686563
- Testing
- Intervention Group: Gamma stimulation, Control Group: Theta stimulation
- Where
- Portugal
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Maria Paço
Mental Health, Neurological Health
Brain Cooling Biomarkers
This research is being done to examine the effects of brain cooling on cognition, electrophysiological brain activity via EEG scans, inflammation of the brain, and mood in healthy subjects.
- Trial name
- NCT06542419
- Testing
- Brain Cooling
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Penn State University
Primary Care
Integrating Well-Woman and Well-Baby Care to Improve Parenting and Family Wellness
We hypothesize that relative to families who receive standard individual postpartum and pediatric care, families that receive group care will be more likely to have: Improved maternal and child health behaviors: i.e increased…
- Trial name
- NCT00782028
- Testing
- Centering parenting/Group well child care, Standard Care
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Depressive Disorder, Major
Effects of Escitalopram on the Sleep EEG Power in Patients With Major Depressive Disorder
The main objective was to compare the differences of PSG parameters and plasma melatonin levels before and after treatment with escitalopram for 8 weeks.
- Trial name
- NCT04013464
- Testing
- Escitalopram
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Peking University Sixth Hospital
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