Clinical trials: Dexamethasone Administration
C08.381.840.500.475, C08.381.840.500.737
Dexamethasone Before Elective Cesarean Section at Term in Reducing Neonatal Respiratory Distress Syndrome
Prophylactic antenatal administration of corticosteroid enhance fetal lung maturity and reduce the probability of respiratory morbidity in preterm births.
- Trial name
- NCT04816097
- Testing
- Dexamethasone phosphate
- Volunteers
- 950 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Refractive Surgery
The RESTORE Study, A Randomized, Controlled, Masked (Reading Center) Prospective Study
To determine patient preference and treatment outcomes with an intracanalicular dexamethasone (0.4mg) insert compared to standard steroid drop regimen in the contralateral eye following bilateral PRK surgery.
- Trial name
- NCT04396990
- Testing
- Dextenza 0.4Mg Ophthalmic Insert, Topical Prednisolone
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Vance Thompson Vision
Symptomatic Irreversible Pulpitis (SIP), Dental Pain
Local Dexamethasone Administration in Symptomatic Irreversible Pulpitis
Symptomatic irreversible pulpitis is associated with a high incidence of inadequate pulpal anesthesia during endodontic treatment, particularly in mandibular molar teeth.
- Trial name
- SIPDEX (NCT07672873)
- Testing
- Saline (0.9%, sterile, for infusion), Dexamethasone
- Where
- Turkey (Türkiye)
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Marmara University
Post-Cesarean Pain, Cesarean Section Complications
Postoperative Dexamethasone on Post-Cesarean Pain
Investigating if giving post-operative dexamethasone to patients with a history of opioid use disorder on medication assisted treatment during pregnancy improves their pain scores and decreases their opioid use after cesarean…
- Trial name
- NCT04067609
- Testing
- Dexamethasone
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Yale University
Laparoscopic Cholecystectomy
Dexamethasone-Enhanced TAP Block in Lapchole
The transversus abdominis plane (TAP) block is widely used as part of analgesia for abdominal surgeries such as laparoscopic cholecystectomy. While bupivacaine is commonly used for TAP blocks with reported success.
- Trial name
- NCT07182110
- Testing
- Dexamethasone enhanced TAP Block, Marcaine- 0.25%
- Where
- Lebanon
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Makassed General Hospital
Cataract
Efficacy of Dextenza Insert in Upper vs Lower Punctum Following Cataract Surgery With PCIOL.
To assess the safety and effectiveness of treatment with an intracanalicular dexamethasone (0.4mg) insert in the operating room following cataract surgery/intraocular lens implant (IOL) with or without iStent/Hydrus/Goniotomy…
- Trial name
- DEXTENZA (NCT05372315)
- Testing
- Dextenza 0.4Mg Ophthalmic Insert
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Iworks Laser and Vision Center
Retinal Vein Occlusion, Macular Edema
Efficacy of an Intravitreal DEX Implant in Retinal Vein Occlusion Following Treatment With Anti-VEGF Injections.
To test the efficacy of a 0.7 mg intravitreal dexamethasone implant (Ozurdex®) on macular function and recalcitrant macular edema associated with retinal vein occlusion following treatment with 2 or more prior intravitreal…
- Trial name
- NCT01449682
- Testing
- Ozurdex
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Retina Macula Institute
Diabetic Macular Edema
Comparative Study of Dexamethasone Implant to Intravitreal Aflibercept in Subjects With Diabetic Macular Edema
This study is an interventional, prospective randomized study comparing the dexamethasone implant to intravitreal aflibercept. Subjects will have an initial single injection of aflibercept and will be randomized if diabetic…
- Trial name
- PRECISION (NCT04411693)
- Testing
- Dexamethasone implant, Aflibercept
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Asthma
Dexamethasone Versus Prednisone for Asthma Treatment in the Pediatric Inpatient Population; a Feasibility Study
Current corticosteroid regimens for children hospitalized with asthma typically include a 5-day course of prednisone or prednisolone. However, these medications taste poorly and are associated with vomiting and poor compliance.
- Trial name
- NCT03133897
- Testing
- Dexamethasone, Prednisone
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Eastern Ontario
Tinnitus
Evaluation of Adding Lidocaine to Dexamethasone in Intra-tympanic Injection for Management of Tinnitus
Importance; Tinnitus is a heterogeneous diagnosis that may occur alone, in the presence of hearing loss or as a component of other disorders and can be quite disabling.
- Trial name
- tinnitus (NCT03265197)
- Testing
- Intra-tympanic injection of drugs, Data management of intratympanic drugs
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- saad elzayat
Croup
Croup Dosing Study
Croup is a common childhood respiratory disease that often leads to frequent emergency department visits. It is a viral infection that causes cough, throat, and airway swelling, making breathing difficult.
- Trial name
- NCT06272383
- Testing
- 0.15 mg/kg dexamethasone
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Distal Radius Fracture
Randomized Controlled Trial Assessing the Effect of Dexamethasone on Postoperative Function After Distal Radius Fixation
The study is designed to assess the use of intraoperative dexamethasone on postoperative analgesia and stiffness after open reduction and internal fixation of distal radius fractures.
- Trial name
- NCT04889547
- Testing
- Dexamethasone, No dexamethasone
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Postoperative Pain Management, Postoperative Pain
Evaluation of Effectivity of Quadratus Lumborum Blocks With Adjuvant
İn recent years abdominal wall blocks are widely used for to reduce intraoperative anesthetic recuirements and postoperative analgesia.Quadratus lumborum blocks are one of the abdominal wall blocks to used at laparoscopic…
- Conditions
- Postoperative Pain Management, Postoperative Pain, Analgesia, Nerve Blocks
- Trial name
- AdjuvantQLB (NCT06028061)
- Testing
- Adjuvant-free Quadratus lumborum block, Quadratus lumborum block III with Adjuvant
- Where
- Turkey (Türkiye)
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- Gaziosmanpasa Research and Education Hospital
Periodontal Pocket, Pain
The Use of Submucosal Dexamethasone After Periodontal Surgery
The aim of this study is to evaluate the effectiveness of submucosal 8 mg (2 mL) dexamethasone on postoperative pain, swelling, chewing efficiency, trismus, healing, and discomfort after periodontal flap surgery
- Conditions
- Periodontal Pocket, Pain, Swelling/ Edema, Patient Satisfaction
- Trial name
- NCT06119893
- Testing
- submucosal 8 mg (2 mL) dexamethasone application, submucosal 2 mL 0.9% isotonic sodium chloride application
- Where
- Turkey (Türkiye)
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Yuzuncu Yil University
Pain
Using Dexamethasone After Uvulopalatopharyngoplasty
This study looks at lessening the pain after a Uvulopalatopharyngoplasty (UPPP) surgery by using Dexamethasone (a corticosteroid).
- Trial name
- NCT00584168
- Testing
- Dexamethasone
- Where
- 2 sites in United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Dry Eye
The DEPOT Study (Dry Eye Prescription Options for Therapy)
Assessing DEXTENZA efficacy and safety when placed within the lower eyelid canaliculus for dry eye flares in comparison to topical loteprednol suspension.
- Trial name
- NCT04911361
- Testing
- Dexamethasone
- Where
- 3 sites in United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Research Insight LLC
Cataract
"A Prospective Study of the Efficacy of Intracameral Dexamethasone (Dexycu™) Compared to Standard of Care Treatment for Post-Cataract Surgical Pain and Anterior Chamber Inflammation"
Cataract surgery is the most common surgical procedure performed on humans today. The postoperative regimen includes a combination of steroids, NSAIDs (non-steroidal anti-inflammatory drugs) and antibiotics.
- Trial name
- NCT04781335
- Testing
- Dexycu, Standard of Care post operative eye drops (steroid, antibiotic, NSAID)
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- The Eye Institute of West Florida
Dexamethasone Administration, Post Extraction Complication
The Effectiveness of Using a Single Post-operative Intramuscular Dexamethasone Injection on Patients with Surgical Extraction of Lower Third Molar
Evaluating the effectiveness of using a single immediate postoperative intramuscular Dexamethasone injection on pain, swelling, trismus and tissue healing in the first seven days.
- Trial name
- NCT06809855
- Testing
- Dexamethasone
- Where
- Iraq
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Yassir R. Al-khannaq
Post Spinal Anesthesia Shivering
The Effect of Different Doses of Dexamethasone on Post Spinal Anesthesia Shivering
The precise etiology of post-spinal anesthesia shivering (PSAS) is not fully understood. The incidence ranges between 20 to 80%.
- Trial name
- NCT06999070
- Testing
- Dexamethasone 0.1mg/kg, Dexamethasone 0.3mg/kg
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Assiut University
Dry Eye Syndromes
ACCURATE Study for Subjects With Dry Eyes
To determine treatment and imaging outcomes in bilateral ocular surface disease management with an intracanalicular dexamethasone (0.4 mg) insert compared to standard topical over-the-counter artificial tears lubrication…
- Trial name
- ACCURATE (NCT04237012)
- Testing
- Dextenza 0.4Mg Intracanalicular Insert, Over the counter Artificial tears
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- The Eye Centers of Racine and Kenosha