Clinical trials: Depressive Disorders
Mental Health, Neurological Health
Brain Cooling Biomarkers
This research is being done to examine the effects of brain cooling on cognition, electrophysiological brain activity via EEG scans, inflammation of the brain, and mood in healthy subjects.
- Trial name
- NCT06542419
- Testing
- Brain Cooling
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Penn State University
Hyperlipidemias, Xerosis
Combined Effect of Acitretin and Narrow Band Ultraviolet B on Vitiligo Repigmentation
Since abnormal keratinocyte (KC) proliferation and differentiation as well as defective E cadherin expression were reported in vitiligo lesions, the investigators set to study the potential efficacy of combining Retinoids, which…
- Conditions
- Hyperlipidemias, Xerosis, Depression, Liver Diseases
- Trial name
- NCT04245319
- Testing
- Acitretin, Narrow band ultraviolet B
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Cairo University
Mild to Moderate Depressive Symptoms
Online Self-healing Program
Background. Almost two thirds of adolescents experience a mental disorder before the age of 25. Among mental disorders, depression is one of the most common among young people aged between 15 to 24, with a prevalence of 13.5% to…
- Trial name
- iCBT-A (NCT07374653)
- Testing
- Online Cognitive Behaviural Therapy, Online Relaxation
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- City University of Hong Kong
Major Depressive Disorder
Study of Ibuprofen Effects on Brain Function
The aim of this project is to determine whether the acute oral administration of Ibuprofen changes the activation pattern in the amygdala and other brain structures during functional magnetic resonance imaging.
- Trial name
- NCT02507219
- Testing
- Ibuprofen
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Laureate Institute for Brain Research, Inc.
Smoking, Depression
Smoking Cessation for Depressed Smokers
Objectives: Primary Aim: To conduct a preliminary randomized trial in smokers with current recurrent major depressive disorder (MDD), current MDD with a single episode of 2 years or more, and current dysthymia comparing combined…
- Trial name
- NCT00494728
- Testing
- Smoking Cessation Treatment, Nicotine Replacement Therapy, CBASP
- Where
- United States
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Substance-Related Disorders, Mental Disorder
Community Health Worker Training to Reduce Depression and Substance Use Stigma in TB/HIV Care in South Africa
Poor engagement in care contributes to HIV- and TB-related morbidity and mortality in South Africa (SA). Community health workers (CHWs) are frontline lay health workers who work to re-engage patients who are lost to follow-up…
- Conditions
- Substance-Related Disorders, Mental Disorder, Social Stigma, Depression
- Trial name
- Siyakhana (NCT05282173)
- Testing
- Siyakhana CHW Training
- Where
- South Africa
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- University of Maryland, College Park
Breathing Exercises
The Effect of Diaphragmatic Breathing Exercise on Pain, Anxiety, and Depression
Background: After total knee replacement (TKR) surgery, patients often experience intense levels of pain, stress, and anxiety that can adversely affect postoperative recovery.
- Trial name
- NCT04225169
- Testing
- Breathing exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Çankırı Karatekin University
Depression, Anxiety
Effectiveness of the Safe Haven Application (App) Among Undergraduates
The goal of this randomized controlled trial is to evaluate the effectiveness of the Safe Haven app in reducing mental health symptoms and enhancing mental health literacy in undergraduates at a national university in southern…
- Trial name
- NCT07340983
- Testing
- Safe Haven App
- Where
- Taiwan
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- National Cheng-Kung University Hospital
Primary Headache, Psychological Distress
Impact of MBI on Biopsychosocial Factors and QOL in Children With Primary Headaches
The Randomized Controlled Trial aims to evaluate the effectiveness of a Mindfulness-Based Intervention (MBI) in improving the quality of life and reducing psychological distress in children with primary headaches.
- Conditions
- Primary Headache, Psychological Distress, Emotion Regulation, Childhood Trauma
- Trial name
- NCT06822673
- Testing
- Mindfulness Based Intervention
- Where
- Pakistan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Fatima Jinnah Women University
Depression, Impaired Glucose Tolerance
Mood and Insulin Resistance in Adolescents At-Risk for Diabetes
Background: Type 2 diabetes is a chronic disease that puts individuals at risk for serious health problems like heart disease, kidney failure, vision problems, and stroke.
- Trial name
- NCT01425905
- Testing
- The Blues Program, Hey Durham
- Where
- United States
- Volunteers
- 174 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Anxiety, Depression
Project THINK: Trial of a Brief Cognitive Restructuring Intervention
This project will involve testing a brief (~30 minute) digital intervention aimed at teaching youth the evidence-based strategy of changing unhelpful thoughts (i.e., cognitive restructuring).
- Conditions
- Anxiety, Depression, Stress
- Trial name
- NCT05720741
- Testing
- Project THINK, Project SHARE
- Where
- United States
- Volunteers
- 597 people, healthy volunteers welcome
- Sponsor
- Harvard University
Depressive Symptoms
Cultural Adaptation of the TIM&SARA Prevention Program
Disparities between African-American and European-American youth regarding academic outcomes, mental health, and physical health exist.
- Trial name
- NCT03831139
- Testing
- TIM&SARA
- Volunteers
- 740 people, healthy volunteers welcome
- Sponsor
- University of Louisville
Depression, Post-traumatic Stress Disorder
Evaluating Implementation Strategies to Scale-up Transdiagnostic Evidence-based Mental Health Care in Zambia
This study utilizes a Hybrid Type 1 multi-arm parallel group randomized control design to compare the effectiveness of an evidence-based treatment (CETA) delivered either in-person or via telephone, compared with a treatment as…
- Conditions
- Depression, Post-traumatic Stress Disorder, Anxiety, Substance Abuse
- Trial name
- NCT03458039
- Testing
- In-person CETA, Telephone CETA, Treatment as Usual (TAU)
- Where
- Zambia
- Volunteers
- 456 people, healthy volunteers welcome
- Sponsor
- Centre for Infectious Disease Research in Zambia
Depressive Disorder, Endogenous Depression
A Clinical Trial of Fluvoxamine for Melancholia
This study aims at investigating the special effectiveness of antidepressant effect of Fluvoxamine for endogenous depression. The investigators also aim to assess the effect of Fluvoxamine on the multimodal magnetic resonance…
- Conditions
- Depressive Disorder, Endogenous Depression, Melancholia
- Trial name
- NCT04160377
- Testing
- Fluvoxamine
- Where
- China
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Lingjiang Li
Depression, Anxiety Disorders
Rumination-focused CBT Training for the Prevention of Depression and Anxiety
Depression and anxiety disorders are highly prevalent and associated with reduced quality of life for patients and enormous economic costs for society.
- Trial name
- NCT01223677
- Testing
- Rumination Focused CBT
- Where
- Netherlands
- Volunteers
- 251 people, healthy volunteers welcome
- Sponsor
- VU University of Amsterdam
Major Depressive Disorder, Bipolar Disorder
Brain Mechanisms of Human Motivation
This study aims to investigate reward learning across the mood disorder spectrum and to investigate the predictive validity of reward learning for subsequent symptom severity.
- Trial name
- NCT01976975
- Where
- United States
- Volunteers
- 270 people, healthy volunteers welcome
- Sponsor
- Mclean Hospital
Depression, Awareness
Faith and Community in Action: Increasing Awareness and Management of Depression in African American Communities
Specific Aims/Study Objectives: 1. Evaluate acceptability and implementation of the "Oh Happy Day: Still I Rise Class," which comprise a one-time 4-hour class in which participants will learn about depression with the goal of…
- Conditions
- Depression, Awareness, Self-management
- Trial name
- NCT03940157
- Testing
- Oh Happy Day Class - Still I Rise
- Where
- United States
- Volunteers
- 113 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Emotional Distress, Anxiety
Conceptualization and Scale Development of Excessive Emotional Behaviors
Emotional disorders, including anxiety and depression, represent a major global health burden and are increasingly conceptualized within a transdiagnostic framework.
- Conditions
- Emotional Distress, Anxiety, Depression Anxiety Disorder
- Trial name
- NCT07558772
- Where
- China
- Volunteers
- 637 people, healthy volunteers welcome
- Sponsor
- Xinghua Liu
Depression
Mobile Sensing and Support for Depression
The objective of this study is two fold, first to explore the potential of context sensitive intervention delivery to provide in-situ support for people with depressive symptoms, second to explore the detection of daily-life…
- Trial name
- MOSS (NCT02776839)
- Testing
- Mobile sensing
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Depressive Disorder
Effect of Nicotine on Brain Reward Pathways
The investigators will determine whether an acute dose of nicotine, in the form of the nicotine lozenge, impacts brain and behavioral measures of mood and reward responsiveness in individuals with major depressive disorder.
- Trial name
- NCT02346539
- Testing
- Nicotine polacrilex
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Mclean Hospital
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