Clinical trials: Diabetes Mellitus, Experimental
Diabetes Mellitus, Type 2
An Investigational Drug Study in Patients With Type 2 Diabetes Mellitus (MK0431-023)
The purpose of this study is to determine the safety and effectiveness of an investigational drug in patients with Type 2 Diabetes Mellitus.
- Trial name
- NCT00094757
- Testing
- Comparator: sitagliptin 100 mg, Comparator: sitagliptin 200 mg, Comparator: pioglitazone
- Volunteers
- 521 people
- Sponsor
- Merck Sharp & Dohme LLC
Diabetes Mellitus, Type 1, Type 1 Diabetes
"FEXIS": (Feasibility of an Extended Wear CSII Set in Participants With T1DM)
Over 1 million patients globally currently manage their Type 1 Diabetes mellitus using continuous subcutaneous insulin infusion with an infusion set that needs to be changed every 3 days.
- Conditions
- Diabetes Mellitus, Type 1, Type 1 Diabetes, Type 1 Diabetes Mellitus, Diabetes Mellitus, Insulin-Dependent, 1
- Trial name
- FEXIS (NCT04503564)
- Testing
- coil-reinforced soft polymer indwelling cannula
- Where
- Australia
- Volunteers
- 20 people
- Sponsor
- Capillary Biomedical, Inc.
Atrial Fibrillation (AF), Heart Failure
Somatic Health Screening for Adults in Outpatient Psychiatric Care in Denmark (SomaScreen)
People with severe mental illness have a substantially increased risk of undiagnosed and insufficiently treated somatic disease.
- Conditions
- Atrial Fibrillation (AF), Heart Failure, Asthma (Diagnosis), Chronic Obstructive Pulmonary Disease (COPD)
- Trial name
- SomaScreen (NCT07518446)
- Testing
- Somatic Health Screening for Adults in Outpatient Psychiatric Care in Denmark (SomaScreen)
- Where
- Denmark
- Volunteers
- 2,800 people
- Sponsor
- Amager Hospital
Healthy, Type 2 Diabetes
Study of Renal Blood Flow During Human Endotoxemia
The purpose of the present protocol is to study whether endotoxemia will affect the renal blood flow in type 2 diabetics and healthy volunteers.
- Conditions
- Healthy, Type 2 Diabetes, Endotoxemia
- Trial name
- NCT00413465
- Testing
- Escherichia Coli Endotoxin
- Where
- Denmark
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Type 2 Diabetes
The Effects of Dapagliflozin in Normal Clinical Practice in T2D
The aim of the study is to evaluate the benefits, documented in experimental settings, of treatment with Dapagliflozin in subjects with type 2 diabetes in normal clinical practice.
- Trial name
- PRECARE (NCT05418946)
- Testing
- Dapagliflozin 10mg
- Where
- Italy
- Volunteers
- 1,400 people
- Sponsor
- University of Milan
Diabetes Mellitus, Type 2
MBCT for DM Distress: a Pilot Qusai-experimental Study
Background: Diabetes-related distress (DRD) is very common among people with type II diabetes mellitus (DM). DRD led to poorer DM control and may led to adverse prognosis.
- Trial name
- NCT03484689
- Testing
- Mindfulness-based cognitive therapy MBCT
- Where
- Hong Kong
- Volunteers
- 20 people
- Sponsor
- Chinese University of Hong Kong
Diabetes
Study of an Investigational Glucose Meter System
The purpose of this study is to demonstrate that untrained subjects who have diabetes or pre-diabetes can operate the investigational Blood Glucose Monitoring System (BGMS) and obtain valid glucose results.
- Trial name
- NCT01466075
- Testing
- Apollo Evolution Investigational BG Monitoring System
- Where
- United States
- Volunteers
- 207 people
- Sponsor
- Ascensia Diabetes Care
Obesity, Diabetes Mellitus, Type 2
Intestinal Metabolic Reprogramming as a Key Mechanism of Gastric Bypass in Humans
The purpose of this research study is to determine how gastric bypass surgery effects metabolism in obesity and Type 2 Diabetes.
- Conditions
- Obesity, Diabetes Mellitus, Type 2, Endocrine System Diseases, Glucose Metabolism Disorders
- Trial name
- NCT02710370
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- University of Pittsburgh
Type2Diabetes
Evaluation of SGLT2-i Effectivness and Safety in Elderly Type 2 Diabetes Patients
The aim of the study is to evaluate the benefits, documented in experimental settings, of treatment with SGLT2-i in subjects with type 2 diabetes and older than 70 years in normal clinical practice.
- Trial name
- SOLDMiDiab02 (NCT05477017)
- Testing
- SGLT2 inhibitor
- Where
- Italy
- Volunteers
- 800 people
- Sponsor
- University of Milan
Diabetes Mellitus
Comparison of First and Second Capillary Blood Drops for Blood Glucose Measurement
This study aimed to evaluate the effects of different capillary blood sampling techniques on blood glucose measurement results in people with diabetes.
- Trial name
- NCT07624266
- Testing
- Capillary Blood Sampling Techniques
- Where
- Turkey (Türkiye)
- Volunteers
- 64 people
- Sponsor
- Ordu University
Chronic Disease, Cardiovascular Diseases
CEPPPIA Pilot. Experimental Center of Participative and Individualized Predictive Prevention in Auvergne
The state of health in France appears to be good with regard to major indicators such as life expectancy at birth. However, France is characterized by a high standardized rate of premature mortality (deaths occurring before the…
- Conditions
- Chronic Disease, Cardiovascular Diseases, Cancers, Diabetes Mellitus
- Trial name
- CEPPPIA (NCT03378895)
- Testing
- online questionnaire
- Where
- France
- Volunteers
- 251 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Diabetes Mellitus, Type 2
A Research Study to Compare Insulin 287 Once a Week to Insulin Glargine (100 Units/mL) Once a Day in People With Type 2 Diabetes.
The study compares 2 medicines for people with type 2 diabetes: insulin 287 (a new medicine) and insulin glargine (a medicine doctors can already prescribe).
- Trial name
- NCT03751657
- Testing
- Insulin icodec, Metformin, Dipeptidyl peptidase-4 inhibitors
- Where
- 49 sites in United States, Canada and 5 more
- Volunteers
- 247 people
- Sponsor
- Novo Nordisk A/S
Diabetes
Evaluation of a Noninvasive Diabetes Screening Device in Subjects at Risk for Diabetes
The purpose of this research study is to test the safety and effectiveness of the SCOUT DS in measuring the concentration of substances (advanced glycation endproducts) in the skin.
- Trial name
- ENGINE (NCT01080157)
- Testing
- SCOUT DS measurement
- Where
- 12 sites in United States
- Volunteers
- 509 people, healthy volunteers welcome
- Sponsor
- VeraLight, Inc.
Diabetes Mellitus, Type 2
Psychoneuroimmunology Therapy in Uncontrolled Diabetic Patients: A Quasi-experimental Study
The Psychoneuroimmunotherapy (PNIT) is the study, modification and implementation of the interactions between the processes of adaptive behavior, neurological, endocrine and immune.
- Trial name
- PNIT (NCT02536820)
- Testing
- psychoneuroimmune therapy, Conventional treatment
- Volunteers
- 500 people
- Sponsor
- Fundación Salutia
Diabetes, Cardiovascular Diseases
Community-Based Lifestyle Intervention for Primary and Secondary Prevention of Diabetes in Arab Women in East-Jerusalem
Given the extremely high incidence of diabetes in Arab women and the current lack of interventions, all non-diabetic women can be considered "at risk" and warrant secondary prevention.
- Conditions
- Diabetes, Cardiovascular Diseases, Health Behavior
- Trial name
- NCT04143737
- Testing
- Healthy lifestyle intervention
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Obesity, Diabetes Mellitus, Type 2
Behavior Intervention for Weight Loss for Type 2 Diabetes Mellitus Adults With Obesity Problem (BMI of ≥23kg/m2)
This quasi-experimental study aims to determine the effectiveness of a health intervention (Chance2Act) on behaviour change to act for weight loss among overweight/obese type 2 diabetes adults.
- Conditions
- Obesity, Diabetes Mellitus, Type 2, Behavior
- Trial name
- BMI (NCT05736536)
- Testing
- Chance2Act
- Where
- 2 sites in Malaysia
- Volunteers
- 104 people
- Sponsor
- Universiti Teknologi Mara
Type 2 Diabetes Mellitus
Phase 4: Investigational Study to Evaluate Metformin XR Monotherapy Versus Metformin IR Monotherapy in Subjects With Type 2 Diabetes
The purpose of this study is determine if Metformin XR monotherapy in subjects with type 2 diabetes is non-inferior to Metformin IR monotherapy
- Trial name
- NCT01864174
- Testing
- Metformin XR, Metformin IR
- Where
- 156 sites in United States, Canada and 8 more
- Volunteers
- 1,736 people
- Sponsor
- Bristol-Myers Squibb
Type 1 Diabetes Mellitus
Improving Self-Efficacy, Quality of Life and Glycemic Control in Adolescents With Type 1 Diabetes
Empowerment in healthcare, particularly in the context of chronic illness management such as diabetes, entails equipping patients with knowledge, expertise, and self-assurance to proactively oversee their health and make…
- Trial name
- NCT06694467
- Testing
- Education program
- Where
- Turkey (Türkiye)
- Volunteers
- 68 people
- Sponsor
- Near East University, Turkey
Diabetes Mellitus, Peripheral Neuropathy
Diabetes Peripheral Neuropathy and Small-fibre Nerve Damage: A Comparative Study
The purpose of this study is to investigate whether patients with diabetes-related peripheral neuropathic pain also have non-recognized damage to the intestine caused by autonomic neuropathy.
- Conditions
- Diabetes Mellitus, Peripheral Neuropathy, Small Fibre Neuropathy, Autonomic Neuropathy
- Trial name
- NCT01160887
- Where
- Norway
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Haukeland University Hospital
Diabetes Mellitus, Type 2
Investigational Study of Delayed Release Metformin
In Phase 1 and 2 studies already conducted, Metformin DR, with its targeted delivery to the distal small intestine, has shown the potential to be a safe and effective way to improve glycemic control in patients with T2DM and CKD…
- Trial name
- DREAM-T2D (NCT04854512)
- Testing
- Metformin DR, Metformin IR
- Where
- 87 sites in United States, Brazil and 6 more
- Volunteers
- 675 people
- Sponsor
- Anji Pharma