Clinical trials: Development Disorders
Autism, Autism in Children
Developing a Novel Therapy for Aversive Sensory Experiences in Autism
The goal of this study is to assess whether a new psychological treatment can lead to changes in sensory experiences in autistic young people.
- Trial name
- NCT06682858
- Testing
- Group Cognitive Behavioural Therapy
- Where
- United Kingdom
- Volunteers
- 25 people
- Sponsor
- King's College London
Diarrhea, Diarrhea Infectious
A Baseline Study in Support of Clinical Evaluation of an Oral Shigella Vaccine Development in Africa
This study aims to address the paucity of accurate incidence data of diarrheal diseases associated with Shigella in Zambia and Burkina Faso.
- Trial name
- ShigOraVax (NCT04312906)
- Testing
- no intervention
- Where
- 3 sites in Burkina Faso, Zambia
- Volunteers
- 1,334 people, healthy volunteers welcome
- Sponsor
- Centre for Infectious Disease Research in Zambia
Medical Device-Related Pressure Injury, Pressure Injury
ADDIE-Based Training Program for Nurses on Medical Device-Related Pressure Injuries
Medical device-related pressure injuries (MDRPIs) are a significant and increasing problem in clinical settings, particularly in intensive care units, adversely affecting patient outcomes and increasing healthcare costs.
- Conditions
- Medical Device-Related Pressure Injury, Pressure Injury, Nursing Education
- Trial name
- NCT07553026
- Testing
- ADDIE-Based Training Program
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- University of Gaziantep
Cardiac Event
Minimally Invasive Cardiac Output Monitoring Device
The overall goal of this collaborative study is to advance the novel "pulse contour analysis" to the point at which it can be incorporated into a real-time device.
- Trial name
- NCT01675063
- Testing
- Retia Non-Invasive Sensors
- Where
- United States
- Volunteers
- 77 people
- Sponsor
- University of Michigan
Mitral Regurgitation, Heart Failure
Development and Validation of the Prediction Model for Functional Mitral Regurgitation Regression in Heart Failure Patients Taking Guideline-directed Medical Therapy
This observational study is to develop and validate the prediction model for functional mitral regurgitation regression in heart failure patients taking GDMT.
- Trial name
- NCT06278727
- Testing
- angiotensin-converting enzyme inhibitors/angiotensin II receptor blocker/angiotensin receptor-neprilysin inhibitor, The development of the prediction model
- Where
- China
- Volunteers
- 270 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Autism Spectrum Disorder
Diagnostic Performance of Exome Sequencing in Autism Spectrum Disorders
Evaluation of the diagnostic performance of exome sequencing in a prospective series of patients with autism spectrum disorders (ASD).
- Trial name
- REDIA (NCT04043351)
- Testing
- blood test
- Where
- France
- Volunteers
- 300 people
- Sponsor
- University Hospital, Rouen
Autism Spectrum Disorder
A Study of Bumetanide for the Treatment of Autism Spectrum Disorders
The investigators are going to carry out a randomized double-blind placebo-controlled trial to study the efficiency and mechanism of bumetanide on the treatment of children with Autism Spectrum Disorder.
- Trial name
- NCT03156153
- Testing
- Bumetanide
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Fetal Alcohol Spectrum Disorders, Fetal Alcohol Syndrome
RCT of Prenatal Choline Supplementation During Pregnancy to Mitigate Adverse Effects of Prenatal Alcohol Exposure
Although the adverse effects associated with prenatal alcohol exposure (PAE) are well known, many women continue to drink heavily during pregnancy, putting their infants at risk for fetal alcohol spectrum disorders.
- Trial name
- NCT04395196
- Testing
- Choline bitartrate
- Where
- South Africa
- Volunteers
- 288 people, healthy volunteers welcome
- Sponsor
- Wayne State University
Autistic Disorder
An Evaluation of a Developmentally-Based Parent Training Program for Children With Autism
The purpose of this study is to assess the efficacy of a parent training program in the treatment of social and communication deficits in children with autism.
- Trial name
- NCT01400269
- Testing
- Pacific Autism Center for Education (PACE ) developmentally based parent delivered intervention
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Stanford University
Obstructive Sleep Apnea, Down Syndrome (Trisomy 21)
Oro-myofunctional Characteristics and Obstructive Sleep Apnea in Infants With Down Syndrome
Obstructive Sleep Apnea (OSA) is characterised by repetitive collapse of the upper airway during sleep, inducing breathing disturbances that can result in oxygen desaturation and frequent arousals.
- Trial name
- OMF21 (NCT07195253)
- Testing
- Polysomnography (PSG) to explore OSA, Oro-myo-functional clinical evaluation, Sleep Disturbance Scale for Children
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Hospices Civils de Lyon
Autism, Gastrointestinal Symptoms
A Study to Assess the Role of a Gluten Free-dairy Free (GFCF) Diet in the Dietary Management of Autism Associated Gastrointestinal Disorders
Doctors at MassGeneral Hospital for Children (MGHfC) are doing a research study to learn if a gluten free-dairy free (GFCF) diet is helpful in improving gastrointestinal symptoms associated with autism.
- Trial name
- GFCF (NCT01116388)
- Testing
- GFCF product with GFCF diet, product containing gluten and casein (milk protein) with GFCF diet
- Where
- 2 sites in United States
- Volunteers
- 65 people
- Sponsor
- Massachusetts General Hospital
Iron Deficiency Anemia, Iron Deficiency Anemia of Pregnancy
Neuroimaging Ancillary Study
As a follow-up to the RAPIDIRON Trial (NCT05358509), and in combination with the RAPIDIRON-KIDS Study (NCT05504863), this study will involve infants of RAPIDIRON Trial participants recruited at one site in Karnataka and is…
- Conditions
- Iron Deficiency Anemia, Iron Deficiency Anemia of Pregnancy, Neurodevelopmental Disorder of Foetus, Iron Deficiency Anemia Treatment
- Trial name
- NCT05545527
- Testing
- Ferric carboxymaltose, Iron isomaltoside, Ferric Sulfate
- Where
- India
- Volunteers
- 184 people
- Sponsor
- Thomas Jefferson University
Autism, Autism Spectrum Disorder
Coaching Children With Anxiety and Autism Through Telehealth
This study will examine a telehealth parenting intervention to reduce anxiety in 20 families of children between 4 and 8 years old with autism and anxiety. Caregivers and children complete 12 telehealth treatment sessions.
- Conditions
- Autism, Autism Spectrum Disorder, Anxiety
- Trial name
- CAT (NCT05588570)
- Testing
- CAT
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Cirrhosis, Liver, Gastroesophageal Varices
Development of 4D Flow MRI for Risk Stratification of Variceal Bleeding in Cirrhosis
The goal of this research is to validate novel non-invasive Magnetic resonance imaging (MRI) biomarkers to detect Gastroesophageal varices (GEV) in patients with cirrhosis, including fractional flow change in the portal vein and…
- Conditions
- Cirrhosis, Liver, Gastroesophageal Varices, Fontan Procedure
- Trial name
- NCT04867954
- Testing
- Ensure Plus®, Pre-clinical validation contrast enhanced MRI, Clinical validation MRI
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Growth Hormone Deficiency
Safety, Pharmacokinetics and Pharmacodynamics Study of HL-032 in Healthy Male Volunteers
The purpose of this study is to evaluate the safety, pharmacokinetics and pharmacodynamics of HL-032 after oral administration in healthy male volunteers.
- Trial name
- HL-032 (NCT01440686)
- Testing
- Somatropin
- Where
- South Korea
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- HanAll BioPharma Co., Ltd.
Diabetic Foot Ulcer (DFU), Diabete Mellitus
AI-Based Diabetic Foot Recurrence Cohort
Diabetic foot ulcer (DFU) is a major adverse outcome of diabetes, which itself is one of the most significant chronic diseases. The recurrence of DFU involves multiple risk factors, including altered foot loading patterns…
- Conditions
- Diabetic Foot Ulcer (DFU), Diabete Mellitus, Diabetic Foot Ulcer Treatment, Artificial Intelligence (AI) in Diagnosis
- Trial name
- NCT07452354
- Testing
- Researchers predefined groups based on risk stratification to formulate personalized follow-up strategies.
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Peking University Third Hospital
Autistic Disorder
An Evaluation of Low Level Laser Light Therapy for Autistic Disorder 2
The purpose of this study is to determine whether the Erchonia HLS Laser is effective in the treatment of irritability associated with autistic disorder in children and adolescents aged five (5) to twelve (12) years.
- Trial name
- NCT04895605
- Testing
- Erchonia HLS Laser
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Erchonia Corporation
Autism Spectrum Disorder, Cerebral Palsy
Upper Extremity Function Before and After Hippotherapy in Children With Autism Spectrum Disorder and/or Cerebral Palsy
The goal of this feasibility trial is to learn if hippotherapy and physical therapy in the equine environment can be used to improve upper extremity function in children with cerebral palsy or autism spectrum disorder who present…
- Trial name
- NCT06530680
- Testing
- Hippotherapy
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Ohio State University
Pulmonary Hypertension, Pulmonary Arterial Hypertension
Anxiety Self-management Intervention for Pulmonary Hypertension
Pulmonary hypertension (PH) is a disorder of high blood pressure that impacts the heart and lungs. Approximately, 50% of individuals with PH experience anxiety or panic disorders.
- Conditions
- Pulmonary Hypertension, Pulmonary Arterial Hypertension, Anxiety, Anxiety Disorders
- Trial name
- NCT04450862
- Testing
- Cognitive Behavioural therapy self help intervention for anxiety
- Where
- 2 sites in United Kingdom
- Volunteers
- 64 people
- Sponsor
- University of Sheffield
Autism Spectrum Disorder
Understanding the Mechanisms of Autism : an MRI and Social Cognition Study
The main goal of this study is to investigate anatomo-functional brain abnormalities associated with autism spectrum disorders using a multimodal brain imaging approach, as well as its links to social cognition difficulties…
- Trial name
- ECLAT (NCT06334588)
- Testing
- MRI, Eye-tracking, Clinical Scales
- Where
- France
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
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