Clinical trials: Depressive State
Advanced Cancers
The Use of Light Therapy for Managing Sleep Disturbances in Patients With Advanced Cancer
The goal of this research study is to learn if a type of light therapy can be used to help patients with advanced cancer who are having difficulty sleeping to sleep better.
- Trial name
- NCT01193530
- Testing
- Bright Light Therapy, Dim Red Light Therapy, Questionnaires
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- M.D. Anderson Cancer Center
Depression, Depressive Symptoms
Evaluation of a Proactive Identification and Digital Mental Health Intervention Approach to Address Unmet Psychosocial Needs of Individuals Living With Cancer
The purpose of this research study is to evaluate a mobile application (app) for depression treatment called "Moodivate" among cancer survivors.
- Conditions
- Depression, Depressive Symptoms, Cancer
- Trial name
- NCT05932810
- Testing
- Behavioral Activation Therapy app, Treatment as Usual
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Medical University of South Carolina
Leg Cramp, Nocturnal
Effect of Theraworx/[pH]Uel on Night-time Leg Cramps and Spasm Symptoms
The purpose of this study is to determine the effect of Theraworx/[pH]uel on the frequency and severity of night-time cramps and spasms symptoms, including quality of life, depression and sleep quality when compared to a placebo.
- Trial name
- NCT03159260
- Testing
- Theraworx
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- Sport and Spine Rehab Clinical Research Foundation
Chronic Pain
A Depression and Opioid Pragmatic Trial in Pharmacogenetics (Chronic Pain Trial)
This study is comprised of three separate pharmacogenetic trials grouped into a single protocol due to similarities in the intervention, the hypotheses, and the trial design.
- Trial name
- ADOPT PGx (NCT05966142)
- Testing
- Pharmacogenetic testing, Clinical decisions support
- Where
- 10 sites in United States
- Volunteers
- 1,048 people
- Sponsor
- Duke University
Postpartum Depression
Escitalopram (Lexapro) for the Treatment of Postpartum Depression
The purpose of this study is to determine whether women with postpartum major depressive disorder (MDD) will experience a significant decrease in depressive symptoms from baseline over an eight-week treatment intervention with…
- Trial name
- LexaproPPD (NCT00833469)
- Testing
- Escitalopram
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Massachusetts General Hospital
Bipolar Depression
Magnetic Resonance Imaging Study of Lisdexamfetamine for Bipolar Depression
There have been reports that stimulants may be effective for bipolar depression without triggering mania. This study will examine whether lisdexamfetamine can improve depressive symptoms over the course of eight weeks.
- Trial name
- NCT01051440
- Testing
- Lisdexamfetamine
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Steward St. Elizabeth's Medical Center of Boston, Inc.
Depression
Buprenorphine for Late-Life Treatment Resistant Depression
The goals of this pilot study are to gather data about the safety and clinical effect of low-dose buprenorphine in older adults with treatment resistant depression.
- Trial name
- BUILD (NCT01071538)
- Testing
- Buprenorphine
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Pittsburgh
PTSD, Depression
Online and Shared Decision-Making Interventions to Engage Service Men and Women in Post-Deployment Mental Health Care
OEF/OIF/OND war Veterans have unique post-deployment care needs that the VA is striving to understand and address. Unfortunately, there is a significant disparity in utilization of mental health (MH) care and VA access as most…
- Conditions
- PTSD, Depression, Substance Use Disorder, Traumatic Brain Injury
- Trial name
- eSDM (NCT03539068)
- Testing
- WEB-ED+ Treatment Arm
- Where
- United States
- Volunteers
- 1,312 people
- Sponsor
- VA Office of Research and Development
Bipolar Depression, Suicidal Ideas
Sequential Therapy for the Treatment of Severe Bipolar Depression.
NeuroRx is developing NRX-101, a fixed-dose combination oral capsule composed of d-cycloserine (DCS) and lurasidone for the maintenance of remission from Severe Bipolar Depression with Acute Suicidal Ideation (C-SSRS level 4 or…
- Conditions
- Bipolar Depression, Suicidal Ideas, Suicidal Ideation, Suicide, Attempted
- Trial name
- STABIL-B (NCT02974010)
- Testing
- NRX-101 Oral Capsule, Lurasidone Oral Capsule, Ketamine Intravenous Infusion
- Where
- 4 sites in United States
- Volunteers
- 22 people
- Sponsor
- NeuroRx, Inc.
Major Depressive Disorder
Closed-loop Optimized rTMS for Depression
Targeted and individualized treatments for mental health disorders are critically needed. Repetitive transcranial magnetic stimulation (rTMS) represents the front-line of new and innovative approaches to normalizing dysfunctional…
- Trial name
- NCT04142320
- Testing
- Neuronavigated rTMS
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- Stanford University
Burnout, Caregiver, Burnout, Professional
Frontline Clinician Psilocybin Study
This study aims to investigate the effects of a single dose of psilocybin, delivered in the contextof pre- and post-dose psychotherapy, on symptoms of depression and burnout suffered by healthcare clinicians as a result of…
- Conditions
- Burnout, Caregiver, Burnout, Professional, COVID-19, Depression
- Trial name
- NCT05163496
- Testing
- Psilocybin (Usona Institute)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Washington
Major Depressive Disorder
Repetitive Transcranial Magnetic Stimulation for Treating Depression: A Functional Magnetic Resonance Imaging Study
This protocol, "Repetitive Transcranial Magnetic Stimulation (rTMS) for the Treatment of Major Depressive Disorder (MDD): A Functional Connectivity Magnetic Resonance Imaging (fcMRI) Study," is an open-label pilot treatment…
- Trial name
- NCT01162382
- Testing
- Transcranial Magnetic Stimulation
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Washington University School of Medicine
Major Depression, Multiple Sclerosis
Escitalopram (Lexapro) for Depression MS or ALS
The purpose of this study is to see if escitalopram (Lexapro) improves symptoms of major depressive disorder in patients who have ALS or MS.
- Conditions
- Major Depression, Multiple Sclerosis, Amyotrophic Lateral Sclerosis
- Trial name
- NCT00965497
- Testing
- escitalopram
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- University of South Carolina
Depressive Disorder, Treatment-Resistant
Treatment Resistant Depression (Pilot)
Treatment resistant depression (TRD) is a major public health problem. Current therapeutic options for this patient population remain limited.
- Trial name
- NCT01179009
- Testing
- Ketamine, Clonidine
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Washington University School of Medicine
Bone Marrow Transplant, Information Disclosure
Effects of Digital Stories Intervention on Psychosocial Well-being
Patients and caregivers undergoing hematopoietic stem cell transplantation often continue to experience anxiety, depression, isolation, and other psychosocial distress.
- Conditions
- Bone Marrow Transplant, Information Disclosure, Hematopoietic Stem Cell Transplantation, Psychosocial Health
- Trial name
- NCT03654599
- Testing
- Baseline Surveys, Digital Stories Intervention, Information Control Intervention
- Where
- United States
- Volunteers
- 202 people
- Sponsor
- Arizona State University
Depression, Anxiety
Mobile Mental Health Apps for Suicide Prevention
Access to mental health care by essential workers and the unemployed during the COVID19 pandemic has been challenging. Usual access to mental health care is limited by social distancing, and for many now unemployed due to…
- Conditions
- Depression, Anxiety, Emotional Regulation
- Trial name
- NCT04536935
- Testing
- Mobile Mental Health App - 1, Mobile Mental Health App - 2, Mobile Mental Health App - 3
- Where
- United States
- Volunteers
- 838 people
- Sponsor
- University of Washington
Critical Illness, Chronic Disease
Improving Communication About Serious Illness
The purpose of this study is to improve care delivered to patients with serious illness by enhancing communication among patients, families, and clinicians in the outpatient setting.
- Conditions
- Critical Illness, Chronic Disease, Terminal Care, Palliative Care
- Trial name
- ICSI (NCT01933789)
- Testing
- Communication Feedback Form for Patients with Serious Illness
- Where
- 6 sites in United States
- Volunteers
- 817 people
- Sponsor
- University of Washington
Major Depression
A Family-based Primary Care Intervention to Enhance Older Men's Depression Care
Despite the public health importance of clinical depression, more than 50% of depressed adults receive inadequate or no treatment, with even higher rates of under-treatment in men and minorities.
- Trial name
- NCT02143024
- Testing
- Family-based depression intervention, Usual care plus educational materials
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- University of California, Davis
Major Depressive Disorder
Efficacy and Safety of Vortioxetine (Lu AA21004) in the Treatment of Patients With Major Depressive Disorder
The purpose of this study is to determine the efficacy and safety of vortioxetine, once daily (QD), in adults with major depressive disorder.
- Trial name
- NCT00672620
- Testing
- Vortioxetine, Duloxetine
- Where
- 38 sites in United States
- Volunteers
- 611 people
- Sponsor
- Takeda
Depression, Major Depressive Disorder
Flavanol Augmentation for Antidepressant Non-Responsive Late Life Depression
The goal of this proposal is to conduct the first pilot study of whether consuming flavanol supplements will augment the cognitive and mood benefits of antidepressant medication in older adults with Late LifeDepression (LLD).
- Trial name
- Flavanol (NCT02943096)
- Testing
- CocoaVia
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- New York State Psychiatric Institute
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