Clinical trials: Detrusor, Overactive
Overactive Bladder, Urinary Urgency
Optimal Injection Interval for Intra-Detrusor Botulinum Toxin
The goal of this clinical trial is to see if patients deciding their own follow up times can increase the effectiveness of botulinum toxin (BTX or "Botox") injection for overactive bladder (OAB).
- Conditions
- Overactive Bladder, Urinary Urgency, Urinary Incontinence, Urge Urinary Incontinence
- Trial name
- NCT06483217
- Testing
- Patient-directed follow up
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Louisiana State University Health Sciences Center in New Orleans
Mild Cognitive Impairment, Spinal Cord Injuries
Effects of Antimuscarinics on Cognition in Spinal Cord Injury
Prospective evaluation of the cognitive function of in-house patients suffering from an acute traumatic spinal cord injury before and three months after the initiation of antimuscarinic treatment.
- Trial name
- NCT01600404
- Testing
- antimuscarinic treatment
- Where
- Switzerland
- Volunteers
- 32 people
- Sponsor
- Swiss Paraplegic Research, Nottwil
Urinary Incontinence
Study of OnabotulinumtoxinA (BOTOX®) for Urinary Incontinence Due to Neurogenic Detrusor Overactivity in Pediatric Patients
This study will evaluate the 3 doses of onabotulinumtoxinA (botulinum toxin Type A) for the treatment of urinary incontinence due to neurogenic detrusor overactivity in pediatric participants between the ages of 5 to 17 years to…
- Trial name
- NCT01852045
- Testing
- OnabotulinumtoxinA
- Where
- 31 sites in United States, Belgium and 6 more
- Volunteers
- 114 people
- Sponsor
- Allergan
Overactive Bladder, Underactive Bladder
The Treatment Efficacy of Prolotherapy in Bladder Voiding Dysfunction
Voiding dysfunction including overactive bladder, underactive bladder, and neuropathic bladder. Voiding dysfunction has a great impact on life quality, especially in the elderly society.
- Trial name
- NCT05485142
- Testing
- prolotherapy
- Where
- Taiwan
- Volunteers
- 80 people
- Sponsor
- Taichung Armed Forces General Hospital
Detrusor Overactivity, Overactive Bladder
Study of 2 Doses of Solifenacin Succinate in Female Subjects With Overactive Bladder.
The purpose is to see if solifenacin has any effect on bladder wall thickness and urine inflammatory marker measurements after 12 weeks of treatment.
- Trial name
- SHRINK (NCT01093534)
- Testing
- solifenacin
- Where
- 79 sites in United States, Austria and 18 more
- Volunteers
- 547 people
- Sponsor
- Astellas Pharma Inc
Overactive Bladder
Use of Transcutaneous Posterior Tibial Nerve Stimulation (TPTNS) in Maintaining OAB Symptoms Improvement.
This study will help to determine the effectiveness of a self-supervised, home-based Transcutaneous Posterior Tibial Nerve Stimulation treatment protocol in maintaining Overactive Bladder (OAB) symptoms improvement in women…
- Trial name
- NCT02377765
- Testing
- Transcutaneous Stimulation, Percutaneus Stimulation
- Where
- United Kingdom
- Volunteers
- 24 people
- Sponsor
- Liverpool Women's NHS Foundation Trust
Urinary Bladder, Overactive
Pulsed Electromagnetic Stimulation for Treatment of Overactive Bladder
To assess the initial safety and clinical feasibility of neuromodulation therapy in treating patients with documented overactive bladder. The specific aim is improved urinary frequency and urgency after 12 weeks of treatment
- Trial name
- NCT00805779
- Testing
- MagPro R30
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- EMKinetics, Inc
Mixed Urinary Incontinence, Urinary Incontinence, Stress
Pharmacological vs Surgical Treatment for Mixed Incontinence
In patients with symptoms of mixed incontinence (loss of urine associated with coughing/sneezing/laughing, and loss of urine associated with the strong urge to void), is surgical treatment with tension free vaginal tape or…
- Conditions
- Mixed Urinary Incontinence, Urinary Incontinence, Stress, Urinary Incontinence, Urge
- Trial name
- NCT00523068
- Testing
- Tolterodine, tension free vaginal tape
- Where
- United Kingdom
- Sponsor
- Imperial College London
Spinal Cord Injuries
Combined Magnetic Stimulation and Ultrasound for Detrusor Overactivity in SCI
This clinical trial aims to investigate whether the combination of high-frequency sacral nerve root magnetic stimulation and bladder-directed ultrasound therapy can effectively improve detrusor overactivity (involuntary bladder…
- Trial name
- NCT07704268
- Testing
- Transcranial Magnetic Stimulation (TMS) Device /Ultrasound therapy device
- Where
- China
- Volunteers
- 44 people
- Sponsor
- Shengjing Hospital
Neurogenic Bladder, Detrusor Underactivity
A Comparative Analysis of Portable Bladder Scanner to Determine Age/ Volume Specific Accuracy in 0-6 Years of Children
As a part of the urodynamic studies, urinary catheterization is inserted to measure residual urine, however, it has shown to be an invasive procedure, cause urinary tract infection, and traumatic experience.
- Conditions
- Neurogenic Bladder, Detrusor Underactivity, Detrusor Overactivity
- Trial name
- NCT04543552
- Testing
- Bladder scan
- Where
- South Korea
- Volunteers
- 34 people
- Sponsor
- Seoul National University Hospital
Neurogenic Detrusor Overactivity
A Two-week Open-label Pharmacodynamic and Pharmacokinetic Study of Multiple Doses of a Darifenacin Liquid Oral Suspension in Children (2 - 15 Years) With Neurogenic Detrusor Overactivity
This study will evaluate the pharmacodynamics and pharmacokinetics of darifenacin liquid oral suspension in children, ages 2-15 years, with neurogenic detrusor overactivity.
- Trial name
- NCT00712322
- Testing
- Darifenacin
- Where
- 12 sites in United States, Colombia
- Volunteers
- 35 people
- Sponsor
- Warner Chilcott
Neurogenic Detrusor Overactivity, Pediatric
A Clinical Study to Investigate How Solifenacin Fluid is Taken up, How Long it Stays in the Body and How Effective and Safe it is in Treating Children Aged From 6 Months to Less Than 5 Years With Symptoms of Neurogenic Detrusor Overactivity (NDO)
The purpose of this study was to evaluate long term efficacy and safety of treatment with solifenacin succinate (the study drug) in children with neurogenic detrusor overactivity after multiple dose administration.
- Trial name
- NCT01981954
- Testing
- Solifenacin succinate
- Where
- 8 sites in United States, Belgium and 4 more
- Volunteers
- 23 people
- Sponsor
- Astellas Pharma Europe B.V.
Overactive Detrusor
"Swallow my Urine Back" : Inhibition of Detrusor Overactivity by Swallowing Maneuver
The purpose of this study is to find out whether swallowing has an effect on the degree of urinary urgency and on the amplitude of detrusor contraction during filling cystometry in patients with detrusor overactivity (DO).
- Trial name
- NCT01408771
- Volunteers
- 20 people
- Sponsor
- Assaf-Harofeh Medical Center
Spinal Cord Injuries
Transcutaneous Spinal Cord Stimulation With Bladder and Pelvic Floor Muscle Training
Spinal Cord Injury (SCI) disrupts signals between the brain and the rest of the body, this includes signals needed to control the bladder and bowels.
- Trial name
- NCT05504200
- Testing
- Bladder and Pelvic Floor Muscle Training
- Where
- United Kingdom
- Volunteers
- 15 people
- Sponsor
- RNOH RIC
Neurogenic Bladder, Overactive Detrusor
Efficacy of Two Onabotulinum Toxin Doses
The changes in bladder function after the injection of Onabotulinum toxin into the detrusor in individuals with neurogenic bladder overactivity will be investigated retrospectively.
- Trial name
- NCT03388086
- Testing
- Injection of Onabotulinum toxin
- Where
- Switzerland
- Volunteers
- 56 people
- Sponsor
- Swiss Paraplegic Research, Nottwil
Neurogenic Bladder
Effect of Botulinum Toxin A on Neurogenic Detrusor Overactivity in Chronic Spinal Cord Injured Patients
This study investigated the changes in urothelial dysfunction and sensory protein expression in the bladder urothelium with time after onabotulinumtoxin injection in spinal cord injured (SCI) patients.
- Trial name
- NCT03063827
- Testing
- OnabotulinumtoxinA 200 UNT, Urothelial sensory protein levels
- Volunteers
- 36 people
- Sponsor
- Buddhist Tzu Chi General Hospital
Spinal Cord Injuries, Neuromodulation
Improving Pelvic Rehabilitation Using Epidural Stimulation After Spinal Cord Injury
The investigators will recruit up to 20 volunteers with chronic, supra-sacral SCI. Following screening, eligible participants will enter 'Phase I', they will complete baseline outcome measures and then have the epidural spinal…
- Conditions
- Spinal Cord Injuries, Neuromodulation, Neurogenic Bladder, Neurogenic Bowel
- Trial name
- ImPRESS (NCT06515223)
- Testing
- Epidural Spinal Cord Stimulation
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- University College, London
Overactive Bladder
"The Effectiveness of Transvertebral Magnetic Neuromodulation in Patients With Detrusor Overactivity"
The main hypothesis of this study is that magnetic neuromodulation can be used to correct bladder overactivity. The investigators assume that the transvertebral magnetic stimulation can improve both the subjective state of…
- Trial name
- NCT04578899
- Testing
- Transvertebral magnetic stimulation
- Where
- Russia
- Volunteers
- 80 people
- Sponsor
- Joint-Stock Company North-West Center for Evidence-Based Medicine, Russian Federation
Overactive Bladder, Urinary Urge Incontinence
Over Active Bladder Instillation Study - Botox
The purpose of this study is to determine whether women with overactive bladder (OAB) who receive direct instillation via a catheter of a Botulinum-A Toxin (Botox) with Dimethyl Sulfoxide (DMSO) solution experience significantly…
- Conditions
- Overactive Bladder, Urinary Urge Incontinence, Urinary Incontinence, Detrusor Hyperreflexia
- Trial name
- NCT00667095
- Testing
- Botox Instillation, DMSO Instillation
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Mayo Clinic
Voiding Dysfunction
Clinical Implication of DAC (Detrusor After-contraction)
The aims of this study are to confirm whether detrusor after-contraction (DAC) is a true contraction or not with a new approach and to understand clinical implication of DAC
- Trial name
- DAC (NCT01154946)
- Where
- South Korea
- Volunteers
- 2,309 people
- Sponsor
- Seoul National University Hospital