Clinical trials: Depth of Anesthesia
Depressive Disorder, Major, Treatment Resistant Depression
Efficacy of Deep Anaesthesia With Isoflurane as a Fast-response Antidepressant Agent
In this study the investigators will submit patients with treatment resistant depression to deep anesthesia with isoflurane to get 15 minutes of cortical burst suppression on electroencephalogram, once a week for six weeks.
- Conditions
- Depressive Disorder, Major, Treatment Resistant Depression, Depressive Episode
- Trial name
- ISORADAR (NCT04171193)
- Testing
- Isoflurane, Sertraline Pill
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- University of Sao Paulo
Opioid-free Anesthesia, Anesthesia Depth Monitoring
Anesthesia Depth During Opioid Free Anesthesia
Opioid-free anesthesia is feasible and effective but still not common practice. Anesthesia depth monitoring is not investigated for use in anesthesia combining low dose infusions of several drugs with different sedative patterns…
- Trial name
- NCT06227143
- Testing
- Anesthesia depth monitoring
- Where
- Sweden
- Volunteers
- 30 people
- Sponsor
- Region Halland
General Anesthesia
Comparison of Two Electroencephalograms (EEG) Monitors in Patients Undergoing General Intravenous Anesthesia
Quantium Medical Company has an ElectroEncephalograph-based (EEG-based) algorithm with two outputs: qCON for unconsciousness and qNOX for anti-nociception.
- Trial name
- Bis-qCON-IV (NCT03753217)
- Testing
- qCON Monitor
- Where
- France
- Volunteers
- 35 people
- Sponsor
- Hopital Foch
Anesthesia
Prediction of Propofol Effect-Site Concentration Associated With Deep Anesthesia
The goal of this observational study is to explore the variability of the concentration at the effect site (Ce) of propofol to reach deep anesthesia (DA) during induction of general anesthesia in adults.
- Trial name
- PRESCOD-AI (NCT06346158)
- Testing
- Cognitive testing, electroencephalogram, High density electroencephalogram
- Where
- Canada
- Volunteers
- 110 people
- Sponsor
- Ciusss de L'Est de l'Île de Montréal
Mastectomy, Postoperative Pain
Comparison of Postoperative Analgesic Effectiveness of Superficial and Deep Serratus Plane Blocks for Mastectomy
Pain after breast surgery can be quite severe and can significantly affect quality of life. By successfully treating acute pain, it is aimed to prevent the formation of pain memory and to ensure that chronic pain never occurs.
- Conditions
- Mastectomy, Postoperative Pain, Analgesia
- Trial name
- NCT06438211
- Testing
- superficial or deep serratus anterior plane block for mastectomy
- Where
- Turkey (Türkiye)
- Volunteers
- 63 people
- Sponsor
- TC Erciyes University
Propofol Adverse Reaction
Propofol Induction Based on Lean Body Weight on the Depth of Anesthesia
Propofol has significant hemodynamic side effects. It is a lipophilic agent and is generally used at a dose of 2-2.5 mg/kg for induction.
- Trial name
- propofol (NCT06862349)
- Testing
- Group T received propofol at a dose of 2-2.5 mg/kg based on total body weight, Group L received propofol at 2-2,5mg/kg dose based on lean body weight, which was calculated from CT imaging by a radiologist.
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Ankara City Hospital Bilkent
Pain Management, Sedation
The Effect of Continuous Femoral Nerve Block With Modulation of Depth of Anesthesia on Prognosis of Patients Receiving Total Knee Arthroplasty
The interaction of analgesia and sedation ot their effect on the prognosis of surgical patients still need to be elucidated.Currently, how to optimize intra-operative Analgesia and sedation to improve the prognosis of surgical…
- Conditions
- Pain Management, Sedation, Peripheral Nerve Block, Total Knee Arthroplasty
- Trial name
- NCT02576015
- Testing
- peri-operative continuous femoral nerve block with light sedation, post-operative continuous femoral nerve block, lidocaine
- Where
- China
- Volunteers
- 380 people
- Sponsor
- Min Su
Pain Management After Surgery, Regional Anaesthesia
We Have Two Groups. Both Groups Received a Deep Serratus Anterior Plane Block. One Group Had a Catheter for Continuous Infusion, While the Other Received IV Analgesics Postoperatively. Analgesic Effects Between the Two Groups Were Compared
The aim of this observational study is to compare the analgesic efficacy of continuous infusion via peripheral catheter versus single-shot serratus anterior plane block in women aged 18 to 80 undergoing breast-conserving surgery.
- Trial name
- DSAPB (NCT07053397)
- Testing
- Serratus Anterior Plane Block (SAPB) group, DSAPB
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Istanbul Medeniyet University
Depth of Anesthesia, Nociception
Anesthesia Induction Scheme for Painless Gastrointestinal Endoscopy Patients Based on Nociceptive Stimulation Monitoring
Nociception is the encoding and processing of noxious stimulation and is considered an objective indicator for monitoring pain. Currently, a new clinically-applied medical-engineering integrated monitoring device for noxious…
- Conditions
- Depth of Anesthesia, Nociception, Painless Gastrointestinal Endoscopy
- Trial name
- NCT06604156
- Testing
- EEG monitoring
- Where
- China
- Volunteers
- 220 people
- Sponsor
- Min Su
Parkinson's Disease
Evaluation of the Benefit Provided by Acupuncture During a Surgery of Deep Brain Stimulation
The effectiveness of Deep Brain Stimulation (DBS) in certain movement disorders is widely demonstrated. The success of this procedure requires that the patient is awake and cooperative.
- Trial name
- ACUplus (NCT02236260)
- Testing
- Electroacupuncture, Local Anesthesia (lidocaine hydrochloride)
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Nantes University Hospital
Hip Fracture Surgery
Predicted Level of General Anaesthesia in Hip Fracture Surgery
The purpose of this study is to evaluate if prediction of general anaesthesia level by the Smartpilot® View device can improve the quality of anaesthesia in patients undergoing hip fracture surgery.
- Trial name
- NAPfem (NCT02556658)
- Testing
- General anesthesia managed by the Smartpilot® View, General anesthesia managed without the Smartpilot® View
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Angers
Anesthesia
Bispectral Index (BIS) Values Required for an Adequate Depth of Anesthesia in Elderly Patients Using Propofol
A correlation between the bispectral index values and electroencephalographic patterns at the loss of consciousness (LOC) when using propofol in elderly patients, has not been determined.
- Trial name
- NCT03195530
- Testing
- Propofol
- Where
- Chile
- Volunteers
- 12 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Aging, Inflammation
Macrophage/Monocyte Driven Inflammation and Anesthetic Sensitivity in Aging
The goal of this observational study is to determine whether macrophage/monocyte mediated inflammatory signaling contributes to reduced anesthetic requirements in older adults undergoing major abdominal surgery.
- Conditions
- Aging, Inflammation, Blood-Brain Barrier Permeability, Anesthesia Brain Monitor
- Trial name
- MACRO-AGE (NCT07372417)
- Where
- Chile
- Volunteers
- 60 people
- Sponsor
- University of Chile
Stress
Evaluation Of Stress Levels Of Pediatric Dentist Performing Dental Treatment In The Operating Room
This study will measure the stress levels of pediatric dentists performing dental treatments under deep sedation and general anesthesia.
- Trial name
- NCT07541508
- Where
- Turkey (Türkiye)
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- TC Erciyes University
Mitral Regurgitation, Local Anaesthesia
Deep Sedation Instead of General Anaesthesia in Percutaneous Mitral Valve Repair Using the MitraClip® System
Percutaneous mitral valve repair (PMVR) with the MitraClip® system has emerged as a therapeutic alternative to surgical valve repair in patients who are at high risk and unsuitable for surgery.
- Conditions
- Mitral Regurgitation, Local Anaesthesia, Percutaneous Repair
- Trial name
- NCT02023762
- Volunteers
- 21 people
- Sponsor
- Heinrich-Heine University, Duesseldorf
Monitoring of Depth of Anesthesia, AAI Index
Monitoring of Adequate Course of General Anesthesia
Clinical monitoring is the most common method of adjustment of the appropriate level of general anesthesia. However, the episodes of intraoperative awareness are still reported, suggesting that clinical observations may not be…
- Trial name
- MoDA (NCT03331692)
- Testing
- monitoring of the proper level of general anesthesia
- Where
- Poland
- Volunteers
- 208 people, healthy volunteers welcome
- Sponsor
- Military Institute od Medicine National Research Institute
Depth of Anesthesia (DOA)
Effectiveness of the NeuroSENSE for Monitoring the Hypnotic Depth of Anesthesia
The objective of this clinical study is to investigate whether the NeuroSENSE is an adequate monitor of hypnotic depth-of-anesthesia (DOA).
- Trial name
- NCT02088671
- Testing
- Propofol induction followed by randomized doses of desflurane, Recording of EEG using NeuroSENSE, Data collection
- Where
- 2 sites in Canada
- Volunteers
- 76 people
- Sponsor
- NeuroWave Systems Inc.
Mental Function
Restoration of Consciousness With Ultrasonic Deep Brain Stimulation During Anesthetic Sedation
The purpose of this study is to see if mental functions take place during different levels of anesthesia using two commonly used drug (propofol and dexmedetomidine) and will include low-intensity focused ultrasound pulsation…
- Trial name
- NCT07221539
- Testing
- Propofol for fMRI, Dexmedetomidine for fMRI, Dorsolateral prefrontal cortex (DLPFC) pulsation
- Where
- United States
- Volunteers
- 168 people, healthy volunteers welcome
- Sponsor
- University of Michigan
General Anesthesia
Optimal Insertion Depth of FOB for Oral FOB Intubation
For oral fiberoptic intubation, the preliminary insertion depth of the fiberoptic bronchoscope should be important because the excessive insertion depth or too shallow depth might be the reason why the clinicians cannot perform…
- Trial name
- NCT05277064
- Testing
- Oral FOB
- Where
- South Korea
- Volunteers
- 211 people
- Sponsor
- Seoul National University Hospital
Immunotoxicity, Anesthesia
Anesthetic Depth Effects Upon Immune Competent Cells
Anesthesia depth affects the proliferation of lymphocytes to NK-cells and memory T-cells effect and the phagocytosis activity of macrophages in healthy patients.
- Conditions
- Immunotoxicity, Anesthesia, Inert Gas Narcosis
- Trial name
- BIS-MA (NCT02794896)
- Testing
- High dose propofol, fentanyl and sevoflurane, Low dose propofol, fentanyl and sevoflurane
- Where
- Germany
- Volunteers
- 16 people
- Sponsor
- Heidelberg University