Clinical trials: Dexmedetomidine
Elderly, Surgery
Impact of Dexmedetomidine on Sleep Quality
Sleep disturbances frequently occur in elderly patients after major surgery; and their occurrence are associated with worse outcomes including increased incidence of delirium.
- Conditions
- Elderly, Surgery, Analgesia, Dexmedetomidine
- Trial name
- NCT03117790
- Testing
- Dexmedetomidine
- Where
- China
- Volunteers
- 118 people
- Sponsor
- Peking University First Hospital
Agitation,Psychomotor, Dementia
Sub-Lingual Dexmedetomidine in Agitation Associated With Dementia
This is an adaptive Phase 1b/2 trial design. It is randomized, double-blind, placebo-controlled, multiple ascending dose study assessing efficacy, pharmacokinetics, safety and tolerability of BXCL-501 dosing in adult (65 years…
- Trial name
- TRANQUILITY (NCT04251910)
- Testing
- Sublingual film containing Dexmedetomidine
- Where
- 5 sites in United States
- Volunteers
- 100 people
- Sponsor
- BioXcel Therapeutics Inc
Laparoscopic Cholecystectomy Surgery
Beneficial Effects of Low-Dose Intravenous Dexmedetomidine Premedication in Patient Undergoing Laparoscopic Cholecystectomy Under General Anesthesia
Laparoscopic cholecystectomy (LC) is considered the standard treatment for gallbladder disease.1 Compared to open cholecystectomy, LC is the preferred treatment approach because it is associated with less surgical trauma, shorter…
- Trial name
- NCT06838650
- Testing
- Dexmedetomidine, Saline
- Volunteers
- 100 people
- Sponsor
- Assiut University
Septic Shock
Effect of Dexmedetomidine on Perfusion Index and Microcirculation in Severe Sepsis and Septic Shock Patients
Septic shock is one of the major causes of death worldwide with in-hospital mortality rates varying between (11.9% to 47.2 %). Alterations in microcirculatory blood flow were associated with high risk of organ dysfunction and…
- Trial name
- NCT03151668
- Testing
- Dexmedetomidine
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Cairo University
Diabetes, Stress
Effects of Different Types of Anesthesia on Stress Response in Laparoscopic Gastric Bypass for Type 2 Diabetes Mellitus
General anesthesia can be considered as a combination of hypnosis, antinociception and immobility. Explore the effect of three kinds of anesthesia,that is the total intravenous anesthesia, inhalation anesthesia and inhalation and…
- Conditions
- Diabetes, Stress, Anesthesia
- Trial name
- NCT01963546
- Testing
- different types of anesthesia, Dexmedetomidine
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Guangzhou General Hospital of Guangzhou Military Command
Injury of Upper Limb
the Effect of Dexmedetomidine in Coracoid Approach Brachial Plexus Block
Dexmedetomidine is an α-2 adrenoreceptor agonist and has been extensively used through intravenous infusion，in order to improved the quality of block in regional anesthesia.
- Trial name
- NCT02961361
- Testing
- ropivacaine, ropivacaine mixed with dexmedetomidine
- Volunteers
- 60 people
- Sponsor
- The First Hospital of Qinhuangdao
Postoperative Pain
Clinical Comparative Study Aiming to Evaluate Postoperative Effect of Using Intrathecal Dexmedetomidine and Fentanyl as an Adjuvant to Heavy Bupivacaine in Lower Limb Vascular Surgeries on Pain Intensity, Analgesic Requirement and Shivering. Patients and Methods After Approval of Medical Institution
Spinal anaesthesia is an excellent choice of numerous operating procedures. This is due to its effectiveness, rapid onset of action, easy to implement, patient stayed awake, and minimal drug cost.(1) It is also beneficial for…
- Trial name
- NCT07035223
- Testing
- 4 µg dexmedetomidine in 0.5 mL of normal saline intrathecal (dexmedetomidine 100 µg/mL will be diluted in 12.5 ml preservative-fr, fentanyl
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Nashwa Ahmed
Chronic Renal Failure, Hip Fracture
Effects of Dexmedetomidine Premedication on Geriatric Patients With Chronic Renal Failure Undergoing Hip Surgery
Geriatric patients (age ≥ 65 years) undergo surgery for hip fractures that develops due to osteoporosis and falls. Dialysis-dependent chronic kidney disease is associated with an increased risk of cardiovascular comorbidity.
- Trial name
- NCT01837290
- Testing
- dexmedetomidine infusion for premedication, Midazolam, saline infusion
- Where
- 3 sites in Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Baskent University
Tracheal Reconstruction
Dexmedetomidine for Bilateral Superficial Cervical Plexus Block for Reconstructive Tracheal Surgery
Tracheal resection and reconstruction (TRR) is the treatment of choice for most patients with tracheal stenosis or tracheal tumors .The post intubation tracheal stenosis is the common indication for (TRR).The immediate…
- Trial name
- NCT03426527
- Testing
- Levobupivacaine, Levobupivacaine-Dexmedetomidine, General Anaesthesia
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Mansoura University
Pediatric, Elective
Laryngeal Mask Airways Are Supraglottic Devices Used to Maintain Airway Patency During Anesthesia and in Difficult Airways. IV Dexmedetomidine Improves LMA Insertion Success and Decreases Coughing, While IV Lidocaine Decreases Postoperative Cough.
Laryngeal Mask Airways Are Supraglottic Devices Used to Maintain Airway Patency During Anesthesia and in Difficult Airways. LMA may help in reducing postoperative pulmonary complications.
- Conditions
- Pediatric, Elective, Surgery in Early Childhood
- Trial name
- DEX LMA (NCT07562308)
- Testing
- Dexamedomedine, Lidocaine (drug)
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Assiut University
Rotator Cuff Tear
Effect of Dexmedetomidine on Postoperative Cognitive Function in Patients Undergoing Shoulder Arthroscopy With Beach Chair Position Under Desflurane Anesthesia
Investigate the effects of dexmedetomidine on postoperative cognitive function in patients undergoing shoulder arthroscopy with beach chair position under desflurane anesthesia.
- Trial name
- NCT02643017
- Testing
- Dexmedetomidine, normal saline
- Where
- South Korea
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Anesthesia
Intranasal Dexmedetomidine Versus Intranasal Midazolam as a Premedication in Pediatrics Undergoing Upper GI Endoscopy
compare the effectiveness of intranasal dexmedetomidine and midazolam as a premedication in sedation of preschool children in GI endoscopy
- Trial name
- NCT06181682
- Testing
- Dexmedetomidine, Midazolam
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Lidocaine, Dexmedetomidine
Dexmedetomidine Combined With Lidocaine Infusion Affect PONV
BACKGROUND: Few researches have manifested that intravenous (IV) lidocaine or dexmedetomidine decreased the incidence of postoperative nausea and vomiting (PONV).
- Conditions
- Lidocaine, Dexmedetomidine, Nausea and Vomiting, Postoperative
- Trial name
- NCT03809923
- Testing
- lidocaine and dexmedetomidine infusion, Saline infusion, Lidocaine infusion
- Where
- China
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Anqing Municipal Hospital
The Effect of Ketamine - Dexmedetomidine Admixture (Ketodex) on Hemodynamic Stability
The Effect of Ketamine - Dexmedetomidine Admixture (Ketodex) on Hemodynamic Stability During Anesthesia Induction in Adults.
The aim of our study to compare two different doses of Dexmedetomidine added to anesthetic dose of ketamine in the induction of general anesthesia in adult patients regarding the hemodynamic profile, adequacy of hypnosis…
- Trial name
- NCT05948267
- Testing
- ketamine- dexmeditomidine admixure, Propofol, Lidocaine and fentanyl
- Where
- 2 sites in Egypt
- Volunteers
- 120 people
- Sponsor
- Kasr El Aini Hospital
To Compare Efficacy of Dexmedetomidine in Bilateral Quadratus Lumborum vs Lumbar Epidural Blocks on Analgesia After Major Lower Abdominal Surgery
Clinical Efficacy and Safety of Dexmedetomidine as an Adjuvant in Quadratus Lumborum Versus Epidural Block in Postoperative Lower Abdominal Cancer Surgeries
Clinical efficacy and safety of dexmedetomidine as an adjuvant in quadratus lumborum versus epidural block in postoperative patients
- Trial name
- NCT06130670
- Testing
- nerve block
- Where
- Egypt
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Assiut University
Microlaryngeal Surgery
Dexmedetomidine Versus Ketamine on Laryngeal Microsurgery
compare effect of IV dexmedetomidine and ketamine on pain score, perioperative hemodynamics and detect side effects of dexmedetomidine and ketamine.
- Trial name
- NCT07048873
- Testing
- Dexmedetomidine, Ketamine, Saline (control group)
- Where
- Egypt
- Volunteers
- 168 people, healthy volunteers welcome
- Sponsor
- Cairo University
Acute Kidney Injury
To Evaluate if Dexmedetomidine Infusion Provides Renal Protection in Patients Undergoing Coronary Artery Bypass Graft
OBJECTIVE: Aim of this study is to follow and compare the changes in serum creatinine and urine output up to 48 hours of surgery in patients receiving dexmedetomidine infusion in addition to standard protocol (Experimental Group)…
- Trial name
- NCT05375188
- Testing
- Dexmedetomidine, Normal Saline
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- National Institute of Cardiovascular Diseases, Pakistan
Obstructive Sleep Apnea
A Comparison of Surgical Outcome Following Drug-induced Sleep Endoscopic Diagnosis Using Propofol or Dexmedetomidine for Sedation : A Prospective Randomized Trial
Obstructive sleep apnea is a common disease, associated with cardiovascular disease, cerebrovascular disease, and many other medical conditions. Therefore the precise diagnosis and treatment are important.
- Trial name
- NCT01895348
- Testing
- Propofol, propofol-remifentanil, Dexmedetomidine-remifentanil
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Yonsei University
Ropivacaine, Infraumbilical Surgery
Caudal Ropivacaine With or Without Dexmedetomidine for Post Operative Analgesia
The goal of this clinical trial is to evaluate the postoperative analgesic effects of caudal Ropivacaine with or without Dexmedetomidine in pediatric infraumbilical surgery.
- Conditions
- Ropivacaine, Infraumbilical Surgery, Dexmedetomidine, Analgesia
- Trial name
- NCT05979558
- Testing
- ropivacaine with dexmedetomidine
- Where
- Nepal
- Volunteers
- 62 people
- Sponsor
- National Academy of Medical Sciences, Nepal
Stress Response of Endotracheal Intubation and Surgical Field Clarity in FESS
Melatonin vs Metoprolol or Dexmedetomidine to Improve Surgical Field in FESS
This randomized controlled study at Zagazig University Hospitals will include 112 patients undergoing elective functional endoscopic sinus surgery, allocated into four groups (Melatonin, Metoprolol, Dexmedetomidine, Control).
- Trial name
- NCT07568873
- Testing
- Melatonin, Metoprolol (MET), Dexmedetomidine
- Where
- Egypt
- Volunteers
- 28 people
- Sponsor
- Zagazig University