Clinical trials: Detrusor, Overactive
Neurogenic Detrusor Overactivity
A Two-week Open-label Pharmacodynamic and Pharmacokinetic Study of Multiple Doses of a Darifenacin Liquid Oral Suspension in Children (2 - 15 Years) With Neurogenic Detrusor Overactivity
This study will evaluate the pharmacodynamics and pharmacokinetics of darifenacin liquid oral suspension in children, ages 2-15 years, with neurogenic detrusor overactivity.
- Trial name
- NCT00712322
- Testing
- Darifenacin
- Where
- 12 sites in United States, Colombia
- Volunteers
- 35 people
- Sponsor
- Warner Chilcott
Bladder Oversensitivity, Detrusor, Overactive
BO and DO in Women With Cystocele Before and After Cystocele Repair
The changes of lower urinary tract function after cystocele repair are important for perioperative consultation and management. Thus, the aim of this retrospective study was to evaluate the prevalence of bladder oversensitivity…
- Trial name
- NCT04981054
- Testing
- Cystocele repair
- Where
- Taiwan
- Volunteers
- 483 people
- Sponsor
- National Taiwan University Hospital
Urodynamic Stress Incontinence, Detrusor Overactivity
USI and/or DO in Women With Cystocele Before and After Cystocele Repair
The changes of lower urinary tract function after cystocele repair are important for perioperative consultation and management. Thus, the aim of this retrospective study was to evaluate the prevalence of urodynamic stress…
- Trial name
- NCT04978714
- Testing
- Cystocele repair
- Where
- Taiwan
- Volunteers
- 483 people
- Sponsor
- National Taiwan University Hospital
Neurogenic Bladder, Detrusor Underactivity
A Comparative Analysis of Portable Bladder Scanner to Determine Age/ Volume Specific Accuracy in 0-6 Years of Children
As a part of the urodynamic studies, urinary catheterization is inserted to measure residual urine, however, it has shown to be an invasive procedure, cause urinary tract infection, and traumatic experience.
- Conditions
- Neurogenic Bladder, Detrusor Underactivity, Detrusor Overactivity
- Trial name
- NCT04543552
- Testing
- Bladder scan
- Where
- South Korea
- Volunteers
- 34 people
- Sponsor
- Seoul National University Hospital
Overactive Bladder Syndrome, Detrusor Overactivity
Effect of beta3-adrenoceptor Agonist on Patients With Overactive Bladder and as a Urinary Biomarker
About one to two million women in Taiwan suffers from overactive bladder (OAB). The most commonly used anti-muscarinic drugs have a high rate of side effects.
- Trial name
- NCT04693897
- Testing
- Mirabegron 50 MG, Solifenacin Succinate 5 MG
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Overactive Bladder, Overactive Bladder Syndrome
Comparison of Different Treatments for Overactive Bladder Syndrome
This study aims to investigate the effects of pelvic floor muscle exercises, electrical stimulation and taping in patients with overactive bladder
- Conditions
- Overactive Bladder, Overactive Bladder Syndrome, Overactive Detrusor
- Trial name
- NCT04197466
- Testing
- Pelvic Floor Exercise Group, Kinesio tape, Electrical stimulation
- Where
- Turkey (Türkiye)
- Volunteers
- 66 people
- Sponsor
- Ankara Yildirim Beyazıt University
Overactive Bladder Syndrome, Urge Incontinence
Oral vs Intravesical Analgesia for Office Bladder Botox Injections
OnabotulinumtoxinA (Botox®) bladder injections are a highly effective treatment for overactive bladder and urgency urinary incontinence.
- Conditions
- Overactive Bladder Syndrome, Urge Incontinence, Urinary Incontinence, Detrusor Hyperreflexia
- Trial name
- OPIL (NCT03755089)
- Testing
- Phenazopyridine, Lidocaine 2% Injectable Solution
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- Women and Infants Hospital of Rhode Island
Benign Prostatic Hypertrophy With Outflow Obstruction, Overactive Detrusor
Prognostic Value of the Urinary Nerve Growth Factor in the Patients With Benign Prostatic Hyperplasia
Persistent detrusor overactivity (DO) after transurethral prostatectomy results in symptomatic failure in more than one third of the patients.
- Trial name
- NCT01781117
- Testing
- Holmium Laser Enucleation of the Prostate (HoLEP), Holmium laser enucleation system and morcellator
- Where
- South Korea
- Volunteers
- 184 people, healthy volunteers welcome
- Sponsor
- KYU-SUNG LEE
Neurogenic Bladder, Overactive Detrusor
Efficacy of Two Onabotulinum Toxin Doses
The changes in bladder function after the injection of Onabotulinum toxin into the detrusor in individuals with neurogenic bladder overactivity will be investigated retrospectively.
- Trial name
- NCT03388086
- Testing
- Injection of Onabotulinum toxin
- Where
- Switzerland
- Volunteers
- 56 people
- Sponsor
- Swiss Paraplegic Research, Nottwil
Overactive Detrusor
Plantarflexion Reduces Urgency and Peak Detrusor Pressure in Patients With Detrusor Overactivity
The purpose of this study is to find out whether plantarflexion has an effect on the degree of urinary urgency and on the amplitude of detrusor contraction during filling cystometry in patients with detrusor overactivity (DO).
- Trial name
- DO (NCT01837654)
- Testing
- Plantarflexion 2nd wave, Plantarflexion - 3rd wave
- Where
- Israel
- Volunteers
- 22 people
- Sponsor
- Assaf-Harofeh Medical Center
Neurogenic Overactive Bladder, Urinary Incontinence
Efficacy Study of Pudendal Neuromodulation for the Treatment of Neurogenic Overactive Bladder
The study is designed to demonstrate that treatment with low level stimulation of the bladder muscles reduces symptoms of urinary incontinence in comparison with no stimulation.
- Conditions
- Neurogenic Overactive Bladder, Urinary Incontinence, Detrusor Overactivity
- Trial name
- ACCEPTANCE (NCT01023269)
- Testing
- InterStim Therapy
- Where
- 8 sites in Belgium, France and 4 more
- Volunteers
- 17 people
- Sponsor
- MedtronicNeuro
Overactive Bladder, Detrusor, Overactive
TPTNS: Home vs Hospital Treatment for Overactive Bladder
Comparison of home versus hospital Transcutaneous Posterior Tibial Nerve Stimulation (TPTNS). TPTNS has been shown to be an effective treatment of overactive bladder in hospital.
- Trial name
- NCT03727711
- Testing
- TPTNS
- Where
- United Kingdom
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- NHS Greater Glasgow and Clyde
Overactive Bladder, Overactive Detrusor
Sensitivity of Extended Cultures in Diagnosing Urinary Tract Infections
There is some evidence to suggest standard urine cultures may not be adequate in identifying patients with low grade urinary tract infections.
- Conditions
- Overactive Bladder, Overactive Detrusor, Urgency-Frequency Syndrome, UTI
- Trial name
- NCT03080389
- Testing
- Extended Urine Culture
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- The Cleveland Clinic
Lower Urinary Tract Symptoms, Cystometry
Reproductibility of Cystometry in Multiple Sclerosis Patient
This study evaluates the reproductibility (quantitative and qualitative) of cystometry in mutiple sclerosis patients.
- Conditions
- Lower Urinary Tract Symptoms, Cystometry, Multiple Sclerosis, Overactive Bladder
- Trial name
- NCT03451175
- Where
- France
- Volunteers
- 31 people
- Sponsor
- Pierre and Marie Curie University
Overactive Bladder, Urge Incontinence
Effects of Transcutaneous and Percutaneous PTNS on Idiopathic OAB
The purpose of this study is to determine if Transcutaneous Tibial Nerve Stimulation (TENS) is as effective as Percutaneous Tibial Nerve Stimulation (PTNS) as therapeutic option for subjects with Idiopathic Overactive Bladder…
- Conditions
- Overactive Bladder, Urge Incontinence, Overactive Detrusor
- Trial name
- NCT02657057
- Testing
- PTNS, TENS SNS
- Where
- Spain
- Volunteers
- 68 people
- Sponsor
- Instituto Médico Tecnológico SL
Urinary Urgency, Urinary Frequency
Efficacy and Safety of Gabapentin in Treating Overactive Bladder
Overactive bladder (OAB) syndrome as defined by International Continence Society is a pathological condition characterized by irritative symptoms: urinary urgency, with or without incontinence, urinary frequency and nocturia.
- Conditions
- Urinary Urgency, Urinary Frequency, Nocturia, Incontinence
- Trial name
- OAB (NCT01486706)
- Testing
- Gabapentin, Solifenacin Succinate
- Where
- Philippines
- Volunteers
- 94 people
- Sponsor
- Michael E. Chua
Detrusor Overactivity
UNGF Assessment in Patients With Detrusor Overactivity Undergoing Sacral Neuromodulation
The purpose of this study is to find a noninvasive test to help physicians diagnose detrusor overactivity (DO), to use this urine test to help diagnose bladder problems, determine if treatments are working, and determine if…
- Trial name
- NCT01850706
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Overactive Bladder, Detrusor Overactivity
A Study To Assess If 10 mg Vardenafil (BAY38-9456) Taken Twice Daily For 6 Weeks Has An Effect On Bladder Function
The purpose of this study is to assess if the study drug, Vardenafil (approved by Health Authorities is available on the market for treatment of erectile dysfunction) has an effect on bladder function and micturition frequency.
- Trial name
- NCT00478881
- Testing
- Vardenafil HCl (Levitra, BAY38-9456)
- Where
- 55 sites in Belgium, Canada and 11 more
- Volunteers
- 397 people
- Sponsor
- Bayer
Multiple Sclerosis, Overactive Detrusor
Study of Darifenacin in Patients Suffering From Multiple Sclerosis and Neurogenic Detrusor Overactivity
The objective of this study is to explore the effects of darifenacin in patients with multiple sclerosis and neurogenic detrusor overactivity.
- Trial name
- NCT00845338
- Testing
- Darifenacin (BAY79-4998)
- Where
- 15 sites in Germany
- Volunteers
- 7 people
- Sponsor
- Bayer
Overactive Bladder, Urinary Urge Incontinence
Over Active Bladder Instillation Study - Botox
The purpose of this study is to determine whether women with overactive bladder (OAB) who receive direct instillation via a catheter of a Botulinum-A Toxin (Botox) with Dimethyl Sulfoxide (DMSO) solution experience significantly…
- Conditions
- Overactive Bladder, Urinary Urge Incontinence, Urinary Incontinence, Detrusor Hyperreflexia
- Trial name
- NCT00667095
- Testing
- Botox Instillation, DMSO Instillation
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Mayo Clinic