Clinical trials: Development Disorders, open to volunteers
Lung Cancer Patients
Machine Learning for Predicting and Managing Quality of Life in Lung Cancer Immunotherapy Patients
The goal of this study is to explore whether health-related quality of life (HRQoL) can be used as a predictive indicator for lung cancer patients and to implement clinical interventions.
- Trial name
- NCT06725225
- Testing
- Symptom cluster-based care intervention, Conventional care intervention
- Volunteers
- 200 people
- Sponsor
- Second Affiliated Hospital of Zunyi Medical University
Autism Spectrum Disorder (ASD), Relative (Related Person)
Developing an Intervention Facilitating the Use of Eye Contact in Adults With Autism
The aim of this study is to develop a methodological intervention for adults with autism that will help them reduce problems arising from eye contact.
- Conditions
- Autism Spectrum Disorder (ASD), Relative (Related Person), Care Giver
- Trial name
- NCT06924008
- Where
- Netherlands
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- UMC Utrecht
Pulmonary Arterial Hypertension (PAH), Quality of Life
Development and Validation of a Chinese Quality of Life Scale for Pulmonary Arterial Hypertension
This study aims to develop and validate a culturally appropriate, reliable, and clinically applicable patient-reported outcome (PRO) instrument to assess quality of life in patients with pulmonary arterial hypertension (PAH) in…
- Conditions
- Pulmonary Arterial Hypertension (PAH), Quality of Life, Patients Reported Outcomes
- Trial name
- NCT07570615
- Testing
- Questionnaire Assessment
- Volunteers
- 300 people
- Sponsor
- Chinese Pulmonary Vascular Disease Research Group
Autism Spectrum Disorder
Trial of an Online Spanish Pivotal Response Treatment Training in Autism Spectrum Disorder
The goal of this clinical trial is to understand if an online course in Spanish can help Spanish-speaking parents use Pivotal Response Treatment (PRT) to support language and social skills in young children with Autism Spectrum…
- Trial name
- PRT-OS (NCT06690255)
- Testing
- Pivotal Response Treatment
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Stanford University
Substance Use
Pre-exposure Prophylaxis (PrEP) Uptake and Adherence Intervention for Women with Trauma-related Conditions
The investigators have previously developed an integrated bio-behavioral intervention to promote PrEP uptake and adherence in cisgender women who are undergoing treatment for trauma-related mental health conditions and who are at…
- Trial name
- NCT06558825
- Testing
- Integrated Intervention to Promote PrEP Uptake, Standard Treatment Condition
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- The University of Texas Health Science Center, Houston
Cognitive Impairment
Dyadic Cognitive Intervention for Older Adults With Cognitive Impairment and Their Spouses
The goal of this randomized controlled clinical trial is to learn if a couple-centered cognitive intervention program can improve cognitive health, reduce caregiving burden, and support overall well-being for community-dwelling…
- Trial name
- NCT07872189
- Testing
- Dyadic Cognitive Intervention Program for Older Couples, Standard Community Health Education on Cognitive Impairment
- Where
- China
- Volunteers
- 136 people
- Sponsor
- Gansu University of Chinese Medicine
Dental Enamel, Dental Enamel Hypomineralization
Retention of Pits and Fissure Sealants on Non Carious vs Initial Carious Enamel Lesions in Posterior Teeth
This clinical study is planned to be conducted to compare retention rates of pits and fissure sealants on non carious (ICDAS score 0) vs Initial carious enamel lesions (ICDAS Score 1,2) in posterior permeant teeth at 3 months, 6…
- Conditions
- Dental Enamel, Dental Enamel Hypomineralization, Dental Enamel Hypoplasia
- Trial name
- NCT07330089
- Where
- Pakistan
- Volunteers
- 420 people, healthy volunteers welcome
- Sponsor
- Foundation University Islamabad
Infertility
Implementing IVM for Fertility Treatment in Clinical Practice
The ovarian reserve consists of a finite pool of follicles that gradually declines throughout a woman's reproductive life. During conventional IVF, exogenous gonadotropins are administered for 10-14 days to support the growth and…
- Trial name
- IVM-DK 2-0 (NCT07894952)
- Testing
- In vitro maturation
- Where
- Denmark
- Volunteers
- 155 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Hvidovre
Neurodevelopmental Disorders, Autism
Sertraline vs. Placebo in the Treatment of Anxiety in Children and AdoLescents With NeurodevelopMental Disorders
There are currently no approved medications for the treatment of anxiety in children and youth with neurodevelopmental disorders (NDDs), both common and rare.
- Conditions
- Neurodevelopmental Disorders, Autism, Autism Spectrum Disorder, Fragile X Syndrome
- Trial name
- CALM (NCT06081348)
- Testing
- Sertraline
- Where
- 7 sites in Canada
- Volunteers
- 130 people
- Sponsor
- Holland Bloorview Kids Rehabilitation Hospital
Heart Failure
CardioMEMS HF System Coverage With Evidence Development Study
The purpose of the CardioMEMS CED Study is to determine if pulmonary artery (PA) pressure-guided heart failure management using the CardioMEMS™ HF System improves long-term health outcomes in heart failure (HF) patients in the…
- Trial name
- NCT06779552
- Testing
- CardioMEMS HF System
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- Abbott Medical Devices
Multiple Myeloma
A Study Comparing JNJ-79635322 and an Anti-B-cell Maturation Antigen (BCMA)xCD3 Bispecific Antibody in Participants With Relapsed or Refractory Multiple Myeloma
The purpose of this study is to evaluate how well JNJ-79635322 works when compared with an anti-B-cell maturation antigen (BCMA)xCD3 bispecific antibody.
- Trial name
- TRIlogy-4 (NCT07258511)
- Testing
- JNJ-79635322, Teclistamab
- Where
- 157 sites in United States, Australia and 13 more
- Volunteers
- 400 people
- Sponsor
- Janssen Research & Development, LLC
Rare Disorders
Implementing Dynamic Consent for Rare Disease Patients
The study aims to test on a cohort of rare patients a digital innovative tool to support patients/parents in the informed consent and assent process and to keep up-to-date a lawful informed and dynamic consent and to use samples…
- Trial name
- ConsDinamico (NCT06656247)
- Testing
- Online consenting
- Volunteers
- 50 people
- Sponsor
- Istituto Ortopedico Rizzoli
Absence Epilepsy, Jeavons Syndrome
BMB-101 in Absence Epilepsy and DEE
The study is a pilot, open-label, study to test whether BMB-101 is safe and effective in reducing the frequency of seizures in subjects with Absence Epilepsy including Epilepsy with Eyelid Myoclonia (also called Jeavons Syndrome)…
- Conditions
- Absence Epilepsy, Jeavons Syndrome, Dravet Syndrome, Lennox Gastaut Syndrome
- Trial name
- NCT06401538
- Testing
- BMB-101
- Where
- 5 sites in Australia
- Volunteers
- 20 people
- Sponsor
- Bright Minds Biosciences Pty Ltd
Achondroplasia
Achondroplasia Natural History Multicenter Clinical Study
The purpose of this study is to create an electronic registry to house phenotypic information from patients with achondroplasia. The initial focus of this registry will be to include U.S. patients with achondroplasia.
- Trial name
- NCT02597881
- Where
- United States
- Volunteers
- 1,500 people
- Sponsor
- Johns Hopkins University
Hereditary Breast and Ovarian Cancer Syndrome, BRCA Mutations
Development and Validation of an Ovarian Cancer Risk Prediction Model for Family Members of Ovarian Cancer Probands
Ovarian cancer is the gynecological malignancy with the highest fatality rate, seriously threatening the life and health of women.
- Trial name
- NCT07039552
- Testing
- risk-reducing salpingo-oophorectomy (RRSO)
- Where
- China
- Volunteers
- 10,000 people
- Sponsor
- Peking University Third Hospital
Problem Behavior, Developmental Delay
Problem Behavior Assessment and Intervention in IDEA Part C Services
The purpose of this study is to evaluate the effect of function-based assessment and intervention to reduce problem behavior in children with developmental disability or delay in the context of IDEA Part C services.
- Conditions
- Problem Behavior, Developmental Delay, Developmental Disability
- Trial name
- NCT06771284
- Testing
- Function-based assessment and intervention
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- University of Nevada, Las Vegas
Sleep, Autism Spectrum Disorder
Transdiagnostic Sleep and Circadian Treatment for Autistic Adolescents
Sleep and circadian problems are associated with deleterious social, emotional, and cognitive outcomes, yet are modifiable. This prospective study will adapt and optimize an empirically supported behavioral intervention that…
- Conditions
- Sleep, Autism Spectrum Disorder, Transdiagnostic
- Trial name
- NCT07612111
- Testing
- Transdiagnostic Intervention for Sleep and Circadian Dysfunction
- Volunteers
- 12 people
- Sponsor
- Milton S. Hershey Medical Center
Stroke, Shoulder Impingement Syndrome
An Innovative Proprioceptive Instrument for Upper Extremities
This study aimed to develop and validate an innovative proprioceptive assessment instrument for the upper extremities, the PropArm-PosiMoF (PropArm). This observational study was conducted in three stages.
- Conditions
- Stroke, Shoulder Impingement Syndrome, Diabetes (DM), Healthy Young Adults
- Trial name
- NCT07779928
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- National Cheng-Kung University Hospital
Perinatal Mental Health, Gestational Weight Gain
Healthy Adaptation to Pregnancy, Postpartum and Parenthood
Healthy Adaptation to Pregnancy, Postpartum and Parenthood (HAP3) The HAP3 study is evaluating a new digital support program for pregnant women and their partners.
- Conditions
- Perinatal Mental Health, Gestational Weight Gain, Postpartum Weight Retention, Child Development
- Trial name
- HAP3 (NCT07837193)
- Testing
- HAP3 Family App
- Where
- Belgium
- Volunteers
- 572 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Shoulder Pain, Rotator Cuff Related Shoulder Pain
Night Pain Module for Rotator Cuff-Related Shoulder Pain
Night pain is common in people with rotator cuff-related shoulder pain and may disturb sleep and daily life. It may include difficulty falling asleep, waking because of pain, increased pain during the night, difficulty returning…
- Trial name
- NCT07838233
- Where
- 3 sites in Turkey (Türkiye)
- Volunteers
- 275 people
- Sponsor
- Istanbul Physical Medicine Rehabilitation Training and Research Hospital
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