Clinical trials: Development Disorders
Environmental Exposure, Infertility
The Effect of Periconceptional Phthalates Exposure on Couples' Reproductive Health
The study is a prospective cohort study, which is aiming to explore periconceptional phthalates exposure and its potential epigenetic effect on fertility, embryo development, and neonatal outcomes.
- Trial name
- NCT03679000
- Where
- China
- Volunteers
- 2,122 people
- Sponsor
- Tongji Hospital
Breast Cancer, Prostate Cancer
Training Data Collection & AI Development
The aim of this study is to facilitate collection of real-world data to test and train the analytics engine for each prototype algorithm.
- Trial name
- LC_SSP (NCT05378854)
- Testing
- LifeChamps Platform
- Where
- Greece
- Volunteers
- 27 people
- Sponsor
- Aristotle University Of Thessaloniki
Infertility (IVF Patients)
Correlation of the Genetic Constitution of the Spent Blastocyst Media
The main objective of this study is to improve niPGT-A (non-invasive Preimplantation Genetic Testing for Aneuploidies) to avoid the need of a biopsy to perform the genetic analysis of the embryo and to help in understanding the…
- Trial name
- CONNECTED (NCT06780605)
- Testing
- niPGT-A, Multifocal TE biopsies and ICM biopsy
- Where
- 2 sites in Cyprus
- Volunteers
- 230 people
- Sponsor
- Igenomix
Autism
Testing a Mobile App to Improve Toothbrushing Skills and Habits in Teens With Autism
The goal of this proposed trial will modify an existing toothbrushing app for teens with autism and compare toothbrushing outcomes with a control app.
- Trial name
- NCT06208722
- Testing
- Testing a Mobile App to Improve Toothbrushing Skills and Habits in Teens With Autism
- Where
- United States
- Volunteers
- 270 people
- Sponsor
- University of Washington
Adult Acute Megakaryoblastic Leukemia (M7), Adult Acute Monoblastic Leukemia (M5a)
Decitabine Followed by Idarubicin and Cytarabine in Treating Patients With Relapsed or Refractory AML and MDS
The goals of this study are to learn about the effectiveness, the side-effects, if waiting to give the idarubicin and cytarabine may change the side effects or effectiveness, and to identify factors to predict for responses to…
- Conditions
- Adult Acute Megakaryoblastic Leukemia (M7), Adult Acute Monoblastic Leukemia (M5a), Adult Acute Monocytic Leukemia (M5b), Adult Acute Myeloblastic Leukemia With Maturation (M2)
- Trial name
- NCT01607645
- Testing
- decitabine, idarubicin, cytarabine
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Fred Hutchinson Cancer Center
Autism Spectrum Disorders
Evaluating the Validity of an Eye Gaze Paradigm in Predicting Autism Spectrum Disorder
The primary purpose of the present study is to evaluate the diagnostic validity of eye tracking measurements acquired during viewing of socially-relevant stimuli in predicting ASD diagnosis.
- Trial name
- EYE (NCT02573428)
- Where
- United States
- Volunteers
- 389 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Small Cell Lung Cancer, Extensive-Stage Small Cell Lung Cancer
MDT-Based Nursing for Small Cell Lung Cancer During Chemo-Immunotherapy
This study aims to develop and evaluate a multidisciplinary team (MDT)-based nursing intervention system for patients with advanced small cell lung cancer (SCLC) receiving chemo-immunotherapy.
- Conditions
- Small Cell Lung Cancer, Extensive-Stage Small Cell Lung Cancer, Lung Neoplasms
- Trial name
- SCLC-MDT (NCT07489339)
- Testing
- Multidisciplinary Team-Based Nursing Intervention, Routine Nursing Care
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Shanxi Province Cancer Hospital
Central Auditory Processing Disorder, Traumatic Brain Injury
Central Auditory Processing Disorders Associated With Blast Exposure
The incidence of central auditory dysfunction in war fighters who are exposed to high-explosive blasts while serving in combat have not been clearly determined.
- Conditions
- Central Auditory Processing Disorder, Traumatic Brain Injury, Hearing Loss
- Trial name
- NCT00554801
- Testing
- Audiological testing
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Hepatocellular Carcinoma (HCC)
HCC Risk Prediction Model Based on Multimodal Data in Chronic Hepatitis B
The investigators propose to construct and validate an early HCC risk prediction model in a multicenter retrospective cohort of hepatitis B-related fibrosis/cirrhosis patients, using multimodal data encompassing longitudinal…
- Trial name
- NCT07780357
- Testing
- No intervention (observational study)
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- Beijing Friendship Hospital
Schizophrenia, Moral Status
Effects of Integrated Moral Reasoning Development Intervention for Management of Violence in Schizophrenia
Moral cognition is an important and multidimensional, but often overlooked, determinant of violence. Very few interventions have systematically examined the role of moral reasoning, anger management and problem-solving together…
- Conditions
- Schizophrenia, Moral Status, Violence
- Trial name
- NCT05207319
- Testing
- integrated Moral Reasoning Development Intervention (MRDI)
- Where
- Taiwan
- Volunteers
- 43 people
- Sponsor
- I-Shou University
Multiple Sclerosis (MS), Neuromyelitis Optica Spectrum Disorders (NMOSD)
A Study of C-CAR168 in the Treatment of Central Nervous System Autoimmune Diseases Refractory to Standard Therapy
This is an investigator-initiated, single-center, open-label study of C-CAR168, an autologous bi-specific CAR-T therapy targeting CD20 and BCMA, for the treatment of adult patients with central nervous system autoimmune diseases…
- Conditions
- Multiple Sclerosis (MS), Neuromyelitis Optica Spectrum Disorders (NMOSD), Autoimmune Encephalitis, Stiff Person Syndrome
- Trial name
- NCT07341828
- Testing
- CD20/BCMA-directed CAR-T cells
- Volunteers
- 15 people
- Sponsor
- Huashan Hospital
Chagas Disease, Lactation
Study Of Nifurtimox Transfer Into Breastmilk In Lactating Women With Chagas Disease
The investigators propose to study the transfer of nifurtimox into breastmilk of lactating women who receive the drug for the treatment of Chagas disease.
- Trial name
- LACTNFX (NCT01744405)
- Where
- Argentina
- Volunteers
- 12 people
- Sponsor
- Hospital de Niños R. Gutierrez de Buenos Aires
Autistic Spectrum Disorder
Dates as a Functional Food for Autism
Autism spectrum disorder (ASD) is a lifelong developmental disability that includes deficits in social communication and social interaction and restricted, repetitive patterns of behavior, interests, or activities.
- Trial name
- NCT04261595
- Testing
- Dates fruit as functional Food, behavioral modification and stimulation, nutritional Guidance
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- National Research Centre, Egypt
Inclusion Body Myositis, Myotonic Dystrophy
Development and Validation of the FBIndex to Determine the Risk of Falls for Patients With Neuromuscular Disorders
Currently, there are no standardised fall risk scores or guidelines on when to use appropriate assistive gait devices (AGDs) for people with neuromuscular disorders (NMDs).
- Conditions
- Inclusion Body Myositis, Myotonic Dystrophy, Limb-girdle and Facioscapulohumeral Muscular Dystrophies, Pompe Disease
- Trial name
- FBIndex (NCT06605612)
- Testing
- FBIndex
- Where
- Germany
- Volunteers
- 108 people
- Sponsor
- LMU Klinikum
Asthma (Diagnosis)
Phase IIa Trial in Participants With Asthma to Evaluate Impact of Intranasal ETH47 on Development of Asthma-related Symptoms Following Rhinovirus Challenge
A Phase IIa trial in participants with asthma to evaluate the impact of intranasal ETH47 on the development of asthma-related symptoms following rhinovirus challenge
- Trial name
- ETH47-201 (NCT07059767)
- Testing
- ETH47
- Where
- 2 sites in United Kingdom
- Volunteers
- 50 people
- Sponsor
- Ethris GmbH
Epilepsy, Epilepsy in Children
An Open-Label Extension of the Study XEN496 (Ezogabine) in Children With KCNQ2-DEE
To assess the long-term safety and tolerability of XEN496 in pediatric subjects with KCNQ2 developmental and epileptic encephalopathy (KCNQ2-DEE) who had participated in the primary study (XPF-009-301).
- Conditions
- Epilepsy, Epilepsy in Children, Epilepsy; Seizure, Disease
- Trial name
- EPIK-OLE (NCT04912856)
- Testing
- XEN496
- Where
- 4 sites in United States, Australia and 1 more
- Volunteers
- 8 people
- Sponsor
- Xenon Pharmaceuticals Inc.
Urinary Incontinence, Stress
Development and Evaluation of a New Diagnostic Test in Female Urinary Stress Incontinence
The investigators hypothesize that an innovative test device simulating transvaginal tape support will increase the performance and reproducibility of the diagnosis of urethral hypermobility before surgery for urinary…
- Trial name
- IEUF (NCT01563653)
- Testing
- 4 diagnostic tests for surgical success
- Where
- 2 sites in France
- Volunteers
- 7 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Inflammatory Bowel Diseases
A Development of Inflammatory Bowel Disease Pattern Identification Algorithm Using Case Series Data
This study aimed to identify inflammatory bowel disease (IBD) patterns based on presenting symptoms and to suggest algorithms for determining pattern and herbal prescriptions for corresponding patterns.
- Trial name
- NCT04296500
- Testing
- Decision tree modeling
- Where
- South Korea
- Volunteers
- 67 people
- Sponsor
- Hyangsook Lee, KMD, PhD
Child Behavior, Autism Spectrum Disorder
Wellness Effects of Animal-assisted Activities With Autism Spectrum Disorder Youth in a Specialized Psychiatric Hospital
Background: Children with Autism Spectrum Disorder (ASD) are at higher risk for developing co-existing mental health conditions and consequently experiencing psychiatric hospitalization, compared to the general pediatric…
- Conditions
- Child Behavior, Autism Spectrum Disorder, Psychiatric Hospitalization, Veterinary Therapeutics
- Trial name
- NCT03369769
- Testing
- Activity
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Deafness
Neurophysiological Measures of Auditory Perception and Rehabilitation in Cochlear Implanted Patients
This study aims at investigating new automatic fitting techniques for cochlear implant patients based on objective measures. For this reason, the evolution of these neurophysiological measures, expressing the encoding of pure…
- Trial name
- NEUROSYLLABIC (NCT02323256)
- Testing
- Auditory steady-state response ASSR, Speech-ABR, Acoustic Change Complex ACC
- Where
- France
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
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