Clinical trials: Depth of Anaesthesia
Anesthesia, Brain Tumor, Supratentorial,Outcome
Study of the Depth of Anesthesia on Postoperative Clinical Outcome in Patients With Supratentorial Tumor
Recent studies have shown that deep anesthesia is associated with poor outcome. There is still lack of randomized controlled trials with large sample size on the effect of depth of anesthesia on the postoperative outcomes in…
- Trial name
- DEPTH (NCT03033693)
- Testing
- Bispectral index will be targeted at 50, Bispectral index will be targeted at 35
- Where
- China
- Volunteers
- 1,461 people
- Sponsor
- Beijing Tiantan Hospital
Depth of Anaesthesia, EEG
EEG Monitoring Under Anaesthesia in Children: Towards Personalized Anaesthesia Care
Electroencephalographic recordings (EEG) present an opportunity to monitor changes in human brain electrical activity during changing states of consciousness during general anesthesia.
- Conditions
- Depth of Anaesthesia, EEG, Anesthesia Emergence Delirium
- Trial name
- EEGPAC (NCT04103138)
- Testing
- Sedline EEG sensor placement, Sedline EEG monitoring
- Where
- Singapore
- Volunteers
- 200 people
- Sponsor
- KK Women's and Children's Hospital
Anesthesia Complication, Immune Suppression
Depth of Anesthesia and Proteomics
The primary aim of the study is to compare cellular activity of T-cells, NK-cells and monocytes after anesthesia. Phagocytosis and cellular lysis activity of neutrophils and monocytes are analyzed by flow cytometry.
- Trial name
- NCT05380778
- Testing
- Deep anesthesia, Shallow anesthesia
- Volunteers
- 18 people
- Sponsor
- Heidelberg University
General Anesthesia
Comparison of Two Electroencephalograms (EEG) Monitors in Patients Undergoing General Intravenous Anesthesia
Quantium Medical Company has an ElectroEncephalograph-based (EEG-based) algorithm with two outputs: qCON for unconsciousness and qNOX for anti-nociception.
- Trial name
- Bis-qCON-IV (NCT03753217)
- Testing
- qCON Monitor
- Where
- France
- Volunteers
- 35 people
- Sponsor
- Hopital Foch
Endoscopic Surgical Procedure
Sedation for Endoscopic Procedures
Endoscopic procedures for biliary strictures, stenting or drainage (ERCP) and ultrasonic imaging or biopsies (EUS) are performed under sedation or anesthesia.
- Trial name
- SEEUPP (NCT05038917)
- Where
- Sweden
- Volunteers
- 500 people
- Sponsor
- Ostergotland County Council, Sweden
Postoperative Delirium, Cognitive Impairment
Postoperative Delirium in the ICU Setting of an Eastern European Centre
The study targets postoperative delirium in patients undergoing major abdominal surgery, with the aim to evaluate the functional baseline and proteomics implicated in pathogenesis, prevention strategies (such as anesthesia depth…
- Trial name
- NCT05474872
- Testing
- BIS monitoring
- Where
- Romania
- Volunteers
- 100 people
- Sponsor
- Institutul Regional de Gastroenterologie & Hepatologie Prof. dr. Octavian Fodor
Anesthesia, Deep Sedation
Comparison of Two Electroencephalograms (EEG) Monitors in Patients Undergoing General Anesthesia
Hypothesis: There is a statistically measurable correlation between qNOX and rough clinical signs of insufficient anti-nociception such as movements during Laryngeal Mask Airway (LMA) insertion, skin Incision, LMA removal.
- Trial name
- NCT02928172
- Testing
- qCON-qNOX, BIS
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Cedars-Sinai Medical Center
General Anesthesia
Comparison of Deep Neuromuscular Block and Moderate Neuromuscular Block on Quality of Recovery in Patients Undergoing Robotic Gastrectomy
The purpose of this study is to investigate and compare the postoperative quality of recovery between the deep neuromuscular blockade and moderate neuromuscular blockade during robotic gastrectomy.
- Trial name
- NCT02762890
- Testing
- Deep neuromuscular blockade, Moderate neuromuscular blockade
- Where
- South Korea
- Volunteers
- 56 people
- Sponsor
- Yonsei University
Depth of Anesthesia
Electroencephalogram Dynamics in Children <=1 Year During Anesthetic Procedures
As part of the clinical routine of the Department of Anesthesiology and Operative Intensive Care Medicine (CCM/CVK), Charité - Universitätsmedizin Berlin at Campus Virchow-Klinikum intraoperative electroencephalography data and…
- Trial name
- NCT04093661
- Where
- Germany
- Volunteers
- 125 people
- Sponsor
- Charite University, Berlin, Germany
Analysis of Anaesthesia Depth
Prediction of Propofol Effect Compartment Concentrations
The goal of this observational study is to learn about the prediction of the effect of Propofol by means of EEGs. The main questions it aims to answer are: Develop models that can reliably predict the effect of Propofol Select…
- Trial name
- Propo2022 (NCT05940142)
- Where
- Austria
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Karl Landsteiner University of Health Sciences
Reversing Vecuronium-Induced Neuromuscular Blockade in Patients Undergoing General Anesthesia Surgery, Reversing Rocuronium-Induced Neuromuscular Blockade in Patients Undergoing General Anesthesia Surgery
A Dose-Finding Study of Amogammadex Sodium for Reversing Vecuronium and Rocuronium-Induced Neuromuscular Blockade
Background context: Amogammadex sodium has completed Phase I-III clinical studies in China for reversal of rocuronium-induced blockade. No clinical studies have yet been conducted for vecuronium-induced blockade.
- Trial name
- NCT07595393
- Testing
- Rocuronium (0.6mg/kg), vecuronium bromide (0.1mg/kg)
- Volunteers
- 64 people
- Sponsor
- Amckaus PTY LTD.
Neuromuscular Blockade
Effects of Depth of Neuromuscular Block on Surgical Operating Conditions in Gynecologic Laparoscopic Surgery
Comparison of the impact of a deep neuromuscular blockade (TOF count = 0 and posttetanic count [PTC] 1-2) and a moderate neuromuscular blockade (TOF count= 1 - 3) on intraoperative surgical conditions assessed by the surgeon as a…
- Trial name
- NCT03441828
- Testing
- Quality of surgical field conditions, Deep Neuromuscular Block, Moderate Neuromuscular Block
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- Federico II University
Anesthesia
Research on Anesthesia Depth Control Strategy Based on Continuous and Non-invasive Monitoring of Exhaled Breath
This study aims to propose a strategy for controlling the depth of anesthesia based on continuous and non-invasive monitoring of exhaled breath: BIS value during intravenous-inhalation combined anesthesia is predicted according…
- Trial name
- NCT07272044
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Emergence Agitation
Effect of Extubation Under Deep Anesthesia on Emergence Agitation of Nasal Surgery
This study analyzed the relationship between extubation timing and Emergence agitation in 18-60 years old adults undergoing nasal surgery, such as nasal septum correction, endoscopic sinus surgery, and nasal bone fracture…
- Trial name
- NCT04844333
- Testing
- Extubation under deep anesthesia
- Where
- 3 sites in China
- Volunteers
- 202 people, healthy volunteers welcome
- Sponsor
- Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
Neuromuscular Blockade, Anesthesia, General
Comparison of the Performances of the cTOFR and the mTOFR During Reversal of Deep Neuromuscular Blockade With Sugammadex
It is known that deep neuromuscular block improves surgical conditions, especially during laparoscopic abdominal surgery. Based on this, in the Perioperative Neuromuscular Blockade Management guide published by the ESAIC…
- Trial name
- NCT06220136
- Testing
- TOFscan monitoring
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people
- Sponsor
- Ankara University
Traumatic Brain Injury, Subarachnoid Hemorrhage
Comparison of Narcotrend and Cerebral Function Analysing Monitor in Intensive Care to Monitor Seizures and Deep Sedation
A study in the use of the Narcotrend depth of anaesthesia monitor to record a) seizures, and b) monitor a level of sedation referred to as 'burst suppression', in sedated patients in the adult and paediatric intensive care.
- Conditions
- Traumatic Brain Injury, Subarachnoid Hemorrhage, Intracerebral Haemorrhage, Encephalitis
- Trial name
- NCT06067750
- Testing
- Narcotrend compared to Cerebral Function Analysing Monitor (CFAM)
- Where
- United Kingdom
- Volunteers
- 44 people
- Sponsor
- Nottingham University Hospitals NHS Trust
Pediatric Surgical Procedures Requiring Endotracheal Intubation Under General Anesthesia
Comparison of Optimal Endotracheal Tube Depth Using Four Different Formulas in Children Aged 1-4 Years and Verification With Fiberoptic Bronchoscopy
. The optimal position of the endotracheal tube (ETT) within the trachea is the middle third portion, distal to the vocal cords.
- Trial name
- NCT06937840
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Ankara University
Anaesthesia
"Light" Versus "Deep" Bispectral Index (BIS) Guided Sedation for Colonoscopy
In this trial, patients undergoing elective colonoscopy under sedation will be randomised to BIS-guided sedation targeting either "light" (bispectral index [BIS] 70-80) or "deep" (BIS<60) sedation.
- Trial name
- NCT01457274
- Testing
- Sedation depth
- Where
- Australia
- Volunteers
- 200 people
- Sponsor
- Melbourne Health
Residual Neuromuscular Block, Cardiovascular Diseases
Effects of Low-pressure Pneumoperitoneum Associated With Deep Pipecuronium-induced Neuromuscular Blockade on Hemodynamic Parameters for High Cardiovascular Risk Patient Undergoing General Anesthesia
Deep neuromuscular block (DNMB) during laparoscopy induces less haemodynamic stress by facilitating low-pressure pneumoperitoneum.
- Conditions
- Residual Neuromuscular Block, Cardiovascular Diseases, Neuromuscular Blockade Monitoring
- Trial name
- NCT06517524
- Where
- Hungary
- Volunteers
- 10 people
- Sponsor
- Tamas Vegh, MD
Bariatric Surgery Candidate
The Impact of Moderate Versus Deep Neuromuscular Blockade on Enhanced Recovery After Bariatric Anesthesia
Most published articles suggest that deep neuromuscular blockade is required for bariatric surgery. However, the evidence for such practice is still inconclusive.
- Trial name
- NCT04466943
- Testing
- Neuromuscular transmission monitoring (NMT)
- Where
- Saudi Arabia
- Volunteers
- 110 people
- Sponsor
- King Saud University