Clinical trials: Depressive and Anxiety Disorders
Posttraumatic Stress Disorder, Major Depressive Disorder
Risk and Resiliency Factors in the RCMP: A Prospective Investigation
The Royal Canadian Mounted Police (RCMP), like all public safety personnel (PSP), are frequently exposed to potentially psychologically traumatic events that contribute to posttraumatic stress injuries (PTSI).
- Conditions
- Posttraumatic Stress Disorder, Major Depressive Disorder, Panic Disorder, Generalized Anxiety Disorder
- Trial name
- NCT05527509
- Testing
- Emotional Resilience Skills Training (ERST), Active Monitoring
- Where
- Canada
- Volunteers
- 960 people, healthy volunteers welcome
- Sponsor
- University of Regina
Obsessive-Compulsive Disorder, Generalized Anxiety Disorder
Improving Attentional and Cognitive Control in the Psychological Treatment of Intrusive Thoughts
The investigators are conducting this study to learn more about the cognitive and attentional processes among individuals with three types of repetitive negative thinking (RNT): mental rituals (as seen in obsessive compulsive…
- Conditions
- Obsessive-Compulsive Disorder, Generalized Anxiety Disorder, Major Depressive Disorder
- Trial name
- NCT04225624
- Testing
- Emotion Regulation Therapy - Attention Regulation (AR-ERT), Supportive Psychotherapy (SPT)
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Massachusetts General Hospital
Anxiety, Postnatal Depression
Transdiagnostic Internet Cognitive-behavior Therapy for Mixed Anxiety and Depressive Symptoms in Postnatal Women
This research project aims to examine the acceptability and efficacy of a French-Canadian adaptation of a postnatal anxiety and depression program.
- Trial name
- postnataIiCBT (NCT06778096)
- Testing
- Postnatal anxiety and depression iCBTprogram
- Where
- 4 sites in Canada
- Volunteers
- 226 people
- Sponsor
- Université de Sherbrooke
Mental Health Issue, Depressive Symptoms
Piloting +Connection is Medicine / The Healing Spirits Program
This study aims to assess what benefit, if any, an individualized coping plan and facilitating connections to care through referral coordination in conjunction with culturally tailored caring messages, (herein called the…
- Conditions
- Mental Health Issue, Depressive Symptoms, Anxiety
- Trial name
- NCT05424679
- Testing
- Safety Planning Intervention, Caring Contacts
- Where
- 4 sites in United States
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Critical Illness Recovery, Behavioral Health Concerns
Behavioral Health Collaborative Care Model in Post-ICU Clinic Family Pilot
This pilot study evaluates the feasibility and acceptability of implementing a Behavioral Health Collaborative Care Model (BH CoCM) for family members of ICU survivors.
- Conditions
- Critical Illness Recovery, Behavioral Health Concerns, Anxiety, Depression - Major Depressive Disorder
- Trial name
- NCT07390786
- Testing
- Behavioral Treatment
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Medical University of South Carolina
Food Insecurity, Dietary Quality
Enjoying Affordable and Tasty Food Together
The goal of this pilot study is to examine the feasibility of a novel meal kit and nutrition education intervention among adults aged 40 years and older, who are lower income, and to evaluate the preliminary impact of the meal…
- Conditions
- Food Insecurity, Dietary Quality, Quality of Life, Cooking Self-efficacy
- Trial name
- PROJECT EATT (NCT07036757)
- Testing
- Meal Kit and Nutrition Education
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of Massachusetts, Lowell
Inhalation Aromatherapy
Effect of Inhalation Aromatherapy on Anxiety and Depressive Symptoms of Geriatric Patients With Parkinson's Disease
The present study aims to: Investigate the effect of inhalation aromatherapy on anxiety and depressive symptoms of geriatric patients with Parkinson's disease.
- Trial name
- NCT05728177
- Testing
- Inhalation Aromatherapy
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Alexandria University
Breast Cancer Female
EMDR Psychotherapy for Anxious-depressive Symptoms in Breast Cancer Patient
The study will consist in an evaluation of the EMDR (Eye Movement Desensitization and Reprocessing) psychotherapy in the context on invasive primitive breast cancer.
- Trial name
- PSYCANCER (NCT03898453)
- Testing
- EMDR psychotherapy, support psychotherapy
- Where
- France
- Volunteers
- 64 people
- Sponsor
- Centre Hospitalier Régional Metz-Thionville
Depressive Disorder, Anxiety Disorders
Happy Nurse Project: Lifestyle Interventions to Maintain Healthy Mental State in Hospital Nurses
The study is to explore the effectiveness of omega-3 fatty acids and mindfulness-based stress management program to maintain healthy mental state in hospital nurses.
- Trial name
- HNP (NCT02151162)
- Testing
- Mindfulness-based stress management program, Omega-3 fatty acids pills, Psychoeducation leaflet
- Where
- 2 sites in Japan
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- National Center of Neurology and Psychiatry, Japan
Breast Cancer Female NOS, General Anxiety Disorder
Psychological State, Immunotherapy Response, and Multi-Omics Signatures in TNBC
This study aims to evaluate whether psychological status affects the response to neoadjuvant immunotherapy in triple-negative breast cancer (TNBC) and how it relates to immune changes during treatment.
- Conditions
- Breast Cancer Female NOS, General Anxiety Disorder, Depressive Disorder
- Trial name
- SCHBCC-N0105 (NCT07290153)
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Fudan University
Major Depressive Disorder, Post Traumatic Stress Disorder
Ketamine Safety and Tolerability in Psychiatric Inpatient Care (KetGD)
This observational registry aims to collect real-world data on ketamine use in psychiatric inpatients within a regional tertiary-reference center.
- Conditions
- Major Depressive Disorder, Post Traumatic Stress Disorder, Obsessive-Compulsive Disorder, Somatoform Disorders
- Trial name
- KetGD (NCT05565352)
- Testing
- Ketamine Hydrochloride
- Where
- Poland
- Volunteers
- 140 people
- Sponsor
- Medical University of Gdansk
Psychological Distress, Pregnancy Related
Mindful Moms: Mechanisms of Mindfulness-based Cognitive Therapy During Pregnancy and Postpartum
The proposed study seeks to elucidate the mechanisms underlying Mindfulness-Based Cognitive Therapy in pregnancy to improve understanding of how and why this treatment modality enhances well-being, which can then be leveraged to…
- Conditions
- Psychological Distress, Pregnancy Related, Postpartum Blues, Postpartum Depression
- Trial name
- NCT05137925
- Testing
- Mindfulness-Based Cognitive Therapy (MBCT), Treatment as Usual (TAU)
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Major Depression Moderate, Major Depression Severe
EEG Microstate Parameters and Neuroinflammatory Biomarkers in Patients With Treatment-Resistant Major Depressive Disorder Receiving ECT
This study aims to investigate the neurophysiological and inflammatory changes associated with electroconvulsive therapy (ECT) in patients diagnosed with Major Depressive Disorder who are resistant to at least two antidepressant…
- Conditions
- Major Depression Moderate, Major Depression Severe, Major Depression With Comorbid Anxiety Symptoms, Major Depression With Panic Attacks
- Trial name
- NCT07748091
- Testing
- Electroconvulsive Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Istanbul University - Cerrahpasa
Generalized Anxiety Disorder (GAD), Major Depressive Disorder (MDD)
AI-Supported Therapy for Depression and Anxiety Compared With Standard CBT
This study is a pivotal, randomised, controlled, non-inferiority trial evaluating "Nook," an AI-delivered, neurosymbolic, clinician-supervised digital psychological intervention for depression and anxiety, compared with standard…
- Trial name
- NCT07620340
- Testing
- AI-Digital CBT, Cognitive Behavioural Therapy
- Volunteers
- 400 people
- Sponsor
- PsyScale
Psoriasis (PsO), Psychological Distress
Online Therapist-guided Receptive Music Therapy in Adults With Psoriasis
This single-center, three-arm randomized controlled trial evaluated a four-week online therapist-guided receptive music therapy program as an adjunct to treatment as usual in adults with moderate-to-severe psoriasis and…
- Conditions
- Psoriasis (PsO), Psychological Distress, Depressive Symptom, Anxiety
- Trial name
- RePSO (NCT05894759)
- Testing
- Therapist-guided receptive music therapy, Audio-based active relaxation control
- Where
- Romania
- Volunteers
- 75 people
- Sponsor
- Grigore T. Popa University of Medicine and Pharmacy
Pain, Anxiety State
App Delivered Brief Mindfulness Intervention for Surgical Patients
This will be a single-site, five-arm, parallel group randomized control trial involving patients undergoing knee or hip replacement surgery.
- Conditions
- Pain, Anxiety State, Depressive State
- Trial name
- NCT05433389
- Testing
- Breath Counting, Body Scan, Mindful Breathing
- Where
- United States
- Volunteers
- 823 people
- Sponsor
- University of Utah
Treatment Resistant Depression, Major Depressive Episode
University of Iowa Interventional Psychiatry Service Patient Registry
The purpose of this study is to examine the effects of interventional/procedural therapies for treatment-resistant depression (TRD) and Obsessive-Compulsive Disorder (OCD).
- Conditions
- Treatment Resistant Depression, Major Depressive Episode, Major Depression, Major Depressive Disorder
- Trial name
- NCT04480918
- Testing
- Electroconvulsive Therapy (ECT), Transcranial Magnetic Stimulation (TMS), Ketamine
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- Mark Niciu
Depression - Major Depressive Disorder, Anxiety
AtWork: The Relation Between Cognitive Functioning, Common Mental Disorders and Work Functioning
Depression and anxiety affects levels of function across different levels like work, increasing levels of sick leave and as well as cognitive functioning.
- Trial name
- AtWork (NCT07349550)
- Where
- Norway
- Volunteers
- 200 people
- Sponsor
- Norwegian University of Science and Technology
Emotional Problem, Anxiety
A Transdiagnostic Internet Intervention for Parents of Children With Anxiety and Depressive Symptoms
The purpose of this study is to evaluate the efficacy of a transdiagnostic, parent-led, Internet-delivered intervention in reducing child and adolescent internalizing problems.
- Conditions
- Emotional Problem, Anxiety, Depression, Psychological Distress
- Trial name
- ParentKIT (NCT05341297)
- Testing
- ParentKIT
- Where
- Romania
- Volunteers
- 111 people
- Sponsor
- Babes-Bolyai University
Autism, Autism Spectrum Disorder
Autism Genomics Sweden - Genetic Guidance and Information Trial
This observational clinical trial aims to evaluate whether providing genetic information about the origins of autism and related psychiatric disorders enhances understanding, well-being, and empowerment in adolescents and young…
- Conditions
- Autism, Autism Spectrum Disorder, ADHD - Attention Deficit Disorder With Hyperactivity, Depression Anxiety Disorder
- Trial name
- AuGeS-GV (NCT06740760)
- Testing
- Genetic counselling, Leaflet
- Where
- Sweden
- Volunteers
- 63 people
- Sponsor
- Karolinska Institutet