Clinical trials: Detrusor, Overactive
Overactive Detrusor
Botulinum Toxin in the Treatment of Idiopathic Detrusor Overactivity
Overactive Bladder (OAB) is a chronic condition caused by instability of the detrusor or bladder muscle, which gives rise to symptoms of urinary urgency and often urinary incontinence.
- Trial name
- NCT02009540
- Testing
- Botulinum toxin injected to bladder body, Botulinum toxin injected into trigone
- Where
- Ireland
- Volunteers
- 60 people
- Sponsor
- Mr HD Flood
Overactive Bladder, Overactive Bladder Syndrome
Yoga for Treatment of Overactive Bladder in Pediatric Patients
The goal of this pilot study is to assess the impact of yoga as a treatment modality in pediatric patients age 8-18 diagnosed with idiopathic overactive bladder as measured by validated questionnaires and urinary biomarkers.
- Conditions
- Overactive Bladder, Overactive Bladder Syndrome, Overactive Detrusor
- Trial name
- NCT05895045
- Testing
- Yoga
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Duke University
Neurogenic Bladder
Device for Bladder Control for Men With SCI
Urinary incontinence, bladder frequency, and bladder urgency are significant medical problems for people with overactive bladder (OAB) or neurogenic bladder overactivity (NDO).
- Trial name
- NCT07668063
- Testing
- Noninvasive electrical stimulation device to improve bladder control
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- VA Office of Research and Development
Urinary Bladder, Overactive, Urodynamics
Evaluation the Efficacy Between Botox Injection and Combination Pharmacotherapy in Patients With Detrusor Overactivity
To investigates the effects of botulinum toxin type A bladder injection compared to combined pharmacotherapy with Mirabegron and Solifenacin.
- Conditions
- Urinary Bladder, Overactive, Urodynamics, Effect of Drug
- Trial name
- NCT05968885
- Testing
- Intradetrusor Botox® (onabotulinumtoxinA) injection, Combine Mirabegron and Solifenacin.
- Where
- Taiwan
- Volunteers
- 300 people
- Sponsor
- Mackay Memorial Hospital
Overactive Bladder Syndrome, Urge Incontinence
Oral vs Intravesical Analgesia for Office Bladder Botox Injections
OnabotulinumtoxinA (Botox®) bladder injections are a highly effective treatment for overactive bladder and urgency urinary incontinence.
- Conditions
- Overactive Bladder Syndrome, Urge Incontinence, Urinary Incontinence, Detrusor Hyperreflexia
- Trial name
- OPIL (NCT03755089)
- Testing
- Phenazopyridine, Lidocaine 2% Injectable Solution
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- Women and Infants Hospital of Rhode Island
Overactive Bladder Syndrome, Detrusor Overactivity
Effect of beta3-adrenoceptor Agonist on Patients With Overactive Bladder and as a Urinary Biomarker
About one to two million women in Taiwan suffers from overactive bladder (OAB). The most commonly used anti-muscarinic drugs have a high rate of side effects.
- Trial name
- NCT04693897
- Testing
- Mirabegron 50 MG, Solifenacin Succinate 5 MG
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Bladder Disorder, Neurogenic
Heart Rate Variability (HRV) in Patients With Neurogenic Detrusor Overactivity (NDO) Before and After Botulinum Neurotoxin Type A (BoNT/A) Intradetrusor Injections
Heart rate variability (HRV) is an important indicator of cardiac autonomic function and predictor of cardiac mortality and of all-cause mortality.
- Trial name
- HRV/Botox (NCT01337024)
- Where
- Switzerland
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Balgrist University Hospital
Spinal Cord Injuries (SCI)
The Predictive Value of Lower Extremity Hypertonia on Neurogenic Detrusor Overactivity After Spinal Cord Injury
The goal of this observational study is to evaluate whether increased lower extremity muscle tone can serve as an independent predictor of neurogenic detrusor overactivity (NDO) in adult patients (aged 18-80 years) with upper…
- Trial name
- NCT07695662
- Volunteers
- 300 people
- Sponsor
- Shengjing Hospital
Overactive Bladder
Safety Study of hMaxi-K Gene Transfer to Treat Overactive Bladder and Detrusor Overactivity
The purpose of this study is to evaluate the safety of a new product that uses human gene transfer (called hMaxi-K) when it is given to patients with overactive bladder.
- Trial name
- NCT00495053
- Testing
- hMaxi-K
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Urovant Sciences GmbH
Overactive Bladder, Overactive Bladder Syndrome
Optimal Intravesical Lidocaine Volume for Pain Relief During Office Intra-detrusor Onabotulinum Toxin a Injections
The purpose of our study is to evaluate the efficacy and safety of different volumes of bladder-numbing medication for pain relief at the time of office bladder Botox injections.
- Conditions
- Overactive Bladder, Overactive Bladder Syndrome, Urinary Urgency, Urinary Frequency
- Trial name
- NCT06695585
- Testing
- Lidocaine 2% without vessel constrictor
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- University of Louisville
Overactive Bladder, Neurogenic Detrusor Overactivity
Study Of Fesoterodine In Pediatric Overactive Bladder Patients Aged 8-17 Years
The purpose of the study is to evaluate the pharmacokinetics, safety, and tolerability of fesoterodine following administration to pediatric patients, aged 8-17 years, with overactive bladder.
- Trial name
- NCT00857896
- Testing
- Fesoterodine
- Where
- 9 sites in United States
- Volunteers
- 21 people
- Sponsor
- Pfizer
Effect of Drug, Urinary Bladder, Overactive
Efficacy of Solifenacin or Mirabegron With Local Estrogen Versus Combination Pharmacotherapy for Overactive Bladder
To investigates the effects of solifenacin or mirabegron with local estrogen versus combination treatment with solifenacin and mirabegron in women with overactive bladder
- Trial name
- NCT06479720
- Testing
- Combined pharmacotherapy with Solifenacin and Mirabegron, Solifenacin with vaginal estrogen cream, Mirabegron with vaginal estrogen cream
- Where
- Taiwan
- Volunteers
- 300 people
- Sponsor
- Mackay Memorial Hospital
Urinary Incontinence
A Long-Term Extension Study of OnabotulinumtoxinA (BOTOX®) for Urinary Incontinence Due to Neurogenic Detrusor Overactivity
This study will evaluate the long-term safety and efficacy of onabotulinumtoxinA (botulinum toxin Type A; BOTOX®) for the treatment of urinary incontinence due to neurogenic detrusor overactivity in participants who successfully…
- Trial name
- NCT01852058
- Testing
- OnabotulinumtoxinA
- Where
- 30 sites in United States, Belgium and 6 more
- Volunteers
- 95 people
- Sponsor
- Allergan
Overactive Bladder
OnabotulinumtoxinA (onaBoNT-A) Versus Oral Oxybutynin ER
Overactive bladder is a condition associated with symptoms of feeling the urge to urinate, urinating often, and may or may not be accompanied by leakage of urine.
- Trial name
- NCT01050114
- Testing
- onaBoNT-A, Oxybutynin ER
- Where
- 2 sites in United States
- Volunteers
- 36 people
- Sponsor
- Christopher Patrick Smith
Overactive Bladder
Audiovisual Stimulus During Urodynamics
Many women have the need to run to the restroom frequently during the night and day, a condition called "overactive bladder". Embarrassing urinary leakage is also commonly associated with these symptoms.
- Trial name
- AVUDE (NCT02670486)
- Testing
- Audiovisual stimulus
- Volunteers
- 218 people, healthy volunteers welcome
- Sponsor
- Women and Infants Hospital of Rhode Island
Lower Urinary Tract Symptoms
Filling and Emptying Cystometries ("Backwards Cystometry"): a Feasibility and Validation Study
This study evaluate the feasibility and the accuracy of an emptying cystometry in order to simplify the manometric follow-up of overactive detrusor in neurological patients under anticholinergic or botulinum toxin injections.
- Trial name
- NCT03255421
- Testing
- Pressure measurement
- Where
- France
- Volunteers
- 11 people
- Sponsor
- Pierre and Marie Curie University
Overactive Bladder, Overactive Bladder Syndrome
Comparison of Different Treatments for Overactive Bladder Syndrome
This study aims to investigate the effects of pelvic floor muscle exercises, electrical stimulation and taping in patients with overactive bladder
- Conditions
- Overactive Bladder, Overactive Bladder Syndrome, Overactive Detrusor
- Trial name
- NCT04197466
- Testing
- Pelvic Floor Exercise Group, Kinesio tape, Electrical stimulation
- Where
- Turkey (Türkiye)
- Volunteers
- 66 people
- Sponsor
- Ankara Yildirim Beyazıt University
Overactive Bladder, Overactive Bladder Syndrome
Transcutaneous Tibial Nerve Stimulation for Idiopathic Overactive Bladder
This study was designed to assess the efficacy of trans cutaneous tibial nerve stimulation on symptoms of overactive bladder in women with idiopathic overactive bladder
- Conditions
- Overactive Bladder, Overactive Bladder Syndrome, Overactive Detrusor
- Trial name
- NCT05977634
- Testing
- Bladder training, Transcutaneous tibial nerve stimulation
- Where
- Turkey (Türkiye)
- Volunteers
- 26 people
- Sponsor
- Ege University
Detrusor Muscle Hyperactivity
Neurogenic Detrusor Overactivity Following Spinal Cord Injury or Multiple Sclerosis
The purpose of this study is to determine the efficacy and safety of a single dose of 750 U of Dysport compared to placebo for the improvement in the daily incontinence episode frequency for each administration mode in subjects…
- Trial name
- NCT01357980
- Testing
- Botulinum toxin type A
- Where
- 17 sites in Czechia, France and 3 more
- Volunteers
- 47 people
- Sponsor
- Ipsen
Urinary Incontinence, Urinary Bladder, Overactive
Evaluation of Safety and Efficacy of Botulinum Toxin Type A (BOTOX®) to Treat Urinary Incontinence Due to Neurogenic Detrusor Overactivity or Overactive Bladder in Korea
This study is a Post-Marketing Surveillance study in Korea to evaluate the safety and efficacy of botulinum toxin Type A to treat urinary incontinence in patients with neurogenic detrusor overactivity (NDO) or overactive bladder…
- Trial name
- NCT02010788
- Testing
- botulinum toxin Type A
- Where
- South Korea
- Volunteers
- 523 people
- Sponsor
- Allergan