Clinical trials: Detection
Blood Stream Infection, Blood Stream Infections
Evaluation of Diagnostic Accuracy and Clinical Performance of the UllCORE Bloodstream Infection (BSI) Test
This study is designed to evaluate the clinical performance of the UllCORE Bloodstream Infection (BSI) Test, an investigational molecular diagnostic test intended to detect microorganisms and selected antimicrobial resistance…
- Conditions
- Blood Stream Infection, Blood Stream Infections, Sepsis, Fungemia
- Trial name
- B-RAPID (NCT07859852)
- Testing
- UllCORE BSI Test
- Where
- 20 sites in United States, France and 3 more
- Volunteers
- 1,500 people
- Sponsor
- Deepull Diagnostics S.L.
Lung Cancer
Chest Imaging, Breath, and Biomarkers in a Screening Trial
The investigators would like to see if lung cancer screening with chest x-rays,computer aided detection (CAD)and a lose dose CT scan can detect lung cancer in early stages when it is more responsive to treatment.
- Trial name
- NCT01663155
- Testing
- chest x-ray with or without CAD, lose dose CT scan
- Where
- United States
- Volunteers
- 1,424 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Lung Cancer
A Preliminary Study on the Detection of Plasma Markers in Early Diagnosis for Lung Cancer
Lung cancer is the most common cancer with the highest morbidity and mortality in the world. Stagement is closely related to the 5 years of survival rate of patients.
- Trial name
- NCT04558255
- Testing
- A machine-learning method which can robustly discriminate early-stage lung cancer patients from controls
- Where
- China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Peking University People's Hospital
COVID, SARS-CoV2
Evaluation of an Alternative Method of Obtaining Viral RNA for the Detection of SARS-CoV-2 Virus Using PCR
The current coronavirus disease pandemic has posed a problem and a challenge for health systems globally. In the framework of a pandemic, a diagnosis is a key tool in containing and monitoring disease outbreaks.
- Conditions
- COVID, SARS-CoV2, Corona Virus Infection
- Trial name
- NCT04468217
- Testing
- Obtainment of nasopharyngeal, oropharyngeal, buccal, nasal and saliva samples
- Where
- Chile
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Neurognos
Coronary Artery Disease, Chest Pain
Coronary Obstruction Detection by Molecular Personalized Gene Expression (Corus CAD or ASGES)
To validate the use of Corus CAD (Age/Sex/Gene Expression score - ASGES) blood assay in subjects who are referred for the work-up of coronary artery disease.
- Conditions
- Coronary Artery Disease, Chest Pain, Cardiovascular Diseases, Coronary Heart Disease
- Trial name
- COMPASS (NCT01117506)
- Testing
- Corus CAD (ASGES)
- Where
- 7 sites in United States
- Volunteers
- 581 people
- Sponsor
- CardioDx
Covid19
Detection of COVID-19 Using Breath Analysis - Validation Study
DETECTION OF THE 2019 NOVEL CORONAVIRUS (SARS-CoV-2) USING BREATH ANALYSIS- VALIDATION STUDY
- Trial name
- COVID-19 (NCT04602949)
- Testing
- Breath Biopsy Analysis
- Where
- Israel
- Volunteers
- 2,558 people, healthy volunteers welcome
- Sponsor
- Scentech Medical Technologies Ltd
Breast Cancer
Characterization of Extracellular Vesicles in Breast Cancer Patients
Extracellular vesicles (EVs) are lipid bilayer-delimited particles, naturally released from cells and mediators of intercellular cross-talk.
- Trial name
- NCT05798338
- Testing
- Blood sample
- Where
- Italy
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Istituti Clinici Scientifici Maugeri SpA
Trace Aluminum Ions in Parenteral Nutrition
Portable Detection, Assessment, and Control of Trace Aluminum Ions in Parenteral Nutrition Formulations for Preterm Infants
The research team will develop a series of multivalent nanozyme materials (MOF@Arg@His) to construct a sensing platform with dual-mode colorimetric and fluorescent responses, thereby markedly improving the sensitivity and…
- Trial name
- PN-Al POCT (NCT07646925)
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Han Tongyan
Prostate Cancer
Whole Body Bone Scan vs 18F-Choline PET/CT in Prostate Cancer
Prostate cancer is currently the leading newly diagnosed cancer in the industrialized world. Treatment of prostate cancer is highly dependent on the stage of the disease. Current methods for staging are known to be inaccurate.
- Trial name
- NCT02232685
- Testing
- 18F-Choline PET/CT
- Where
- Denmark
- Volunteers
- 143 people
- Sponsor
- Odense University Hospital
Inflammatory Arthritis
3D DL Ozteo in the Detection of Osseous Changes in Patients With Inflammatory Arthritis
This project intends to explore and validate the utility of new MRI pulse sequence, 3D DL oZTEo, in the detection of osseous erosions of the hand in patients with inflammatory arthritis.
- Trial name
- NCT06383585
- Testing
- oZTEo
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Mayo Clinic
Locally Advanced Head and Neck Squamous Cell Carcinoma
A Prospective Randomized Controlled Study of Immune Checkpoint Maintenance Therapy After Radiotherapy and Chemotherapy for Locally Advanced Head and Neck Tumors Based on Peripheral Blood CD8Tex Detection in Peripheral Blood
The goal of this prospective, randomized, single-blind controlled clinical study is to explore the efficacy of maintenance therapy with Sintilimab after chemoradiotherapy in locally advanced head and neck squamous cell carcinoma.
- Trial name
- NCT06240689
- Testing
- Sintilimab
- Where
- China
- Volunteers
- 104 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Enterobacteria Non Susceptible to Carbapenem Carrier, Enterobacteria Susceptible to Carbapenem Carrier
Carbapenem-resistant Enterobacteriaceae: Prevalence, Risk Factors and Impact of the Use of the Phenotypic Algorithm for the Detection of Carbapenemases
The non-susceptibility of enterobacteriaceae isolates to carbapenem (CARBA) is an emerging concern with a high impact on infectious disease therapy.
- Trial name
- E-CARB (NCT02127450)
- Where
- France
- Volunteers
- 525 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Metabolic Syndrome
Early Vascular Wall Changes by Magnetic Resonance Imaging (MRI) in Metabolic Syndrome Versus Metabolically Normal Pre-Menopausal Women: A Pilot Study
The purpose of this study is to compare the vascular permeability of blood vessel walls (of the carotid artery) in pre-menopausal women who have metabolic syndrome (syndrome of having at least 3/5 following features- increased…
- Trial name
- NCT01068535
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- University of Washington
Pancreatic Cancer, Pancreatic Ductal Adenocarcinoma (PDAC)
PRedictiOn Algorithms for the DeTECTion of Early Stage Pancreatic Cancer
Conduct a prospective study to assess the accuracy of a pancreatic cancer risk prediction model.
- Trial name
- PRO-TECT (NCT04883450)
- Testing
- Magnetic resonance imaging (MRI)
- Where
- United States
- Volunteers
- 126 people
- Sponsor
- Kaiser Permanente
Solid Tumor
Performance Evaluation of Diagnostic Accuracy of PanTum Detect Test for Detection of Solid Tumours in Known Cancer Population and in Cancer Free Population.
Performance evaluation of diagnostic accuracy (Sensitivity and Specificity) of PanTum detect Test for detection of solid tumours in known cancer population (Sick population) and in cancer free (Healthy) population.
- Trial name
- NCT06456216
- Where
- India
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Max Healthcare Insititute Limited
Locally Advanced Rectal Cancer, Abdominoperineal Resection
Detection and Inflammatory Characterization of Deep Infection After Surgery for Locally Advanced Rectal Cancer With Microdialysis Catheters
The intention of the study is to explore metabolic and inflammatory parameters in the pelvis after abdominoperineal resection for locally advanced rectal cancer in patients that have received radiation therapy before surgery.
- Conditions
- Locally Advanced Rectal Cancer, Abdominoperineal Resection, Infection
- Trial name
- NCT03392584
- Where
- Norway
- Volunteers
- 50 people
- Sponsor
- Oslo University Hospital
Hepatocellular Carcinoma
Circulating Cell-free DNA as a Predictive Biomarker for Hepatocelluar Carcinoma.
Circulating free cell DNA (cfDNA) is extracellular fragmentation of nucleic acids that occurs both in plasma and serum. This kind of DNA which derived from the apoptotic/necrotic cells or the lysis of circulating tumor cells…
- Trial name
- NCT02036216
- Where
- 2 sites in United States, China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Peking Union Medical College Hospital
Helicobacter Pylori
Performances of a H. Pylori Stool PCR Test
Performance of a non-invasive test for the detection of Helicobacter pylori and its resistance to clarithromycin in stool by Real-Time PCR Amplidiag H. pylori + ClariR (Mobidiag).
- Trial name
- HEPYSTOOL (NCT03566004)
- Testing
- Stool specimen collection
- Where
- France
- Volunteers
- 1,200 people
- Sponsor
- Poitiers University Hospital
Cryptogenic Stroke, Atrial Fibrillation
Improving AF Detection in Cryptogenic Stroke
No cause for stroke is found in up to 30% of cases despite extensive investigations. These are called cryptogenic strokes (CS). 1 in 4 stroke survivors will suffer another in 5 years and this is a leading cause of fear and…
- Trial name
- CSAF-AW (NCT05007847)
- Testing
- Apple Watch-based heart rhythm monitoring
- Where
- 4 sites in United Kingdom
- Volunteers
- 27 people
- Sponsor
- Barts & The London NHS Trust
Hepatocellular Carcinoma
GNB4 and Riplet Gene Methylation Combined Detection Kit (Fluorescence PCR Method)
The goal of this observational study is to test the clinical efficacy of "GNB4 and Riplet gene methylation combined detection kit (fluorescence PCR method)"in hepatocellular carcinoma auxiliary diagnosis.
- Trial name
- NCT05668793
- Testing
- GNB4 and Riplet Gene Methylation Combined Detection Kit (Fluorescent PCR Method)
- Volunteers
- 1,000 people
- Sponsor
- Wuhan Ammunition Life-tech Co., Ltd
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