Clinical trials: Diabetes Mellitus, Type 1, Type 2
Neuropathic Pain, Type 1 Diabetes Mellitus
Influence of Diabetes on Tramadol Pharmacokinetics
This study aimed to investigate the influence of uncontrolled type 1 and type 2 diabetes mellitus (DM) on the kinetic disposition, metabolism and pharmacokinetics-pharmacodynamics of tramadol enantiomers in patients with…
- Conditions
- Neuropathic Pain, Type 1 Diabetes Mellitus, Type 2 Diabetes Mellitus
- Trial name
- NCT02246712
- Testing
- Single oral dose of 100 mg racemic tramadol, CYP2D6 phenotype, CYP3A phenotype
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- Universidade Estadual Paulista Júlio de Mesquita Filho
Diabetic Retinopathy
Protein Kinase C (PKC) Inhibitor-Diabetic Retinopathy Phase 3 Study
This study is to test whether or not 32 milligrams (mg) of ruboxistaurin a day over three years will reduce vision loss associated with diabetic retinopathy.
- Trial name
- NCT00604383
- Testing
- ruboxistaurin
- Where
- United States
- Volunteers
- 685 people
- Sponsor
- Chromaderm, Inc.
Type 2 Diabetes Mellitus
One Drop Experts Program for Type 2 Diabetes Self-Management: Impact on A1c
The One Drop Experts Program for Type 2 Diabetes Self-Management Impact on A1c trial is a 12-week long, prospective, intent-to-treat study that aims to evaluate the impact of the One Drop app and Experts program on HbA1c levels…
- Trial name
- NCT02827669
- Testing
- One Drop Experts Program, One Drop Experts Program + Apple Watch
- Where
- United States
- Volunteers
- 297 people
- Sponsor
- Evidation Health
Diabetes (Insulin-requiring, Type 1 or Type 2)
Investigation of the Effectiveness of Prophylactic NPWT (ciNPWT) in High-risk Diabetic Patients With Acute Laparotomy Wounds
The aim of this study is to evaluate the effectiveness of prophylactic Negative Pressure Wound Therapy (NPWT) in patients with diabetes mellitus undergoing laparotomy who are at high risk for Surgical Site Infections (SSI).
- Trial name
- NCT07392853
- Testing
- Prophylactic/Incisional Negative Pressure Wound Therapy
- Where
- Hungary
- Volunteers
- 110 people
- Sponsor
- Semmelweis University
Diabetes, Diabetes Mellitus, Type 1
Evaluation of Levemir® for the Treatment of Type 1 and 2 Diabetes
This study is conducted in Europe. The aim of this observational study is to evaluate the incidence of serious adverse drug reactions while using Levemir® under normal clinical practice conditions.
- Conditions
- Diabetes, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
- Trial name
- PREDICTIVE™ (NCT00655044)
- Testing
- insulin detemir
- Where
- Russia
- Volunteers
- 3,637 people
- Sponsor
- Novo Nordisk A/S
Type 1 Diabetes Mellitus
Effect of a Fixed Pramlintide: Insulin Dose Ratio on Postprandial Glucose in Type 1 Diabetes Mellitus
This study is designed to investigate the clinical efficacy and safety of pramlintide co-administered as a fixed-dose ratio with basal-bolus SC insulin, delivered simultaneously via 2 separate pumps, in subjects with type 1…
- Trial name
- NCT02500979
- Testing
- Pramlintide acetate, Lispro insulin U-100, Regular insulin U-100
- Where
- 3 sites in United States
- Volunteers
- 34 people
- Sponsor
- AstraZeneca
Diabetes Mellitus
Study of Safety and Effectiveness of Apidra® in Combination With Basal Insulin in Patients With Type 1 & 2 Diabetes Mellitus
Primary Objectives: To determine the effect of insulin glulisine on glycemic control (HbA1c, FBG \& PPBG) from baseline to the end of the study.
- Trial name
- SCALE (NCT00526513)
- Testing
- Insulin Glulisine
- Where
- Egypt
- Volunteers
- 188 people
- Sponsor
- Sanofi
Diabetes Mellitus, Diabetes Mellitus, Type 2
Single Dose Study of PF-04991532 in Healthy Subjects
The purpose of this study is to characterize the safety, tolerability, pharmacokinetics (PK) and preliminary food effect of PF-04991532 following single escalating oral doses in healthy adult subjects.
- Conditions
- Diabetes Mellitus, Diabetes Mellitus, Type 2, Glucose Metabolism Disorders
- Trial name
- NCT01102673
- Testing
- PF-04991532
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Pfizer
Diabetes Mellitus, Type 2
A Single Dose Study Of PF-05161704 In Healthy Volunteers
The primary purpose of this study is to evaluate the safety, tolerability and pharmacokinetics of single oral doses of PF-05161704 in healthy volunteers.
- Trial name
- NCT01183715
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Pfizer
Diabetic Macular Edema
Efficacy of Aliskiren in the Treatment of Diabetic Macular Edema
To assess the efficacy of oral aliskiren as a therapy for diabetic macular edema
- Trial name
- NCT00768040
- Testing
- Aliskiren
- Where
- 12 sites in United States, Denmark
- Volunteers
- 39 people
- Sponsor
- Novartis Pharmaceuticals
Type 1 Diabetes (T1D), Type 2 Diabetes (T2DM)
"Sexual Activity and Hypoglycemia Risk in Adults With Type 1 or Type 2 Diabetes Using Insulin Therapy and Continuous Glucose Monitoring"
This observational study examines whether sexual activity influences the risk of hypoglycemia in adults with type 1 or type 2 diabetes treated with insulin therapy and using continuous glucose monitoring (CGM).
- Conditions
- Type 1 Diabetes (T1D), Type 2 Diabetes (T2DM), Hypoglycemia
- Trial name
- SEX-HYPO-CGM (NCT07286500)
- Testing
- No intervention
- Where
- Poland
- Volunteers
- 100 people
- Sponsor
- Medical University of Warsaw
Type 2 Diabetes Mellitus
Study of BMF-219 in Healthy Adult Subjects and in Adult Subjects With Type 2 Diabetes Mellitus (T2D)
A Phase 1/ 2 Randomized, Double-Blind, Placebo-Controlled Single and Multiple Ascending Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of BMF-219, an Oral Covalent Menin Inhibitor, in…
- Trial name
- NCT05731544
- Testing
- BMF-219
- Where
- 39 sites in United States, Canada
- Volunteers
- 443 people, healthy volunteers welcome
- Sponsor
- Biomea Fusion Inc.
Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
Assessment of Mealtime Bolus Insulin Behavior
The main purpose of this study is to estimate missed bolus insulin doses in diabetics. This is a 12-week, single-arm, outpatient, exploratory study with two study periods in Type 1 or Type 2 diabetics, with an investigational…
- Trial name
- NCT03368807
- Testing
- Continuous Glucose Monitoring, Insulin Lispro
- Where
- 6 sites in United States
- Volunteers
- 79 people
- Sponsor
- Eli Lilly and Company
Diabetes Mellitus, Type 1 Diabetes
Cooking Matters for Diabetes - A 6-Week Program for Practical Application of Diabetes Self-Management Education
Our primary objective is to improve glycemic control (Hemoglobin A1c [HbA1c]) over 3 months in individuals with diabetes by teaching practical application of diabetes education through "Cooking Matters" compared to usual care.
- Conditions
- Diabetes Mellitus, Type 1 Diabetes, Type 2 Diabetes
- Trial name
- NCT04152811
- Testing
- Cooking Matters for Diabetes, Usual Diabetes Care
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Ohio State University
Diabetes Mellitus
Single Ascending Dose Trial in Patients With Type 2 Diabetes
The purpose of this study is to determine whether AMG 876 is safe and well tolerated in subjects with type 2 diabetes.
- Trial name
- NCT01492465
- Testing
- AMG 876
- Where
- 3 sites in United States
- Volunteers
- 47 people
- Sponsor
- Amgen
Diabetic Neuropathy, Cognitive Impairment
Neuroprotection by Tocotrienols in Type 1 and Type 2 Diabetes Mellitus
Given that the tocotrienols have been shown to possess neuroprotective effects and that both type 1 and type 2 diabetes can lead to peripheral neuropathy and cognitive impairment, the present study aims to determine the…
- Trial name
- VENUS (NCT01973400)
- Testing
- Tocotrienol
- Where
- Malaysia
- Volunteers
- 300 people
- Sponsor
- Universiti Sains Malaysia
Diabetes, Diabetes Mellitus, Type 1
A Survey to Evaluate Diabetes Management, Control, Chronic Complications, Psychosocial Aspects of Diabetic Subjects in Singapore
This study is conducted in Asia. The aim of this observational study is to evaluate current status of diabetes management, control and complications in diabetic subjects in Asia.
- Conditions
- Diabetes, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
- Trial name
- DiabCare Asia (NCT00836030)
- Testing
- No treatment given
- Where
- Singapore
- Volunteers
- 854 people
- Sponsor
- Novo Nordisk A/S
Diabetes Mellitus, Diabetes Mellitus ( Type 1 and Type 2)
Mindfulness-Based Cognitive Behavioral Program for People With Diabetes Mellitus
This randomized controlled trial evaluated the effectiveness of a mindfulness-based cognitive behavioral program in improving quality of life and glycemic control among adults with diabetes mellitus in Damascus, Syria.
- Conditions
- Diabetes Mellitus, Diabetes Mellitus ( Type 1 and Type 2), Depressive Symptoms
- Trial name
- NCT07779044
- Testing
- Mindfulness-Based Cognitive Behavioral Program
- Where
- Syria
- Volunteers
- 40 people
- Sponsor
- Center for Strategic Studies and Health Training, Syria
Endothelial Dysfunction, Diabetes Mellitus, Type 1
Novel Therapeutics and Endothelial Dysfunction in T1DM Patients
The aim of study is impact of additional treatment with new antidiabetic drugs (semaglutide or empagliflozine) compared to control group in T1DM patients - impact on endothelial function measured by FMD and FPF, arterial…
- Conditions
- Endothelial Dysfunction, Diabetes Mellitus, Type 1, Biomarkers, Endothelial Progenitor Cells
- Trial name
- ENDIS (NCT05857085)
- Testing
- Semaglutide Pen Injector [Ozempic], Empagliflozin 10 MG
- Where
- Slovenia
- Volunteers
- 90 people
- Sponsor
- General and Teaching Hospital Celje
Genetic Variation, Diabetes
Mapping Genes for Type 2 (Non-Insulin Dependent) Diabetes Mellitus
The aim of the project is to positionally clone susceptibility genes for NIDDM. Patients will be ascertained in Finland from previous health surveys and hospital discharge records.
- Trial name
- NCT00339885
- Where
- 4 sites in Finland, Norway
- Volunteers
- 32,379 people, healthy volunteers welcome
- Sponsor
- National Human Genome Research Institute (NHGRI)
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