Clinical trials: Development Disorders
Metopic Synostosis
Comparing Conservative to Surgical Treatment of Trigonocephaly Craniofacial Surgery in Children With Trigonocephaly: an Observational Cohort Study on Clinical Outcomes, Psychosocial Wellbeing, and Costs
RESEARCH QUESTION Is the effectiveness of conservative policy comparable to that of surgery in children with trigonocephaly, with regard to clinical outcomes and psychosocial functioning, stress for parents, and costs? DESIGN…
- Trial name
- Treat Trigono (NCT06069479)
- Testing
- craniofacial surgery
- Where
- Netherlands
- Volunteers
- 440 people
- Sponsor
- Erasmus Medical Center
Anxiety, Stress
Development and Assessment of a 360° Video-Based Virtual Reality Application to Enhance Medical Students' Preparation for Initial Cadaver Dissection
For many medical students, their first experience with cadaver dissection can be stressful and emotionally challenging. This study developed a 360° video-based virtual reality (VR) application to allow students to explore the…
- Trial name
- NCT07521033
- Testing
- A 360° video-based virtual reality application
- Where
- Qatar
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Weill Cornell Medical College in Qatar
Autism Spectrum Disorders, Pervasive Developmental Disorders
An Open-Label Trial of Oxytocin in Adolescents With Autism Spectrum Disorders
This study is an 8-week open-label trial testing oxytocin nasal spray (Syntocinon) as a treatment for social impairment in adolescents with autism spectrum disorders (ASD).
- Conditions
- Autism Spectrum Disorders, Pervasive Developmental Disorders, ASD, PDD
- Trial name
- NCT01931033
- Testing
- Intranasal Oxytocin
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Massachusetts General Hospital
Breast Cancer, Breast Neoplasms
Target-specific immunoPET Imaging of Breast Cancer
The aim of this study is to establish and optimize the Trop2/HER2-targeted PET/CT imaging method, and its physiological and pathological distribution characteristics, on the basis of which the diagnostic efficacy of the above…
- Conditions
- Breast Cancer, Breast Neoplasms, Breast Cancer Metastatic
- Trial name
- NCT06715826
- Testing
- [18F]F-RESCA-RT4, [18F]F-RESCA-RB14
- Where
- China
- Volunteers
- 200 people
- Sponsor
- RenJi Hospital
Adult Acute Megakaryoblastic Leukemia (M7), Adult Acute Minimally Differentiated Myeloid Leukemia (M0)
Lenalidomide and Combination Chemotherapy in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia
This phase I trial studies the side effects and the best dose of lenalidomide when given together with combination chemotherapy in treating patients with relapsed or refractory acute myeloid leukemia.
- Conditions
- Adult Acute Megakaryoblastic Leukemia (M7), Adult Acute Minimally Differentiated Myeloid Leukemia (M0), Adult Acute Monoblastic Leukemia (M5a), Adult Acute Monocytic Leukemia (M5b)
- Trial name
- NCT01904643
- Testing
- lenalidomide, mitoxantrone hydrochloride, etoposide
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Stanford University
Latent Tuberculosis
Microneedles for Diagnosis of LTBI
This study will evaluate new technique, microneedle, to detect latent tuberculosis (TB) in healthy volunteers
- Trial name
- NCT04552015
- Testing
- TST vs PPD microneedle test
- Where
- Thailand
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- The HIV Netherlands Australia Thailand Research Collaboration
Attention Deficit Hyperactivity Disorders, Developmental Delays
Cognitive Training for Attention Deficit Hyperactivity Disorder and Developmental Delays
To explore whether children with Attention Deficit Hyperactivity Disorder and developmental delays who receive cognitive training and conventional rehabilitation can improve executive function more than traditional rehabilitation…
- Trial name
- NCT06277440
- Testing
- cognitive training, active control
- Where
- Taiwan
- Volunteers
- 20 people
- Sponsor
- Taipei Medical University
Post-Traumatic Stress Disorder, Chronic, Depressed Mood
An Interrupted Time-Series Pilot Trial of LGBTQ-Affirming Cognitive Processing Therapy for Interpersonal and Developmental Trauma
The researchers are testing a single-group cognitive-behavioral intervention for treating traumatic stress related to interpersonal and developmental trauma in LGBTQ adults.
- Conditions
- Post-Traumatic Stress Disorder, Chronic, Depressed Mood, Depressive and Anxiety Disorders, Anxiety
- Trial name
- NCT07863817
- Testing
- Cognitive Processing Therapy
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Alabama at Birmingham
Psychological Trauma
To Repeat or Not to Repeat - Preventing Intergenerational Transfer of Adverse Childhood Experiences
The main aim of the study is to examine patients' and therapists' experiences with prenatal psychotherapy provided to pregnant women with adverse childhood experiences and how this may influence intergenerational transmission of…
- Trial name
- NCT04528589
- Testing
- prenatal psychotherapy
- Where
- Norway
- Volunteers
- 23 people
- Sponsor
- University Hospital, Akershus
Sleep, Psychological Distress
The Development and Evaluation of Sleep Intervention for Perinatal Family
Background: Sleep disruptions and disturbances are highly prevalent among new mothers and fathers and negatively affect their mental health and infant development outcomes.
- Conditions
- Sleep, Psychological Distress, Perinatal Problems
- Trial name
- NCT06487650
- Testing
- sleep intervention, Control group
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Taipei Medical University
Autism Spectrum Disorder
Neuroimaging of Escitalopram in Autism Spectrum Disorder
The goal of this clinical trial is to evaluate the acute effects of escitalopram (Lexapro®) on select brain networks during task-based functional magnetic resonance imaging (fMRI) in adolescent individuals with autism spectrum…
- Trial name
- NCT06826326
- Testing
- Escitalopram 10mg
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Kathryn Unruh
Cerebral Palsy
Development of a Robotic Ankle Assist Device
The overall objectives of this work is to establish feasibility of a robotic ankle assist device (RAAD) to improve mobility in free-living settings and to establish the RAAD as an effective tool to provide increased dose and…
- Trial name
- NCT04516343
- Testing
- Robotic Ankle Assist Device (RAAD)
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- BiOMOTUM, Inc.
Adrenal Hyperplasia, Congenital
Role of the Protein Osteoprotegerin in the Bone Health of Women With Congenital Adrenal Hyperplasia
21-hydroxylase deficiency (21-OHD) is an inherited disorder that results from a mutation on the CYP21A2 gene. It affects the adrenal glands and is the most common cause of congenital adrenal hyperplasia (CAH).
- Trial name
- NCT00694525
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Office of Rare Diseases (ORD)
Bowel Disease, Crohn Disease
Development of New Diagnostic Tools in Capsule Endoscopy
Patients participating to this study will provide images and videos of capsule endoscopy to train, tune and evaluate technological bricks of artificial intelligence solutions, in order to improve diagnostic performances of the…
- Conditions
- Bowel Disease, Crohn Disease, Celiac Disease, Chronic Diarrhea
- Trial name
- NOCE (NCT06152289)
- Where
- France
- Volunteers
- 10,000 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Autism Spectrum Disorder, Microbiota
Gut-oral Axis Microbiome in Autism Spectrum Disorders
Autism Spectrum Disorder (ASD) is a neurodevelopment disorder characterized by impairment in social interaction, communication, and behavior, as well as sensory challenges.
- Trial name
- NCT05830591
- Testing
- Characterization of the microbiome in oral and fecal samples
- Where
- Italy
- Volunteers
- 86 people
- Sponsor
- IRCCS Burlo Garofolo
Breast Cancer, Physical Activity
Development of Exercise Promotion Program Using a Mobile Community
This study aims to investigate the effect of a mobile community based on a smart phone application to enhance physical activities of breast cancer survivors.
- Trial name
- NCT03190720
- Testing
- Mobile community
- Where
- South Korea
- Volunteers
- 64 people
- Sponsor
- Asan Medical Center
Poly Cystic Ovary Syndrome
Efficacy of Metformin With and Without Probiotics in Women With PCOS
This prospective interventional study evaluated the effectiveness of metformin alone compared with metformin combined with probiotics in women with polycystic ovary syndrome (PCOS).
- Trial name
- MEP-PCOS (NCT07874646)
- Testing
- Metformin, Probiotics
- Where
- India
- Volunteers
- 60 people
- Sponsor
- Dhivyaprasath Palaniappan
Developmental Dysplasia of the Hip
Evaluation of Aid to Diagnosis for Congenital Dysplasia of the Hip in General Practice
Developmental dysplasia of the hip (DDH) is one of the most common inborn diseases. Early diagnosis of this condition is very important and it can be harmful both to miss DDH and label normal infants as having DDH.
- Trial name
- HipDyS (NCT04101903)
- Testing
- The 6-week Hip Checklist
- Where
- United Kingdom
- Volunteers
- 172 people
- Sponsor
- Great Ormond Street Hospital for Children NHS Foundation Trust
Prostate Cancer
Focal Prostate Radiofrequency Ablation
To assess the early histological outcomes of tissue ablation, adverse events and genitourinary side-effect profile of focal radiofrequency ablation using a coiled bipolar device to treat localized prostate cancer in men with…
- Trial name
- ProRAFT (NCT02294903)
- Testing
- Coiled Bipolar Radiofrequency Ablation
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Trod Medical N.V.
Autism, ADHD
Spanish-language Executive Function Intervention for Children With Autism and/or ADHD
The goal of this clinical trial is to learn whether the Spanish-language version of Unstuck and On Target (SL-Unstuck), an executive functioning (EF) intervention, is feasible, acceptable, and effective for Spanish-speaking…
- Trial name
- NCT07084324
- Testing
- Unstuck and On Target
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Colorado, Denver
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