Clinical trials: Developmental Delay (Disorder)
Hypogonadotropic Hypogonadism, Kallmann Syndrome
Investigation of the Genetic Causes of Kallmann Syndrome and Reproductive Disorders
The aims of this study are: 1) to identify genes that play a role in human pubertal development and reproduction, 2) to characterize the phenotypic spectrum of patients with these gene defects, and 3) to discern the mode of…
- Conditions
- Hypogonadotropic Hypogonadism, Kallmann Syndrome, Puberty, Delayed, Puberty, Precocious
- Trial name
- NCT00494169
- Where
- United States
- Volunteers
- 4,042 people
- Sponsor
- Massachusetts General Hospital
Down Syndrome, Gross Motor Development Delay
Investigating Trunk Control in Young Children With Down Syndrome
Overall, the purpose of this dissertation research is to investigate trunk control in young children with DS. This will be done in three studies: 1.
- Trial name
- NCT03544840
- Testing
- Physical Therapy Home Program
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Texas Woman's University
Neurodevelopmental Disorders, Attention Deficit Hyperactivity Disorder
Videoconferencing-based Focused Acceptance and Commitment Therapy for Parents of SHCN Children
The purpose of the proposed non-randomized waitlist-controlled design study is to evaluate the feasibility, acceptability, and potential effectiveness of using a Videoconferencing-based Individual Focused Acceptance and…
- Conditions
- Neurodevelopmental Disorders, Attention Deficit Hyperactivity Disorder, Autism Spectrum Disorder, Development Delay
- Trial name
- NCT05803252
- Testing
- Focused Acceptance and Commitment Therapy, Waitlist Control
- Where
- 5 sites in Hong Kong
- Volunteers
- 104 people
- Sponsor
- Chinese University of Hong Kong
Premature Infant, Developmental Delay
A Parent Administered Sensorimotor Intervention and Developmental Outcome of Preterm Infants
Advances in medical technologies over the last three decades have increased survival rates in infants born preterm . Preterm infants are at high risk of developing developmental delays.
- Trial name
- NCT03836326
- Testing
- Sensorimotor intervention, Control, Story telling attention refocusing intervention
- Where
- Canada
- Volunteers
- 94 people
- Sponsor
- Dr. Sandra Fucile
Cerebral Palsy, Genetic Disease
Genetic Etiology in Patients With Cerebral Palsy
Cerebral palsy (CP) is a permanent disorder of movement or posture due to non-progressive impairments of the developing brain. Current estimates indicate that as many as 30% of CP cases may be genetic in nature.
- Conditions
- Cerebral Palsy, Genetic Disease, Developmental Delay, Metabolism, Inborn Errors
- Trial name
- GenCP (NCT05123768)
- Testing
- NGS
- Where
- Slovenia
- Volunteers
- 150 people
- Sponsor
- University Medical Centre Ljubljana
Developmental Delay
18 Month Follow Up of Preterm Infants Enrolled in the Cord Clamping Study
The purpose of this study is to examine differences in the long-term effects of immediate versus delayed cord clamping at birth on developmental outcomes of our study infants at 18-22 months corrected age.
- Trial name
- 18mo (NCT01426698)
- Testing
- delayed cord clamping
- Where
- United States
- Volunteers
- 208 people
- Sponsor
- University of Rhode Island
Stuttering/ Developmental
The Effect of the Non-invasive Brain Stimulation on the Speech Fluency Enhancement
The aim of this study is to determine the effectiveness of concurrent transcranial direct current stimulation (tDCS) and fluency training in adults with developmental stuttering.
- Trial name
- NCT03990168
- Testing
- Anodal tDCS, fluency intervention/ Delayed Auditory Feedback
- Where
- Iran
- Volunteers
- 50 people
- Sponsor
- Iran University of Medical Sciences
Developmental Delay
Responsiveness of the Object Permanence Scale
The aim of the study is the examining responsiveness of the Object Permanence Scale. The sample of the study will be 7-16 months old babies with motor developmental delay.
- Trial name
- NCT05749783
- Where
- Turkey (Türkiye)
- Volunteers
- 27 people
- Sponsor
- Tokat Gaziosmanpasa University
CTNNB1 Neurodevelopmental Syndrome
CTNNB1 Neurodevelopmental Syndrome - Natural History Study
The aim of the Dragonfly study is to characterise and monitor the neurodevelopment of children and adults diagnosed with CTNNB1 syndrome through an international collaborative effort.
- Trial name
- Dragonfly (NCT07167732)
- Testing
- A General Medical and Neurological Assessment, World Health Organisation (WHO) Motor Milestones, Burke-Fahn-Marsden Dystonia Rating Scale
- Where
- 2 sites in Australia, Slovenia
- Volunteers
- 250 people
- Sponsor
- University Medical Centre Ljubljana
Mental Retardation, Developmental Delay
Biomarker for Sanfilippo Type A-B-C-D Disease (BioSanfilippo)
Development of a new MS-based biomarker for the ear-ly and sensitive diagnosis of Sanfilippo Disease Type A-B-C-D from blood (plasma)
- Trial name
- BioSanfilippo (NCT02298686)
- Where
- 5 sites in Egypt, Germany and 2 more
- Sponsor
- CENTOGENE GmbH Rostock
Motor Delay
Project Initiate: Transition to Community Therapy Services After NICU Discharge
Project Initiate is a pilot study of early neuromotor outcomes in high risk newborn infants who are referred to Early Intervention services after NICU discharge.
- Trial name
- NCT05251051
- Testing
- pediatric physical therapy, Care Coordination
- Where
- 4 sites in United States
- Volunteers
- 63 people
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
Autism Spectrum Disorder, Developmental Delay
Validation of a Salivary miRNA Diagnostic Test for ASD
This study involves sample collection to identify biomarkers relating to Autism Spectrum Disorder(ASD) in the saliva of children who are between the ages of 18 months to 6 years and 11 months.
- Trial name
- NCT05418023
- Testing
- Salivary Collection, Adaptive Assessment, Medical and Demographic questionnaire
- Where
- 16 sites in United States
- Volunteers
- 6,604 people
- Sponsor
- Quadrant Biosciences Inc.
Problem Behavior, Developmental Delay
Problem Behavior Assessment and Intervention in IDEA Part C Services
The purpose of this study is to evaluate the effect of function-based assessment and intervention to reduce problem behavior in children with developmental disability or delay in the context of IDEA Part C services.
- Conditions
- Problem Behavior, Developmental Delay, Developmental Disability
- Trial name
- NCT06771284
- Testing
- Function-based assessment and intervention
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- University of Nevada, Las Vegas
MNRI, Development Delay
Effects of MNRI Therapy on Fine Motor Skills in Children With Developmental Delays.
Developmental delay refers to a child's failure to achieve age-appropriate developmental milestones and may affect multiple developmental domains.
- Trial name
- NCT07764926
- Testing
- MNRI, Conventional Physiotherapy without MNRI
- Where
- Pakistan
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Sarcoidosis, Pulmonary
Risk Indicators of Sarcoidosis Evolution-Unified Protocol
The purpose of this study is to develop prediction models that can prognosticate patients with sarcoidosis using clinical data and blood markers that can be obtained during a clinic visit.
- Trial name
- RISE-UP (NCT05567133)
- Where
- 2 sites in United States
- Volunteers
- 200 people
- Sponsor
- University of California, San Francisco
Motor Delay
Effects of Conventional Physical Therapy With and Without Cuevas Medek Exercises in Developmental Delay
There are several etiologies for developmental delay (DD). One of the main causes of developmental delay is cerebral palsy (CP), which has a variety of clinical characteristics brought on by damage to the developing brain.
- Trial name
- NCT06522451
- Testing
- conventional physical therapy, Conventional physical therapy along with cuevas medek exercises
- Where
- Pakistan
- Volunteers
- 24 people
- Sponsor
- Riphah International University
Developmental Delay
Effects of Rainbow Parachute Games on UE Strength and Social-Emotional Skills in Children With Developmental Delay
Conducted as a randomized trial, this study examines the impact of rainbow parachute games on upper extremity strength and social-emotional skills in children (ages 5-8) with developmental delays.
- Trial name
- NCT07756931
- Testing
- Rainbow parachute Games, Rhyming Activities
- Where
- Pakistan
- Volunteers
- 12 people
- Sponsor
- Riphah International University
CLIFAHDD, Congenital Contractures of the Limbs and Face, Hypotonia, and Developmental Delay
Aprepitant for the Treatment of CLIFAHDD
There are no drug treatments for individuals with Congenital Contractures of the Limb and Face, Hypotonia, and Developmental Delay (CLIFAHDD), an ultra-rare and severe neurodevelopmental disease.
- Conditions
- CLIFAHDD, Congenital Contractures of the Limbs and Face, Hypotonia, and Developmental Delay, NALCN Channelopathy, Ataxia - Other
- Trial name
- NCT07845825
- Testing
- Aprepitant Powder for Oral Suspension
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Angelman Syndrome, Nervous System Diseases
Dietary Supplements for the Treatment of Angelman Syndrome
Angelman syndrome (AS) is a complex genetic disorder that affects the nervous system. The purpose of this study is to determine the effectiveness of certain dietary supplements in treating the symptoms of AS.
- Trial name
- NCT00348933
- Testing
- Betaine, Creatine, Metafolin
- Where
- 4 sites in United States
- Volunteers
- 90 people
- Sponsor
- University of California, San Diego
Fibromyalgia
Tools for the Differential Diagnosis of Fibromyalgia Based on Cognitive Tasks
The goal of this observational study is to test for behavioural and neurophysiological biomarkers in fibromyalgia patients. The main questions it aims to answer are: Is there a measurable decline in working memory? Could these…
- Trial name
- NCT05910372
- Testing
- Color Comparison Task, N-back Task
- Where
- Argentina
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- National Council of Scientific and Technical Research, Argentina