Clinical trials: Diabetes During Pregnancy
Preterm Birth, Preeclampsia
The ROOT Study: Scaling the 'Standard of Care Plus' Obstetric Nutrition Model to Optimize Maternal and Infant Health
The 'Standard of Care Plus' ('PLUS') model in the ROOT Study consists of analyzing select micronutrient and gene variants of pregnant females to construct trimester-specific and personalized nutrition and lifestyle…
- Conditions
- Preterm Birth, Preeclampsia, Gestational Diabetes Mellitus (GDM), Small for Gestational Age (SGA)
- Trial name
- ROOT (NCT07559773)
- Testing
- 'Standard of Care PLUS'
- Volunteers
- 500 people
- Sponsor
- GrowBaby Life Project
Gestational Diabetes
Effect of Extra Virgin Olive Oil Addition in the Diet of Women With Gestational Diabetes Mellitus (OLIDIAG)
Gestational diabetes mellitus (GDM) is associated to adverse maternal and neonatal outcomes. The aim of this study is to address whether the addition of extra virgin olive oil to the diet of women with GDM improves maternal…
- Trial name
- OLIDIAG (NCT05120388)
- Testing
- Extra Virgin Olive Oil Addition
- Where
- Argentina
- Volunteers
- 190 people
- Sponsor
- Center for Pharmacological and Botanical Research
Gestational Diabetes Mellitus (GDM)
Effect of Fiber Supplementation on the Need for Medication With Gestational Diabetes
The hypotheses to be tested are 1) Fiber supplementation will decrease the need for medication in patients with gestational diabetes, and 2) Fiber supplementation will decrease adverse maternal and neonatal outcomes in these…
- Trial name
- NCT06867861
- Testing
- Fiber
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- Eastern Virginia Medical School
Exercise, Mobile Health
Monitored Home Exercise in Pregnancy
The Study Investigators intend to study the adherence to and effect of a prescribed, monitored at-home exercise regimen in a pregnant population at risk for gestational diabetes, with a specific goal of understanding factors…
- Conditions
- Exercise, Mobile Health, Pregnancy, Gestational Diabetes
- Trial name
- NCT03551535
- Testing
- Monitored, At-Home Exercise Intervention
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Gestational Diabetes
Metabolic Risk Following Gestational Diabetes Mellitus
Gestational diabetes (GDM) is defined by abnormal glucose tolerance during gestation. This complication occurs in 4-10% and is associated with fetal complications and macrosomia.
- Trial name
- IMAGE (NCT02133729)
- Testing
- Blood sampling and OGTT
- Where
- 7 sites in France
- Volunteers
- 255 people
- Sponsor
- Hospices Civils de Lyon
Motivational Interviewing, Self Efficacy
The Effect of Motivational Interviewing on Self-Efficacy and Quality of Life in Gestational Diabetes Mellitus
This study is a randomized controlled experimental study planned to investigate the effect of motivational interviewing on health management self-efficacy and quality of life in pregnant women with gestational diabetes mellitus.
- Conditions
- Motivational Interviewing, Self Efficacy, Quality of Life, Gestational Diabetes Mellitus
- Trial name
- NCT06243939
- Testing
- Motivational Interview to Increase Health Management Self-Efficacy and Quality of Life in Pregnant Women Diagnosed with Gestational Diabetes Mellitus
- Where
- Turkey (Türkiye)
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Cukurova University
Gestational Diabetes
Preconception Lifestyle Interventions to Improve Future Metabolic Health (Before the Beginning)
The aim of this study is to investigate whether the combination of high intensity exercise and time restricted eating before and during pregnancy can reduce the risk of hyperglycaemia during pregnancy.
- Trial name
- NCT04585581
- Testing
- time-restricted eating, high intensity exercise, Standard Care
- Where
- Norway
- Volunteers
- 167 people
- Sponsor
- Norwegian University of Science and Technology
Chronic Renal Impairment, Diabetes Mellitus
Renal Safety of Iopamidol Versus Iodixanol During Coronary Angiography in Diabetic Patients
The purpose of this study is to compare the incidence of contrast-induced nephropathy (CIN) following the administration of iopamidol-370 (Iopamiro-370) and iodixanol-320 (Visipaque 320) in patients with moderate-to-severe…
- Trial name
- RECARE (NCT00782639)
- Testing
- Iopamidol injection 76%, iodixanol
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Bracco Diagnostics, Inc
Atrial Fibrillation, T2DM (Type 2 Diabetes Mellitus)
RE-ELECT. Dabigatran vs Warfarin in AF Patients With T2DM and CKD
Kidney function in patients with atrial fibrillation (AF) is tending to decline over a time which is clearly demonstrated in clinical studies.
- Conditions
- Atrial Fibrillation, T2DM (Type 2 Diabetes Mellitus), Chronic Kidney Diseases
- Trial name
- RE-ELECT (NCT03789695)
- Testing
- Dabigatran Etexilate
- Where
- Russia
- Volunteers
- 200 people
- Sponsor
- Irina Ermolaeva
Glucose Intolerance After a Recent History of Gestational Diabetes
Semaglutide for the Treatment of Glucose Intolerance in Women With Prior Gestational Diabetes
Gestational diabetes (GDM) is an important contributor to the increasing prevalence of type 2 diabetes (T2DM). Women with glucose intolerance in early postpartum are a particularly high-risk group with about 50% who will develop…
- Trial name
- SERENA (NCT05569772)
- Testing
- Semaglutide Pen Injector
- Where
- 13 sites in Belgium
- Volunteers
- 252 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
GDM, Pathogenesis
Study on Serum Metabolomics of GDM
This study aims to collect serum samples from healthy non-pregnant women, pregnant women with and without Gestational Diabetes Mellitus (GDM).
- Conditions
- GDM, Pathogenesis, Diagnosis
- Trial name
- NCT05881616
- Testing
- Specimen samples and baseline data collection
- Where
- China
- Volunteers
- 480 people, healthy volunteers welcome
- Sponsor
- Zhejiang University
Gestational Diabetes, Hypertension in Pregnancy
Sleep Improvement Therapy Affects Pregnancy Outcomes in Chinese Singletons and Twins by Improving Sleep Quality
During pregnancy, the physical and psychological changes of pregnant women, hyperemesis gravidarum, uterine compression, frequent urination, hip or pelvic pain, back pain, leg cramps, gastroesophageal reflux, changes in mental…
- Conditions
- Gestational Diabetes, Hypertension in Pregnancy, Preterm Labor, NICU Infants
- Trial name
- NCT06687044
- Testing
- Sleep restriction, Stimulation control, Cognitive therapy
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Jun Wei
Gestational Diabetes, Type 2 Diabetes Mellitus
Mobile-based Lifestyle Intervention in Women With Glucose Intolerance After Gestational Diabetes
Although lifestyle modification programs have been shown to be effective in preventing diabetes in older populations, interventions in women with recent gestational diabetes (GDM) clearly need to be adapted to address their…
- Conditions
- Gestational Diabetes, Type 2 Diabetes Mellitus, Glucose Intolerance, Healthy Lifestyle
- Trial name
- MELINDA (NCT03559621)
- Testing
- mobile-based lifestyle intervention
- Where
- 7 sites in Belgium
- Volunteers
- 240 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Fetal Macrosomia, Congenital Abnormality
Fish Oil Supplementation in Women With Gestational Diabetes
Gestational diabetes is the development of diabetes during pregnancy. Left untreated, gestational diabetes and preeclampsia can lead to serious -- or even fatal -- complications for both mother and child.
- Conditions
- Fetal Macrosomia, Congenital Abnormality, Other Respiratory Problems After Birth
- Trial name
- NCT02371343
- Testing
- Fish oil, Ocean plus, Sunflower Oil
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Dr. Sami Ulus Children's Hospital
Type 2 Diabetes, Gestational Diabetes Mellitus (GDM)
Co-designing Enhanced Models of Care for First Nations Children at Risk for Childhood-onset Type 2 Diabetes
The overall objective: to co-design and implement targeted and timely community led strategies to improve the health of the Next Generation and end the intergenerational impact of T2D in this population.
- Trial name
- NCT07692321
- Testing
- Breastfeeding and perinatal education and support, Purchasing HbA1c machines for communities, Continuous Glucose Monitoring
- Where
- Canada
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Gestational Diabetes, Pregnancy Complications
Timing of Ambulation and Infant Birth Weight in Gestational Diabetes
This is a randomized controlled trial to assess the effect of routine exercise counseling compared to the recommendation for postprandial ambulation on infant birthweight among pregnant people with gestational diabetes mellitus.
- Conditions
- Gestational Diabetes, Pregnancy Complications, Pregnancy in Diabetic, Fetal Macrosomia
- Trial name
- NCT06157684
- Testing
- Postprandial ambulation
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Women and Infants Hospital of Rhode Island
Gestational Diabetes Mellitus
Islet Function in Gestational Diabetes
The purpose of this research is to understand how the function of the human pancreas changes during and after pregnancy.
- Trial name
- NCT07806695
- Testing
- Exendin 9-39
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Mayo Clinic
Leiomyoma, Laparoscopy
Combined Vaginal Misoprostol and Perivascular Vasopressin
Injection of Vasopressin into the uterine tissue surrounding fibroids constricts blood vessels, and has been found to be beneficial by decreasing blood flow to fibroids, and thereby resulting in less bleeding with removal.
- Conditions
- Leiomyoma, Laparoscopy, Uterine Myomectomy
- Trial name
- NCT03815344
- Testing
- Standard, Standard-vaginal misoprostol
- Where
- United States
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Antonios Likourezos
Hyperuricemia, Gout
Effect of Quercetin Supplements on Healthy Males: a Four-Week Randomized Cross-Over Trial
The purpose of this study was to test the effect of chronic consumption of Quercetin 500 mg tablets on blood uric acid and other biomarkers in adult males.
- Conditions
- Hyperuricemia, Gout, Kidney Calculi, Diabetes
- Trial name
- NCT01881919
- Testing
- Treatment, Control
- Where
- United Kingdom
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Leeds
Gestational Diabetes
MOD Diet in Gestational Diabetes Mellitus
Gestational diabetes (GDM) is a condition of high blood glucose (or "blood sugar") during pregnancy. GDM can cause harmful short-term and long-term health effects for mom and baby.
- Trial name
- MOD (NCT04570111)
- Testing
- MOD Diet, Standard Care Diet
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- University of Kansas Medical Center