Clinical trials: Depressive Illness
Maternal Depressive Symptom and Child Development
Effect of Community Based Depression Management and Child Development
Investments in Early childhood Development (ECD) programs produce higher economic return through maximizing human potential. In developing countries over 200 million children do not reach their developmental potential.
- Trial name
- NCT02719054
- Testing
- Cognitive behavioral therapy: Alter of negative thinking, positive thinking and social support and psychosocial stimulation: play stimulation and parenting
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh
Pregnancy Related, Depression
Art Therapy in Obstetric Patients
This is a prospective study examining the potential impact art therapy has on postpartum depression and mother-baby bonding in women. Women who receive care at Washington Hospital Center's will be recruited for this study.
- Trial name
- NCT05503056
- Testing
- art therapy, nothing
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Medstar Health Research Institute
Bipolar Disorder, Depressive Disorder
Prediction on the Recurrence of Manic and Depressive Episodes in Bipolar Disorder
Mood disorders (including bipolar disorder and major depressive disorder) are chronic mental disorders with high recurrent rate. The more the number of recurrence is, the worse long-term prognosis is.
- Trial name
- NCT05828056
- Testing
- Wearable activity tracker
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- National Taiwan University Hospital
Major Depressive Disorder, Alcohol Use Disorder
Double-blind Pilot Trial of Mirtazapine for the Treatment of Co-occurring AD/MDD.
Mirtazapine is a non-SSRI (selective serotonin reuptake inhibitor) medication with a unique structure and mechanism of action. Recent study results suggest that mirtazapine may be more effective and faster acting than other…
- Trial name
- PT-MAD (NCT02185131)
- Testing
- Mirtazapine
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- University of Pittsburgh
Major Depressive Disorder
Rapid Antidepressant Effects of Leucine
This randomized double-blind placebo-controlled crossover study seeks to evaluate the antidepressant effect of L-leucine, an essential amino acid, in patients with Major Depressive Disorder (MDD).
- Trial name
- NCT03079297
- Testing
- L-Leucine, Maltodextrin
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- University of Texas Southwestern Medical Center
Depression, Anxiety
Impact of Ketamine On Depressive Symptoms In Patients Undergoing Lumbo-peritoneal Shunt Insertion
Postoperative depression is a perioperative psychological complication that severely affects patient recovery and quality of life. In extreme cases, it may lead to suicidal behavior.
- Trial name
- NCT06060210
- Testing
- normal Saline, Ketamine
- Where
- Egypt
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Benha University
Affective Disorder, Major Depressive Disorder
The Effect of IPS-MA- A Modified Early Supported Employment Intervention for Individuals With Mood or Anxiety Disorders
The aim of the present study, is to evaluate the effect of a supported employment intervention, IPS-modified for people with mood and anxiety (IPS-MA) on employment or education, when offered to people with onset mood or anxiety…
- Conditions
- Affective Disorder, Major Depressive Disorder, Bipolar Disorder, Anxiety Disorder
- Trial name
- NCT01721824
- Testing
- The IPS-MA method
- Where
- Denmark
- Volunteers
- 326 people
- Sponsor
- Amager Hospital
Depression, Unipolar Depression
Effectiveness of Light Therapy Across Seasons
This study investigates whether the antidepressant effects of bright light therapy (BLT) differ between the spring/summer season and the autumn/winter season in adults with depressive disorders.
- Conditions
- Depression, Unipolar Depression, Bipolar Depression Depressed Phase
- Trial name
- NCT07599124
- Testing
- Bright Light Therapy
- Where
- Netherlands
- Volunteers
- 212 people
- Sponsor
- Geestelijke Gezondheidszorg Eindhoven (GGzE)
Systemic Lupus Erythematosus, Depression
LUPUS Brain: tACS to Target the Neurophysiology of Depression, Cognitive Deficits, and Pain in Patients With SLE
The purpose of this study is to investigate the effects of a type of non-invasive transcranial alternating current stimulation (tACS) on patients diagnosed with systemic lupus erythematosus (SLE) who are experiencing depression.
- Trial name
- NCT04141046
- Testing
- XCSITE100 Stimulator - Individualized theta-tACS, XCSITE100 Stimulator - Individualized alpha-tACS
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University of North Carolina, Chapel Hill
Autism Spectrum Disorder
The Relationship Between Parents' Fatigue and Quality of Life
By comparing them to a healthy control group, this study aims to investigate the relationship between the participation of children with autism spectrum disorder (ASD) in home, school, and community environments and their…
- Trial name
- NCT05422261
- Where
- Turkey (Türkiye)
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- Akdeniz University
Burnout, Anxiety
Art Therapy to Address Hospital Clinician Burnout
A structured group art therapy intervention, comprising six 60 - 90-minute weekly workshops.
- Conditions
- Burnout, Anxiety, Stress, Depression
- Trial name
- CHArt (NCT05728086)
- Testing
- Group art therapy
- Where
- United Kingdom
- Volunteers
- 131 people, healthy volunteers welcome
- Sponsor
- Barts & The London NHS Trust
Major Depressive Disorder, Dysthymia Disorder
Oxytocin Add-on for Stable Depressed Patients
The objective of the study is to compare the efficacy of intranasal oxytocin versus intranasal placebo to improve depression symptoms in patients with Major Depressive Disorder (MDD) or Dysthymia Disorder.
- Trial name
- NCT01211756
- Testing
- Oxytocin
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- David Feifel
Depression, Post-Traumatic Stress Disorder
Depression Screening in Primary Care: Using HIT for Patients With Limited English
This study assessed the potential of Health Information Technology (HIT) to improve the screening, diagnosis, and treatment of depression and post-traumatic stress among LEP Southeast Asians.
- Trial name
- NCT03191929
- Testing
- HIT Intervention, Minimal Intervention Control Arm
- Volunteers
- 410 people
- Sponsor
- Dara Sorkin
Depression, Sleep
The Acute Effect of Aerobic Exercise on Sleep in Patients With Depression
The aim of this trial is to investigate the effects of a single bout of aerobic exercise on sleep in patients with depression.
- Conditions
- Depression, Sleep, Sleep Disorder, Sleep Disturbance
- Trial name
- EASED (NCT03673397)
- Testing
- Aerobic exercise, bicycle ergometer
- Where
- Switzerland
- Volunteers
- 92 people
- Sponsor
- Oberwaid AG
Mood, Stress
Walking Green: The Effects of Walking in Forested and Urban Areas
This research hypothesizes that moderate physical activity in a "green environment" (e.g. a forest preserve path) has increased benefits on psychological measures (stress, anxiety, mood, depression, attention) and on…
- Conditions
- Mood, Stress, Anxiety, Depression
- Trial name
- NUWG (NCT03950661)
- Testing
- Walking
- Where
- United States
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Depression, Anxiety, Mental Health Issue
Clinical Outcomes of a Digital Mental Health Intervention for Moderate/Severe Depression and Anxiety
A digital mental health intervention (BetterHelp, Mountain View, CA) provides users with access to online therapy care for treatment of depression and anxiety.
- Conditions
- Depression, Anxiety, Mental Health Issue, Mental Health Wellness 2
- Trial name
- NCT07081061
- Testing
- BetterHelp
- Where
- United States
- Volunteers
- 86 people
- Sponsor
- Teladoc Health
Depression, Alexithymia
Effects of 12-week Exercises on Alexithymia, Depression and Quality of Life in Geriatric Individuals
The aim of this study is to investigate the effects of aerobic and resistance exercises on depression, alexithymia levels and quality of life of elderly individuals.
- Conditions
- Depression, Alexithymia, Quality of Life, Physical Inactivity
- Trial name
- EXQUALITY (NCT05342142)
- Testing
- Aerobic and ResistanceExercise
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey
Treatment Resistant Depression, Major Depressive Disorder
Dose-Optimized and Spaced Transcranial Direct Current Stimulation for Treatment-Resistant Depression
This study aims to evaluate the feasibility, safety, and tolerability of an innovative approach to treating Major Depressive Disorder (MDD), particularly in cases where patients have not responded well to traditional therapies.
- Trial name
- DOS (NCT06730841)
- Testing
- Dose-Optimized and Spaced Transcranial Direct Current Stimulation, Spaced Transcranial Direct Current Stimulation
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- University of California, San Diego
Depression
Can Additional Drug Therapy Accelerate Response Time to Antidepressants
Antidepressants are commonly prescribed and are effective for treating depression. However, they generally take 4-6 weeks for a therapeutic response.
- Trial name
- NCT00221494
- Where
- United States
- Sponsor
- Mark Frye
Stroke, Depression
Poststroke Depression of Clinical Trial Registration
The investigators aim to explore the relationship between gut microbiota composition and earlier poststroke depression via 16S rRNA sequencing.
- Trial name
- IFEPSDAIS (NCT03863951)
- Where
- China
- Volunteers
- 100 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
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