Clinical trials: Diabetes Mellitus, Type 1 Diabetes
Diabetes, Diabetes Mellitus, Type 1
A Randomised Trial Evaluating Continuous Subcutaneous Infusion of Formulations of NN1218 and NovoLog® in Subjects With Type 1 Diabetes
This trial is conducted in the United States of America (USA). The aim of the trial is to evaluate continuous subcutaneous infusion of NN1218 formulations and NovoLog® in subjects with type 1 diabetes.
- Trial name
- NCT01682902
- Testing
- Faster-acting insulin aspart, insulin aspart
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- Novo Nordisk A/S
Type 2 Diabetes Mellitus (T2DM)
A Phase 1/2 Study to Evaluate ALN-KHK in Overweight to Obese Healthy Volunteers and Obese Patients With T2DM
To evaluate the safety, tolerability, pharmacokinetics (PK) and pharmacodynamics (PD) of single ascending doses of ALN-KHK and to evaluate the safety, tolerability, efficacy, PK and PD of multiple doses of KHK.
- Trial name
- NCT05761301
- Testing
- ALN-KHK
- Where
- 15 sites in United States, Canada
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Alnylam Pharmaceuticals
Type 1 Diabetes Mellitus, Endothelial Dysfunction
High-Intensity Exercise and Endothelial Function in Type 1 Diabetes(HIIT-T1D)
To study the effect of 8 week high-intensity interval training (HIIT) compared with moderate intensity (MCT) interval training and sedentary patients(CON) with type 1 diabetes.
- Trial name
- HIIT-T1D (NCT03451201)
- Testing
- High Intensity Interval Training, Moderate Continuous Exercise Training, Non-exercise
- Where
- Brazil
- Volunteers
- 36 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Diabetes Mellitus Non Insulin Dependent Oral Agent Therapy
A Study to Evaluate the Efficacy and Safety of BRL 49653C in Non-insulin Dependent Diabetes
At least 30% of patients initially treated with sulphonylureas for NIDOM will have a poor response, and in the remaining 70% the subsequent failure rate is approximately 4% to 5% per year.
- Trial name
- NCT01706211
- Testing
- BRL 49653C
- Where
- Taiwan
- Volunteers
- 77 people
- Sponsor
- National Taiwan University Hospital
Type 1 Diabetes Mellitus
Non Invasive Assessment of Liver Glycogen Kinetics and ATP Synthesis in Type1 Diabetics
Patients with Type 1 diabetes (T1DM) suffer from impaired postprandial hepatic glycogen storage and breakdown, if they are under poor glycaemic control.
- Trial name
- NCT00481598
- Testing
- magnet resonance spectroscopy
- Where
- Austria
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Landsteiner Institut
Diabetes Mellitus, Type 1, Closed-Loop
Safety Assessment of DBLUS System in Adolescent and Adult Patients With Type 1 Diabetes and Assessment of Its Clinical Efficacy (DIABELOOP SP8)
This clinical trial is a randomized trial including a 3-month single-arm part and a 6-month extension phase. Following randomization between the 1st group and 2nd group, a 2-week baseline period in open-loop for 148 adults and 30…
- Trial name
- DIABELOOP SP8 (NCT04190277)
- Testing
- Open-loop condition, Closed-loop condition
- Where
- 9 sites in France
- Volunteers
- 184 people
- Sponsor
- Centre d'Etudes et de Recherche pour l'Intensification du Traitement du Diabète
Type 1 Diabetes
Pramlintide in Adolescents With Type 1 Diabetes
The investigators hypothesize that subcutaneous pramlintide as an adjunct to mealtime insulin immediately prior to meals can significantly reduce post-prandial glucose concentrations compared with mealtime insulin alone in…
- Trial name
- NCT00842075
- Testing
- pramlintide
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Colorado, Denver
Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
User Experience With DuraTouch® in Patients With Type 1 or Type 2 Diabetes
This study looks at overall impact of the use of DuraTouch® in terms of ease, convenience to use and satisfaction in participants with either type 1 or type 2 diabetes.The study will last for about 12 weeks.
- Trial name
- NCT07052292
- Testing
- DuraTouch®
- Where
- 11 sites in Poland
- Volunteers
- 128 people
- Sponsor
- Novo Nordisk A/S
Type 2 Diabetes
Feed-Back Suppression of Meal-Induced Glucagon-like Peptide 1 (GLP-1) Secretion
The present study is a phase I, single-centre, double-blind, randomized, cross-over (3 treatments, 3 treatment periods and 6 sequences), stratified (background medication: metformin vs.
- Trial name
- NCT02749032
- Testing
- Mixed meal test, Vildagliptin, Sitagliptin
- Where
- Germany
- Volunteers
- 24 people
- Sponsor
- Michael A. Nauck
Type 1 Diabetes
The Effects of Different Exercise Modalities in Adolescents With Type 1 Diabetes Using AID Systems
Objective: The overall objective of this study is to assess the efficacy of the current recommended guidelines for physical activity (PA) in response to acute moderate intensity continous exercise (MICE) and high intensity…
- Trial name
- MODE2022 (NCT05619198)
- Testing
- High Intensity Interval Exercise, Moderate Intensity Continous Exercise
- Where
- Denmark
- Volunteers
- 24 people
- Sponsor
- Steno Diabetes Center Copenhagen
Type 1 Diabetes Mellitus
Comparing the Metabolic Control of Once to Twice-daily Insulin Detemir Injections
An open-label, treat to target, intervention study in order to compare the metabolic control of once to twice-daily insulin Detemir injections in children and adolescence with type 1 diabetes mellitus.
- Trial name
- NCT00542399
- Testing
- Levemir (insulin detemir), Levemir twice a day
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- Rabin Medical Center
Diabetes, Hypoglycemia
A Study to Improve Diabetes Management Among Adults Experiencing Severe Hypoglycemia
This pilot study will assess the feasibility, preliminary efficacy, and acceptability of the Diabetes-REM (Rescue, Engagement, and Management), a comprehensive patient-centered intervention delivered by community paramedics in…
- Conditions
- Diabetes, Hypoglycemia, Diabetes Type 1, Diabetes Type 2
- Trial name
- NCT04874532
- Testing
- Community Paramedic Program, Education Material
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Mayo Clinic
Type 2 Diabetes
Nutraceutical Citrulline in Pregnancy
The purpose of this study is to determine if oral of L-citrulline (3 grams/day) for 3 weeks provided in mid-pregnancy to pregnant women with type 2 diabetes will increase the plasma L-arginine/ADMA ratio, lower maternal blood…
- Trial name
- NCT02772887
- Testing
- L-Citrulline
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Pittsburgh
Type 1 Diabetes, Adolescent
Additional Insulin for High Fat/Protein in Type 1 Diabetes
Aim: Dietary carbohydrate is the predominant macronutrient affecting postprandial blood glucose excursions, dietary fat and protein can also significantly impact the postprandial glycemic profile.
- Trial name
- NCT05152121
- Testing
- Carb and fat counting
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Ege University
Type 2 Diabetes Mellitus
Evaluation of Fixed Dose Combination of Glimepiride and Metformin in Chinese Type 2 Diabetes Patients Inadequately Controlled With Metformin
Primary Objective: To evaluate the efficacy of fixed dose combination of glimepiride and metformin (AMARYL M 1/250mg) in comparison with glimepiride (AMARYL) alone in terms of glycemic control as reflected by HbA1c during a…
- Trial name
- NCT01457911
- Testing
- Glimepiride and Metformin hydrochloride combination (HOE490), Glimepiride (HOE490)
- Where
- 22 sites in China
- Volunteers
- 244 people
- Sponsor
- Sanofi
Type 1 Diabetes
The Effect of Improved Glycemic Control on the Composition and Function of High-Density Lipoproteins (HDL) in Patients With Type 1 Diabetes
The HAGI-T1D study aims to determine the effect of improved glycemic control on the composition and function of high-density lipoproteins (HDL) in patients with type 1 diabetes (T1D).
- Trial name
- HAGI-T1D (NCT07564752)
- Testing
- Blood test, Urine sample
- Where
- France
- Volunteers
- 143 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Dijon
Diabetes Mellitus, Type 1
Wound Healing After Tooth Extraction in Individuals With Type 1 Diabetes Mellitus
Dental treatment to individuals with diabetes mellitus, particularly type 1 diabetes (T1DM), has always represented a challenge to the dentist.
- Trial name
- NCT02953249
- Where
- Brazil
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
New-onset Type 1 Diabetes Mellitus
Study of Antithymocyte Globulin for Treatment of New-onset T1DM
Antithymocyte globulin (e.g., Thymoglobulin®) is an antibody preparation that is commonly used to treat and prevent organ transplant rejection.
- Trial name
- START (NCT00515099)
- Testing
- Antithymocyte globulin
- Where
- 9 sites in United States
- Volunteers
- 58 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Diabetes Mellitus, Type 1
Effect of HCL Insulin Delivery System on Glycemic Control in Patients With T1D
The goal of this study is compare the effect of hybrid closed loop system (HCL) for automatic insulin dosing treatment on the glycemic control of type 1 diabetes (T1D) in patient with different initial glycated hemoglobin.
- Trial name
- NCT05924932
- Testing
- Tandem t:slim X2 with hybrid closed loop system Control IQ, glucose sensor: Dexcom G6, MiniMed 780G, with hybrid closed loop system SmartGuard, sensor Guardien 4
- Where
- Czechia
- Volunteers
- 120 people
- Sponsor
- Masaryk Hospital Usti nad Labem
Type I Diabetes
Evaluation of the Function "Stop Before Hypoglycemia" on External Insulin Pump
This study compares the apparition of hypoglycaemia in type I diabetic patients between 2 phases: the one without the use of SmartGuard® function and the one with the use of SmartGuard® function.
- Trial name
- AAHPI (NCT03653533)
- Testing
- MiniMed™ 640G, Captor CGM Enlite®, SmartGuard®
- Where
- France
- Volunteers
- 8 people
- Sponsor
- ARAIR Assistance
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