Clinical trials: Development Disorders, open to volunteers
Osteogenesis Imperfecta (OI), Osteogenesis Imperfecta
Prospective Observational Cohort Study of Cardiac Structure and Function in Children and Adults With Osteogenesis Imperfecta
This prospective observational investigation will examine the incidence and progression of cardiologic findings in individuals with OI across different age groups.
- Trial name
- OI Cardio (NCT07287241)
- Testing
- Imaging evaluation, Echocardiography
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Istituto Ortopedico Rizzoli
Amyotrophic Lateral Sclerosis
Development of Targeted RNA-Seq for Amyotrophic Lateral Sclerosis Diagnosis
Genetic diagnosis of Amyotrophic Lateral Sclerosis (ALS) could identify the origin of the disease, potentially allowing the patient to pursue targeted/gene therapy.
- Trial name
- ROSA (NCT06083584)
- Testing
- RNA sequencing
- Where
- 7 sites in France
- Volunteers
- 192 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Autism
Improving Caregiver Engagement in Early Interventions
The goal of this study is to test the effectiveness of the FANS-EI program in supporting caregiver engagement in caregiver-mediated early interventions for young children with autism.
- Trial name
- NCT07500363
- Testing
- FANS-EI, Early Intervention
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- University of California, Davis
Preterm, Parent-Child Relations
Sensory Optimization of the Hospital Environment
The long-term goal of this project is to improve the health and well-being of preterm infants and their parents. Although there is evidence to support positive multisensory interventions in the NICU, these interventions are often…
- Conditions
- Preterm, Parent-Child Relations, Parents, Development, Infant
- Trial name
- SOOTHE (NCT05230199)
- Testing
- SENSE multisensory program, Monitored standard of care
- Where
- United States
- Volunteers
- 215 people
- Sponsor
- University of Southern California
Autism Spectrum Disorder, Autism
Achieving Steady Work Among Adults With Autism Through Specialized Employment Program
Individuals with autism spectrum disorder (ASD) have significantly higher levels of unemployment and underemployment compared to their typically developing peers and all other groups with neurodevelopmental disorders, even though…
- Trial name
- NCT04107064
- Testing
- NaW, NaW-DS
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Lawrence Fung
Autism Spectrum Disorder, Obesity
Semaglutide in Youth With Autism Spectrum Disorder
This study is a 6-month, two-arm, RCT which will evaluate the effectiveness and safety of semaglutide in adolescents aged 12-18 years with autism spectrum disorder (ASD) and obesity.
- Trial name
- GLP1 (NCT07770152)
- Testing
- Glucagon-like peptide-1 receptor agonist：Semaglutide, Lifestyle Management (LSM) Counseling
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Repeated IVF Failure, Female Infertility
Investigate the Efficacy of Using NMN to Improve Embryo Development Capacity.
The objective of this study is to investigate the efficacy of NMN supplementation in enhancing embryo developmental capacity and improving IVF success rates in patients experiencing IVF failures.
- Trial name
- NCT06629636
- Testing
- NMN capsule
- Where
- Japan
- Volunteers
- 60 people
- Sponsor
- Sunkaky Medical Cooperation
Autism Spectrum Disorder
DSM-5 Personality Disorders in Adults With Autism
Rationale: Self-report measures are frequently used for research and clinical assessments of adults with autism spectrum disorder (ASD).
- Trial name
- NCT06726187
- Testing
- Structured Clinical Interview for DSM-5 Screening Personality Questionnaire (SCID-5-SPQ).
- Where
- Netherlands
- Volunteers
- 102 people
- Sponsor
- Parnassia Groep
Spinal Cord Injuries, Neuropathic Pain
Novel Soluble Epoxide Hydrolase Inhibitor for Neuropathic Pain in Patients With Spinal Cord Injury
The goal of this clinical trial is to evaluate safety and tolerability of multiple oral doses of EC5026 in male and female patients with neuropathic pain due to traumatic or non-traumatic (degenerative) spinal cord injury.
- Conditions
- Spinal Cord Injuries, Neuropathic Pain, Degenerative Disc Disease, Spinal Stenosis
- Trial name
- NCT06438471
- Testing
- EC5026 oral tablet
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- EicOsis Human Health Inc.
Autism Spectrum Disorder
Adaptation of the NEAR Cognitive Remediation Method to Child and Adult Autism by Including Social Scenarios and Skills
The investigators currently provide the NEAR method (neuropsychological educational approach to cognitive remediation) for people with neurocognitive difficulties, without distinguishing between ASD and schizophrenia.
- Trial name
- NEAR-TSA (NCT05786898)
- Testing
- NEAR-TSA
- Where
- France
- Volunteers
- 66 people
- Sponsor
- Centre Hospitalier St Anne
Intellectual Disability, Autism
Sensors for Communication for Persons Who Cannot Communicate Unequivocally
Some persons with intellectual disability or comprehensive cerebral palsy cannot communicate unequivocally how they are, how they react to situations and people, whether they are in pain or experience discomfort, anger or fear.
- Conditions
- Intellectual Disability, Autism, Cerebral Palsy
- Trial name
- NCT04199299
- Testing
- Heart rate and respiration rate sensors
- Where
- Norway
- Volunteers
- 100 people
- Sponsor
- University of Oslo
Neoplasms, Lymphomas
Collection of Tissue Samples for Cancer Research
Background: -Patients who are being evaluated and/or treated at the NIH Clinical Center and adult patients at participating sites will be entered onto this tissue procurement protocol for collection of tissue specimens.
- Conditions
- Neoplasms, Lymphomas, Multiple Myeloma, Myelodysplastic Syndrome
- Trial name
- NCT00900198
- Testing
- Biopsy
- Where
- 17 sites in United States, Canada
- Volunteers
- 5,000 people
- Sponsor
- National Cancer Institute (NCI)
Developmental Dysplasia of Hip
Improving Neonatal Hip Screening With Artificial Intelligence
The goal of this trial is to pilot a portable ultrasound device that uses artificial intelligence to screen for hip dysplasia. Researchers will gather data to understand the feasibility of performing a larger trial in birthing…
- Trial name
- NCT07794644
- Testing
- Artificial intelligence augmented ultrasound
- Volunteers
- 100 people
- Sponsor
- Murdoch Childrens Research Institute
Challenging Behavior
A Single-Arm Pilot Trial for Mitigating Relapse of Severe Problem Behavior
The goal of this study is to improve how we teach self-control and communication skills to children and adolescents with challenging behaviors.
- Trial name
- NCT06732219
- Testing
- Functional Communication Training, Extinction-Correlated Stimuli, Caregiver Fading
- Where
- 2 sites in United States
- Volunteers
- 10 people
- Sponsor
- Auburn University
Dementia, Caregiver
ED PLWD/Care Partner Text Messaging
The purpose of this research study is to develop and test a text-messaging intervention for emergency department (ED) discharge care transitions experienced by caregivers of older adults with cognitive impairment.
- Conditions
- Dementia, Caregiver, Emergency Department, Mobile Health Technology (mHealth)
- Trial name
- CAPTURE (NCT07423871)
- Testing
- CAPTURE Text Message Care Transition Support
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Yale University
Autism Disorder
TRIal of PPF3 vs. PlaCEbo in the TReatment of Children and AdolescenTs With NeurOdeveloPmental DisorderS
A Randomized Placebo-Controlled TRIal of PPF3 vs. PlaCEbo in the TReatment of children and AdolescenTs with NeurOdeveloPmental DisorderS
- Trial name
- TRICERATOPS (NCT07893964)
- Testing
- PPF3
- Where
- 4 sites in Canada
- Volunteers
- 100 people
- Sponsor
- Holland Bloorview Kids Rehabilitation Hospital
Intensive Care Unit, Intraventricular Hemorrhage
Prediction of Undesired Obstruction in External Ventricular Drains.
Acute obstructive hydrocephalus often complicates intraventricular hemorrhage (IVH). The insertion of an external ventricular drain (EVD) is typically necessary in order to alleviate intracranial pressure by draining excess…
- Conditions
- Intensive Care Unit, Intraventricular Hemorrhage, External Ventricular Drain
- Trial name
- EVD-OBS (NCT06466811)
- Testing
- Patients of intensive care unit, Patients of surgical intensive care unit
- Where
- France
- Volunteers
- 640 people
- Sponsor
- Nantes University Hospital
Aquired Brain Injury, Stroke
Group-based Emotional Awareness and Expression Therapy to Support Recovery After Acquired Brain Injury: A Clinical Development and Evaluation Study
Difficulties in understanding and managing emotions may hinder recovery, rehabilitation, and participation in everyday life after acquired brain injury (ABI).
- Conditions
- Aquired Brain Injury, Stroke, MTBI - Mild Traumatic Brain Injury, mTBI
- Trial name
- NCT07852936
- Testing
- TAU + Group Therapy (EAET), Treatment as Usual (TAU)
- Where
- Sweden
- Volunteers
- 110 people
- Sponsor
- Uppsala University
Coronary Disease, Coronary Artery Disease
Evaluation and Treatment Strategy Development of Coronary Heart Disease Guided by OCT Based on Multimodal Deep Learning
This is a retrospective, multicenter, observational study aimed at assessing stent apposition for coronary stent implantation by an optical coherence tomography system constructed by deep learning algorithms and evaluating the…
- Trial name
- NCT06544681
- Testing
- Coronary stenting with planned drug eluting stent (DES).
- Volunteers
- 2,000 people
- Sponsor
- Xiang Ma
Gastric Cancer (GC), Premalignant Lesion
AI-Based Risk Prediction Model for Upper Digestive Tract Cancer
Upper digestive tract cancers are often preceded by pre-malignant lesions, but there is limited evidence regarding optimal risk prediction models and screening strategies for disease progression and cancer development.
- Conditions
- Gastric Cancer (GC), Premalignant Lesion, Gastric Intestinal Metaplasia, Atrophic Gastritis
- Trial name
- NCT07605312
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
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