Clinical trials: Dexmedetomidine Analgesia
Intrathecal Dexmedetomidine, Adductor Canal Block
Combined Intrathecal Dexmedetomidine and Adductor Canal Block for Analgesia After Total Knee Arthroplasty
The aim of this work is to evaluate the effect of combined intrathecal dexmedetomidine and adductor canal block for analgesia after total knee arthroplasty (TKA).
- Conditions
- Intrathecal Dexmedetomidine, Adductor Canal Block, Analgesia, Total Knee Arthroplasty
- Trial name
- NCT06837844
- Testing
- Intrathecal Dexmedetomidine, Adductor Canal Block, Intrathecal Dexmedetomidine + Adductor Canal Block
- Where
- Egypt
- Volunteers
- 75 people
- Sponsor
- Kafrelsheikh University
Pain, Postoperative
Comparison of Doses of Dexmedetomidine With Bupivacaine in Caudal Block for Duration of Analgesia in Paediatric Infraumblical Surgeries.
Various methods are used to control post-operative pain among children. Amongst these methods, caudal block is one of the most favoured, prominent and dependable methods for providing reliable analgesia in surgeries below…
- Trial name
- NCT04700228
- Testing
- Bupivacaine Hydrochloride, Dexmedetomidine
- Where
- Pakistan
- Volunteers
- 162 people, healthy volunteers welcome
- Sponsor
- Dr. Ruth K.M. Pfau Civil Hospital, Karachi
Dexmedetomidine, Ketamine
Safety and Efficacy of Esketamine - Dexmedetomidine Combination Versus Dexmedetomidine Monotherapy for Hyperactive Delirium in ICU Patients on Non-Invasive Respiratory Support (SEED-NIRS Trial): Study Protocol of a Randomized Controlled Trial
This investigator-initiated, randomized, controlled, single-blind, superiority trial aims to assess the efficacy and safety of esketamine combined with dexmedetomidine for the management of agitation or delirium in intensive care…
- Conditions
- Dexmedetomidine, Ketamine, Analgesia, Respiratory Therapy
- Trial name
- SEED-NIRS (NCT07377981)
- Testing
- Esketamine combined with dexmedetomidine, Dexmedetomidine
- Where
- China
- Volunteers
- 356 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Sedation and Analgesia
a Comparive Study of Ketamine-Propofol Versus Dexmedetomidine-Propofol Sedation in Pediatric Patients Undergoing Cardiac Catheterization for Device Closure of Simple Left-to-right Shunts
This study aims To compare the safety and efficacy of ketamine-propofol versus dexmedetomidine-propofol sedation in pediatric patients undergoing cardiac catheterization for device closure of simple left-to-right shunts
- Trial name
- NCT07669012
- Testing
- Ketamine + propofol, Dexmedetomidine + propofol
- Where
- Egypt
- Volunteers
- 124 people
- Sponsor
- Ain Shams University
PENG Block
Efficacy of Dexmedetomidine As an Adjuvant to Bupivacaine in Pericapsular Nerve Group Block in Hip Replacement Surgeries
Our aim will be to investigate the efficacy of dexmedetomidine as an adjuvant to bupivacaine in ultrasound guided pericapsular nerve group (PENG) block for postoperative analgesia in hip replacement surgeries.
- Trial name
- NCT06736392
- Testing
- Ultrasound guided Pericapsular Nerve Group Block, Isobaric Bupivacaine 0. 25%, 20 ml isobaric bupivacaine 0.25% and 1.5μg/kg dexmedetomidine
- Volunteers
- 60 people
- Sponsor
- Assiut University
Spinal Surgery, Pain Intensity
Dexmedetomidine-esketamine Combination and Moderate-to-severe Pain After Spinal Surgery
Spinal surgery is generally followed by severe postoperative pain, and poor pain control may cause adverse outcomes such as cardiovascular events, neurocognitive disorders, and chronic postsurgical pain (CPSP).
- Conditions
- Spinal Surgery, Pain Intensity, Dexmedetomidine, Esketamine
- Trial name
- NCT07523321
- Testing
- Combined dexmedetomidine-esketamine administration
- Where
- China
- Volunteers
- 274 people
- Sponsor
- Peking University First Hospital
Analgesia, Sedation
Intranasal Dexmedetomidine for Procedural Pain Management in Elderly Adults in Palliative Care
Dexmedetomidine is allowed in Switzerland for intravenous (IV) medication in the intensive care unit in the adult patient. Its active molecule, Dexmedetomidine (Dex), is a selective and powerful α2-Adrenoreceptors (AR) agonist…
- Conditions
- Analgesia, Sedation, Anxiolysis
- Trial name
- INDEX (NCT03151863)
- Testing
- Opioids, Dexmedetomidine
- Where
- Switzerland
- Volunteers
- 33 people
- Sponsor
- Walid HABRE
Pain
Ultrasound-Guided Continuous Serratus Anterior Plane Block vs Dexmedetomidine Infusion in Patients With Rib Fractures.
The aim of this work is to compare analgesic efficacy in patients with multiple rib fractures who will be managed with Ultrasound-guided continuous serratus anterior plane block versus patients who will be managed with…
- Trial name
- NCT05965895
- Testing
- Ultrasound-guided continuous serratus anterior plane block, intravenous dexmedetomidine infusion
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Beni-Suef University
Pain, Postoperative
Dexmedetomidine Versus Fentanyl on Postoperative Analgesic Profile in Laparoscopic Sleeve Gastrectomy
Dexmedetomidine (Dex) activates the α2 adrenergic receptor that is present within the locus coeruleus, leading to anxiolysis, hypnosis, analgesia, and sedation.
- Trial name
- NCT06186895
- Testing
- Dexmedetomidine, Fentanyl
- Where
- Egypt
- Volunteers
- 64 people
- Sponsor
- Helwan University
Morbid Obesity, Bariatric Surgery Candidate
Analgesia Management in Bariatric Surgery
Following laparoscopic bariatric surgery, multimodal analgesia is recommended to avoid the adverse effects of opioids by reducing their use.
- Conditions
- Morbid Obesity, Bariatric Surgery Candidate, Pain, Postoperative
- Trial name
- NCT04836819
- Testing
- Lidocain, Ketamine, Dexmedetomidine
- Where
- Turkey (Türkiye)
- Volunteers
- 78 people
- Sponsor
- Ondokuz Mayıs University
Total Knee Anthroplasty, Nerve Block
Liposomal Bupivacaine Versus Ropivacaine With Perineural Dexamethasone or Dexmedetomidine as Adjuncts for Adductor Canal Block Combined With IPACK Block in Total Knee Arthroplasty
Effective postoperative pain management remains a cornerstone of enhanced recovery protocols following total knee arthroplasty (TKA).
- Conditions
- Total Knee Anthroplasty, Nerve Block, Ropivacaine, Liposomal Bupivacaine
- Trial name
- NCT07509866
- Testing
- Liposomal bupivacaine (LB), Ropivacaine with Perineural Dexamethasone, Ropivacaine with Perineural Dexmedetomidine
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Huazhong University of Science and Technology
Scoliosis Correction, Esketamine
Different Dose Esketamine and Dexmedetomidine Combination for Supplemental Analgesia After Scoliosis Correction Surgery
Scoliosis correction surgery is associated with severe pain. Patients after scoliosis correction surgery usually require high dose opioids and long duration analgesia, which may increase side effects and drug tolerance.
- Conditions
- Scoliosis Correction, Esketamine, Dexmedetomidine, Postoperative Analgesia
- Trial name
- NCT06062550
- Testing
- Esketamine
- Where
- China
- Volunteers
- 312 people
- Sponsor
- Peking University First Hospital
Postoperative Pain, Postoperative Vomiting
Efficacy of Dexmedetomidine for Postoperative Analgesia in Infantile Cataract Surgery
The purpose of the present study was to evaluate the efficacy and safety of subtenon block (SB)anesthesia with dexmedetomidine in combination with bupivacaine versus intravenous dexmedetomidine for postoperative analgesia and…
- Trial name
- NCT02495220
- Testing
- SB dexmedetomidine bupivacaine block, intravenous dexmedetomidine
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Assiut University
Hypertension Arterial, Desaturation
Dexmedetomidine During Carotid Endarterectomy: a Registry on Safety and Satisfaction of Patients and Operators (DexTEA)
From an anesthesiological perspective, carotid endarterectomy (CEA) is an operation that is increasingly being performed with locoregional techniques and sedation.
- Conditions
- Hypertension Arterial, Desaturation, Bradycardia, Surgery (Major Vascular)
- Trial name
- NCT07105527
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Saint Camillus International University of Health Sciences
Postoperative Pain
Combined Intrathecal Morphine and Dexmedetomidine Analgesia
The current study investigated the effect of adding dexmedetomidine to intrathecal morphine for postoperative analgesia in cancer patients undergoing major abdominal surgery.
- Trial name
- ITMandDEX (NCT02435537)
- Testing
- Dexmedetomidine (Precedex), Bupivacaine, Morphine
- Volunteers
- 90 people
- Sponsor
- Assiut University
Inflammation, Analgesia
Comparison of the Effects of Dexmedetomidine and Ketamine Infusion on the Inflammatory Response in Liver Resection
Resection is being performed with increasing frequency in the treatment of surgical diseases of the liver. Ischemia-reperfusion injury is a major cause of liver injury occurring during surgical procedures, including hepatic…
- Trial name
- NCT06219928
- Testing
- Control Group, Ketamine Group, Dexmedetomidine
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Ataturk University
Labor Pain
Analgesic Additives to Epidural Bupivacaine in Normal Labor
The aim of the study will be to compare the role of Dexmedetomidine, Nalbuphine and fentanyl as additives to epidural bupivacaine in painless vaginal delivery as regard of effectiveness analgesia and maternal safety.
- Trial name
- NCT05746351
- Testing
- Dexmedetomidine, fentanyl, Nalbuphine
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Assiut University
Pain, Rescue Analgesia
COMPARISON OF BUPIVACAINE WITH AND WITHOUT DEXMEDETOMIDINE IN CAUDAL BLOCK AMONG CHILDREN UNDERGOING INGUINAL HERNIOTOMY
A random controlled trial, was held at Jinnah Hospital in Lahore, consisting of 60 male pediatrics (6 months to 12 years), who were undergoing unilateral inguinal herniotomy or hydrocele repair.
- Trial name
- NCT07140627
- Testing
- Bupivacain, Dexmedetomidine & Bupivacaine.
- Where
- Pakistan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Allama Iqbal Medical College
Neurosurgery, Brain Cancer
DEXmedetomidine for Postoperative Analgesia and Delirium Prevention After NEUROsurgery (DEX-NEURO Trial)
Post-craniotomy pain is common and often undertreated. Inadequate analgesia can lead to patient discomfort and higher opioid consumption, which may result in respiratory depression, sedation risks and impaired neurological…
- Conditions
- Neurosurgery, Brain Cancer, Meningioma
- Trial name
- DEX-NEURO (NCT07398066)
- Testing
- Dexmedetomidine, Normal Saline (0.9% NaCl)
- Volunteers
- 60 people
- Sponsor
- University of Malaya
Analgesia, Anesthesia
Analgesic Depth Evaluation During General Anesthesia With Dexmedetomidine-remifentanil Infusion. A Pilot Study
The aim of this study is to verify the feasibility of an evaluation of the depth of analgesia during an opioid sparing anesthesia (OSA) carried out with continuous infusion of dexmedetomidine in addition to general multimodal…
- Trial name
- NCT05785273
- Testing
- Pupillometer
- Where
- Italy
- Volunteers
- 45 people
- Sponsor
- Università degli Studi di Brescia