Clinical trials: Dexmedetomidine Infusion
Lidocaine, Dexmedetomidine
Effect of Lidocaine Plus Dexmedetomidine Infusion on PONV
BACKGROUND: Few researches have manifested that intravenous (IV) lidocaine or dexmedetomidine decreased the incidence of postoperative nausea and vomiting (PONV).
- Conditions
- Lidocaine, Dexmedetomidine, Nausea and Vomiting, Postoperative
- Trial name
- NCT03788018
- Testing
- lidocaine and dexmedetomidine IV, saline IV
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Xu Siqi
Dexmedetomidine, Esketamine, Postoperative Pain and Recovery Quality
The Clinical Study of Dexmedetomidine and Esketamine Combined Infusion Undergoing Modified Radical Mastectomy
BACKGROUND: Some studies have revealed that intravenous dexmedetomidine and esketamine alleviated postoperative pain and improve the quality of recovery after surgery.
- Trial name
- NCT05283408
- Testing
- Dexmedetomidine infusion, Co-administration dexmedetomidine and low-dose esketamine infusion, Co-administration dexmedetomidine and high-dose esketamine infusion
- Where
- China
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- Anqing Municipal Hospital
Bariatric Surgery, Lidocaine
Intravenous Lidocaine Infusion Versus Intravenous Dexmedetomidine Infusion During Sleeve Gastrectomy
Although laparoscopic (LAP) bariatric surgery is minimally invasive. Following any laparoscopic procedure, patients typically experience the peak of postoperative pain within the first 24 hours.
- Conditions
- Bariatric Surgery, Lidocaine, Dexmedetomidine
- Trial name
- NCT07327905
- Testing
- intravenous lidocaine, intravenous dexmedetomidine
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Alexandria University
Analgesia
Opioid Sparing Analgesia: Dexmedetomidine Versus Lidocaine for Intracranial Surgeries in Children
Perioperative pain control is necessary in children as inadequate treatment may lead to progression of perception of pain and development of chronic pain in the future.
- Trial name
- NCT04535089
- Testing
- Dexmedetomidine injection, Lidocaine Iv
- Where
- Egypt
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Zagazig University
Morbid Obesity, Surgery
Ketamine Infusion vs Dexmedetomidine Infusion in Obese Patients Undergoing Bariatric Surgery
The surgeries that involve treatment of morbid obesity, i.e. bypass procedure and sleeve gastrectomy, are collectively covered under the term 'bariatric surgery'.
- Trial name
- NCT04576975
- Testing
- Ketamine, Dexmedetomidine, Normal Saline 0.9%
- Where
- Egypt
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Dexmedetomidine Plus Esketamine Affect Postoperative Sleep Quality
The Effect of Dexmedetomidine and Esketamine Combined Infusion Quality of Sleep Undergoing Modified Radical Mastectomy
BACKGROUND: Some studies have revealed that intravenous dexmedetomidine and esketamine improve the quality of sleep after surgery.
- Trial name
- NCT06414941
- Testing
- Dexmedetomidine administration, Dexmedetomidine plus low-dose esketamine administration, Dexmedetomidine plus high-dose esketamine administration
- Where
- China
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Anqing Municipal Hospital
Lidocaine, Dexmedetomidine
Dexmedetomidine Combined With Lidocaine Infusion Affect PONV
BACKGROUND: Few researches have manifested that intravenous (IV) lidocaine or dexmedetomidine decreased the incidence of postoperative nausea and vomiting (PONV).
- Conditions
- Lidocaine, Dexmedetomidine, Nausea and Vomiting, Postoperative
- Trial name
- NCT03809923
- Testing
- lidocaine and dexmedetomidine infusion, Saline infusion, Lidocaine infusion
- Where
- China
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Anqing Municipal Hospital
Anxiety and Fear
A Comparison Between Dexmedetomidine and Propofol-fentanyl Infusions for Sedation for Colonoscopy Procedures
Background: Different intravenous sedative drugs have been utilized for colonoscopy, with many anesthetists for painless sedation or monitored anesthesia care.
- Trial name
- NCT06148103
- Testing
- Patients who received Dexmedetomodine, patients who received propofol-fentanyl
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Zulekha Hospitals
Labor Pain
Dexmedetomidine for Intermittent Epidural Boluses Versus Continuous Epidural Infusion for Labour Epidural Analgesia
The aim of this study is to compare two modes of labour epidural analgesia: programmed intermittent epidural boluses (PIEB) versus continuous epidural infusion (CEI), with patient controlled epidural analgesia (PCEA), using…
- Trial name
- NCT05781854
- Testing
- Epidural analgesia with bupivacaine and dexmedetomidine
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Assiut University
Pain, Hypospadias
Dexmedetomidine Infusion and Surgical Pleth Index In Pediatrics
This non-invasive dimensionless score index -SPI-reflects the Patients' sympathetic response to surgical stimulation. Its effectiveness in detecting the balance between nociceptor activation and analgesia was not only reported…
- Trial name
- NCT05727969
- Testing
- Dexmedetomidine, Lactated Ringer, Hypospadias
- Where
- Egypt
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Fayoum University Hospital
Opioid Free Anesthesia, Opioid Based Anesthesia
Intraoperative Infusion of Dexmedetomidine Versus Lidocaine or Magnesium Sulphate for Enhanced Quality of Recovery After Spine Surgery Fixation
Thoracolumbar fixation is a major spine surgery; it is performed to stabilize the spine after trauma, deformity or advanced degenerative disease.
- Conditions
- Opioid Free Anesthesia, Opioid Based Anesthesia, Spine Fixation Surgeries, Opiod-Related Disorders
- Trial name
- NCT07843953
- Testing
- Group ( L): LICOCAINE, GROUP Dexmedetomidine, Group M: Magnesium sulphate
- Volunteers
- 117 people, healthy volunteers welcome
- Sponsor
- Zagazig University
Hemodynamics Instability, Post Operative Pain
Evaluating Perioperative Outcomes: Dexmedetomidine vs Lignocaine in Laparoscopic Chlolecystectomy
Nowadays laparoscopic surgery is the first choice for many surgeries. Such surgeries have revolutionized the surgical practice and has markedly reduced the incidence of intraoperative and postoperative complications.
- Conditions
- Hemodynamics Instability, Post Operative Pain, Gastrointestinal Dysfunction, Cholecystitis
- Trial name
- NCT06740903
- Testing
- inj. dexmedetomidine infusion @ 0.2-0.4 μg/kg/h, inj. lignocaine infusion @1-2 mg/kg/h
- Where
- Pakistan
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Sahiwal medical college sahiwal
Pharmacodynamic Interaction
Pharmacodynamic Interactions of Propofol and Dexmedetomidine on Intravenous Anesthesia
The purpose of this study is to determine pharmacodynamic interactions of propofol and dexmedetomidine,exploring the effect of dexmedetomidine on propofol unconsciousness median effective concentration (EC50).
- Trial name
- PIPDIA (NCT02777619)
- Testing
- 0.0ng/ml Dexmedetomidine, 0.4ng/ml Dexmedetomidine, 0.6ng/ml Dexmedetomidine
- Where
- China
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Guangzhou General Hospital of Guangzhou Military Command
Dexmedetomidine, Intubation Complication
Dexmedetomidine Infusion Dose Versus Rapid Bolus Dose Before Tracheal Intubation.
Dexmedetomidine bolus dose may provide similar or less hemodynamic changes (less bradycardia and less hypertension) than infusion dose during induction of anaesthesia and tracheal intubation.
- Trial name
- NCT06327399
- Testing
- Dexmedetomidine infusion, Dexmedetomidine bolus, Atropine Sulfate
- Where
- Egypt
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Kasr El Aini Hospital
Inflammation, Analgesia
Comparison of the Effects of Dexmedetomidine and Ketamine Infusion on the Inflammatory Response in Liver Resection
Resection is being performed with increasing frequency in the treatment of surgical diseases of the liver. Ischemia-reperfusion injury is a major cause of liver injury occurring during surgical procedures, including hepatic…
- Trial name
- NCT06219928
- Testing
- Control Group, Ketamine Group, Dexmedetomidine
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Ataturk University
Anesthesia; Reaction
Dexmedetomidine Combined With Lidocaine Infusion Affect Inflammation Cytokines
Objective: The present study was to evaluate the effects of dexmedetomidine alone, lidocaine alone and their combined infusion on postoperative inflammation cytokines after Laparoscopic hysterectomy.
- Trial name
- NCT03276533
- Testing
- Saline, Lidocaine, Dexmedetomidine
- Where
- China
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Anqing Municipal Hospital
Pre-Eclampsia
Peri-operative Dexmedetomidine Infusion in Pre-eclamptic Patients
The purpose of this study is to investigate the effects of dexmedetomidine infusion on the stress response to intubation, postoperative analgesia, and renal functions (urinary output [UOP], creatinine and glomerular filtration…
- Trial name
- NCT03391609
- Testing
- Dexmedetomidine infusion
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Assiut University
Nasal Disease, Agitation, Emergence
Dexmedetomidine and Agitation After Nasal Surgery
The main objective of study is to compare dexmedetomidine single bolus dose before extubation with continuous infusion as regards their efficacy in mitigating the incidence of emergence agitation in obese adults undergoing nasal…
- Trial name
- NCT06867302
- Testing
- Dexmedetomidine in 0.9 % NaCl 1,000 Mcg/250 mL (4 Mcg/mL) INTRAVEN INFUSION BOTTLE (ML), Dexmedetomidine Injection [Precedex]
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Fayoum University Hospital
Postoperative Agitations in Pediatric Patients
Dexmedetomidine Versus Magnesium Infusion in Reducing Agitations in Pediatric Patients Undergoing Adenotonsillectomy
The aim of this study is evaluating the efficacy and safety of dexmedetomidine versus Magnesium for reducing emergence agitation after adenotonsillectomy in children.
- Trial name
- NCT05164627
- Testing
- Dexmedetomidine, Magnesium Sulphate, Normal saline
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Gastric Emptying, Healthy
Effect of Dexmedetomidine on Gastric Emptying and Gastrointestinal Transit
The aim of the study is to determine the effect of dexmedetomidine infusion on gastric emptying and oro-caecal transit time in healthy volunteers, judged by measuring plasma paracetamol concentrations after paracetamol ingestion…
- Trial name
- GADEX (NCT01084473)
- Testing
- Dexmedetomidine, Morphine
- Where
- Finland
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Turku