Clinical trials: Development Disorders, open to volunteers
Multiple Myeloma
BCMA Polymorphisms in Patients With Multiple Myeloma
The aim of this study is to investigate the effect of B cell maturation antigen (BCMA, TNFRSF17) gene polymorphisms on treatment response and survival in patients with multiple myeloma.
- Trial name
- BCMA in MM (NCT07906418)
- Testing
- BCMA polymorphism analysis
- Where
- Turkey (Türkiye)
- Volunteers
- 420 people, healthy volunteers welcome
- Sponsor
- Başakşehir Çam & Sakura City Hospital
Amelogenesis Imperfecta, Dental Fluoroses
Colorimetric, Ultra-structural and Elemental Comparison of Dental Enamel Defects
The study focuses on the analysis of enamel defects grouping together hypomineralization and hypoplasia. It focuses on 3 very characteristic enamel pathologies that are most often encountered in dental consultations: Molar…
- Conditions
- Amelogenesis Imperfecta, Dental Fluoroses, Hypomineralization Molar Incisor
- Trial name
- COLOEMAIL (NCT04704089)
- Testing
- spectrophotometer, Biological (protein analysis by western blot or mass spectrometry of matrix proteins), structural (electron microscopy) and physico-chemical analyses
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Mental Health Issue, Depression
Development and Validation of Psycho-Social Program (PSP)
The study aims to determine the effectiveness of a structured psycho-social program (PSP) in improving mental health outcomes among patients with Type 2 diabetes mellitus (T2DM).
- Conditions
- Mental Health Issue, Depression, Diabetes Distress, Quality of Life
- Trial name
- PSP-T2DM (NCT07456410)
- Testing
- Psycho-Social Program
- Where
- Pakistan
- Volunteers
- 80 people
- Sponsor
- Government College University Faisalabad
Ischemia Limb, Blood Circulation Disorder
Ischemia Detection During Development of Acute Compartment Syndrome
This is an open, observational, prospective, descriptive, single-centre study including 60 patients. The study is designed to investigate if IscAlert sensor system can be used for reliable and continuous tissue carbon dioxide…
- Conditions
- Ischemia Limb, Blood Circulation Disorder, Carbon Dioxide, Biosensing Techniques
- Trial name
- IDEA (NCT06079255)
- Testing
- IscAlert sensor(s) in patient with risk of acute compartment syndrome
- Where
- Norway
- Volunteers
- 60 people
- Sponsor
- Oslo University Hospital
Autism Spectrum Disorder, Child
AI Toothbrush and Visual Pedagogy to Improve Oral Hygiene in Children With Autism Spectrum Disorder
This randomized clinical trial evaluates the effectiveness of an AI-enabled electric toothbrush and visual pedagogy materials in improving oral hygiene among children with autism spectrum disorder (ASD).
- Conditions
- Autism Spectrum Disorder, Child, Oral Health, Artificial Intelligence
- Trial name
- NCT07160517
- Testing
- Visual Pedagogy and Manual Toothbrushing
- Where
- Brazil
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Heart Failure
Effects of a Wed-based FRAIL-SM Program Among Patients With Heart Failure
This study aims to examine the effects of web-based FRAIL-SM (Family involvement, self-Regulation skills training, Autonomy, Information sharing and Linkage, Self-Management) on frailty, self-management behaviors and quality of…
- Trial name
- NCT07068308
- Testing
- web-based FRAIL-SM program
- Where
- Taiwan
- Volunteers
- 328 people
- Sponsor
- National Yang Ming Chiao Tung University
Solid Tumor Cancer, Neoplasms
AI-Driven Tumor Response Evaluation for Solid Tumors
Purpose: This study is developing and validating an artificial intelligence (AI)-driven system to evaluate tumor response using changes in total tumor volume.
- Conditions
- Solid Tumor Cancer, Neoplasms, Hepatocellular Carcinoma
- Trial name
- NCT07685548
- Testing
- Observational Data Collection
- Volunteers
- 6,120 people
- Sponsor
- Shanghai Zhongshan Hospital
Asthma, Respiratory Tract Infections
VItamin D in pregnanCy for prevenTion Of eaRlY Childhood Asthma
The overall aim of the study is to develop a nutritional preventive vitamin D supplementation strategy in pregnancy for early childhood asthma/persistent wheeze during the first three years of life as we hypothesize that…
- Conditions
- Asthma, Respiratory Tract Infections, Gastrointestinal Infection, Croup
- Trial name
- VICTORY (NCT06570889)
- Testing
- Cholecalciferol D3, Olive oil
- Where
- Denmark
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Professor Klaus Bønnelykke
Postpartum Depression (PPD), Breastfeeding
Methyl Donor-Rich Diet in the Postpartum Period
This study aims to evaluate the effects of a methyl-donor-rich diet during the postpartum period on maternal depression, breastfeeding success, and infant weight.
- Conditions
- Postpartum Depression (PPD), Breastfeeding, Maternal Nutrition, Infant Development
- Trial name
- NCT07887178
- Testing
- Methyl Donor-Rich Dietary Intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Istanbul University - Cerrahpasa
Cannabis Use Disorder
A Brief Intervention for Cannabis Use
The purpose of this study is to compare two brief interventions targeting potentially problematic cannabis use in emerging adults (ages 18-25). Brief interventions are two 40-50 minute sessions separated by 1 week.
- Trial name
- Bloom (NCT06395389)
- Testing
- Health Education (HealthEdu), Bloom
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- Medical University of South Carolina
Psoriasis
Development of Predictive Psoriasis Response Endotypes Using Single Cell Transcriptomics
The investigators propose to improve the possibility of reaching skin resolution by identifying certain markers or gene patterns that may predict patient response to certain psoriasis drugs ahead of time, thus eliminating or…
- Trial name
- NCT05270733
- Testing
- Ustekinumab
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- University Hospitals Cleveland Medical Center
Breast Cancer
ThermoBreast - Non-contact Breast Cancer Imaging Using AI-enhanced Thermography.
Breast cancer is one of the most worrisome health concerns facing women. Early detection and active patient monitoring are crucial to survival. The chances of a cure are high when detected and treated in the early stages.
- Trial name
- ThermoBreast (NCT06266026)
- Testing
- ThermoBreast - AI-based evaluation of dynamic breast thermography imaging
- Where
- Germany
- Volunteers
- 28,000 people, healthy volunteers welcome
- Sponsor
- ThermoMind Ltd.
Genome Instability, Genetic Predisposition to Disease
Mutational Oncology in Clinical Practice
The study of biological profiling is of fundamental importance in the diagnosis and treatment of many diseases, particularly oncological ones, and for this reason, the integration of molecular characterization into clinical…
- Conditions
- Genome Instability, Genetic Predisposition to Disease, Gene Rearrangement
- Trial name
- FPG-500 (NCT06020625)
- Testing
- Diagnostic Test
- Where
- Italy
- Volunteers
- 20,000 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Rett Syndrome, RTT
Neurophysiologic Biomarkers in Rett Syndrome
The goal of this observational study is to identify candidate biomarkers in individuals with Rett Syndrome (RTT). The main questions it aims to answer are: Do these biomarkers change during clinical changes in individuals with…
- Conditions
- Rett Syndrome, RTT, Rett Syndrome, Atypical
- Trial name
- NCT05932589
- Testing
- EEG and Auditory and Visual Evoked Potentials (AEP and VEP), Clinical assessment
- Where
- 6 sites in United States
- Volunteers
- 222 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Philadelphia
Artifical Intelligence, Cataract
Development of a Mobile Terminal-Based Intelligent Detection System for Multiple Anterior Segment Diseases of the Eye
This is a multi-center, cross-sectional study evaluating a smartphone-based artificial intelligence (AI) system for anterior segment eye disease screening.
- Conditions
- Artifical Intelligence, Cataract, Pterygium, Keratopathy
- Trial name
- LENS (NCT07634913)
- Testing
- Smartphone-based on-device artificial intelligence system for anterior segment eye disease screening
- Where
- China
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Zhongshan Ophthalmic Center, Sun Yat-sen University
Down Syndrome, Fetal Aneuploidy
Specimen Collection From Pregnant Women at Increased Risk for Fetal Aneuploidy
The specimen collection is designed for the purpose of the development of a noninvasive prenatal test for T21.
- Trial name
- NCT01429389
- Where
- 14 sites in United States, Canada
- Volunteers
- 2,000 people
- Sponsor
- Sequenom, Inc.
Severe Acute Malnutrition in Childhood
Severe Acute Malnutrition and Child Development Clinical Trial in Mwanza
This is a randomized clinical trial to learn whether ready-to-use therapeutic foods enriched with choline and docosahexaenoic acid (DHA) together with psychosocial stimulating activities work well to improve child development in…
- Trial name
- BRIGHTSAM (NCT06781918)
- Testing
- Ready to Use Therapeutic Food (RUTF), Psychosocial stimulation
- Where
- Tanzania
- Volunteers
- 800 people
- Sponsor
- National Institute for Medical Research, Tanzania
Infertility (IVF Patients), ICSI
Development of an AI Platform for the Analysis of Sperm and Prediction of Their Clinical Potential
Prospective, multicenter research study with a split-sample design on semen samples, without intervention, to develop an artificial intelligence platform for the analysis of sperm samples and prediction of their clinical…
- Conditions
- Infertility (IVF Patients), ICSI, IVF Outcomes, Male Infertility
- Trial name
- Spermy01 (NCT07456397)
- Testing
- Swim-up, Density gradient centrifugation, HyperSperm
- Where
- 5 sites in Spain
- Volunteers
- 500 people
- Sponsor
- Fecundis Lab SL
Alzheimer Disease and Related Dementias, Cognition
Home-Based Brain Stimulation for Motoric Cognitive Risk Syndrome
The objective of this study is to determine the effects of a 6-month, home-based personalized transcranial direct current stimulation (tDCS) intervention targeting the left dorsolateral prefrontal cortex on cognitive function…
- Conditions
- Alzheimer Disease and Related Dementias, Cognition, Mobility Disability
- Trial name
- TDCS4MCR (NCT06821568)
- Testing
- Personalized Transcranial Direct Current Stimulation (tDCS)
- Where
- 2 sites in United States, Israel
- Volunteers
- 128 people
- Sponsor
- Hebrew SeniorLife
Cardiovascular Risk Factors, Insulin Resistance
Pilot Validation of the STELA Preventive Medicine Platform to Reduce Modifiable Health Risk Factors in Adults (CPM-STELA)
This study evaluates a comprehensive digital health platform called STELA, developed at the Center for Preventive Medicine (CPM) of AGEL Hospital Trinec-Podlesi in Czechia.
- Conditions
- Cardiovascular Risk Factors, Insulin Resistance, Obesity, Dyslipidemias
- Trial name
- CPM-STELA (NCT07551960)
- Testing
- STELA Digital Preventive Medicine Platform, Comprehensive Preventive Health Assessment
- Where
- Czechia
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Nemocnice AGEL Trinec-Podlesi a.s.
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