Clinical trials: Diabetes During Pregnancy
High-Risk Pregnancy
Longitudinal Measures of Leptin in Pregnant Women Who Developed Preeclampsia
Background: Obesity in pregnancy is increasing and is a risk factor for metabolic pathology such as preeclampsia. Leptin is an adipokine which has a direct relationship to obesity.
- Trial name
- NCT01649167
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Materno-Perinatal Hospital of the State of Mexico
GDM
Effect of a Continuous Glucose Monitoring on Maternal and Neonatal Outcomes in Gestational Diabetes Mellitus
Gestational diabetes mellitus (GDM) is defined as carbohydrate intolerance first diagnosed during pregnancy [1]. It is associated with adverse pregnancy outcome for the mother, and the fetus with consequences regarding future…
- Trial name
- NCT02838147
- Testing
- FreeStyle sensors., Glucometer
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center
Diabetes Mellitus, Type 2, Renal Insufficiency
Efficacy and Safety of Empagliflozin (BI 10773) in Patients With Type 2 Diabetes and Renal Impairment
This study will investigate the efficacy and safety of the BI 10773 in type 2 diabetic patients with renal impairment in order to provide these data for approval for BI 10773 as an antidiabetic agent by regulatory authorities.
- Trial name
- NCT01164501
- Testing
- BI 10773
- Where
- 127 sites in United States, Canada and 13 more
- Volunteers
- 741 people
- Sponsor
- Boehringer Ingelheim
GDM
Efficacy of Lactobacillus Rhamnosus LRa05 in Gestational Diabetes
This study aims to comprehensively evaluate the multifaceted impacts of Lactobacillus rhamnosus LRa05 on patients with gestational diabetes.
- Trial name
- NCT06901791
- Testing
- Conventional treatment and Probiotic
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Wecare Probiotics Co., Ltd.
Pregnancy Related
Myo-inositol During Pregnancy to Prevent Gestational Diabetes
Myoinositol is an insulin-like compound that is present in both plant and animal cells. Humans synthesize it naturally, but it is also obtained in our diet.
- Trial name
- NCT06575868
- Testing
- Myo-inositol
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Tufts Medical Center
Diabetes, Gestational Diabetes
Safety and Efficacy of Insulin Aspart vs. Regular Human Insulin in Gestational Diabetes
This trial is conducted in the United States of America (USA). The purpose of this study is to test whether NovoLog (insulin aspart) is a safe and at least as effective alternative to regular human insulin for the control of…
- Trial name
- NCT00065130
- Testing
- human insulin, insulin NPH, insulin aspart
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Novo Nordisk A/S
Gestational Diabetes, Hyperglycemia
Gestational Metabolic Abnormalities and Maternal and Infant Nutrition and Health
Childhood obesity is on the rise and is a major risk factor for type 2 diabetes later in life. Recent evidence indicates that abnormalities that increase risk for diabetes may be initiated early in infancy.
- Conditions
- Gestational Diabetes, Hyperglycemia, Insulin Resistance, Obesity
- Trial name
- NCT01405547
- Where
- Canada
- Volunteers
- 271 people, healthy volunteers welcome
- Sponsor
- Anthony Hanley
Gestational Diabetes
Efficacy of Treatment for Gestational Diabetes Diagnosed by the IADPSG Criteria.
There is a lack of international uniformity in the approach to the screening and diagnosis of gestational diabetes mellitus (GDM).
- Trial name
- NCT02708758
- Testing
- Medical Nutrition Therapy
- Where
- Mexico
- Volunteers
- 400 people
- Sponsor
- Instituto Nacional de Perinatologia Isidro Espinosa de los Reyes
Gestational Diabetes, Obesity
Early Gestational Diabetes Screening in the Gravid Obese Woman
Specific Aim 1: To test the hypothesis that early GDM screening between 14-18 weeks in obese women (body mass index ≥30.0) will result in improved perinatal outcomes.
- Trial name
- EGGO (NCT01864564)
- Testing
- Early Screen
- Where
- 2 sites in United States
- Volunteers
- 962 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Gestational Diabetes Mellitus
A Novel Device for Gestational Diabetes Control
Rationale of the study: Gestational diabetes mellitus (GDM) is very common and the rate of women suffering from it expected to increase in the next years.
- Trial name
- NCT05812547
- Testing
- Lumen, Glucose monitoring mobile app
- Volunteers
- 120 people
- Sponsor
- Rambam Health Care Campus
Healthy Adults, Copeptin
Copeptin Changes After Food Intake
The purpose of this study is to determine whether copeptin levels are affected by food intake.
- Trial name
- CoMeal (NCT01772914)
- Where
- Switzerland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Pregnant Women With Singleton Pregnancies
Harvesting Health: Advancing Nutrition and Wellness for Moms and Babies
This is a randomized controlled trial to assess whether a personalized food kit to pregnant women is feasible, improves diet quality, and enhances pregnancy and birth outcomes compared to standard prenatal care.
- Trial name
- HH (NCT07659821)
- Testing
- Food Kit
- Where
- 3 sites in United States
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Texas A&M University
Healthy, Vitamin D Deficiency
Can Correction of Low Vitamin D Status in Infancy Program for a Leaner Body Composition?
One in four infants are born with low amounts of vitamin D stored in their body. This study is designed to test whether improving vitamin D status quickly after birth helps infants to build muscle and to normalize growth.
- Conditions
- Healthy, Vitamin D Deficiency, Gestational Diabetes
- Trial name
- NCT02563015
- Testing
- cholecalciferol, Reference 400
- Where
- Canada
- Volunteers
- 139 people, healthy volunteers welcome
- Sponsor
- McGill University
Gestational Diabetes, Vascular Endothelial Function
Oxidative Stress in Microvascular Dysfunction Following Gestational Diabetes
The purpose of this investigation is to examine the role of oxidative stress in aberrant microvascular function in otherwise healthy women with a history of GDM.
- Trial name
- NCT05946785
- Testing
- Acetylcholine, insulin aspart
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Anna Stanhewicz, PhD
Gestational Diabetes, Weight Gain During Pregnancy
The IBEP Study: an Intervention for Lifestyle Modification in Women With Gestational Diabetes
The IBEP study is a randomized control trial of a healthy lifestyle intervention program for women with gestational diabetes. The primary aim of the study is to evaluate whether women with gestational diabetes enrolled in an…
- Conditions
- Gestational Diabetes, Weight Gain During Pregnancy, Weight Loss After Pregnancy
- Trial name
- IBEP (NCT01858233)
- Testing
- Intensive Behavioral Modification
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- University of Pennsylvania
Health Problems in Pregnancy, Pregnancy Outcomes
Peking University Birth Cohort in Weifang (PKUBC-WF)
The PKUBC-WF is a prospective cohort study carried out in Weifang city of Shandong, China. The primary aim of this study is to investigate the short-term and long-term effects of pre-pregnant and prenatal exposure on maternal and…
- Conditions
- Health Problems in Pregnancy, Pregnancy Outcomes, Gestational Diabetes, Gestational Hypertension
- Trial name
- NCT06234332
- Testing
- No Interventions
- Where
- China
- Volunteers
- 2,800 people, healthy volunteers welcome
- Sponsor
- Peking University
Gestational Diabetes
Myoinositol Supplementation, Insulin Resistance and Fetal Sonographic Parameters in Gestational Diabetes Diet Treated
The aim of this study is to verify the beneficial effects on insulin resistance and fetal sonographic parameters of a diet supplementation of myoinositol taken during the third trimester by pregnant women affected by gestational…
- Trial name
- MYOGDM (NCT03763669)
- Testing
- Myoinositol
- Where
- Italy
- Volunteers
- 120 people
- Sponsor
- University of Messina
Polycystic Ovary Syndrome, Pregnancy Complications
A Prospective Cohort Study on the Serum Kisspeptin Levels Throughout Pregnancy in PCOS
The current study aims to investigate the dynamic serum kisspeptin levels throughout pregnancy and to explore its predictive value for GDM in PCOS.
- Trial name
- NCT06545994
- Testing
- Observation
- Where
- China
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Fudan University
Gestational Diabetes, Endothelial Dysfunction
Role of ET-1, Physical Activity, and Sedentary Behavior in Microvascular Dysfunction Following GDM
Women with a history of gestational diabetes mellitus (GDM) are at a 2-fold greater risk for the development of overt cardiovascular disease (CVD) following the effected pregnancy.
- Conditions
- Gestational Diabetes, Endothelial Dysfunction, Physical Inactivity
- Trial name
- NCT06547619
- Testing
- Insulin aspart
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Anna Stanhewicz, PhD
Gestational Diabetes, Gestational Hypertension
sFlt-1:PlGF Ratio in Gestational Diabetes: PREDICTION (PREeclampsia in DIabetiC gestaTION) Study
The ratio of soluble fms-like tyrosine kinase 1 (sFlt-1) to placental growth factor (PlGF) is elevated in pregnant women before the clinical onset of preeclampsia and can be used to predict the preeclampsia.
- Conditions
- Gestational Diabetes, Gestational Hypertension, Pre-Eclampsia
- Trial name
- PREDICTION (NCT04877119)
- Where
- Italy
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Azienda Ospedaliero, Universitaria Pisana