Clinical trials: Dexamethasone Administration
Multiple Myeloma Stage I
Daratumumab Intensified Treatment to Eligible MM New Patients CTD-Dara Induction, Follow by Dara Consolidation
The best induction protocol to eligible multiple myeloma patients was not established. Combination of three drugs demonstrated better outcomes than two drugs combo.
- Trial name
- MAXDARA (NCT03792620)
- Testing
- Cyclo Thal Dex Daratumumab
- Where
- Brazil
- Volunteers
- 20 people
- Sponsor
- Grupo de Estudos Multicentricos em Onco-Hematologia
Covid19, Dexamethasone
Early Treatment Strategy With High-dose Dexamethasone in Patients With SARS-CoV-2
Early identification and treatment of this inflammatory cascade using existing therapeutic strategies with proven safety profiles could change the course and prognosis of COVID-19 infection, reducing mortality rates.
- Trial name
- NCT05293210
- Testing
- Dexamethasone
- Volunteers
- 200 people
- Sponsor
- Hospital Universitario Infanta Leonor
Lymphoma
Combination Chemotherapy With or Without Interferon Alfa in Treating Patients With Low-Grade Non-Hodgkin's Lymphoma
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Interferon alfa may interfere with the growth of cancer cells and slow the growth of non-Hodgkin's lymphoma.
- Trial name
- NCT00003639
- Testing
- recombinant interferon alfa, chlorambucil, dexamethasone
- Where
- United Kingdom
- Volunteers
- 200 people
- Sponsor
- Scotland and Newcastle Lymphoma Group
Knee Osteoarthritis, Gonarthrosis; Primary
Oral vs Intravenous Dexamethasone in Total Knee Arthroplasty
This prospective observational cohort study aims to evaluate the association between perioperative dexamethasone administration and early postoperative recovery following primary total knee arthroplasty.
- Conditions
- Knee Osteoarthritis, Gonarthrosis; Primary, Total Knee Arthroplasty
- Trial name
- TKA (NCT07442812)
- Testing
- Routine perioperative management
- Where
- Turkey (Türkiye)
- Volunteers
- 270 people
- Sponsor
- Haseki Training and Research Hospital
Post Operative Pain Control, Endodontic Treatment
Intracanal Dexamethasone Extrusion and Postoperative Endodontic Pain
The aim of this research is to assess the effect of intentionally extruding a corticosteroid intracanal solution into the periapical tissues on the postoperative pain after root canal treatment in patients with symptomatic…
- Trial name
- NCT06894069
- Testing
- Dexamethasone
- Volunteers
- 80 people
- Sponsor
- University of Jordan
CAEBV
Selinexol Combined With Dexamethasone in the Treatment of CAEBV
This study is a single-center, prospective, observational clinical study to evaluate the Effecive and Safty of Selinexol and Dexamethasone in CAEBV
- Trial name
- NCT05347381
- Testing
- Selinexol and Dexamethasone
- Where
- China
- Volunteers
- 6 people
- Sponsor
- Beijing Friendship Hospital
Multiple Myeloma
Pomalidomide (POM) in Combination With Low Dose Dexamethasone (LD-Dex) in Patients With Relapsed or Refractory Multiple Myeloma
To provide pomalidomide access to relapsed/refractory multiple myeloma subjects with a likelihood of benefit from the pomalidomide treatment while the medication is not commercially available
- Trial name
- PEXIUS (NCT01632826)
- Testing
- Pomalidomide
- Where
- 42 sites in United States, Canada
- Sponsor
- Celgene
Local Anesthetic, Ultrasound
TAP Block With Methyl-prednisolone as a Pain Treatment Modality After Total Abdominal Hysterectomy Procedures
The aim of this work to compare between the efficacy of ultrasound guided TAP block with dexamethasone as an adjuvant versus ultrasound guided TAPB with methyl prednisolone as an adjuvant to local anesthetic for postoperative…
- Conditions
- Local Anesthetic, Ultrasound, Pain, Acute
- Trial name
- NCT06131593
- Testing
- TAPB with dexamethasone as an adjuvant to local anesthetics, TAPB with methylprednisolone as an adjuvant to local anesthetics
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Kasr El Aini Hospital
Cataract
Tobramycin-Dexamethasone Versus Tobramycin-Dexamethasone Plus Ketorolac After Phacoemulsification Surgery
This randomized controlled trial compares two regimens of topical therapy: tobramycin 0.3% - dexamethasone 0.1% (TobraDex®, Alcon), one drop four times/day combination of tobramycin 0.3% - dexamethasone 0.1% (TobraDex®, Alcon)…
- Trial name
- NCT00992355
- Testing
- Tobramycin 0.3% - Dexamethasone 0.1%, Tobramycin 0.3% - Dexamethasone 0.1% plus Ketorolac tromethamine 0.5%
- Where
- Greece
- Volunteers
- 97 people
- Sponsor
- Veroia General Hospital
MULTIPLE MYELOMA (MM)
Evaluation of the Safety and the Efficacy of Carfilzomib Combined With Cyclophosphamide and Dexamethasone (CCyd) or Lenalidomide and Dex (CRd) Followed by ASCT or 12 Cycles of Carf Combined With Dex and Len for Patients Eligible for ASCT With Newly Diagnosed Multiple Myeloma.
This study will evaluate the safety and the efficacy of carfilzomib combined with cyclophosphamide and dexamethasone (CCyd) or lenalidomide and dexamethasone (CRd) followed by autologous transplantation ASCT or 12 cycles of…
- Trial name
- FORTE (NCT02203643)
- Testing
- Carfilzomib, Cyclophosphamide, Lenalidomide
- Where
- Italy
- Volunteers
- 477 people
- Sponsor
- Mario Boccadoro
Pericarditis Acute
Dexamethasone Compared to Non-steroidal Anti-inflammatory Drugs in the Treatment of Acute Pericarditis
The treatment of acute pericarditis is empiric and is based on treatment with medications with anti-inflammatory properties such as non-steroidal anti-inflammatory drugs (NSAID) and corticosteroids.
- Trial name
- Dexa-P (NCT04323280)
- Testing
- Dexamethasone therapy, NSAID therapy
- Where
- Israel
- Volunteers
- 10 people
- Sponsor
- Rabin Medical Center
Multiple Myeloma
Bendamustine, Wkly Bortezomib, Lenalidomide and Dexamethasone for Multiple Myeloma
The purpose of the study is to determine the safety and efficacy of the use of bendamustine in combination with a commonly used combination chemotherapy to treat relapsed and refractory multiple myeloma.
- Trial name
- BVRD (NCT01484626)
- Testing
- Bendamustine
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Loyola University
Nausea and Vomiting, Unspecified Adult Solid Tumor, Protocol Specific
APF530 or Aloxi (Palonosetron Hydrochloride) Combined With Dexamethasone in Preventing Nausea and Vomiting in Patients Receiving Chemotherapy for Cancer
This randomized phase III trial is studying APF530 and dexamethasone to see how well they work compared with palonosetron and dexamethasone in preventing nausea and vomiting in patients receiving chemotherapy for cancer.
- Trial name
- NCT00343460
- Testing
- APF530, dexamethasone, Palonosetron Hydrochloride
- Where
- 52 sites in United States
- Volunteers
- 1,428 people
- Sponsor
- Heron Therapeutics
Cervical Radiculopathy
Oral Dexamethasone for the Treatment of Cervical Radiculopathy
The purpose of this study is to determine whether dexamethasone is effective in the treatment of pain and disability resulting from a compressed spinal nerve in the neck (cervical radiculopathy).
- Trial name
- NCT00308594
- Testing
- Dexamethasone
- Volunteers
- 100 people
- Sponsor
- University of Manitoba
Diabetic Macular Edema
Curcumin and Intravitreal Dexamethasone in Diabetic Macular Edema
The aim of the study is to explore the effect of a curcumin formulation in combination to intravitreal dexamethasone therapy in patients with diabetic macular edema on morphological retinal characteristics and retreatment times.
- Trial name
- DIABEC (NCT03598205)
- Testing
- DIABEC plus intravitreal dexamethazone
- Where
- 3 sites in Italy
- Volunteers
- 72 people
- Sponsor
- Fondazione G.B. Bietti, IRCCS
Proliferative Vitreoretinopathy
Oral Colchicine Combined With Intravitreal Infusion of Dexamethasone, LMW Heparin and 5-FU for Management of Proliferative Vitreoretinopathy (PVR)
To evaluate the efficacy of oral colchicine combined with intraoperative infusion of dexamethasone, low molecular weight heparin and 5-FU during vitrectomy for management of established proliferative vitreoretinopathy (PVR)
- Trial name
- NCT00370760
- Testing
- oral colchicine, dexamethasone, low molecular weight heparin, 5-FU
- Where
- Iran
- Sponsor
- Shahid Beheshti University of Medical Sciences
Bronchiolitis
Bronchiolitis in Infants Placebo Versus Epinephrine and Dexamethasone Study
We hypothesize that infants with bronchiolitis treated with inhaled epinephrine in the Emergency Department (ED) and a 2-day course of oral dexamethasone will have fewer hospitalizations over 7 days compared to infants treated…
- Trial name
- BIPED (NCT03567473)
- Testing
- Oral dexamethasone, Nebulized Epinephrine, Nebulized normal saline
- Where
- 12 sites in Australia, Canada and 1 more
- Volunteers
- 864 people
- Sponsor
- Children's Hospital of Eastern Ontario
Periodontal Pocket, Pain
The Use of Submucosal Dexamethasone After Periodontal Surgery
The aim of this study is to evaluate the effectiveness of submucosal 8 mg (2 mL) dexamethasone on postoperative pain, swelling, chewing efficiency, trismus, healing, and discomfort after periodontal flap surgery
- Conditions
- Periodontal Pocket, Pain, Swelling/ Edema, Patient Satisfaction
- Trial name
- NCT06119893
- Testing
- submucosal 8 mg (2 mL) dexamethasone application, submucosal 2 mL 0.9% isotonic sodium chloride application
- Where
- Turkey (Türkiye)
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Yuzuncu Yil University
Immune Thrombocytopenia
The Combination of High-dose Dexamethasone and Acetylcysteine as the Treatment of Newly-diagnosed ITP
A single-arm, open-label study to evaluate the efficacy and safety of Acetylcysteine plus high-dose Dexamethasone in adults newly diagnosed with primary immune thrombocytopenia (ITP).
- Trial name
- NCT04368598
- Testing
- Dexamethasone, Acetylcysteine
- Where
- China
- Volunteers
- 44 people
- Sponsor
- Peking University People's Hospital
Multiple Myeloma
Study of Lenalidomide and Dexamethasone With or Without Pembrolizumab (MK-3475) in Participants With Newly Diagnosed Treatment Naive Multiple Myeloma (MK-3475-185/KEYNOTE-185)
The purpose of this study is to compare the efficacy of lenalidomide and low dose dexamethasone with pembrolizumab (MK-3475) to that of lenalidomide and low dose dexamethasone without pembrolizumab in terms of progression-free…
- Trial name
- NCT02579863
- Testing
- Pembrolizumab, Lenalidomide, Dexamethasone
- Volunteers
- 310 people
- Sponsor
- Merck Sharp & Dohme LLC