Clinical trials: Diabetes, Type I
Diabetic Nephropathy, Nephrotic Syndrome
Adrenocorticotropic Hormone (ACTH) Treatment of Nephrotic Range Proteinuria in Diabetic Nephropathy (NRDN)
This is a prospective open labeled trial examining the efficacy of ACTHar Gel (porcine ACTH) on the level of proteinuria in patients with diabetic nephropathy and nephrotic range proteinuria.
- Trial name
- ACTH-NRDN (NCT01028287)
- Testing
- ACTH
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Southeast Renal Research Institute
Type 1 Diabetes
Randomized Study of Real-Time Continuous Glucose Monitors (RT-CGM) in the Management of Type 1 Diabetes
Subjects with intensively-treated type 1 diabetes and glycated hemoglobin (HbA1c) 7.0%-10.0% in 3 age groups (>25, 15-24, 8-14) will be randomized to a continuous glucose monitoring (CGM) group or control group.
- Trial name
- NCT00406133
- Testing
- Continuous glucose monitor
- Where
- 11 sites in United States
- Volunteers
- 451 people
- Sponsor
- Jaeb Center for Health Research
Type 1 Diabetes
Study of Insulin Therapy Augmented by Real Time Sensor IN Type 1 Children and Adolescents (START-IN!)
Glycemic control in children and adolescent with type 1 diabetes remains inadequate, exposing them to the risk of vascular complications in adulthood.
- Trial name
- START-IN (NCT00949221)
- Testing
- monitor Paradigm 754 VEO, MINILINK Real Time, Medtronic, CE
- Where
- France
- Volunteers
- 150 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Type 1 Diabetes Mellitus, Exercise
Impact of Physical Activity on Blood Glucose Stability and Energy Stores in Individuals With Type 1 Diabetes
Whereas physical activity clearly results in improvements in glycemic control in type 2 diabetes, in individuals with type 1 diabetes (T1DM) the impact of exercise on blood sugar control is more complex.
- Conditions
- Type 1 Diabetes Mellitus, Exercise, Hypoglycemia, Carbohydrate Metabolism
- Trial name
- CARBEX1 (NCT02068638)
- Testing
- IHE first, CONT second, CONT first, IHE second, GLU first, GLU-FRU second
- Where
- Switzerland
- Volunteers
- 27 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Diabetes Mellitus, Type 1
Managing of Missed Meal Bolus by HCL Systems
The goal of this interventional study is to compare glycemic outcomes after missed meal bolus in children and adolescents with type 1 diabetes (CwD) treated by one of the three most common used types of hybrid closed loop (HCL)…
- Trial name
- NOELLE (NCT06230276)
- Testing
- enteral nutrition (Resource Fibre, 2 kcal/ml) for breakfast
- Where
- Czechia
- Volunteers
- 45 people
- Sponsor
- Zdeněk Šumník
Type 1 Diabetes Mellitus
IGF-I Induced Muscle Glucose Uptake and Interstitial IGF-I Concentrations
Hormonal disturbances in the GH-IGF-I axis are considered important for the deterioration of glycemic control in T1DM particularly in adolescents.
- Trial name
- NCT01588093
- Testing
- Increlex, 0.9% Saline
- Where
- Sweden
- Volunteers
- 8 people
- Sponsor
- Peter Bang
Type 1 Diabetes
DIATOR-Diabetes Intervention With Atorvastatin
Clinical studies have shown that immunomodulators (like Anti-CD3 antibodies) have effects on beta-cell-preservation. The lipid-lowering agent atorvastatin is also a potent immunomodulator.
- Trial name
- NCT00974740
- Testing
- Atorvastatin
- Where
- 12 sites in Germany
- Volunteers
- 63 people
- Sponsor
- Profil Institut für Stoffwechselforschung GmbH
Type 1 Diabetes
The Lira Pump Trial
A randomized placebo-controlled clinical trial investigating the effects of Liraglutide as an add-on to intensive insulin therapy in overweight insulin pump treated type 1 diabetes patients in suboptimal glycemic control.
- Trial name
- NCT02351232
- Testing
- Liraglutide
- Where
- 2 sites in Denmark
- Volunteers
- 44 people
- Sponsor
- Hvidovre University Hospital
Type 1 Diabetes
Calcineurin Inhibitor (CNI)-Free Immunosuppressive Regimen in T1D Patients Receiving Islet Transplantation
Our final objective is to develop an adoptive therapy with tolerogenic donor-specific Tr1 cells in T1D patients undergoing pancreatic islet transplantation (Tx).
- Trial name
- ECIT-1 (NCT01346085)
- Testing
- CNI free immunosuppression
- Where
- 2 sites in Italy, Switzerland
- Volunteers
- 10 people
- Sponsor
- Ospedale San Raffaele
Hypoglycemia
Identifying the Brain Substrates of Hypoglycemia Unawareness in Type 1 Diabetes
The purpose of this study is to investigate how the brain responds to low blood glucose in non-diabetic individuals. The ultimate goal is to understand the brain substrates of hypoglycemia unawareness, a condition that can occur…
- Trial name
- NCT02866435
- Testing
- Insulin, Glucose, Potassium phosphate
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Diabetes Mellitus, Type 1
CHO-loading Before and High Intermittent CHO-intake During Physical Exercise in T1D
Prolonged physical exercise (PE) is a challenge in type 1 diabetes with an increased incidence of both hypoglycemia and hyperglycemia.
- Trial name
- NCT03722225
- Testing
- Carbohydrate loading and high intermittent carbohydrate intake during physical exercise
- Volunteers
- 10 people
- Sponsor
- Örebro University, Sweden
Type 1 Diabetes, Type 1 Diabetes Mellitus Maturity Onset
Evaluating ImmuNe Changes in the Evolution of Pre Type 1 Diabetes With Adult ONset
Little is known about how type 1 diabetes or coeliac disease develop in adults. Studies following children at risk of type 1 diabetes from birth have shown that the marker of type 1 diabetes autoimmunity (antibodies against the…
- Trial name
- INCEPTiON (NCT06006468)
- Testing
- High genetic risk for type 1 diabetes, High gentic risk for Coeliac disease
- Where
- United Kingdom
- Volunteers
- 2,250 people, healthy volunteers welcome
- Sponsor
- Royal Devon and Exeter NHS Foundation Trust
Type 1 Diabetes
BeAT1D: Benign Autoimmunity and Type 1 Diabetes
National multi-center non-interventional case-control cohort study with collection of biological samples to characterize the autoimmune T and B lymphocytes involved in the development of type 1 diabetes.
- Trial name
- BeAT1D (NCT05139784)
- Testing
- Biosampling
- Where
- 17 sites in France
- Volunteers
- 1,160 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Type 1 Diabetes (Juvenile Onset), Continuous Glucose Monitoring System
Mediterranean Diet and Oxidative Stress in Type 1 Diabetes (MEDOX-T1D)
Achieving optimal glycemic control in type 1 diabetes requires a holistic approach that includes individualized medical nutrition therapy in addition to appropriate insulin therapy.
- Conditions
- Type 1 Diabetes (Juvenile Onset), Continuous Glucose Monitoring System, Oxidative Stress
- Trial name
- MEDOX-T1D (NCT07544368)
- Testing
- Mediterranean Diet Intervention
- Volunteers
- 54 people
- Sponsor
- Istanbul University
Overweight
Sumatriptan and Glucose
The purpose of this study is to establish the proof of concept for a brain serotonin pathway controlling blood glucose control in humans.
- Trial name
- NCT04690270
- Testing
- Sumatriptan 100 mg
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Retinal Ischemia, Diabetes Complications
Changes in the Diameter of Retinal Vessels After Remote Ischemic Conditioning in Patients With Type 1 Diabetes
Remote ischemic conditioning (RIC) is a therapeutic strategy for protecting organs or tissue against the detrimental effects of acute ischemia-reperfusion injury.
- Conditions
- Retinal Ischemia, Diabetes Complications, Ischemia, Diabetes Mellitus, Type 1
- Trial name
- NCT03906383
- Testing
- Remote Ischemic Conditioning
- Where
- Denmark
- Volunteers
- 21 people
- Sponsor
- University of Aarhus
Type 1 Diabetes Mellitis
Effectiveness of Artificial-Intelligence (AI) Bolus Priming Added to an Existing Fully Automated Control Algorithm (AIDANET)
Bolus Priming (BP) based on Artificial Intelligence (AI) learning of meal patterns, added to our established Automated insulin delivery as Adaptive Network (AIDANET) algorithm and running on iPhone Diabetes Assistant (iDiAs)…
- Trial name
- AIDANET AI (NCT07517770)
- Testing
- Hybrid Closed Loop (HCL) x 2 weeks, AIDANET x 2 weeks, AIDANET AI x 4 weeks
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Sue Brown
Weight Management, Type 2 Diabetes
A Study on the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of HRS-1596 Tablets in Healthy Participants With a Single Dose and in Obese Participants With Multiple Doses
This study is a randomized, double-blind, placebo-controlled, dose-escalation study that examines the safety, tolerability, pharmacokinetics and pharmacodynamics in healthy participants and multiple administrations in obese…
- Trial name
- NCT07841860
- Testing
- HRS-1596
- Where
- China
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- Fujian Shengdi Pharmaceutical Co., Ltd.
Type 1 Diabetes
Outpatient Reduction of Nocturnal Hypoglycemia by Using Predictive Algorithms and Pump Suspension in Children
The purpose of this study is to see whether low blood sugar at night can be reduced by using a system that turns off the insulin pump automatically.
- Trial name
- PSO4 (NCT01823341)
- Testing
- Pump suspension algorithm
- Where
- 3 sites in United States, Canada
- Volunteers
- 97 people
- Sponsor
- Jaeb Center for Health Research
Diabetes Mellitus, Type 1
Islet Cell Transplantation Alone in Patients With Type I Diabetes Mellitus: Steroid-free Immunosuppression
The goal of islet cell transplantation in patients with Type 1 Diabetes Mellitus is to provide constant normal blood glucose levels.
- Trial name
- NCT00021788
- Testing
- islet cell transplantation
- Where
- United States
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)