Clinical trials: Descemet's Membrane Disorder
Fuchs Endothelial Corneal Dystrophy, FECD3
Study With QR-504a to Evaluate Safety, Tolerability & Corneal Endothelium Molecular Biomarker(s) in Subjects With FECD3
PQ-504a-001 (Fuchs Focus) is an open-label, single-dose, exploratory study to evaluate safety, tolerability, and corneal endothelium molecular biomarker(s) in subjects with Fuchs Endothelial Corneal Dystrophy with Trinucleotide…
- Conditions
- Fuchs Endothelial Corneal Dystrophy, FECD3, Corneal Diseases, LRS
- Trial name
- Fuchs Focus (NCT05052554)
- Testing
- QR-504a
- Where
- United Kingdom
- Sponsor
- ProQR Therapeutics
Descemet's Membrane Disorder
AC Deflation in Descemet's Membrane Detachment
using a relatively new technique to manage post-cataract surgery complication and measuring its efficacy
- Trial name
- NCT07364708
- Testing
- group A will undergo direct intracameral air injection and group B will undergo anterior chamber deflation then intracameral air injection
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Minia University
Fuchs' Endothelial Corneal Dystrophy, Descemet Membrane Endothelial Keratoplasty
Predictive Factors of Graft Detachment Following Dmek
The aim of this study was to identify the predictive factors of graft detachment after Descemet Membrane Endothelial Keratoplasty (DMEK) surgery.
- Conditions
- Fuchs' Endothelial Corneal Dystrophy, Descemet Membrane Endothelial Keratoplasty, Pseudophakic Bullous Keratopathy, Graft Detachment
- Trial name
- PDF DMEKDETACH (NCT05531760)
- Testing
- Descemet Membrane Endothelial Keratoplasty
- Where
- France
- Volunteers
- 170 people
- Sponsor
- Centre Hospitalier Régional Metz-Thionville
Fuchs Endothelial Corneal Dystrophy, Descemet Membrane Endothelial Keratoplasty (DMEK)
Influence of Supine Positioning on the Outcomes After Descemet Membrane Endothelial Keratoplasty (DMEK)
The goal of this clinical trial is to learn if a longer period of lying on the back after corneal transplant surgery (Descemet Membrane Endothelial Keratoplasty, DMEK) helps the transplant stick better in the eye.
- Trial name
- SUPINE (NCT07373821)
- Testing
- Duration of Supine Positioning
- Where
- Germany
- Volunteers
- 102 people
- Sponsor
- University Hospital Heidelberg
Fuchs' Endothelial Dystrophy, Bullous Keratopathy
Air Versus SF6 for Descemet's Membrane Endothelial Keratoplasty (DMEK)
This blinded, randomized study compares the use of air and sulfur hexaflouride (SF6) tamponade in Descemet Membrane Endothelial Keratoplasty.
- Trial name
- NCT03407755
- Testing
- Intraocular gas
- Where
- Denmark
- Volunteers
- 104 people
- Sponsor
- Glostrup University Hospital, Copenhagen
Fuchs' Endothelial Dystrophy
Supine Positioning for Graft Attachment After Descemet Membrane Endothelial Keratoplasty
This randomized controlled trial evaluates the efficacy and safety of postoperative supine head positioning on graft attachment after Descemet membrane endothelial keratoplasty in patients with Fuchs' endothelial corneal…
- Trial name
- SUPER-DMEK (NCT05399095)
- Testing
- Supine positioning: 5 days, Supine positioning: 1 days
- Where
- Germany
- Volunteers
- 90 people
- Sponsor
- University Eye Hospital, Freiburg
Fuchs Endothelial Corneal Dystrophy, Pseudophakic Bullous Keratopathy
The Postoperative Head Position as a Predictor of the Surgical Outcome After DMEK
This study aims to investigate the influence of postoperative head position on clinical outcomes after DMEK via a wearable sensor.
- Conditions
- Fuchs Endothelial Corneal Dystrophy, Pseudophakic Bullous Keratopathy, Chemical Burn of Cornea, Posterior Polymorphous Corneal Dystrophy
- Trial name
- NCT04387331
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- Peter Wiedemann
Map Dot Fingerprint Dystrophy, Post-penetrating Keratoplasty
Brillouin Microscopy Used to Evaluate Corneal Mechanical Properties
This study aims to explore the mechanical properties of the cornea using a non-invasive imaging technique called Brillouin microscopy.
- Conditions
- Map Dot Fingerprint Dystrophy, Post-penetrating Keratoplasty, Post-Descemet Membrane Endothelial Keratoplasty, Healthy Corneas
- Trial name
- NCT06914817
- Testing
- Brillouin optical scanning system (Intelon Optics) (BOSS)
- Where
- Austria
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Vienna Institute for Research in Ocular Surgery
Cataract, Fuchs Endothelial Corneal Dystrophy
Partial Range Of Field IOLs in DMEK-Enabled Procedures
Study Overview This study aims to evaluate the visual outcomes, quality of vision, and patient satisfaction after receiving an extended range PRoF intraocular lens (IOL) during triple Descemet Membrane Endothelial Keratoplasty…
- Trial name
- PROFIDE (NCT07441616)
- Testing
- combined cataract and lamellar endothelial keratoplasty
- Where
- Belgium
- Volunteers
- 10 people
- Sponsor
- Universitair Ziekenhuis Brussel
Corneal Dystrophies, Hereditary
Descemet Membrane Endothelial Keratoplasty (DMEK)
To evaluate isolated Descemet membrane transplantation as a refinement of previous advanced techniques for corneal transplantation, like Descemet Stripping Endothelial Keratoplasty (DSEK)
- Trial name
- DMEK (NCT00521898)
- Testing
- Descemet Membrane Endothelial Keratoplasty (DMEK)
- Where
- Netherlands
- Volunteers
- 1,000 people
- Sponsor
- Netherlands Institute for Innovative Ocular Surgery
Corneal Edema, Corneal Endothelial Disorder
The Belgian Endothelial Surgical Transplant of the Cornea
This study is designed as a randomised multicentric parallel group pragmatic trial of Descemet Stripping Automated Endothelial Keratoplasty (DSAEK) versus Descemet Membrane Endothelial Keratoplasty (DMEK) in corneal endothelial…
- Conditions
- Corneal Edema, Corneal Endothelial Disorder, Fuchs' Endothelial Dystrophy, Bullous Keratopathy
- Trial name
- BESTCornea (NCT05436665)
- Testing
- UT-DSAEK, DMEK
- Where
- 11 sites in Belgium
- Volunteers
- 220 people
- Sponsor
- University Hospital, Antwerp
Fuchs Endothelial Corneal Dystrophy
Effect of Descemet Membrane Polishing in Fuchs Endothelial Corneal Dystrophy
Fuchs endothelial corneal dystrophy (FECD) is the leading indication for corneal transplantation worldwide. It is characterized by the accumulation of guttae and progressive loss of corneal endothelial cells, leading to corneal…
- Trial name
- Fuchs Polishin (NCT07539012)
- Testing
- Fuchs Polishing
- Where
- 5 sites in France
- Volunteers
- 20 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Fuchs' Endothelial Dystrophy
Assessment of Corneal Graft Attachment in Patients With Fuchs Endothelial Corneal Dystrophy Following DMEK Using Ultra-high Resolution OCT
Fuchs endothelial corneal dystrophy (FECD) is a progressive disease characterized by the loss of endothelial cells, thickening of Descemet's membrane and deposition of extracellular matrix in the form of guttae.
- Trial name
- NCT02542644
- Testing
- Ultrahigh resolution Spectral Domain OCT
- Where
- 2 sites in Austria
- Volunteers
- 12 people
- Sponsor
- Medical University of Vienna
Fuchs Endothelial Dystrophy
Ripasudil for Enhanced Corneal Clearing Following Descemet Membrane Endothelial Keratoplasty in Fuchs' Dystrophy
Recently, published literature has reported that performing a descemetorhexis in combination with topical Rho kinase (ROCK) inhibitor therapy was successful in clearing edematous corneas in patients with Fuchs Endothelial Corneal…
- Trial name
- NCT03813056
- Testing
- Glanatec, Optive, Ophthalmic Solution, Descemet Membrane Endothelial Keratoplasty
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- Michael D. Straiko, MD
Corneal Dystrophies, Hereditary
Descemet Stripping (Automated) Endothelial Keratoplasty (DSEK or DSAEK)
To evaluate the transplantation of a posterior corneal disc for the management of corneal endothelial disorders in Descemet Stripping Endothelial Keratoplasty (DSEK) or Descemet Stripping Automated Endothelial Keratoplasty…
- Trial name
- DSAEK (NCT00543660)
- Testing
- Descemet Stripping Automated Endothelial Keratoplasty (DSAEK)
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- Netherlands Institute for Innovative Ocular Surgery
Limbal Stem-cell Deficiency, Congenital Aniridia
Treatment of LSCD With DM
Limbal Stem Cell Deficiency (LSCD) is a blinding disease that accounts for an estimated 15-20% of corneal blindness worldwide. Current treatments are limited.
- Trial name
- NCT05909735
- Testing
- transplantation of a Descemet's Membrane corneal onlay, partial LSCD, transplantation of a Descemet's Membrane corneal onlay, total/near-total LSCD
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- University of Minnesota
Corneal Endothelial Dystrophy, Corneal Edema
Loteprednol Etabonate 0.25% for Prevention of Cornea Transplant Rejection
The purpose of this study is to assess off-label use of loteprednol etabonate 0.25% ophthalmic suspension (Eysuvis) for prevention of immunologic rejection in the first year after Descemet membrane endothelial keratoplasty…
- Trial name
- NCT05136443
- Testing
- loteprednol etabonate 0.25% ophthalmic suspension
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Price Vision Group
Corneal Endothelial Cell Loss, Fuchs' Endothelial Dystrophy
Technique And Results In Endothelial Keratoplasty
To assess and compare the complications and results of different lamellar endothelial keratoplasty techniques and its variations.
- Trial name
- TREK (NCT02470793)
- Testing
- Descemet Stripping Automated Endothelial Keratoplasty, Descemet Membrane Endothelial Keratoplasty
- Where
- Spain
- Volunteers
- 62 people
- Sponsor
- EDUARD PEDEMONTE-SARRIAS
Fuchs Endothelial Corneal Dystrophy
Targeting Reactive Oxygen Species Production as a Novel Therapeutic in Fuch's Endothelial Corneal Dystrophy
This protocol will investigate whether topical application of N-acetyl cysteine (NAC) eye drops decreases oxidative stress and confers cytoprotection in patients with FECD.
- Trial name
- NCT04440280
- Testing
- N-acetyl cysteine (NAC) 10% solution, N-acetyl cysteine (NAC) 20% solution, Visine Dry Eye Relief eye drops
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Massachusetts Eye and Ear Infirmary
Cataract, Corneal Endothelial Keratopathy
Staged and Combined Surgery for Cataract Patients With Corneal Endothelial Dysfunction
The purpose of this study is to evaluate the safety and efficacy of staged and combined phacoemulsification with intraocular lens implantation and Descemet membrane endothelial keratoplasty (DMEK) to treat cataract patients with…
- Conditions
- Cataract, Corneal Endothelial Keratopathy, Phacoemulfisication+IOL Implantation, Endothelial Keratopathy
- Trial name
- NCT02523950
- Testing
- Staged phacoemulsification and DMEK, Combined phacoemulsification and DMEK, Intraocular lens (IOL) implantation
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Haotian Lin