Clinical trials: Detection
Knee Osteoarthritis, Knee Arthroplasty
Development of an Outcome Score for Patients With Knee Osteoarthritis and Knee Joint Endoprosthesis Using an App
Total knee arthroplasty (TKA) and total hip arthroplasty (THA) is one of the most frequent orthopedic procedures. Over 50% of patients report higher expectations than their surgeons, and 10-50% remain dissatisfied…
- Conditions
- Knee Osteoarthritis, Knee Arthroplasty, Hip Osteoarthritis, Hip Arthroplasty
- Trial name
- KneeApp (NCT07212699)
- Testing
- KneeApp
- Where
- Germany
- Volunteers
- 1,250 people, healthy volunteers welcome
- Sponsor
- Technical University of Munich
Cancer, Cancer Comorbidities
The Cancer Stage Shifting Initiative: Registry and Biorepository to Research and Address Health Disparities in Cancer Care
The goal of this observational study is to establish a patient registry and a biorepository (sample collection and storage) to investigate health disparities, access, and barriers to cancer screening and early detection…
- Trial name
- CSSI (NCT07461493)
- Where
- 2 sites in United States
- Volunteers
- 100,000 people, healthy volunteers welcome
- Sponsor
- National Minority Quality Forum
Healthy Volunteers
Transient Lower Esophageal Sphincter Relaxations and High Resolution Manometry
Transient lower esophageal sphincter relaxations (tLESr) are the main mechanism of gastro-oesophageal reflux disease. They occur without any deglutition in patients but also in healthy volunteers. They are induced by meal.
- Trial name
- NCT00931593
- Testing
- Esophageal high resolution manometry associated or not with manometry with perfused Dentsleeve probe (as determined by randomization)
- Where
- 3 sites in France
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Gastric Cancer
Use of a Liquid Biopsy Signature to Detect Early-onset Gastric Cancer
Early-onset gastric cancer (EOGC) is a lethal malignancy with a poor prognosis. It differs from late-onset gastric cancer (LOGC) in clinical and molecular characteristics.
- Trial name
- NCT06023121
- Testing
- Measurement of levels of an exosome-based liquid biopsy signature
- Where
- China
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Chinese PLA General Hospital
Glaucoma
Comparison of Critical Flicker Fusion Versus Automated Visual Fields in the Detection of Early Glaucoma
The purpose of this study is to evaluate if critical flicker fusion is a more reliable method for detection of early glaucoma compared to automated visual fields in comparison to subjects without evidence of glaucoma or optic…
- Trial name
- NCT01076114
- Where
- United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Non-Viable Pregnancy
Detection of Kisspeptins and miRNAs in Patients With Non-viable Pregnancy
Ectopic pregnancy (EP) is a pathology that affects 3%-16% of pregnancies in humans, being the main cause of morbidity and maternal mortality in the first trimester of pregnancy worldwide.
- Trial name
- TESTKM (NCT03877939)
- Testing
- Blood samples collection for analysis
- Where
- 2 sites in Spain
- Volunteers
- 433 people, healthy volunteers welcome
- Sponsor
- Vida Recoletas Sevilla
Breast Cancer
Validation of Molecular Diagnostic Assays to Detect Cancer Biomarkers in Blood & Primary Tumor in ER+/HER2- MBC
Conventional biopsy and surgical tumor resection are invasive procedures that capture only one instance of the progression of the tumor. However, the genome of tumor is not static, but it is constantly altered during treatment.
- Trial name
- NCT04480814
- Testing
- PIK3CA kit
- Where
- 4 sites in Greece
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Pharmassist Ltd
Fluid Loss
Evaluation of Physiological Variables and Detection of Blood Loss Using the Zynex Fluid Monitoring System, Model CM-1600
The study is a prospective, non-randomized, non-blinded, non-significant risk, multi-center study enrolling up to 500 healthy adult subjects consented to undergo a whole blood donation procedure.
- Trial name
- NCT05463198
- Testing
- CM-1600
- Where
- 4 sites in United States
- Volunteers
- 351 people, healthy volunteers welcome
- Sponsor
- Zynex Monitoring Solutions
Alzheimer Disease
Davos Alzheimer's Collaborative Study: Sequential Administration of Digital Testing To Screen For Cognitive Impairment Followed By Blood Based Biomarkers To Assist With Timely Detection And Accurate Diagnosis Of Alzheimer's Disease
The purpose of this study is to investigate how we can detect Alzheimer's disease early by using an online memory test and a simple blood test.
- Trial name
- DAC (NCT05379348)
- Testing
- Cognitive Assessment
- Where
- United States
- Volunteers
- 1,423 people, healthy volunteers welcome
- Sponsor
- AdventHealth Translational Research Institute
Cancer
iDentification and vAlidation Model of Liquid biopsY Based cfDNA Methylation and pRotEin biomArKers for Pancreatic Cancer (DAYBREAK Study)
DAYBREAK is a prospective, multi-omics, observational study aimed at early detecting pancreatic cancer by combined assays for biomarkers of cfDNA methylation, serum protein markers, blood miRNA markers and others, in which of 450…
- Trial name
- NCT05495685
- Where
- China
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Changhai Hospital
Delirium
Testing the Validity of the "Modified Confusion Assessment Method for the Emergency Department" (mCAM-ED)"
The proposed Study validates the accuracy of the modified Confusion Assessment Method for the Emergency Department
- Trial name
- Val_mCAM-ED (NCT02782143)
- Where
- Switzerland
- Volunteers
- 289 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Artificial Intelligence, Colonic Polyp
Intelligent-C Endoscopy Module for Real-time Detection of Colonic Lesions
To conduct an single blinded, non-randomized, prospective, single center trial to validate the performance of a novel state-of-the-art Artificial Intelligence model (AI-Model) for colorectal lesion detection during routine…
- Trial name
- iIDEAS/RTD (NCT05784935)
- Testing
- Real time AI detection model
- Where
- India
- Volunteers
- 380 people, healthy volunteers welcome
- Sponsor
- Asian Institute of Gastroenterology, India
Knowledge, Satisfaction
Deep Learning Model Detecting Pressure Injury
In the health care system, pressure injuries, which are among the quality indicators, are a serious patient safety problem that affects the length of hospital stay and the cost of care.
- Trial name
- NCT06641258
- Testing
- Control Group (Standard Procedure), Experimental Group
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Beykent
Helicobacter Pylori
Pilot Study of a Gastric String Test Combined With a Rapid Antigen Assay for Helicobacter Pylori Detection
This single-center, open-label, prospective pilot study aims to evaluate the feasibility, safety, and preliminary diagnostic performance of a minimally invasive gastric string sampling device combined with a rapid antigen assay…
- Trial name
- NCT07906938
- Testing
- HP String Test With Rapid Antigen Assay
- Where
- Taiwan
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Fu Jen Catholic University Hospital
Ankle Osteoarthritis
Improving the Detection, Classification and Treatment of Misaligned Arthritic Ankles
The Veteran population is prone to foot and ankle maladies from common injuries such as sprains, and diseases such as ankle osteoarthritis (cartilage damage).
- Trial name
- IDCT (NCT03440008)
- Testing
- Dynamic 3D bone motion capture, wedged insole
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Prostate Cancer
Stockholm3 Use Prior to MRI for Prostate Cancer Detection in a Clinical Care Pathway: a Multi-centered Validation
Men meeting local clinical standard of care to undergo a prostate MRI for suspicion of prostate cancer will be included. Blood sample will be drawn on the day of MRI or immediately prior to MRI for measurement of the prostate…
- Trial name
- S3M-MRI (NCT06573736)
- Testing
- Stockholm3
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Human Microbiome
Detection of Luminal and Mucosa-associated Microbiome in Healthy Controls vs. Local and Systemic Inflammation
This study should reveal differences in composition of luminal and mucosa-associated microbiome of the human gastrointestinal tract.Therefore bacterial species of different intestinal location sites (small intestine and colon)…
- Trial name
- NCT03157687
- Where
- Germany
- Volunteers
- 117 people, healthy volunteers welcome
- Sponsor
- University of Erlangen-Nürnberg Medical School
Oral Cancer, Diagnoses Disease
Exfoliated Cytology in Detection of Oral Premalignant and Malignant Lesions
Micronuclei have been used since 1937 as an indicator of genetic toxic exposure due to their association with chromosomal alterations.
- Trial name
- NCT04955197
- Testing
- exfoliated cytology
- Where
- Egypt
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Cairo University
Neoplasm, Colorectal, Neoplasm, Breast
Development, Implementation and Evaluation of an Individual Decision Aid in Swedish Cancer Screening Programs
Background: Sweden has a long tradition of organized national population-based screening programs. Participation rates differ between programs and regions, are relatively high in some groups, but lower in other.
- Conditions
- Neoplasm, Colorectal, Neoplasm, Breast, Neoplasm, Ovarian
- Trial name
- BESTa (NCT05512260)
- Testing
- Individual decision aid (iDA)
- Where
- Sweden
- Volunteers
- healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Multidrug Resistant Klebsiella Pneumoniae Infection
Phenotypic and Genotypic Detection of Biofilm Formation and Efflux Pump Activity in Multi-drug Resistant Klebsiella Pneumoniae
1. Sample: urine, pus and sputum samples. 2. Culture: the samples will be inoculated on the MacConkey agar and subcultured on eosine methylene blue agar. 3. Identification of isolates will be done by: Colony morphology.
- Trial name
- Klebsiella (NCT07541690)
- Testing
- Genotypic Detection of Biofilm Formation and Efflux Pump Activity.
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Sohag University
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