Clinical trials: Diabetes Mellitus, Insulin-Dependent, 1
Diabetes Mellitus, Non-Insulin-Dependent
NNC 90-1170 Mechanism of Action: A Double-Blind, Randomized, Single-Center, Placebo-Controlled, Crossover Study to Examine Beta-Cell Responsiveness to Graded Glucose Infusion in Subjects With Type 2 Diabetes
The purpose of this research study is to investigate the mechanism of action of a new investigational medication (drug), NNC 90-1170, which is being developed for the treatment of type 2 diabetes (adult onset type of diabetes.
- Trial name
- NCT00013910
- Testing
- NNC 90-1170
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- National Center for Research Resources (NCRR)
Diabetes Mellitus, Type 1
The isCGM Use and Hypoglycemic Episodes and Fear of Hypoglycemia in Newly Diagnosed Type 1 Diabetes
The aim of this trial is to investigate the impact of FreeStyle Libre use compared to SMBG on hypoglycemia episodes and fear of hypoglycemia in adults aged 18-35 with newly diagnosed type 1 diabetes.
- Trial name
- PENELOPE (NCT06414824)
- Testing
- Intermittently Scanned Continuous Glucose Monitoring, Standard Blood Glucose Monitoring
- Where
- 4 sites in Poland
- Volunteers
- 28 people
- Sponsor
- Jagiellonian University
T1D, T1DM
Pre-Exercise Whey and Pea Protein in Adolescents With Type 1 Diabetes
The goal of this clinical trial is to learn whether drinking whey protein or pea protein before exercise affects blood sugar levels and appetite in adolescents with type 1 diabetes.
- Trial name
- NCT07836673
- Testing
- low whey protein, moderate whey protein, low Pea protein
- Volunteers
- 30 people
- Sponsor
- University of Jordan
Type1diabetes, Hypoglycemia
Galactose - the Ideal Carbohydrate Supplement for Exercise in Type 1 Diabetes
In this study, 14 subjects with type 1 diabetes are studied in a randomized crossover study in which the subjects cycle at a fixed intensity at 60% of their maximum oxygen capacity (VO2 max) for 1 hour.
- Conditions
- Type1diabetes, Hypoglycemia, Hyperglycemia
- Trial name
- NCT05557227
- Testing
- 1-hour cycling
- Where
- Denmark
- Volunteers
- 14 people
- Sponsor
- University of Aarhus
Type 1 Diabetes
Verapamil In Preclinical Type 1 Diabetes
Type 1 diabetes (T1D) is preceded by a presymptomatic phase featured by the presence of islet autoantibodies (aAbs) without (Stage 1) or with (Stage 2) dysglycemia.
- Trial name
- VIP-1 (NCT07880769)
- Testing
- Verapamil 120 Mg/24 Hours Oral Capsule, Extended Release, blood sampling, EKG and cardiological evaluation
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Diabetes, Type 1 Diabetes
T1DTechCHW: Enhancing the Community Health Worker Model to Promote Diabetes Technology Use in Young Adults From Underrepresented Minority Groups
The objective of this study is to test the early effects and implementation of an enhanced community health worker (CHW) model (T1D-CATCH) that encourages and supports diabetes technology use in young adults from underrepresented…
- Conditions
- Diabetes, Type 1 Diabetes, Young Adult, Diabetes Mellitus
- Trial name
- T1DTechCHW (NCT05211869)
- Testing
- T1D-CATCH
- Where
- United States
- Volunteers
- 119 people
- Sponsor
- Albert Einstein College of Medicine
Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
A Canadian Study of the Effectiveness of Tresiba® (Insulin Degludec) After Switching Basal Insulin in a Population With Type 1 or Type 2 Diabetes Mellitus
The purpose of this study is to collect historical data in real life conditions in a large group of people who have type 1 or type 2 diabetes and were treated with Tresiba® (insulin degludec) for at least 6 months.
- Trial name
- CAN-TREAT (NCT03674866)
- Testing
- Insulin degludec
- Where
- 32 sites in Canada
- Volunteers
- 662 people
- Sponsor
- Novo Nordisk A/S
Type 1 Diabetes Mellitus
Physical Activity to Prevent and Treat Hyperglycemia From a Mistimed Bolus Insulin Dose
People living with type 1 diabetes (PwT1D) are recommended to administer insulin 10-15 minutes before meal consumption (pre-bolus), to account for the delay in the glucose lowering action associated with subcutaneously…
- Trial name
- Missed Dose (NCT06686329)
- Testing
- Control (CON), Missed Dose (MISS), Missed Dose + 15min walk (MISS+EX)
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Jane Yardley
Type 1 Diabetes Mellitus
The Effect of Diabetes Education Digital Games and Video Animation on Quality of Life
This research will be conducted to evaluate the effect of digital game and video animation-based diabetes education on the quality of life of children with Type 1 Diabetes.
- Trial name
- NCT05649553
- Testing
- digital game and video animation based diabetes education
- Where
- Turkey (Türkiye)
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Pamukkale University
Diabetes Type 1, Diabetes Mellitus, Type 2
Antenatal Hand Milking for Pregnant Women With Diabetes'
The project is a descriptive cohort study with a retrospective and a prospective group where pregnancy and childbirth data will be studied.
- Conditions
- Diabetes Type 1, Diabetes Mellitus, Type 2, GDM
- Trial name
- NCT04794283
- Testing
- Breast milk
- Where
- Sweden
- Volunteers
- 186 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Diabetes, Type1diabetes
Continuous Ketone Monitoring in People With Type 1 Diabetes Using SGLT2 Inhibitors
Type 1 diabetes is an autoimmune disease where the body attacks the insulin-producing cells in the pancreas. In the absence of insulin, the body is unable to effectively use glucose for energy, resulting in high blood sugar…
- Conditions
- Diabetes, Type1diabetes, T1D
- Trial name
- EmpaCKM (NCT06753994)
- Testing
- SGLT-2 inhibitor
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- McGill University
Type 1 Diabetes
Insulin Omission Surrogate (iOS)
Type 1 Diabetes management is requiring and implies numerous lifestyle modifications. Insulin restriction to control weight is a frequent phenomenon, affecting up to 40% of PWT1D.
- Trial name
- iOS (NCT05476861)
- Where
- Canada
- Volunteers
- 751 people
- Sponsor
- Laval University
Type 1 Diabetes Mellitus
Pharmacologic Response and Safety of Inhaled Insulin in Type 1 Diabetes
The purpose of this study was to compare the pharmacokinetic (PK) response after inhaled insulin administration with 3 different inhalation regimens and with subcutaneous insulin administration.
- Trial name
- Samba-01 (NCT02713841)
- Testing
- inhaled human insulin (INH), sc insulin lispro (LIS)
- Volunteers
- 12 people
- Sponsor
- Dance Biopharm Inc.
CTLA4 Haploinsufficiency
Neurologic and Immunologic Characteristics of CTLA-4 and LRBA Hereditary Deficiency
CTLA4 and LRBA deficiencies are rare genetic disorders, recently described, and associated with multiple clinical features. It ranges from recurrent infections, auto-immunity, and organ infiltration with lymphocytes.
- Trial name
- NCT05040256
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Montpellier
Diabetes Mellitus Type 1
ZP4207(Dasiglucagon) Administered to T1D Patients to Assess the PK and PD Compared to Marketed Glucagon
The trial is a single-centre, randomised, sequential, cross-over trial assessing pharmacokinetic and pharmacodynamic responses after micro-doses of ZP4207 (dasiglucagon*) administered subcutaneously to patients with type 1…
- Trial name
- NCT02916251
- Testing
- ZP4207(dasiglucagon) glucagon analogue, Glucagon (Native glucagon)
- Where
- Germany
- Volunteers
- 38 people
- Sponsor
- Zealand Pharma
Diabetes Mellitus, Type 1, Hypoglycemia
The Role of Glucose-Dependent Insulinotropic Polypeptide in the Pathological Glucose Homeostasis Of Type 1 Diabetes
In the present project the investigators will evaluate whether glucagonotropic properties of the gut-derived incretin hormone glucose-dependent insulinotropic polypeptide (GIP) may be utilized as a safeguard against hypoglycemia…
- Trial name
- NCT03734718
- Testing
- GIP
- Where
- Denmark
- Volunteers
- 20 people
- Sponsor
- Steno Diabetes Center Copenhagen
Type-1-Diabetes
Early Feasibility Evaluation of the UniBE Hybrid Closed-loop Insulin Delivery System in Type 1 Diabetes: UBLoop-Genesis
The study is investigating the early feasibility of a novel algorithm for a hybrid closed-loop (HCL) insulin delivery system in adult patients with Type 1 diabetes.
- Trial name
- UBLoop-Gen (NCT07087340)
- Testing
- UBLoop System
- Where
- Switzerland
- Volunteers
- 6 people
- Sponsor
- University of Bern
Type 1 Diabetes
Rapamycin Versus Mycophenolate Mofetil in Kidney-Pancreas Recipients
This study was designed to determine which maintenance immunosuppressive agent, rapamycin or mycophenalate mofetil, resulted in better outcome in patients with type 1 diabetes and renal failure, who presented for a…
- Trial name
- NCT00533442
- Testing
- Rapamycin, Mycophenolate Mofetil, Tacrolimus
- Where
- United States
- Volunteers
- 170 people
- Sponsor
- University of Miami
Type 1 Diabetes Mellitus
Phase 2 Trial of BMF-219 in Participants With Type 1 Diabetes Mellitus
Phase 2 Trial of BMF-219 in Participants with Type 1 Diabetes Mellitus.
- Trial name
- NCT06152042
- Testing
- BMF-219
- Where
- 11 sites in United States, Canada
- Volunteers
- 37 people
- Sponsor
- Biomea Fusion Inc.
Bariatric Surgery Status in T1D
Long-term Results After Bariatric Surgery in Type 1 Diabetes Patients
There is a lack of long-term data on the impact of bariatric surgery in type 1 diabetes (T1D). The aim of this study is to gain long-term outcome data on the effects of bariatric surgery in obese patients with T1D.
- Trial name
- NCT06394479
- Testing
- Outcome after bariatric surgery in patient with T1D
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- Sana Klinikum Offenbach
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