Clinical trials: Developing Countries
Cerebrovascular Disease
Quality of Life of Stable Stroke Survivors in Pakistan
In study the investigators sought to 1. Assess the quality of life experience in stable post stroke survivors in Pakistan and detail important factors influencing quality of life. 2.
- Trial name
- NCT02351778
- Volunteers
- 350 people
- Sponsor
- Aga Khan University
Bacterial Infection, Sepsis
Efficacy Study of Community-Based Treatment of Serious Bacterial Infections in Young Infants
Approximately one-third of neonatal deaths in developing countries are due to infections acquired through the birth canal and/or exposure to an unclean environment soon after birth.
- Conditions
- Bacterial Infection, Sepsis, Infant, Newborn
- Trial name
- NCT00189384
- Testing
- ceftriaxone, procaine penicillin and gentamicin, oral cotrimoxazole and gentamicin
- Where
- Pakistan
- Volunteers
- 426 people
- Sponsor
- Aga Khan University
Asthma
Equivalence of a Human-Powered Nebulizer to an Electric Nebulizer
This is an equivalence study comparing an electric nebulizer with a human-powered nebulizer--one that does not need electricity--in the treatment of mild to moderate asthma exacerbations in a regional clinic in San Salvador, El…
- Trial name
- NCT01795742
- Testing
- Human-Powered Nebulizer
- Where
- El Salvador
- Volunteers
- 110 people
- Sponsor
- Marquette University
Soft Tissue Injuries
"Enhancing Surgical Safety in Developing Nations: Investigating Antibiotics' Role in Hand Surgeries."
The goal of this clinical trial is to compare the use of antibiotics with no use in people undergoing soft tissue hand surgery in developing countries.
- Trial name
- NCT05990842
- Testing
- Antibiotic
- Volunteers
- 51 people
- Sponsor
- Marcos Felipe Marcatto de Abreu
Surgical Procedures, Operative, Artificial Intelligence (AI)
Artificial Intelligence in Surgical Practice in Sudan: National Survey of Doctors
This is a national survey of doctors in Sudan who are involved in providing surgical care. The aim is to understand their awareness, experiences, and opinions about using artificial intelligence (AI) in surgery.
- Conditions
- Surgical Procedures, Operative, Artificial Intelligence (AI), Wounds and Injuries, War Injury
- Trial name
- NASAPS (NCT07138105)
- Testing
- National AI in Surgical Practice Survey - Sudan
- Where
- Sudan
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Sudan Medical Specialization Board
Sickle Cell Disease, Sickle Cell Anemia
Risk Clinical Stratification of Sickle Cell Disease in Nigeria, Assessment of Efficacy/Safety of Hydroxyurea Treatment
The vast majority of births with sickle cell disease (SCD) occur in Africa and 90% are thought to die before the age of five. Hydroxyurea (HU) is the only drug approved by the FDA for the treatment of sickle cell anemia.
- Trial name
- NCT02149537
- Testing
- hydroxyurea
- Where
- Nigeria
- Volunteers
- 53 people
- Sponsor
- Loyola University
Hypothermia, Immature Newborn
Evaluation of Use of Plastic Bags to Prevent Neonatal Hypothermia-Part I
The overall hypothesis is that plastic bags used in combination with WHO thermoregulation care will reduce the incidence of hypothermia in preterm/low birth weight and full term infants when compared to routine WHO…
- Trial name
- NCT01604317
- Testing
- Resuscitation-torso plastic bag, Resuscitation-partial-head plastic bag
- Where
- Zambia
- Volunteers
- 182 people
- Sponsor
- University of Alabama at Birmingham
Diarrhea, Pneumonia
64N Nutraceutical for the Prevention of Childhood Diarrhea and Pneumonia in Low Resource Settings
The purpose of this study is to compare the occurrence of childhood diarrheal disease and pneumonia in subjects under the age of 5 years in low resource settings who have received prophylactic 64N nutraceutical (64N)as a neonate…
- Trial name
- NCT02231047
- Testing
- 64N Nutraceutical, No 64N Nutraceutical
- Where
- Guatemala
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- H2O Health and Agriculture LLC
Intestinal Volvulus, Colon, Sigmoid
Best Management of Sigmoid Volvulus: A Prospective Randomized Trial
The purpose of this study is to obtain a better understanding of the best management of left-sided colonic emergencies.
- Trial name
- NCT01682395
- Testing
- Resection and anastomosis, Resection and colostomy, Mesosigmoidopexy
- Where
- Malawi
- Volunteers
- 29 people
- Sponsor
- University of North Carolina, Chapel Hill
Infant Malnutrition, Nutrition Knowledge
Improving the Nutrition Status of Infants in South-Western Uganda
Undernutrition and growth restriction due to poor diet and inadequate nutrient intake continues to be a global challenge, particularly in the developing countries including Uganda.
- Conditions
- Infant Malnutrition, Nutrition Knowledge, Growth, Cognitive Development
- Trial name
- CHNUDEV (NCT02098031)
- Testing
- Improving nutrition knowledge among mothers
- Where
- Uganda
- Volunteers
- 511 people, healthy volunteers welcome
- Sponsor
- University of Oslo
Immunity
A Clinical Study to Investigate the Effect of a Partially Hydrolysed Infant Formula With Added Synbiotics on the Development of Allergic Manifestations in Infants at High Risk of Developing Allergy
With the rising prevalence of allergic diseases and the subsequent risk of developing other immune-related disorders, primary prevention of allergy has become a major priority.
- Trial name
- MAESTRO (NCT03062995)
- Testing
- Infant Formula with added synbiotics, Standard Infant formula
- Volunteers
- healthy volunteers welcome
- Sponsor
- Nutricia Research
Dementia, Behavioral Symptoms
Evaluating the Effectiveness of a Community Based Intervention for Persons With Dementia and Their Caregivers in a Developing Country
The aim of this trial was to apply a home based, flexible, stepped-care intervention designed to improve the awareness and knowledge of family caregivers regarding dementia, to maximise their caregiving resources and to improve…
- Conditions
- Dementia, Behavioral Symptoms, Mental Health
- Trial name
- NCT00479271
- Testing
- Home based, flexible, stepped care intervention, Home based, flexible, stepped care intervention after 6 months. Families will be free to choose any health care they desire during the waiting period.
- Where
- India
- Sponsor
- London School of Hygiene and Tropical Medicine
Bariatric Surgery Candidate, Laparoscopic Sleeve Gastrectomy
Outcomes of Laparoscopic Sleeve Gastrectomy
The aim of this study is to assess 5 year long-term outcomes of laparoscopic sleeve gastrectomy emphasizing weight loss and modification of comorbidities such as type 2 diabetes mellitus, hypertension and gastroesophageal reflux…
- Conditions
- Bariatric Surgery Candidate, Laparoscopic Sleeve Gastrectomy, Obesity, Morbid
- Trial name
- NCT03983122
- Testing
- Laparoscopic sleeve gastrectomy
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Bakirkoy Dr. Sadi Konuk Research and Training Hospital
Tuberculosis
Should Low Birth Weight Infants Be Vaccinated With BCG Vaccine at Birth in Developing Countries?
The World Health Organization (WHO) currently recommends BCG vaccination at birth in developing countries. Pre-term infants should be vaccinated when they reach the chronological age of 40 weeks.
- Trial name
- NCT00146302
- Testing
- Bacille Calmette Guerin (BCG)
- Where
- Guinea-Bissau
- Volunteers
- 2,320 people
- Sponsor
- Bandim Health Project
Quality Improvement
Evaluation of the Implementation of a Quality Improvement Program Through Morbidity and Mortality Reviews
Morbidity and mortality reviews represent an opportunity to discuss adverse events and healthcare issues. Aim is to report the first experience of implementing a standardized procedure of morbidity and mortality reviews, and…
- Trial name
- NCT05286411
- Where
- Morocco
- Volunteers
- 13 people
- Sponsor
- Moroccan Society of Surgery
Vaccination Refusal
Increasing COVID-19 Vaccine Uptake in Developing Countries (Bihar)
Working with governments in Bihar, India, we will evaluate a number of mechanisms to increase vaccine uptake. These include household vaccination visits instead of community vaccination clinic.monetary and non-monetary…
- Trial name
- NCT05225064
- Testing
- Incentives to be vaccinated, Mask, Encouragement to wear a mask
- Where
- India
- Volunteers
- 114,512 people, healthy volunteers welcome
- Sponsor
- Yale University
Pediatric Acute Myeloid Leukemia Induction
Low Dose Induction for Pediatric Acute Myeloid Leukemia Patients
the standard induction treatment for pediatric acute myeloid leukemia has high early morbidity and mortality that jeopardize the outcome especially in developing countries.
- Trial name
- NCT07867600
- Testing
- Low dose Ara C/ anthracycline combined with GCSF
- Where
- 2 sites in Egypt
- Volunteers
- 33 people
- Sponsor
- Azza Shibl Sayed
Immune Thrombocytopenia Purpura
Outcome Study of Conventional Steroids Vs. Steroids Combined with Mycopehnolate in Newly Diagnosed Immune Thrombocytopenia Purpura.
Immune thrombocytopenia Purpura (ITP) is an autoimmune condition delineated by humoral as well as cell mediated immune response against thrombocyte surface proteins GPIIb/IIIa receptors, affecting primary homeostasis leading to…
- Trial name
- NCT06288932
- Testing
- Mycophenolate Mofetil (MMF) Treatment
- Where
- Pakistan
- Volunteers
- 118 people
- Sponsor
- National Institute of Blood and Marrow Transplant (NIBMT), Pakistan
Surgical Procedures, Operative, Artificial Intelligence (AI)
Artificial Intelligence for Surgical Care in War-Torn Sudan: Feasibility, Barriers, and Ethical Perspectives
This study is designed to examine how artificial intelligence (AI) could be applied to support surgical care in Sudan during the ongoing armed conflict.
- Conditions
- Surgical Procedures, Operative, Artificial Intelligence (AI), War Injury, Wounds and Injuries
- Trial name
- NCT07149012
- Testing
- Artificial Intelligence Awareness and Feasibility Assessment
- Where
- Sudan
- Volunteers
- 185 people
- Sponsor
- Sudan Medical Specialization Board
Surgical Wound Infection
Determining the Worldwide Epidemiology of Surgical Site Infections After Gastrointestinal Surgery
Surgical site infection (SSI) is the most common complication following major gastrointestinal surgery, affecting between 25-40% of patients.
- Trial name
- GlobalSurg 2 (NCT02662231)
- Testing
- Emergency, or elective gastrointestinal resection
- Where
- 2 sites in United Kingdom
- Volunteers
- 12,539 people
- Sponsor
- University of Edinburgh