Clinical trials: Depressive State
Stroke, Depression
MEditation for Post Stroke Depression
The purpose of this study is to establish the feasibility and acceptability of a breath-based meditation in stroke survivors with post-stroke depression (PSD) and their informal caregivers, as well as to examine the effects of…
- Trial name
- MEND (NCT03239132)
- Testing
- Breath-based meditation, Meditation educational materials
- Where
- United States
- Volunteers
- 71 people
- Sponsor
- The University of Texas Health Science Center, Houston
Cystic Fibrosis
Impact of the Introduction of ORKAMBI on Anxiety, Depression, Quality of Life and Adherence of Adolescents and Young Adults
The aim of this project is to evaluate the psychological reshuffle induced by ORKAMBI. The particular focus of this study is the consequence of its introduction on anxiety, depression, quality of life and adherence to all cystic…
- Trial name
- ORK-AJA (NCT03659214)
- Testing
- Questionnaires
- Where
- France
- Volunteers
- 19 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Depression, Type 1 Diabetes
Cognitive Behavioral Therapy (CBT) for Adherence and Depression in Type 1 Diabetes
This study is a pilot behavioral intervention trial, designed to initially examine cognitive behavioral therapy for medical adherence and depression (CBT-AD) in patients with depression and poorly controlled type 1 diabetes.
- Trial name
- NCT01527981
- Testing
- Cognitive behavioral therapy for adherence and depression
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Massachusetts General Hospital
Treatment Resistant Depression
The Safety and Efficacy of Psilocybin in Participants With Treatment Resistant Depression
The Safety and Efficacy of Psilocybin in Participants with Treatment Resistant Depression
- Trial name
- P-TRD (NCT03775200)
- Testing
- Psilocybin
- Where
- 25 sites in United States, Canada and 8 more
- Volunteers
- 233 people
- Sponsor
- COMPASS Pathways
Traumatic Brain Injury
Observational Study of Cortical Spreading Depression in Human Brain Trauma
Since the primary damage from traumatic brain injury (TBI) is irreversible, the focus of medical management of TBI is preventing secondary injury that can be life-threatening and worsen patient outcome.
- Trial name
- COSBID-TBI (NCT00803036)
- Where
- 5 sites in United States, United Kingdom
- Volunteers
- 165 people
- Sponsor
- University of Cincinnati
Stress Disorders, Post-Traumatic, Depressive Symptoms
Mindfulness-based Intervention to Address PTSD in Trauma-exposed, Homeless Women
Posttraumatic stress disorder (PTSD) is a major public health concern that disproportionately effects minorities and those with low-socioeconomic status, such as homeless women, creating a critical health disparity.
- Conditions
- Stress Disorders, Post-Traumatic, Depressive Symptoms, Hydrocortisone, Substance Use
- Trial name
- NCT04605198
- Testing
- Modified Mindfulness-based Stress Reduction, Health Promotion Wellness Classes
- Where
- 2 sites in United States
- Volunteers
- 156 people
- Sponsor
- University of California, Los Angeles
Anxiety, Depression
Sexual and Gender Minority Youth (SGMY) and Online Interventions to Increase Help-seeking for Anxiety and/or Depression
the investigators will use 4 technology based tools (combinations of youtube videos, links to online resources, tiktok videos, and other media) in a study of 96 Sexual and Gender Minority Youth (SGMY) to determine the…
- Conditions
- Anxiety, Depression, Adolescent Behavior, Sexual and Gender Minorities
- Trial name
- NCT06083987
- Testing
- Intersectionality and Identity, Confidentiality, Educating Your Community
- Where
- United States
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Depressive Disorder, Treatment-Resistant
Lithium Versus Quetiapine in Treatment Resistant Depression
LQD is a multicentre randomised clinical trial comparing the clinical and cost effectiveness of lithium versus quetiapine when used as add-on therapies to antidepressant medication for patients with treatment resistant…
- Trial name
- LQD (NCT03004521)
- Testing
- Quetiapine, Lithium
- Where
- United Kingdom
- Volunteers
- 276 people
- Sponsor
- King's College London
Arrhythmia, Quality of Life
Psychosomatic Effects of Implantable Cardioverter Defibrillator With Home Monitoring Function (QUANTUM)
Quality of life (QOL) and psychological well-being of patients with implantable cardioverter-defibrillators (ICDs) are significantly influenced by the experience of shock therapies.
- Trial name
- NCT00325221
- Testing
- HM on, HM Off
- Where
- 7 sites in Austria, Germany and 1 more
- Volunteers
- 148 people
- Sponsor
- Biotronik SE & Co. KG
Positive Affect, Depression
Virtual Reality-Reward Training for Anhedonia
The purpose of this study is to compare the effects of Virtual Reality-Reward Training (VR-RT) with an active control condition, Virtual Reality-Memory Training (VR-MT), on positive affect and other clinical symptoms.
- Trial name
- VR-RT (NCT05342077)
- Testing
- Virtual Reality-Reward Training (VR-RT), Virtual Reality-Memory Training (VR-MT)
- Where
- United States
- Volunteers
- 59 people
- Sponsor
- University of California, Los Angeles
Depression
Transcranial Direct Current Stimulation for Depression
Background: Depression is a common mental disorder characterized by persistent low mood and anhedonia. Pharmacological and psychotherapeutic treatments demonstrate only moderate efficacy.
- Trial name
- NCT07500064
- Testing
- transcranial direct current stimulation (tDCS)
- Where
- China
- Volunteers
- 50 people
- Sponsor
- The Second Hospital of Anhui Medical University
Internalizing Mental Health Symptoms, Sleep Problems
Pilot Sleep Extension and Mood
The goal of this interventional study is to learn if a digital sleep extension intervention can improve sleep and mood in young urban adults with mood symptoms.
- Trial name
- NCT06675799
- Testing
- Sleep Extension, Healthy Living Psychoeducation
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- University of Illinois Chicago
Depressive Symptoms
Intervention Effect of Emotional Working Memory Training on University Students With Depressive Symptom
Objective: To investigate the effects of emotional working memory training (EWM-T) on depressive symptoms and rumination among university students.
- Trial name
- NCT05861414
- Testing
- EWM-T
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Yu-hua Weng
Major Depressive Disorder
ALTO-300 in Depression (ALTO-300-004)
The purpose of this study is to collect biologically-based data for defining predictors and correlates of the effects of ALTO-300.
- Trial name
- NCT05157945
- Testing
- ALTO-300 PO Tablet
- Where
- 4 sites in United States
- Volunteers
- 148 people
- Sponsor
- Alto Neuroscience
Depression, Anxiety Disorders
Rumination-focused CBT Training for the Prevention of Depression and Anxiety
Depression and anxiety disorders are highly prevalent and associated with reduced quality of life for patients and enormous economic costs for society.
- Trial name
- NCT01223677
- Testing
- Rumination Focused CBT
- Where
- Netherlands
- Volunteers
- 251 people, healthy volunteers welcome
- Sponsor
- VU University of Amsterdam
Depression - Major Depressive Disorder, Depression Disorder
Virtual Reality-Based Mindfulness as an Adjunct to Treatment as Usual in Treatment-Resistant Depression
The primary aim of this study is to evaluate the efficacy and tolerability of a combined Virtual Reality (VR)-based mindfulness intervention and pharmacological treatment compared with pharmacological treatment alone in reducing…
- Conditions
- Depression - Major Depressive Disorder, Depression Disorder, Depression Chronic, Treatment-Resistant Major Depressive Disorder
- Trial name
- NCT07422519
- Testing
- Virtual-Reality-based mindfulness intervention, Esketamine Treatment as Usual (ESK)
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Depression, Interpersonal Relations
IPT-based Group Intervention by Non-specialist for Improvement of Depressive Symptoms in Community Young Adults in Brazil
Major depressive disorder is a highly prevalent, recurrent, and debilitating disease, the third cause of years of lost life in the world, and it may be the most common disease in 2030, according to the World Health Organization…
- Trial name
- NCT06480019
- Testing
- Interpersonal psychotherapy
- Where
- Brazil
- Volunteers
- 50 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Alcohol Abuse or Dependence, Alcohol Use Disorder
Examination of Whether an Exercise Programme Reduces Alcohol Consumption Among Alcohol-Dependent Adults
This study is composed of two phases. Phase 1 will determine baseline demographic characteristics of participants, currently drinking harmful amounts of alcohol, who would be interested in an alternative treatment option to…
- Trial name
- AOA (NCT03848000)
- Testing
- Exercise Programme, NHS Standard Care
- Where
- United Kingdom
- Volunteers
- 53 people
- Sponsor
- Queen Mary University of London
Psychological Distress, Depressive Symptoms
Nature Photography for Mental Well-Being and Nature Connectedness in Young Adults
This study tests whether a nature photography intervention can improve mental well-being and nature connectedness in young adults with mild emotional distress, and examines self-compassion as a key mechanism in this process.
- Conditions
- Psychological Distress, Depressive Symptoms, Anxiety Symptoms
- Trial name
- NCT07803367
- Testing
- Nature-Based Mindful Photography, Human-Made Object Photography, Self-Guided Digital Stress Management Handbook
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Beijing Normal University
Depressive Disorder, Depression in Adolescence
Evaluation of a Website to Improve Depression Literacy in Parents of Adolescents With Depression
The aim of this study is to evaluate the efficacy and acceptability of the website "ich bin alles" (https://www.ich-bin-alles.de/) to improve depression literacy (knowledge about depression, which aid the recognition, treatment…
- Trial name
- NCT05335564
- Testing
- General information about depression
- Where
- Germany
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Ludwig-Maximilians - University of Munich
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