Clinical trials: Detection
Diabetic Retinopathy
Validation of the Artificial Intelligence Subsystem of the DDART Medical Device for the Automated Detection of Lesions Compatible With Diabetic Retinopathy in a Random Sample of Retinal Fundus Photographs
To validate the artificial intelligence subsystem of the DDART medical device for the automated detection of lesions compatible with diabetic retinopathy in a random sample of retinal fundus photographs.
- Trial name
- NCT07758582
- Testing
- Color retinal fundus photograph
- Where
- Greece
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Democritus University of Thrace
Esophageal Cancer
The Utility of Circulating Tumour Cells and Plasma microRNA in Esophageal Adenocarcinoma
Circulating microRNA (circ miRNA) and circulating tumor cell (CTC) levels are hypothesized to be associated with response to chemoradiation in patients undergoing treatment for locally advanced esophageal adenocarcinoma.
- Trial name
- NCT02812680
- Testing
- Blood Draw
- Where
- Canada
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Concussion
Concussion Testing: A Novel Non-invasive Concussion Detection Device
The purpose of this study is to establish and evaluate a distinctive signal for concussion.
- Trial name
- NCT02370914
- Testing
- Nautilus NeuroWaveTM System, SCAT
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Jan Medical, Inc.
Cancer
LEVANTIS-0087A: GAGomes for Multi-Cancer Early Detection in Asymptomatic Adults (LEV87A)
LEVANTIS-0087A (LEV87A) is a retrospective in vitro diagnostics clinical validation population cohort-based case-control study to validate the diagnostic performance of free GAGome-based tests for multi-cancer early detection…
- Trial name
- LEV87A (NCT05235009)
- Testing
- Combined free GAGome MCED test
- Where
- Sweden
- Volunteers
- 9,170 people, healthy volunteers welcome
- Sponsor
- Elypta
Serrated Polyp, Colorectal Neoplasms
Increasing Serrated Polyp Detection With a Brief Awareness Training
In this non-randomized controlled trial, a semi-random group of Dutch endoscopist receive an oral training about the significance of serrated polyps.
- Trial name
- NCT03902899
- Testing
- Educational intervention (oral presentation)
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Cervical Cancer
Standard Operating Procedures for Cervical (Pre)Cancer Biomarker Detection in First-void Urine (BM-SOP Study)
The aim of the study is to develop robust analytical protocols for first-void urine sample preparation and biomarker assays to analyze a panel of biomarkers in first-void urine for improved diagnosis of cervical (pre)cancer…
- Trial name
- BM-SOP (NCT02714127)
- Testing
- First-void urine collection, Cervicovaginal lavage fluid collection
- Where
- Belgium
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Universiteit Antwerpen
Breast Cancer
Characterization of Breast Masses Incidentally Detected on Chest CT
Although Computed tomography (CT) is not routinely used to evaluate beast masses, It is common to discover Incidental breast lesions on chest CT.
- Trial name
- NCT02755779
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Tel Aviv Medical Center
Lymphedema, Breast Cancer
Early Detection of Lymphedema With Bio-Electrical Impedance Analysis in Patients After Breast Cancer Surgery
Bio-electrical impedance analysis and Tissue Dielectric Constant measurements are objective methods in clinical usage to detect lymphedema in early stage.
- Trial name
- BIA (NCT02748746)
- Testing
- Bio Impedance Analysis Measurement, Tissue Dielectric Constant Measurement
- Where
- Turkey (Türkiye)
- Volunteers
- healthy volunteers welcome
- Sponsor
- Abant Izzet Baysal University
Breast Cancer
Evaluation of the Bexa Breast Examination
Objective: The "Bexa Breast Exam," or "BBE," for the purposes of this study is defined as the use of a Bexa device in conjunction with a portable, focused ultrasound examination to identify and further evaluate abnormal breast…
- Trial name
- BBE (NCT06643767)
- Testing
- Bexa and focus ultrasound
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Sure, Inc.
Cervical Cancer
Cervical Cancer Detection Using Optical Spectroscopy
The objective of the work described in this protocol is to determine the optical signatures of cervical dysplasia using optical technologies.
- Trial name
- NCT00900575
- Testing
- Optical Spectroscopy Bench-Top System, Portable Optical Spectrometer, Transvaginal colposcope
- Where
- United States
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Duke University
Neurologic Impairment by Opioids
Non-intrusive Detection of Temporary Neurologic Impairment by Opioids
The investigators aim to prove the feasibility of a non-invasive means to identify temporary neurological impairment resulting from the use of a commonly prescribed opioid by identifying an oculomotor biosignature associated with…
- Trial name
- NCT05489601
- Testing
- Oxycodone
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Zxerex Corporation
Plaque, Dental
Effectiveness of Plaque Score Detection Techniques
This study investigates the similarity between microbial plaque scores when assessing the entire dentition versus select teeth. The hypothesis posits that plaque buildup on single teeth mirrors that of the entire mouth…
- Trial name
- NCT06511830
- Testing
- Dental Monitoring images
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Cardiac Arrhythmia
Validation of a Smartphone-based Recorder for Detection of Cardiac Arrhythmias
The investigators will evaluate the diagnostic yield of the new AliveCor device versus a 12 lead ECG when used simultaneously to detect cardiac arrhythmia
- Trial name
- NCT03996954
- Testing
- Alivecor recording
- Where
- United Kingdom
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Blackpool Teaching Hospitals NHS Foundation Trust
Drug Mechanism, Healthy
Detection of Paracetamol Concentration in Blood-, Saline- and Urine Samples - a Validation Study for a Novel Technique
The main objective is to assess whether a novel electrochemical tool is reliable in detecting concentration of paracetamol in fingerprick- , saline-, urine-, and serum samples. We will recruit 12 healthy volunteers aged 18-45.
- Trial name
- NCT04690673
- Testing
- Paracetamol, Paracetamol concentration measurements and lipidomic assessment
- Where
- Finland
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Johanna Kujala
Prostate Cancer
Prostasomes as Diagnostic Tool for Prostate Cancer Detection
Prostate cancer is the most frequently diagnosed cancer among men over 50 years old in Western societies, with an incidence that is steadily increasing in most countries.
- Trial name
- NCT03694483
- Testing
- Genetic analysis for the detection of prostasomes
- Where
- United States
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Hackensack Meridian Health
Free Tissue Flaps
Detection of Flap Ischemia Using Interstitial Glucose Monitor
A simple device that objectively assesses flap perfusion - either as a stand-alone tool or an adjunct to the current monitoring method - would be a tremendous improvement in detection of early postoperative flap ischemia and, in…
- Trial name
- NCT02604069
- Testing
- Continuous Glucose Monitor
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Hamilton Health Sciences Corporation
Jaundice, Neonatal
Validation of an Innovative Neonatal Jaundice Detection System (Picterus) in Indonesia
The long-term goal of this project is to establish Picterus as a permanent tool to detect NNJ in the healthcare services of Indonesia.
- Trial name
- NCT05630495
- Testing
- Picterus Jaundice Pro
- Where
- 2 sites in Indonesia
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Picterus AS
Parkinson's Disease
Detection of A-synuclein Aggregate as Biomarker in Diagnosing Parkinson's Disease at Early Stage by Using Protein Misfolding Cyclic Amplification (PMCA)
The study will investigate the biomarker of a-synuclein aggregate in CSF detected by protein misfolding cyclic amplification (PMCA) and its sensitivity and specificity in diagnosing Parkinson's disease at H-Y stage I and disease…
- Trial name
- NCT04536857
- Testing
- Biomarker assay
- Where
- China
- Volunteers
- healthy volunteers welcome
- Sponsor
- Huashan Hospital
Cognitive Decline, Cognitive Deficit
Validation Study SCOBES-AR
Purpose of the study The purpose of this study is to evaluate five tests to see if they are suitable for the early detection of cognitive impairment in people over the age of 60.
- Conditions
- Cognitive Decline, Cognitive Deficit, Cognitive Impairment
- Trial name
- NCT04204239
- Where
- Austria
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- FH Joanneum Gesellschaft mbH
Obstetric Anal Sphincter Injury, Delivery Complication
Detection of Obstetric Anal Sphincter Injuries With ONIRY Device
The main purpose of the study is to confirm the clinical performance and safety of impedance spectroscopy using the ONIRY device for the detection of anal sphincter injuries arising from vaginal deliveries.
- Conditions
- Obstetric Anal Sphincter Injury, Delivery Complication, Obstetric Complication
- Trial name
- NCT04903977
- Testing
- Laboratory tests: blood and faeces tests, Gynaecological and proctological examinations, 3-D Endoanal Ultrasound
- Where
- 5 sites in Czechia, Poland and 2 more
- Volunteers
- 152 people, healthy volunteers welcome
- Sponsor
- OASIS Diagnostics S.A.
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