Clinical trials: Development Disorders
Autism
Omega-3 Fatty Acids for Autism Treatment
Omega-3 fatty acids are among the most commonly used CAM (Complementary Alternative Medical) therapies, and have been reported to be currently used by 28.7% of children with autism.
- Trial name
- NCT00786799
- Testing
- Omega-3 Fatty Acids
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- University of California, San Francisco
Cerebral Palsy, Hemiplegia
Constraint-induced Movement Therapy (CIMT) and Bimanual Training (HABIT) in Children With Hemiplegic Cerebral Palsy
A randomized control trial of bimanual training. The protocols have been developed at Columbia University to be child friendly and draws upon our experience since 1997 with constraint-induced movement therapy in children with…
- Conditions
- Cerebral Palsy, Hemiplegia, Children, Pediatric
- Trial name
- NCT00305006
- Testing
- Constraint-Induced Movement Therapy (CIMT), Hand-Arm Bimanual Intensive Therapy (HABIT)
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Teachers College, Columbia University
Body Dysmorphic Disorders
Smartphone-Administered App Treatment for Adults With Body Dysmorphic Disorder
The investigators are developing and testing a Smartphone-based cognitive behavioral therapy (CBT) "app" for body dysmorphic disorder (BDD).
- Trial name
- NCT03221738
- Testing
- App-Based Cognitive Behavioral Therapy
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Massachusetts General Hospital
Acute Myeloid Leukemia With Multilineage Dysplasia Following Myelodysplastic Syndrome, Adult Acute Megakaryoblastic Leukemia (M7)
Omacetaxine Mepesuccinate, Cytarabine, and Decitabine in Treating Older Patients With Newly Diagnosed Acute Myeloid Leukemia
This phase II trial studies the side effects and how well omacetaxine mepesuccinate, cytarabine, and decitabine work in treating older patients with newly diagnosed acute myeloid leukemia.
- Conditions
- Acute Myeloid Leukemia With Multilineage Dysplasia Following Myelodysplastic Syndrome, Adult Acute Megakaryoblastic Leukemia (M7), Adult Acute Minimally Differentiated Myeloid Leukemia (M0), Adult Acute Monoblastic Leukemia (M5a)
- Trial name
- NCT02029417
- Testing
- cytarabine, omacetaxine mepesuccinate, decitabine
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Roswell Park Cancer Institute
Obesity
Remote Delivery of Weight Management for Adults With IDD
The purpose of this study is to compare different weight loss programs in people with IDD to see which program works better.
- Trial name
- NCT03291509
- Testing
- Video Conference Meetings, In-person Meetings, Enhanced Stop Light Diet
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of Kansas Medical Center
Non-verbal Learning Disorder, Autism Spectrum Disorder
Natural Treatments for the Management of Emotional Dysregulation in Youth With Non-verbal Learning Disability (NVLD) and/or Autism Spectrum Disorders (ASD)
This study consists of a 6-week, open-label, randomized clinical trial study to compare efficacy and tolerability of the natural treatments omega-3 fatty acids, inositol, and N-acetylcysteine (NAC) in the treatment of mood…
- Conditions
- Non-verbal Learning Disorder, Autism Spectrum Disorder, Autism
- Trial name
- NCT03757585
- Testing
- Open-label Treatment with Omega-3 Fatty Acids + Inositol, Open-label Treatment with N-acetylcysteine
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Massachusetts General Hospital
Diabetes Mellitus
Impact of an Interprofessional Shared Decision-making and Goal-setting Decision Aid for Patients With Diabetes
Diabetes care is complicated for people with diabetes as well as for health care providers: they have to watch their diet, exercise, take medications, checking blood sugars and blood pressure, get tests and see multiple doctors.
- Trial name
- NCT02379078
- Testing
- Shared decision-making aid, Generic hard copy diabetes resources, Generic online diabetes resources
- Volunteers
- 225 people
- Sponsor
- Unity Health Toronto
Liver Transplant, Hepatitis C
Liver Fibrosis in Patients Transplanted for Hepatitis C Receiving Either Cyclosporine Microemulsion or Tacrolimus
Following a transplant for hepatitis C cirrhosis, the infection comes back in 70-90% of cases and over time causes fibrosis and eventually cirrhosis of the new liver.
- Trial name
- NCT00260208
- Testing
- Cyclosporine A, Tacrolimus
- Where
- 2 sites in United States, Switzerland
- Volunteers
- 361 people
- Sponsor
- Novartis Pharmaceuticals
Leukemia
Imatinib Mesylate in Treating Patients With Newly Diagnosed Acute Myeloid Leukemia Who Have Received Chemotherapy
RATIONALE: Imatinib mesylate may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. PURPOSE: This phase II trial is studying how well imatinib mesylate works in treating patients with newly…
- Trial name
- NCT00509093
- Testing
- imatinib mesylate, gene expression analysis, mutation analysis
- Where
- 4 sites in United States
- Volunteers
- 32 people
- Sponsor
- Case Comprehensive Cancer Center
Hospitalism in Children, Post Traumatic Stress Disorder
Pilot Testing of an Equity Focused and Trauma-informed Communication Intervention During Family-centered Rounds
Development and pilot testing of a clinician coaching communication intervention to improve communication between medical teams and caregivers (parents, family members) of children in the hospital.
- Trial name
- EFTI (NCT05618652)
- Testing
- Equity Focused and Trauma-Informed Communication Intervention
- Where
- United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Duke University
Attention Deficit Hyperactivity Disorder
Virtual Reality Treatment for Emerging Adults With ADHD
The goal of this pilot randomized clinical trial is to test the impact of a virtual reality program for improving the ability of emerging adults (age 18-25) with attention deficit hyperactivity disorder (ADHD) to stay focused…
- Trial name
- NCT06454604
- Testing
- Meta Quest 3 VR Headset with noise cancelling headphones
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- Rutgers, The State University of New Jersey
Developmental Language Disorder, Specific Language Impairment
Retrieval-Based Word Learning in Developmental Language Disorder
Children with developmental language disorder (DLD; also referred to as specific language impairment) experience a significant deficit in language ability that is longstanding and harmful to the children's academic, social, and…
- Conditions
- Developmental Language Disorder, Specific Language Impairment, Language Development
- Trial name
- NCT05325333
- Testing
- Retrieval-based word learning: Expanding retrieval practice schedule, Retrieval-based word learning: Standard retrieval practice schedule
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Purdue University
Osteoarthritis, Avascular Necrosis
Trilogy AB Acetabular Hip System Post Approval Study
This is a post-approval study with prospective enrollment in the United States and a retrospective enrollment outside the United States to obtain functional, quality of life and radiographic data, which will facilitate assessment…
- Conditions
- Osteoarthritis, Avascular Necrosis, Congenital Hip Dysplasia, Traumatic Arthritis
- Trial name
- NCT00715026
- Testing
- Trilogy AB Acetabular Hip Implant System
- Where
- 2 sites in United States
- Volunteers
- 31 people
- Sponsor
- Zimmer Biomet
Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage IA Breast Cancer AJCC v8
Treatment Effects on Development of Chemotherapy-Induced Peripheral Neuropathy in Patients With Cancer
This trial studies treatment effects on development of chemotherapy-induced peripheral neuropathy in patients with cancer. Treatments for cancer can cause a problem to the nervous system (called peripheral neuropathy) that can…
- Conditions
- Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage IA Breast Cancer AJCC v8, Anatomic Stage IB Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8
- Trial name
- NCT03939481
- Testing
- Chemotherapy, Functional Assessment, Questionnaire Administration
- Where
- 169 sites in United States, Chile and 2 more
- Volunteers
- 1,336 people
- Sponsor
- SWOG Cancer Research Network
Myeloma-Multiple, Myeloma, Plasma-Cell
T-cells Expressing an Anti-SLAMF7 CAR for Treating Multiple Myeloma
Background: Multiple myeloma is a blood cancer that is usually incurable. T cells are part of the immune system. Researchers think changing a person's T cells to recognize their cancer could help the person's body kill tumor…
- Trial name
- NCT03958656
- Testing
- Cyclophosphamide, Fludarabine, Rimiducid
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- National Cancer Institute (NCI)
Gingival Diseases
Development of Clinical Method to Determination Triclosan Retention in Plaque Following Brushing.
Clinical research study to determine the anti-plaque efficacy of prototype dentifrices via a 4-day brushing regiment
- Trial name
- NCT00966953
- Testing
- Fluoride, Triclosan/Fluoride toothpaste, antibacterial plant extract
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
Autism Spectrum Disorder
Improving Driving in Young People With Autism Spectrum Disorders
This study will examine the effects of treatment with the anti-anxiety medicine buspirone on driving performance (eye tracking) in individuals with high-functioning autism spectrum disorder (HF-ASD).
- Trial name
- NCT03538431
- Testing
- Buspirone
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Massachusetts General Hospital
Drinking, Alcohol
Multimodal Sleep Intervention Using Wearable Technology
This research study is examining three different components of a digital sleep intervention: web-based sleep health advice, sleep and alcohol smartphone diary self-monitoring, and personalized sleep and alcohol consumption…
- Trial name
- NCT03658954
- Testing
- Advice, Self-monitoring, Feedback
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Yale University
Autism Spectrum Disorder
Rt-fMRI NF Intervention Study in ASD
This study aims to demonstrate that fMRI neurofeedback training improves the identification and comprehension of emotional facial expressions (and overall social behaviour) in subjects with ASD.
- Trial name
- NF-ASD (NCT02440451)
- Testing
- Neurofeedback using BCI
- Volunteers
- 15 people
- Sponsor
- University of Coimbra
Fibrosis, Kidney Failure
Risk of Nephrogenic Systemic Fibrosis (NSF) in Patients With Moderate Renal Insufficiency After the Administration of Magnevist
Assess potential risk for NSF in subjects with renal impairment (moderate) post magnevist injection. Subjects will be screened within 48 hours of previously scheduled MRI, those meeting the enrollment criteria will be enrolled…
- Conditions
- Fibrosis, Kidney Failure, Renal Insufficiency
- Trial name
- NCT00744939
- Testing
- Gadopentetate dimeglumine (Magnevist, BAY86-4882)
- Where
- 26 sites in United States
- Volunteers
- 168 people
- Sponsor
- Bayer
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