Clinical trials: Diabetes Mellitus, Brittle
Diabetes Mellitus, With Complications
Effects of Pulsatile Intravenous Insulin Therapy on Metabolic Integrity in Patients With Diabetes Mellitus
The purpose of this study is to determine if restoring normal metabolic function in patients with either type I or type II diabetes can improve the impact of the consequences of diabetic complications on the overall quality of…
- Trial name
- NCT00539409
- Testing
- Pulsatile Intravenous Insulin Therapy (Humulin R, Novolog)
- Where
- United States
- Volunteers
- 152 people
- Sponsor
- Florida Atlantic University
Brittle Type 1 Diabetes
Allogeneic Transplantation of Expanded Pancreatic Islet Cells
This study will evaluate the efficacy and safety of allogeneic pancreatic islet cells transplantation in patients with "brittle" type 1 diabetes.
- Trial name
- NCT05990530
- Testing
- YD02-2022
- Where
- China
- Volunteers
- 6 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Brittle Type 1 Diabetes Mellitus
Safety, Tolerability, and Efficacy of Immunomodulation With AT-1501 in Combination With Transplanted Islet Cells in Adults With Brittle T1D
This study will evaluate the safety, tolerability and efficacy of AT-1501 in an immunomodulation regimen in adult patients with T1D undergoing an islet cell transplant.
- Trial name
- NCT05480657
- Testing
- AT-1501 IV Infusion, Isolated cadaveric islet cells
- Where
- United States
- Sponsor
- Eledon Pharmaceuticals
Diabetes Mellitus, Type 1, Diabetes Mellitus, Brittle
Diabeloop for Highly Unstable Type 1 Diabetes
Feasibility study, comparing experimental treatment (DBLHU closed-loop system) with reference treatment (Low Glucose Predictive Suspend system) in 7 patients going through a series of N-of-1 trials.
- Conditions
- Diabetes Mellitus, Type 1, Diabetes Mellitus, Brittle, Closed-Loop
- Trial name
- DBLHU (NCT04042207)
- Testing
- Low Glucose Predictive Suspend system, DBLHU System
- Where
- 2 sites in France
- Volunteers
- 7 people
- Sponsor
- Centre d'Etudes et de Recherche pour l'Intensification du Traitement du Diabète
Type 1 Diabetes Mellitus
Islet Cell Transplant for Type 1 Diabetes
City of Hope National Medical Center, located in Duarte, CA, is hosting a clinical study on islet cell transplantation, an experimental procedure being evaluated as a treatment for patients with type 1 diabetes.
- Trial name
- TCD (NCT01909245)
- Testing
- Allogenic Human Islet Cells, Immunosuppressive Agents, Gastrin 17
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- City of Hope Medical Center
Type 1 Diabetes Mellitus
Human Islet Transplantation in Brittle Type 1 Diabetes Mellitus. The GRAGIL 2 Study.
This research project is supported by a multicentric network of collaborators whose goal is to assess the efficacy of transplanting allogenic pancreas islets to restore insulin secretion in patients with brittle type 1…
- Trial name
- NCT00321256
- Testing
- human pancreatic islet transplantation
- Where
- 6 sites in France, Switzerland
- Volunteers
- 22 people
- Sponsor
- University Hospital, Grenoble
Type 1 Diabetes
Health Economic Analysis of Islet Cell Transplantation for the Stabilization of the Severe Forms of Type 1 Diabetes
The main goal is to perform a cost-utility analysis to compare islet cell transplantation versus best medical treatment (defined as Sensor augmented pump therapy) for patients with brittle type1 diabetes.
- Trial name
- STABILOT (NCT02854696)
- Testing
- Islet graft, best medical care
- Where
- 11 sites in France, Switzerland
- Volunteers
- 42 people
- Sponsor
- University Hospital, Grenoble
Brittle Type 1 Diabetes Mellitus
Allogeneic Regenerative Islet Transplantation for the Treatment of Brittle Type 1 Diabetes Mellitus
This is a single-center, single-arm Phase Investigational Intervention Trial (IIT) clinical trial aimed at evaluating the safety and efficacy of allogeneic regenerative islet transplantation for the treatment of brittle type 1…
- Trial name
- NCT06196996
- Testing
- The method of islet transplantation is through percutaneous transhepatic portal vein puncture.
- Where
- China
- Volunteers
- 18 people
- Sponsor
- Shanghai Changzheng Hospital
Diabetes Mellitus, Type 1
Islet Transplantation in Patients With "Brittle" Type I Diabetes
The purpose of this study is to learn about the safety of islet transplantation for Type 1 diabetes mellitus, which may provide more normal control of blood sugar without the need for insulin shots.
- Trial name
- NCT01630850
- Testing
- Allogenic islet cells (human, U. Chicago), Intraportal infusion of islet cells
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Chicago
Type 1 Diabetes Mellitus, Hypoglycemia
Islet Transplant for Type 1 or Surgical Diabetes
The purpose of this study is to evaluate the safety and efficacy of islet transplants from human cadaver donors into type 1 or surgical diabetes mellitus patients who experience frequent acute or advanced chronic complications…
- Conditions
- Type 1 Diabetes Mellitus, Hypoglycemia, Labile Diabetes, End-stage Renal Disease
- Trial name
- EXAX (NCT01606475)
- Testing
- Allogeneic islets of Langerhans
- Where
- United States
- Sponsor
- University of Minnesota
Diabetes Mellitus
Effects of Pulsed Intravenous (IV) Insulin on Brittle and Uncontrolled Diabetes
The purpose of this study is to determine if restoring normal metabolic function in patients with either type I or type II diabetes can improve the impact of the consequences of diabetic complications specifically on the wide…
- Trial name
- NCT01029444
- Testing
- Pulsatile Intravenous Insulin Therapy (Humulin, Humulog, Novolog )
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Florida Atlantic University
Type 1 Diabetes
Calcineurin Inhibitor (CNI)-Free Immunosuppressive Regimen in T1D Patients Receiving Islet Transplantation
Our final objective is to develop an adoptive therapy with tolerogenic donor-specific Tr1 cells in T1D patients undergoing pancreatic islet transplantation (Tx).
- Trial name
- ECIT-1 (NCT01346085)
- Testing
- CNI free immunosuppression
- Where
- 2 sites in Italy, Switzerland
- Volunteers
- 10 people
- Sponsor
- Ospedale San Raffaele
Diabetes Mellitus, Type 1
Improving Islet Transplantation Outcomes With Gastrin for Type I Diabetes
This clinical study will evaluate the safety and effectiveness of Gastrin treatment with islet transplantation to help patients with difficult to control type 1 diabetes make insulin again and improve blood sugar control.
- Trial name
- NCT03746769
- Testing
- Allogenic Human Islet Cells, Gastrin 17
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- City of Hope Medical Center
Brittle Type I Diabetes Mellitus
Effectiveness of Oral Insulin in Unstable Type 1 Diabetes Patients
The intent of the proposed study is to assess the potential of oral insulin to mitigate diabetic instability and reduce the frequency and severity of hypoglycemic episodes in patients with type 1 diabetes.
- Trial name
- NCT00867594
- Testing
- ORMD 0801
- Where
- Israel
- Volunteers
- 12 people
- Sponsor
- Hadassah Medical Organization
Type 1 Diabetes Mellitus
Safety, Tolerability, and Efficacy of Immunomodulation With A Monoclonal Antibody Against CD40L in Combination With Transplanted Islet Cells in Adults With Brittle Type 1 Diabetes Mellitus (T1D)
Tegoprubart (AT-1501) is a monoclonal antibody. Antibodies are Y-shaped proteins that are produced naturally by the subject's immune system to attack and fight foreign substances that cause illness.
- Trial name
- Tegoprubart (NCT06305286)
- Testing
- Islet transplantation with Tegoprubart (AT-1501) immunosupression-based therapy
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- University of Chicago
Diabetes Mellitus, Type 1, Type 1 Diabetes
Feasibility of Closed-loop Automated Insulin Delivery System by Primary Care & Endocrinology, in Person & Via Telehealth
This is a study assessing the feasibility of using the insulin-only configuration of the iLet bionic pancreas with initiation in pump-naïve people with type 1 diabetes in a primary care practice with either in-person training and…
- Conditions
- Diabetes Mellitus, Type 1, Type 1 Diabetes, Diabetes, Autoimmune, Diabetes type1
- Trial name
- NCT05168657
- Testing
- Bionic Pancreas, Usual Care
- Where
- 2 sites in United States
- Volunteers
- 54 people
- Sponsor
- University of Colorado, Denver