Clinical trials: Developing Countries
Human Papillomavirus 16, Human Papillomavirus 18
Integrated Cervical Cancer Screening in Mayuge District Uganda (ASPIRE Mayuge)
The purpose of this pragmatic cluster randomized control trial is to test the effectiveness of cervical cancer screening follow-up completion using two implementation approaches for self-collected HPV testing in a rural…
- Conditions
- Human Papillomavirus 16, Human Papillomavirus 18, Papillomavirus Infections, Cervical Cancer
- Trial name
- ASPIRE (NCT04000503)
- Testing
- Self-collected HPV testing for cervical cancer screening
- Where
- Uganda
- Volunteers
- 2,019 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Immunity
A Clinical Study to Investigate the Effect of a Partially Hydrolysed Infant Formula With Added Synbiotics on Gut Microbiota Composition and Clinical Effectiveness in Infants at High Risk of Developing Allergy
With the rising prevalence of allergic diseases and the subsequent risk of developing other immune-related disorders, primary prevention of allergy has become a major priority.
- Trial name
- TEMPO (NCT03067714)
- Testing
- Infant formula with added synbiotics, Standard infant formula
- Where
- 59 sites in Belgium, Czechia and 11 more
- Volunteers
- 855 people, healthy volunteers welcome
- Sponsor
- Nutricia Research
Cardiovascular Disease
Scaling-up Packages of Interventions for Cardiovascular Disease Prevention in Selected Sites in Europe and Sub-Saharan Africa: An Implementation Research
Cardiovascular disease is the leading cause of death in the world. 17.5 million people died in 2012 due to a cerebrovascular disease (31% of all causes of death).
- Trial name
- SPICES_PHASE_1 (NCT03154736)
- Testing
- Interview
- Where
- 21 sites in France
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- University Hospital, Brest
Sexual Abstinence, HIV
Affecting the Epidemiology of HIV in Uganda
The investigators propose to develop a comprehensive, text messaging-based HIV prevention program for Ugandan adolescents 18-22 years of age.
- Conditions
- Sexual Abstinence, HIV, Contraceptive Usage
- Trial name
- NCT02729337
- Testing
- ITG (In This Together)
- Where
- Uganda
- Volunteers
- 203 people, healthy volunteers welcome
- Sponsor
- Center for Innovative Public Health Research
Immunity
A Clinical Study to Investigate the Effect of a Partially Hydrolysed Infant Formula With Added Synbiotics on the Development of Allergic Manifestations in Infants at High Risk of Developing Allergy
With the rising prevalence of allergic diseases and the subsequent risk of developing other immune-related disorders, primary prevention of allergy has become a major priority.
- Trial name
- MAESTRO (NCT03062995)
- Testing
- Infant Formula with added synbiotics, Standard Infant formula
- Volunteers
- healthy volunteers welcome
- Sponsor
- Nutricia Research
Bariatric Surgery Candidate, Laparoscopic Sleeve Gastrectomy
Outcomes of Laparoscopic Sleeve Gastrectomy
The aim of this study is to assess 5 year long-term outcomes of laparoscopic sleeve gastrectomy emphasizing weight loss and modification of comorbidities such as type 2 diabetes mellitus, hypertension and gastroesophageal reflux…
- Conditions
- Bariatric Surgery Candidate, Laparoscopic Sleeve Gastrectomy, Obesity, Morbid
- Trial name
- NCT03983122
- Testing
- Laparoscopic sleeve gastrectomy
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Bakirkoy Dr. Sadi Konuk Research and Training Hospital
Organophosphate Poisoning
Farming, Personal Protective Equipment, Nepal
According to the World Health Organization pesticide poisoning is a major health problem due to the millions of cases annually occurring worldwide.
- Trial name
- NCT02137317
- Testing
- LAPPE (locally adapted personal protective equipment)
- Where
- Nepal
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Bispebjerg Hospital
Surgical Procedures, Operative
Determining Universal Processes Related to Best Outcome in Emergency Gastrointestinal Surgery: an International Evaluation
A multicentre, international evaluation of emergency abdominal surgery to establish surgical outcomes and identify common, modifiable best practice processes.
- Trial name
- GlobalSurg-1 (NCT02179112)
- Testing
- Emergency Abdominal Surgery
- Where
- United Kingdom
- Volunteers
- 10,745 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Child Malnutrition
Developing Low-Cost Universal Malnutrition Screening for Low Income Countries - the MAMMS Trial
Acute malnutrition affects 52 million children, costs $2.1 trillion globally, and contributes to 45% of deaths among children under five years of age.
- Trial name
- NCT03967015
- Testing
- Maternal Administered Malnutrition Monitoring System (MAMMS)
- Where
- 3 sites in Kenya
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- University of Washington
Other Specified Effects of Reduced Temperature
Field Application of Shanchol in Adults in Bangladesh
Background: Cholera is a public health problem globally and in Bangladesh and its prevention is important. Despite recent availability of an effective and affordable oral cholera vaccine (OCV), its field application remains a…
- Trial name
- NCT01762930
- Testing
- Shanchol
- Where
- Bangladesh
- Volunteers
- 1,015 people, healthy volunteers welcome
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh
Cholera, Typhoid
Studies of Immune Responses to Orally Administered Vaccines in Developing Country
The efficacy and immunogenicity of enteric vaccines have generally been found to be lower in children in the developed than in the developing countries.
- Trial name
- NCT01019083
- Testing
- Control, Zinc Sulphate, Albendazole and Secnidazole
- Where
- Bangladesh
- Volunteers
- 1,016 people, healthy volunteers welcome
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh
Diarrhea, Dysentery (Bloody Diarrhea)
Solar Disinfection of Drinking Water
SODISWATER is a European Union funded health impact assessment study investigating the effect of sunlight to inactivate microbial pathogens in drinking water.
- Trial name
- SODISWATER (NCT01082107)
- Testing
- Solar disinfection in transparent containers (plastic bottles)
- Where
- South Africa
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Council for Scientific and Industrial Research, South Africa
Poisoning by Carbon Monoxide From Domestic Fuels, Respiratory Conditions Due to Other External Agents
Feasibility Intervention Trial of Two Types of Improved Cookstoves in Three Developing Countries
The underlying concept behind this feasibility trial is to achieve a reduction in indoor smoke from biomass fuels and minimize changes in cooking practices such that it prompts one of the two improved, ventilated cookstoves to be…
- Trial name
- NCT01686867
- Testing
- Improved, ventilated cookstove
- Where
- 3 sites in Kenya, Nepal and 1 more
- Volunteers
- 137 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Surgical Procedure, Unspecified, Laparoscopic Cholecystectomy
Opioid-based Versus Opioid-free Anaesthesia for Laparoscopic Cholecystectomy
This is a prospective, randomized, parallel-group, double-blinded clinical trial. The study is approved by the DUHS institutional review board (IRB) and the trial will be registered at clinical trial registry.
- Trial name
- NCT06476600
- Testing
- Dexmedetomidine injection, Nalbuphine Injection
- Where
- Pakistan
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Atif Shafqat
Hospital-acquired Infections
Infection Prevention and Control Intervention to Reduce Hospital-acquired Infections
Hospital-acquired infections (HAIs) are significant public health issues, especially in low- and middle-income countries (LMICs).
- Trial name
- IPC-HAI (NCT05547373)
- Testing
- Infection prevention and control (IPC)
- Where
- Cambodia
- Volunteers
- 192 people, healthy volunteers welcome
- Sponsor
- National University of Singapore
Sexual Abstinence, Condom Use
CyberSenga: Internet-based HIV Prevention in Uganda
The investigators propose to design and test an Internet-based HIV prevention program for adolescents in Uganda.
- Trial name
- NCT00906178
- Testing
- CyberSenga
- Where
- Uganda
- Volunteers
- 366 people, healthy volunteers welcome
- Sponsor
- Center for Innovative Public Health Research
Mental Disorder, Depressive Disorder
Reducing Stigma Among Healthcare Providers (RESHAPE-cRCT)
A growing number of trials have demonstrated treatment effectiveness for mental illness by non-specialist providers, such as primary care providers, in low-resource settings.
- Conditions
- Mental Disorder, Depressive Disorder, Anxiety Disorder, Alcohol Use Disorder
- Trial name
- RESHAPE-cRCT (NCT04282915)
- Testing
- Reducing Stigma among Healthcare Providers (RESHAPE), mental health Gap Action Programme
- Where
- Nepal
- Volunteers
- 8,705 people, healthy volunteers welcome
- Sponsor
- George Washington University
Diarrhea, Pneumonia
64N Nutraceutical for the Prevention of Childhood Diarrhea and Pneumonia in Low Resource Settings
The purpose of this study is to compare the occurrence of childhood diarrheal disease and pneumonia in subjects under the age of 5 years in low resource settings who have received prophylactic 64N nutraceutical (64N)as a neonate…
- Trial name
- NCT02231047
- Testing
- 64N Nutraceutical, No 64N Nutraceutical
- Where
- Guatemala
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- H2O Health and Agriculture LLC
Infections, Meningococcal, Meningitis, Meningococcic
Fractional Dose Tetravalent A, C, Y, W135 Meningococcal Polysaccharide Vaccine
Hypothesis: Lower doses of each A/C/Y/W135 component of the meningococcal polysaccharide vaccine could confer a similar functional immunogenic response as the dose of 50 μg currently being used, and subsequently be equally…
- Trial name
- NCT00271479
- Testing
- A, C, Y, W135 meningococcal polysaccharide vaccine
- Where
- 2 sites in Norway, Uganda
- Volunteers
- 720 people, healthy volunteers welcome
- Sponsor
- Epicentre
Smoking Cessation
Smoking Cessation App. in Arabic
Smoking remains a significant global health challenge, causing over 8 million deaths annually, with the burden predominantly in low- and middle-income countries.
- Trial name
- iEndSmokin (NCT06766227)
- Testing
- iEndSmokin App, Educational Session
- Where
- Jordan
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Yarmouk University