Clinical trials: Development Disorders
Autism Spectrum Disorder, Movement Disorders
Database Of Clinical Data For Individuals With Variants In The IRF2BPL Gene
This protocol serves as a data collection tool for individuals with variants (missense, nonsense, frameshifts) in the IRF2BPL gene (MIM 611720), which causes Neurodevelopmental Regression, Seizures, Autism and Developmental Delay…
- Conditions
- Autism Spectrum Disorder, Movement Disorders, Seizures, Dystonia
- Trial name
- IRF2BPL (NCT03892798)
- Testing
- No interventions are planned
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Focal Epilepsy
TMS Combined With EEG/EMG as a Biomarker Predicting Antiepileptic Drug Response
Ιn the present study (BIOEPI), the following three hypotheses will be investigated: 1. The proposed TMS-EEG / EMG protocol (which includes software for calculating the cerebral cortex stimulation threshold) in combination with…
- Trial name
- BIOEPI (NCT05278221)
- Testing
- Software EstimLT
- Where
- Greece
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Aristotle University Of Thessaloniki
Opioid-Related Disorders, Parent-Child Relations
Modified ABC: A Home-based Parenting Program for Opioid-dependent Mothers and Their Infants
This study will assess the efficacy of the modified Attachment and Biobehavioral Catch-Up Intervention, adapted for use with peripartum mothers receiving medication-assisted treatment for opioid use disorder.
- Conditions
- Opioid-Related Disorders, Parent-Child Relations, Infant Development, Parenting
- Trial name
- mABC (NCT03891628)
- Testing
- Modified Attachment and Biobehavioral Catch-up, Modified Developmental Education for Families
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- University of Delaware
Telemedicine, Digital Health
Development of an International Remote Digital Care System for Accessible, Inclusive and Sustainable Pregnancy Care
Pregnancy care is under increasing pressure due to a rising number of women needing medical care, a shortage of obstetric healthcare professionals, and growing healthcare costs.
- Conditions
- Telemedicine, Digital Health, Pregnancy Complications
- Trial name
- PregnaDigit EU (NCT07191236)
- Where
- 4 sites in Netherlands, Spain and 1 more
- Volunteers
- 450 people
- Sponsor
- UMC Utrecht
Developmental Dysplasia of the Hip, Hip Dysplasia
Sequelae of Developmental Dysplasia of the Hip
The aim of this study is to assess long term effects of developmental dysplasia of the hip (DDH) to overall health and quality of life later in life.
- Trial name
- NCT02431871
- Where
- Finland
- Volunteers
- 340 people
- Sponsor
- University of Oulu
Knee Osteoarthritis, Knee Arthroplasty
Development of an Outcome Score for Patients With Knee Osteoarthritis and Knee Joint Endoprosthesis Using an App
Total knee arthroplasty (TKA) and total hip arthroplasty (THA) is one of the most frequent orthopedic procedures. Over 50% of patients report higher expectations than their surgeons, and 10-50% remain dissatisfied…
- Conditions
- Knee Osteoarthritis, Knee Arthroplasty, Hip Osteoarthritis, Hip Arthroplasty
- Trial name
- KneeApp (NCT07212699)
- Testing
- KneeApp
- Where
- Germany
- Volunteers
- 1,250 people, healthy volunteers welcome
- Sponsor
- Technical University of Munich
Facioscapulohumeral Muscular Dystrophy
Clinical Trial Readiness to Solve Barriers to Drug Development in FSHD
The primary cause of facioscapulohumeral muscular dystrophy (FSHD), a common adult-onset dystrophy, was recently discovered identifying targets for therapy.
- Trial name
- ReSolve (NCT03458832)
- Testing
- FSHD-specific functional rating scale, Electrical Impedance Myography
- Where
- 14 sites in United States, France and 4 more
- Volunteers
- 324 people
- Sponsor
- University of Kansas Medical Center
Kidney Transplant; Complications, Polycystic Kidney Diseases
Evaluation of Iliac and Renal Artery for Mechanism of Intracranial Aneurysm in ADPKD
ADPKD is the most common form of hereditary kidney disease and is known to occur in 1 of 400 to 1000 population in the U.S. ADPKD consists of 2.8% of patients receiving kidney transplantation in our center.
- Conditions
- Kidney Transplant; Complications, Polycystic Kidney Diseases, Aneurysm, Brain
- Trial name
- NCT03726463
- Testing
- Kidney transplantation
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Asan Medical Center
Solid Tumor, Childhood, Brain Tumor, Pediatric
Social Emotional Development in Young Children With Cancer
Many children with cancer are diagnosed in early childhood, and as such, will likely miss key social experiences such as participation in preschool or kindergarten, playing on playgrounds, and other normative experiences.
- Trial name
- NCT03086421
- Testing
- Questionnaires
- Where
- United States
- Volunteers
- 119 people
- Sponsor
- St. Jude Children's Research Hospital
PolG, Primary Mitochondrial Myopathy
Mitochondrial Video Assessment Source Material Study
Source material collection of videos to develop the Mitochondrial Video Assessment (MVA) for patients with mitochondrial myopathies.
- Trial name
- NCT06180421
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- The Emmes Company, LLC
Autism
Early Pharmacotherapy Aimed at Neuroplasticity in Autism : Safety and Efficacy
The purpose of this study is to determine the efficacy, safety, and population pharmacokinetics and determinants of drug responses to buspirone in children with autism using a randomized, double blind, cross over study in…
- Trial name
- NCT00166621
- Testing
- Buspirone
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Chugani, Diane C.
Acute Pancreatitis
Study to Assess the Prognostic Value of the Antithrombin III in the Acute Pancreatitis (AT-PROPANC)
This is an epidemiological, observational, prospective, multicentric study in 400 adult patients admitted to hospital for mild acute pancreatitis to to assess the prognostic value of the antithrombin III in the development of…
- Trial name
- AT-PROPANC (NCT02373293)
- Where
- 2 sites in Spain
- Volunteers
- 400 people
- Sponsor
- Francisco Javier García Borobia
Infant, Premature, Diseases, Brain White Matter Disease Periventricular
Initial Efficacy Study of Supporting Play, Exploration, & Early Development Intervention
The primary aims of this randomized controlled trial are to evaluate efficacy potential of SPEEDI at enhancing reaching and play based problem solving compared to infants receiving usual care.
- Trial name
- SPEEDI (NCT02153736)
- Testing
- SPEEDI Intervention
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Virginia Commonwealth University
HIV Infections, Adolescent Development
Tailored Motivational Interviewing Implementation-Effectiveness Trial in Multidisciplinary Adolescent HIV Care Settings
The goal of this study is to test a multi-faceted Tailored Motivational Interviewing Implementation intervention (TMI), based on the Dynamic Adaptation Process (DAP) to scale up an Evidence-based Practice (EBP) in…
- Conditions
- HIV Infections, Adolescent Development, Care Eliciting Behavior, Patient Non-Compliance
- Trial name
- TMI (NCT03681912)
- Testing
- Competency: 12-Item Motivational Interviewing (MI) Coach Rating Scale (CRS), Randomized Guided Development of COPs with an internal facilitator after one year of implementation., CoP development without internal facilitation.
- Where
- United States
- Volunteers
- 188 people, healthy volunteers welcome
- Sponsor
- Florida State University
Autism Spectrum Disorder
Effects of Hippotherapy in Children With Autism Spectrum Disorder
Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder characterized by difficulties in social communication and interaction, as well as impairments in physical function domains such as postural control, balance…
- Trial name
- NCT07739693
- Testing
- Hippotherapy Program, Special Education Program
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Fenerbahce University
Pectus Excavatum
Lung Ultrasound for the Postoperative Diagnosis of Pneumothorax in Children
This study will be conducted to determine the advantages and limitations of sonography compared with chest radiography, in the detection of post procedure iatrogenic pneumothorax in patients underwent to Pectus Excavatum (PE)…
- Trial name
- ECO_NUSS (NCT03073616)
- Testing
- Lung ultrasound
- Where
- Italy
- Volunteers
- 66 people
- Sponsor
- Nicola Disma, MD
Autism Spectrum Disorder
Evaluating BOSCC and ELSA as Outcome Measures in the Context of a JASPER Intervention Trial
Research teams in Boston University, UCLA, and Weill Cornell will recruit 90 participants in 3 years (10 participants per site per year) and evaluate JASPER, play-based intervention, using the BOSCC and ELSA-T.
- Trial name
- EBJ (NCT04146428)
- Testing
- clinician-mediated JASPER, parent-mediated JASPER
- Where
- 4 sites in United States
- Volunteers
- 84 people
- Sponsor
- University of California, Los Angeles
Pressure Injury, Nursing Competency
NURSING COMPETENCY SCALE IN PRESSURE INJURY PREVENTION: A SCALE DEVELOPMENT STUDY
Pressure injuries remain an important patient safety problem and are associated with prolonged hospitalization, increased healthcare costs, pain, and reduced quality of care.
- Trial name
- NCSPIP (NCT07590765)
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of Yalova
Attention Deficit Hyperactivity Disorder, Autism Spectrum Disorder
Evaluation of the Efficacy of Hippotherapy for Children With Developmental Disorders
Hippotherapy is every program of horseback riding meant to treat people with physiological, mental, social, cognitive or behavioral problems.
- Trial name
- NCT00717392
- Where
- Israel
- Volunteers
- 40 people
- Sponsor
- Sheba Medical Center
Cutaneous T-Cell Lymphoma
Novel Flow-cytometry Approaches to Improve the Detection of Tumor Cells in CTCL
Identification and quantitation of circulating tumor cells in patients with cutaneous T-cell lymphoma -mycosis fungoides (MF)/Sézary syndrome (SS)- are required for diagnosis and precising the actual staging and response to…
- Trial name
- NCT06382844
- Testing
- Detection and quantitation of (blood) tumor cells in patients with mycosis fungoides (MF) / Sézary syndrome (SS).
- Where
- Spain
- Volunteers
- 100 people
- Sponsor
- Instituto de Investigación Biomédica de Salamanca
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