Clinical trials: Dermatologic
Actinic Keratoses
Follow-up Study to Evaluate Sustained Clearance Rates of Actinic Keratoses up to One Year
The objective of this study was to obtain long-term sustained clearance rates for subjects previously treated with imiquimod creams in studies GW01-0702, GW01-0703, GW01-0704 and GW01-0705.
- Trial name
- NCT00668733
- Volunteers
- 179 people
- Sponsor
- Graceway Pharmaceuticals, LLC
Atopic Dermatitis, Atopic
A Study of the Effects of Camoteskimab in Adults With Moderate to Severe Atopic Dermatitis
This is a Phase 2a, multicenter, randomized, double-blind, placebo-controlled study with an open-label extension to evaluate the efficacy and safety of camoteskimab in adults with moderate to severe AD.
- Conditions
- Atopic Dermatitis, Atopic, Dermatitis, Dermatologic Disease
- Trial name
- NCT06436183
- Testing
- Camoteskimab
- Where
- 35 sites in United States, Canada
- Volunteers
- 62 people
- Sponsor
- Apollo Therapeutics Ltd
Psoriasis
Randomized Placebo-controlled Study of ISA247 in Plaque Psoriasis
The purpose of this study is to determine which dose of voclosporin is effective in the treatment of plaque psoriasis compared to placebo.
- Trial name
- SPIRIT (NCT00244842)
- Testing
- voclosporin
- Where
- 31 sites in Canada
- Volunteers
- 451 people
- Sponsor
- Aurinia Pharmaceuticals Inc.
Epidermolysis Bullosa
Establishment of the National Epidermolysis Bullosa Registry
OBJECTIVES: I. Develop a large roster of well-characterized patients with various forms of inherited and acquired epidermolysis bullosa (EB). II.
- Trial name
- NCT00004761
- Sponsor
- National Center for Research Resources (NCRR)
Advanced Malignant Neoplasm, Dermatologic Complication
Spironolactone in Preventing Rash in Patients With Advanced Cancer Receiving Panitumumab and Cetuximab
This randomized phase II trial studies how well giving spironolactone works in preventing rash in patients with cancer that has spread to other places in the body and are receiving panitumumab and cetuximab.
- Trial name
- NCT01867294
- Testing
- Doxycycline, Management of Therapy Complications, Questionnaire Administration
- Where
- 5 sites in United States
- Volunteers
- 19 people
- Sponsor
- Academic and Community Cancer Research United
Psoriasis
BI 655066 (Risankizumab) Compared to Placebo and Active Comparator (Ustekinumab) in Patients With Moderate to Severe Chronic Plaque Psoriasis
The purpose of this study is to assess the safety and efficacy of BI 655066/ABBV-066 (risankizumab) for the treatment of moderate to severe chronic plaque psoriasis in adult patients.
- Trial name
- NCT02684370
- Testing
- risankizumab, ustekinumab
- Volunteers
- 560 people
- Sponsor
- AbbVie
Dermatologic Complications
Preliminary Study of Peel Force and Discomfort of Removal of Adhesive Barriers in Normal and Peristomal Skin
This purpose of this study is to look at three commercially available ostomy barriers on peristomal (around the stoma) skin. Repeated barrier application and removal over years causes changes to the skin that the investigators…
- Trial name
- NCT02003404
- Testing
- Control Abdominal Skin, Peristomal Abdominal Skin
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Hollister Incorporated
Epidermolysis Bullosa Acquisita
Phase II Pilot Study of Extracorporeal Phototherapy for Epidermolysis Bullosa Acquisita
OBJECTIVES: I. Evaluate immunomodulation with extracorporeal photochemotherapy (ECP) in patients with epidermolysis bullosa acquisita. II. Investigate the effect of ECP on lymphocyte activity.
- Trial name
- NCT00004359
- Testing
- methoxsalen
- Volunteers
- 10 people
- Sponsor
- National Center for Research Resources (NCRR)
Tuberous Sclerosis Complex
Dermatologic Patterns of Tuberous Sclerosis Patients and Somatic Mutation Relationship
Tuberous Sclerosis is a rare genetic disorder that affects about one in 15,000 individuals. It is part of the phacomatoses: a germline mutation of the gene Tuberous Sclerosis Complex 1 (TSC1) or TSC2 causes a protein dysfunction…
- Trial name
- NCT04112537
- Where
- France
- Volunteers
- 90 people
- Sponsor
- University Hospital, Montpellier
Pain
Safety Study of S-Caine Peel (Skin Numbing Cream) Before a Painful Dermatologic Procedure in Adults
The purpose of this study is to evaluate the safety of one treatment of S-Caine™ Peel (skin numbing cream) applied on healthy skin before a painful dermatologic procedure in adults.
- Trial name
- NCT00107835
- Testing
- S-Caine™ Peel (lidocaine and tetracaine cream 7%/7%)
- Where
- 5 sites in United States
- Volunteers
- 408 people
- Sponsor
- ZARS Pharma Inc.
Pain, Procedural Pain
E-MOHS Trial of TENS and Vibration During Local Anesthesia
The E-MOHS Trial is a randomized controlled trial evaluating whether active vibration plus transcutaneous electrical nerve stimulation reduces pain during local anesthetic infiltration in adults undergoing Mohs micrographic…
- Conditions
- Pain, Procedural Pain, Local Anesthesia, Mohs Surgery
- Trial name
- E-MOHS (NCT07852455)
- Testing
- Active Vibration:TENS
- Where
- 3 sites in United States
- Volunteers
- 90 people
- Sponsor
- University of Minnesota
Skin Cancer, Skin Wound
Preoperative Image-based Education Effect on Postoperative Satisfaction of Patients Undergoing First-time Dermatologic Surgery
This research study aims to understand whether visual and written education on wound appearance can improve patients' experience and understanding of what their wound will look like following dermatologic surgery.
- Trial name
- NCT05643755
- Testing
- Preoperative image-based education
- Volunteers
- healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Biotherapy, Chronic Inflammatory Disease
Skin Adverse Reactions Occuring in Children Treated by Biotherapy for Chronic Inflammatory Disease
Biological treatments (BT) are commonly prescribed to treat chronic inflammatory diseases in children. Paradoxical reactions during treatment with a biological agent can be defined as the appearance or exacerbation of a…
- Conditions
- Biotherapy, Chronic Inflammatory Disease, Allergic Skin Reaction, Pediatric Disorder
- Trial name
- MDEBMIC (NCT04327752)
- Testing
- dermatological consultation
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Pain
Pain Perception: Lidocaine Rate/Temp/Buffer
This study will collect data from multiple academic institutions. The primary objective for part A of this study is to determine the impact of anesthetic injection rate and temperature on pain perception during dermatologic…
- Trial name
- NCT02823002
- Testing
- Slow, Room Temperature Injection, Rapid, Room Temperature Injection, Slow, Warm Temperature Injection
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Sutured Wounds
A Comparison Study of the Tensile Strength of Sutures Used in Dermatologic Surgery on the Day of Suture Removal, Following Wound Care With Two Different Products
Sutures are an integral part of surgery and available materials are diverse, as are the options for post-procedure care. Both saline and hydrogen peroxide are commonly used cleansing agents.
- Trial name
- NCT01533675
- Testing
- Hydrogen peroxide, Saline
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Miami
Dermatologic Disorders With Heamatologic Malignancies Patients
Prevelance Of Cutaneous Disorders Among Patients With Heamatologic Malignancies
Hematologic malignancies are a diverse group of neoplasms that can have a wide range of clinical and behavioral characteristics.
- Trial name
- NCT06108622
- Testing
- cbc ,u\s renalor hepatic function test if needed
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Sohag University
Ichthyosis
Phase III Study of Monolaurin Cream Therapy for Patients With Congenital Ichthyosis
OBJECTIVES: I. Compare the safety and efficacy of monolaurin cream versus a placebo vehicle cream in suppressing the signs of nonbullous congenital ichthyosiform erythroderma. II.
- Trial name
- NCT00004690
- Testing
- monolaurin cream
- Volunteers
- 90 people
- Sponsor
- Cellegy Pharmaceuticals
Dermatologic Complications, Palmar-plantar Erythrodysesthesia
Pyridoxine in Preventing Hand-Foot Syndrome Caused by Capecitabine in Patients With Cancer
RATIONALE: Pyridoxine may help prevent hand-foot syndrome caused by capecitabine in patients with cancer. It is not yet known whether pyridoxine is more effective than a placebo in preventing hand-foot syndrome in patients with…
- Conditions
- Dermatologic Complications, Palmar-plantar Erythrodysesthesia, Unspecified Adult Solid Tumor, Protocol Specific
- Trial name
- NCT00486213
- Testing
- pyridoxine hydrochloride
- Where
- Singapore
- Volunteers
- 210 people
- Sponsor
- National Cancer Centre, Singapore
Zika Virus Symptoms and the Associated Exanthema
Dermatologic Manifestations of Zika Virus
The purpose of this study is to determine whether any diagnostic patterns exist in the symptom presentation of Zika Virus.
- Trial name
- DMZV (NCT03229421)
- Testing
- Survey
- Where
- Dominican Republic
- Sponsor
- Northwestern University
Dermatology/Skin - Other
Animated Video Consultation for Reducing Pre-Operative Anxiety in Outpatient Dermatologic Surgery
The purpose of this study is to evaluate whether the addition of an animated skin surgery educational video to conventional in-person surgery consultation will help reduce pre-operative anxiety in patients awaiting outpatient…
- Trial name
- NCT03344497
- Testing
- VC Group
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- University of Arizona