Clinical trials: Deterioration, Clinical
Patient Deterioration, Patient Monitoring
Wireless Assessment of Respiratory and Circulatory Distress - Europe
Hospital patient monitoring in Europe is often intermittent, which can delay detection of clinical deterioration during hospitalization and after discharge.
- Conditions
- Patient Deterioration, Patient Monitoring, Clinical Deterioration
- Trial name
- WARD-EU (NCT07451249)
- Testing
- WARD-CSS (Wireless Assessment of Respiratory and Circulatory Distress - Clinical Support System)
- Where
- 5 sites in Denmark, Netherlands and 2 more
- Volunteers
- 1,240 people, healthy volunteers welcome
- Sponsor
- Eske Kvanner Aasvang
Clinical Deterioration, Postoperative Complications
Evaluation of the Modified Early Warning Scoring System
In this study, it was aimed to determine the effect of HRU and HG on patient outcomes in the care process in surgical patients followed according to MEUSS.
- Conditions
- Clinical Deterioration, Postoperative Complications, Nurse's Role
- Trial name
- NCT05575531
- Testing
- MEWSS and Nursing Guide Application
- Where
- Turkey (Türkiye)
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Kocaeli University
Clinical Deterioration
Multicomponent Exercise to Prevent Hospitalization-Associated Disability
The study is a randomized controlled trial conducted in the Geriatrics Department of a tertiary hospital in Spain (Hospital Universitario de Navarra).
- Trial name
- FIS_Prevention (NCT07707310)
- Testing
- Behavioral: Exercise
- Where
- Spain
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Fundacion Miguel Servet
Physician Judgment
Understanding Physician Signout Risk Perception
The purpose of the study is to compare the ability of physicians and a statistical index (the Rothman score) to predict clinical deterioration over the next 24 hours.
- Trial name
- UPS (NCT02648828)
- Testing
- Clinical deterioration
- Where
- United States
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Dementia of the Alzheimer Type, Age-related Cognitive Decline
Dosage and Efficacy of Probucol-induced apoE to Negate Cognitive Deterioration
DEPEND is an open-label but dosage-masked trial of the retired cholesterol-lowering drug probucol as an agent to increase availability of apolipoprotein E (apoE) in the cerebrospinal fluid (CSF) of cognitively intact older…
- Conditions
- Dementia of the Alzheimer Type, Age-related Cognitive Decline, Mild Cognitive Impairment Due to Alzheimer Disease
- Trial name
- DEPEND (NCT02707458)
- Testing
- Probucol
- Where
- Canada
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Douglas Mental Health University Institute
Respiratory Depression, Respiratory Failure
VitalThings Guardian Contactless Monitoring
This is a confirmatory study without any intervention. It is an uncontrolled, non-randomized and open-label study with measurements made with comparators, and it has a preset hypothesis for the primary endpoint.
- Conditions
- Respiratory Depression, Respiratory Failure, Deterioration, Clinical
- Trial name
- VINCENT (NCT06083272)
- Testing
- Vitalthings Guardian M10 fixed and M10 mobile
- Where
- Norway
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- VitalThings
Clinical Reasoning in Nursing Education, Virtual Simulation
MAGICS - Multi-Agent Generative AI in Clinical Simulation for Clinical Deterioration Training
This study compares the effectiveness of a Generative AI-integrated blended simulation programme and high-fidelity simulation alone on nursing students' clinical reasoning and learning experience during deterioration training
- Conditions
- Clinical Reasoning in Nursing Education, Virtual Simulation, Artificial Intelligence in Education, Deterioration, Clinical
- Trial name
- MAGICS (NCT07872735)
- Testing
- Generative AI-integrated Blended Simulation, High Fidelity Simulation
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- National University of Singapore
Respiratory Insufficiency, Clinical Deterioration
Wearable Wireless Respiratory Monitoring System That Detects and Predicts Opioid Induced Respiratory Depression
An observational study will be conducted in approximately 14 participants to evaluate the ability of a wearable, wireless acoustic Respiratory Monitoring System (RMS) to accurately measure a participant's respiratory rate, tidal…
- Trial name
- NCT06442488
- Testing
- Respiratory Monitoring System
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Jeffrey Joseph
Irritable Bowel Syndrome
Predictive Factors for a Clinical Diagnosis of Irritable Bowel Syndrome in a Large Cohort of Young Adults.
The prevalence of IBS in the community has been reported in numerous cross-sectional surveys. However, less is known about the incidence of IBS ,mainly due to its slow development and to patients under-reporting.
- Trial name
- NCT01854060
- Where
- Israel
- Volunteers
- 440,822 people, healthy volunteers welcome
- Sponsor
- Medical Corps, Israel Defense Force
Clinical Deterioration
Prevention of Functional and Cognitive Impairment Through a Multicomponent Exercise Program in Hospitalized Older Adults
The goal of this clinical trial is to determine whether a multicomponent exercise program improves functional capacity and cognitive status in hospitalized elderly patients aged 75 and older.
- Trial name
- PREDISC (NCT06634147)
- Testing
- Exercise
- Where
- 2 sites in Spain
- Volunteers
- 214 people, healthy volunteers welcome
- Sponsor
- Fundacion Miguel Servet
Heart Failure, Cardiomyopathies
Multimodal Physiologic State Intelligence Study
The OMNIPHYS study will investigate whether multimodal ultrasound and other routinely collected clinical and physiologic data can be combined with artificial intelligence to characterize changes in a person's physiologic state…
- Conditions
- Heart Failure, Cardiomyopathies, Pulmonary Hypertension, Myocarditis; Acute or Subacute
- Trial name
- OMNIPHYS (NCT07814118)
- Testing
- OMNIPHYS Multimodal Ultrasound Imaging System
- Where
- United States
- Volunteers
- 25,000 people, healthy volunteers welcome
- Sponsor
- Truway Health, Inc.
Coronavirus Disease 2019 Infectious Disease (COVID-19 Infection)
Amotosalen-Ultraviolet A Pathogen-Inactivated Convalescent Plasma in Addition to Best Supportive Care and Antiviral Therapy on Clinical Deterioration in Adults Presenting With Moderate to Severe COVID-19
This project investigates individual treatments using convalescent severe acute respiratory Syndrome Coronavirus 2 (SARS-CoV-2) plasma in SARS-CoV-2 infected patients at risk for disease progression.
- Trial name
- NCT04389944
- Testing
- convalescent plasma application to SARS-CoV-2 infected patients
- Where
- Switzerland
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland