Clinical trials: Diabetes Insipidus
Pregnancy, Gestational Diabetes Mellitus
Predictability of Gestational Diabetes Mellitus in First and Second Trimester
The objective of the study is, if an early oral glucose tolerance test combined with maternal history, condition and multiple biomarker analysis can be used to detect gestational diabetes mellitus in the first trimester (12-14…
- Trial name
- GDMPredict (NCT02035059)
- Where
- Switzerland
- Volunteers
- 820 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Polyuria-polydipsia Syndrome, Arginine Vasopressin Deficiency
Mannitol-induced Release of Copeptin in Healthy Adults and Patients With Polyuria-Polydipsia Syndrome (MARS Study)
The aims of this study are to investigate whether mannitol stimulates copeptin (part 1: proof-of-concept) and whether the copeptin levels upon mannitol infusion differ in primary polydipsia and arginine vasopressin deficiency…
- Conditions
- Polyuria-polydipsia Syndrome, Arginine Vasopressin Deficiency, Primary Polydipsia
- Trial name
- MARS (NCT06542198)
- Testing
- Mannitol Infusion (blinded), Mannitol Infusion (open label)
- Where
- Switzerland
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Circadian Rhythm, Copeptin Blood Levels
The Circadian Rhythm of Copeptin
The circadian rhythm of copeptin will be examined in healthy subjects.
- Trial name
- Co-Rhythm (NCT02604875)
- Testing
- observation
- Where
- Switzerland
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Hypoosmolality, Hyperosmolality
Assessment of Circulating Copeptin Levels in Healthy Subjects and Patients With Renal Insufficiency After Oral Water Load and Hypertonic Saline Infusion
The are 2 principal goals in this study: 1. To measure plasma copeptin levels in healthy subjects and to correlate them with plasma AVP concentrations and urine osmolalities in iso-, hypo-, and hyperosmolar states. 2.
- Conditions
- Hypoosmolality, Hyperosmolality, Renal Failure
- Trial name
- NCT00696605
- Where
- Switzerland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Hospital Centre Biel/Bienne
Healthy
Oral Vasopressin Modulates Neural Responses to Looming Visual Stimuli: An Eye-tracking Study
The main aim of the present study is to investigate the effects of orally administered vasopressin (AVP) on the perception of time-to-collision of threatening and non-threatening stimuli by combining a validated looming fear…
- Trial name
- NCT06329063
- Testing
- Vasopressin
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Electronic Science and Technology of China
Water Stress, Body Water Dehydration
Influence of Osmotic Stimulation of Vasopressin on Autonomic Function
The regulation of total body water that defines human hydration status is a complex and dynamic process. Current methods of assessing hydration status (e.g.
- Trial name
- NCT04233606
- Testing
- Hypertonic Saline, Normal Saline
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of North Carolina, Greensboro
Diabetes Insipidus, Nephrogenic
Study of Genotype and Phenotype Expression in Congenital Nephrogenic Diabetes Insipidus
OBJECTIVES: I. Determine the relationship between genotype variations and clinical phenotype in patients with congenital nephrogenic diabetes insipidus.
- Trial name
- NCT00004360
- Testing
- chlorothiazide
- Volunteers
- healthy volunteers welcome
- Sponsor
- National Center for Research Resources (NCRR)
Diabetes Insipidus
Copeptin After a Subcutaneous Stimulation With Glucagon in Adults
This study is to evaluate copeptin values after the subcutaneous injection of glucagon in adults (healthy volunteers and patients with diabetes insipidus or primary polydipsia).
- Trial name
- Glucacop (NCT04550520)
- Testing
- Glucagon
- Where
- Switzerland
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Exercise Induced Hyponatremia
The Effects of Estradiol and Progesterone on Arginine Vasopressin Regulation and Serum Sodium Concentration
Women are at greater risk for exercise-induced hyponatremia (low blood sodium concentration) and this risk has been attributed to their lower body weight and size, excess water ingestion and longer racing times relative to men.
- Trial name
- NCT00589134
- Testing
- Gatorade Endurance Formula, ganirelix acetate
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Yale University
Primary Monosymptomatic Nocturnal Enuresis, Copeptin
Serum Copeptin as Biomarker for Diagnosis and Classification of Polyuric Primary Monosymptomatic Nocturnal Enuresis
Primary monosymptomatic nocturnal enuresis (PMNE) is one of the most common urinary system problems in childhood. The exact pathological mechanism has not been fully elucidated yet, but excessive nocturnal urination is considered…
- Trial name
- NCT07496541
- Testing
- copeptin levels in NP-PMNE, Testing the level of copeptin in patients with NNP-PMNE, Testing the level of copeptin in healthy children
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- The Children's Hospital of Zhejiang University School of Medicine
Low Water Intake, High Vasopressin
The Hydration to Optimize Metabolism (H2O Metabolism) Pilot Study
This study evaluates increased hydration (1.5 L of water daily during 6 weeks) on top of habitual water intake in the lowering of the vasopressin marker copeptin and in the lowering of plasma glucose concentration in adults with…
- Trial name
- H2OMetaboPilot (NCT03574688)
- Testing
- Water
- Where
- Sweden
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Region Skane
Oxytocin Deficiency, Hypopituitarism
Identification and Clinical Relevance of an Oxytocin Deficient State (Melatonin Study)
Oxytocin (OT) is a hypothalamic peptide that enters the peripheral circulation via the posterior pituitary gland. OT plays a key role in regulating appetite, psychopathology, prosocial behavior and sexual function.
- Conditions
- Oxytocin Deficiency, Hypopituitarism, Hypothalamic Obesity, Pituitary Dysfunction
- Trial name
- NCT05319301
- Testing
- Melatonin
- Where
- Spain
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Arginine Vasopressin Deficiency, Primary Polydipsia
Plasma Copeptin in Response to Oral Urea in Healthy Adults and Patients With Polyuria-polydipsia Syndrome
The aim of this study is to investigate whether oral urea stimulates copeptin release and, if so, whether it may provide a novel diagnostic test in the differentiation between AVP-D (Arginine vasopressin deficiency) and PP…
- Trial name
- URANOS (NCT05890690)
- Testing
- Urea
- Where
- Switzerland
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Ovarian Neoplasms
Evaluation of Vasopressin in the Vessels of Ovarian Neoplasms
This study will evaluate the expression of arginine vasopressin (AVP) by peptide and mRNA quantitation and also measurement of its V1 receptor mRNA, in the arteries and veins of ovarian malignant (cancerous) or benign…
- Trial name
- NCT00160472
- Testing
- removal of ovarian vessels
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- United States Department of Defense
Copeptin Blood Values
Copeptin in Normal- to Hyperosmolar States
Kinetics of Copeptin in response to osmotic alterations in healthy volunteers
- Trial name
- NCT02647736
- Testing
- Hypertonic saline infusion
- Where
- 2 sites in Germany, Switzerland
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Polyuria-polydipsia Syndrome
Copeptin After an Oral Stimulation With Macimorelin in Healthy Volunteers
This study investigates stimulation of the posterior pituitary gland by oral Macimorelin (a ghrelin receptor Agonist) to be a novel diagnostic test in the polyuria-polydipsia syndrome.
- Trial name
- Macicop (NCT03844217)
- Testing
- Macimorelin 0.5mg/kg body weight, Macimorelin 0.75mg/kg body weight
- Where
- Switzerland
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Dehydrated, Water-Electrolyte Imbalance, Malnutrition, Dehydration (Physiology)
Effects of Increased Water Intake on Hormonal Response, Hydration Status, and Physical Function in Low-drinking Older Adults
DrinkAge is a randomized controlled trial investigating whether increasing daily water intake can improve hydration and health-related outcomes in adults aged 60 years or older who habitually drink relatively little water.
- Trial name
- DrinkAge (NCT07892742)
- Testing
- Water
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Polytechnic University of Santarém
Febrile Seizure
Value of Copeptin Assay in Children With Febrile Seizures at Sohag University Hospital
Febrile seizures are one of the most common clinical diseases in pediatric neurology. It occurs between 6 months and 6 years of age and occurs in ~2-5% of children.
- Trial name
- NCT05215366
- Testing
- copeptin biomarker in children with febrile seizures
- Where
- Egypt
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Sohag University
Healthy
Biological Basis of Individual Variation in Social Cooperation
The project has three overall objectives. The first is to determine whether and how administration of intranasal oxytocin (OT) and intranasal vasopressin (AVP) influence cooperative decision-making and neural responses to…
- Trial name
- NCT01566539
- Testing
- Intranasal Oxytocin (OT) 24 IU, Intranasal Vasopressin (AVP), Intranasal Vasopressin (AVP) 40 IU
- Where
- 2 sites in United States
- Volunteers
- 707 people, healthy volunteers welcome
- Sponsor
- Emory University
Hyponatremia
Saline Infusion Test in Hyponatremia
Observational study of biochemical volume biomarker levels in response to a standardized intravenous isotonic saline infusion in patients with hyponatremia.
- Trial name
- SITH (NCT06498856)
- Testing
- Isotonic saline infusion
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University Hospital, Akershus