Clinical trials: Depressive State
Depression
The Safety and Efficacy of Naltrexone and Scopolamine Utilized in the Treatment of Major Depression
The purpose of this clinical trial is to determine the safety and efficacy of scopolamine utilized in conjunction with naltrexone for the treatment of major depression.
- Trial name
- NCT03386448
- Testing
- Scopolamine and naltrexone
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- The Taub Group
Pulmonary Disease, Chronic Obstructive, Sexual Health
Impact of COPD on Sexual Health, Loneliness, and Well-being
Summary Person-centered care is a hot topic within healthcare, yet communication about patients' sexual health and intimacy issues remain too hot to handle within healthcare.
- Conditions
- Pulmonary Disease, Chronic Obstructive, Sexual Health, Loneliness, Well-Being, Psychological
- Trial name
- NCT06240078
- Where
- Denmark
- Volunteers
- 521 people, healthy volunteers welcome
- Sponsor
- Vejle Hospital
Psychological Distress, Depression - Major Depressive Disorder
Internet-based Support for Adjustment to Prostate Cancer
The study aims to study the efficacy of internet-based cognitive behavior therapy (ICBT) in reducing subjective distress and comorbid psychiatric symptoms in men diagnosed with prostate cancer.
- Conditions
- Psychological Distress, Depression - Major Depressive Disorder, Insomnia, Anxiety
- Trial name
- ISAC (NCT06766526)
- Testing
- Internet-based cognitive behavioral therapy, Non-directive support
- Where
- Sweden
- Volunteers
- 180 people
- Sponsor
- Linkoeping University
Depression, Postpartum, Anxiety
eMBC for Perinatal Depression and Anxiety
Depression and anxiety that occur around the time of pregnancy can adversely impact a person's health and well-being, and their child's health and development.
- Trial name
- eMBC (NCT04836585)
- Testing
- eMBC Intervention
- Where
- Canada
- Volunteers
- 42 people
- Sponsor
- Women's College Hospital
Depression
Aripiprazole as Augmentation for TRD
A sizeable minority of patients suffering from major depression do not have their full set of depressive symptoms relieved by a single medication.
- Trial name
- NCT00174876
- Testing
- Drug Abilify
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- State University of New York - Upstate Medical University
Major Depressive Disorder, Psychedelic Experiences
Antidepressant Response of DMT Masked With Propofol
The aim of this study is to elucidate if the anti-depressive effect of N,N-dimethyltryptamine (DMT) is based on a biological mechanisms including neuroplasticity and anti-inflammatory effect or due to the subjective psychedelic…
- Trial name
- DMT4D (NCT06927076)
- Testing
- N,N-Dimethyltryptamine, Propofol, no sedation
- Where
- Switzerland
- Volunteers
- 112 people
- Sponsor
- University Hospital, Basel, Switzerland
Depression, Depressive Disorder
Study of Mind-Body Skills Groups for Adolescents With Depression in Primary Care
The Center for Mind -Body Medicine has developed a mind-body skills group program that incorporates meditation, guided imagery, breathing techniques, autogenic training, biofeedback, genograms, and self-expression through words…
- Trial name
- NCT03363750
- Testing
- mind-body-skills group
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- Indiana University
Postpartum Women
Sleep Architecture as a Digital Biomarker for Postpartum Depression in Hong Kong Mothers
The goal of this study is to develop a postpartum depression (PND) Risk index using the UK Biobank dataset, and to validate the risk index in Hong Kong postpartum women.
- Trial name
- SLEEP-PD-HK (NCT07600593)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Perimenopause, Menopause
Perimenopausal Estrogen Replacement Therapy Study
Study Background and Objectives: In the U.S. the majority of heart disease deaths are in women, not men. Much of the gender disparity in CVD rates relate to the burden of CV risk in women after the menopause.
- Conditions
- Perimenopause, Menopause, Depression
- Trial name
- PERT (NCT01308814)
- Testing
- Estradiol
- Where
- United States
- Volunteers
- 172 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Depression, Anxiety
Integrating Inuit Knowledge Principles in Multi-Level Mental Health Clinical Trials
This study is looking at how eating more country foods affects mental health among Inuit men and women in Arviat, NU. The goal is to evaluate if eating more of these foods helps people feel less depressed or anxious, and whether…
- Trial name
- NCT07014852
- Testing
- Traditional Country Foods, Cultural Workshops
- Where
- 2 sites in Canada
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Grief, Depressive Symptoms
Accelerated Resolution Therapy for Complicated Grief
This study will examine whether accelerated resolution therapy (ART) is effective for the treatment of prolonged and complicated grief and associated psychological trauma among older adult hospice caregivers who have experienced…
- Conditions
- Grief, Depressive Symptoms, Trauma, Psychological
- Trial name
- NCT03484338
- Testing
- Accelerated Resolution Therapy
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- University of South Florida
Perinatal Depression
Hybrid Health Education Intervention Integrated Within a Mental Health Package for Adolescent Perinatal Depression
The goal of this clinical trial is to develop a hybrid E-zine health education intervention integrated within a mental Health package for adolescent perinatal depression.
- Trial name
- E-zineMH (NCT06154655)
- Testing
- E-zine
- Where
- 2 sites in Nigeria
- Volunteers
- 63 people
- Sponsor
- University of Ibadan
Depression, Depressive Disorder
Improving Outcomes in Depression in Primary Care in a Low Resource Setting
The OptimizeD study aims to improve outcomes in depression in primary care in India. This study will randomize 1500 patients with moderate to severe depression to either psychotherapy based on behavioral activation called the…
- Trial name
- OptimizeD (NCT05944926)
- Testing
- Healthy Activity Program (HAP), Antidepressant medication (fluoxetine)
- Where
- India
- Volunteers
- 1,500 people
- Sponsor
- Harvard Medical School (HMS and HSDM)
Major Depressive Episode, ECT
Metabolomics During ElectroConvulsivoTherapy
Investigators will measure the variation of blood Metabolome through 1H NMR at several time points during the course of electroconvulsivetherapy in patients with a major depressive episode.
- Trial name
- METECT (NCT05973643)
- Testing
- Electroconvulsive therapy
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Hôpital le Vinatier
Schizophrenia, Schizoaffective Disorder
Efficacy and Safety Study of Escitalopram Augmentation in Treatment Resistant Schizophrenia
A primary hypothesis to be explored here is that, given its pharmacodynamic profile and hypothesized mechanisms associated with schizophrenia, escitalopram will, in comparison to placebo, be effective when added to risperidone or…
- Trial name
- NCT00231335
- Testing
- escitalopram
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Emory University
Rosacea, Rosacea Subtype 1 (Erythematotelangiectatic)
Brimonidine 0.33% for Rosacea-Related Facial Erythema
This study looks at whether a topical gel called 0.33% brimonidine can reduce persistent facial redness caused by rosacea. The study was carried out in two parts.
- Trial name
- NCT07431476
- Testing
- Brimonidine 0.33% gel
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people
- Sponsor
- Istanbul Training and Research Hospital
Breast Cancer Female, Depression
Moving on After Breast Cancer Plus- for Breast Cancer Survivors
Breast cancer (BC) ranks second among all the types of cancer and is equally common in developing as well as developed countries.
- Trial name
- MovingonABC (NCT03571984)
- Testing
- Moving on ABC Plus
- Where
- Pakistan
- Volunteers
- 354 people
- Sponsor
- Pakistan Institute of Living and Learning
Depression and Suicide
Cognitive Behavioral Therapy Following Esketamine for Major Depression and Suicidal Ideation for Relapse Prevention
This is a rater-blinded, randomized controlled trial. All patients will receive esketamine for treatment of Major Depression with Suicidal Ideation (MDSI).
- Trial name
- ENDURE (NCT04760652)
- Testing
- Cognitive Behavioral Therapy CBT, TAU
- Where
- 3 sites in United States
- Volunteers
- 93 people
- Sponsor
- Yale University
Perimenopausal Depression, Depression
Raloxifene and Rimostil for Perimenopause-Related Depression
The purpose of this study is to evaluate the effectiveness of the drugs raloxifene and rimostil in treating perimenopause-related depression.
- Trial name
- NCT00030147
- Testing
- Raloxifene, Rimostil, Transdermal Estradiol
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- National Institute of Mental Health (NIMH)
Depression
A PK/PD Genetic Variation Treatment Algorithm Versus Treatment As Usual for Adolescent Management Of Depression
The overall goal of this investigator-initiated trial is to evaluate the impact of platform algorithm products designed to rapidly identify pharmacokinetic (PK) and/or pharmacodynamic (PD) genomic variation on treatment outcome…
- Trial name
- AMOD (NCT02286440)
- Testing
- AssureRx GeneSight genotyping results, Treatment as usual
- Where
- 2 sites in United States
- Volunteers
- 179 people
- Sponsor
- Mayo Clinic
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