Clinical trials: Diabetes Mellitus, Type I
Type 1 Diabetes
Closing the Loop for 36 Hours in Adolescents With Type 1 Diabetes: Evaluation of Reduced Meal Bolusing
The main focus of our research is the development of a closed-loop system for glucose control in people with type 1 diabetes. After having demonstrated the safety and efficacy of overnight closed-loop insulin delivery, we are…
- Trial name
- NCT01629251
- Testing
- Closed-loop insulin delivery
- Where
- United Kingdom
- Volunteers
- 8 people
- Sponsor
- University of Cambridge
Combined Hepatocellular-cholangiocarcinoma, Liver Neoplasms
Phase II Clinical Study on the Efficacy and Safety of the Combination of Cadonilimab and Capecitabine in Adjuvant Therapy for Combined Hepatocellular Carcinoma and Intrahepatic Cholangiocarcinoma
Title: A Study of Cadonilimab Combined with Capecitabine After Surgery for Mixed Type Liver Cancer This is a phase II clinical trial.
- Trial name
- NCT07243951
- Testing
- Cadonilimab, Capecitabine
- Volunteers
- 75 people
- Sponsor
- Shanghai Zhongshan Hospital
Diabetes Mellitus, Type 1, Macroangiopathy
Tissue Changes in Diabetes in Adults and Children Using Multispectral Optoacoustic Tomography.
In this study, blood flow and tissue changes in adult and pediatric patients with diabetes mellitus will be characterized by MSOT and compared with existing methods (ABI testing, neurological testing) (method comparison).
- Trial name
- NCT05935839
- Testing
- Multispectral optoacoustic tomography, Ankle Brachial Index, Neuropathy Disability Score
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Erlangen-Nürnberg Medical School
Type 1 Diabetes Mellitus
At Home Study of a Zone-Model Predictive Control (MPC) Controller and a Health Monitoring System (HMS) With the Diabetes Assistant (DiAs) System and Run-to-Run Adaptation
This clinical trial is a study to assess the performance of an automated glucose control system (Artificial Pancreas, AP) device in home settings for subjects with type 1 diabetes.
- Trial name
- NCT02705053
- Testing
- CGM and Insulin Pump, Closed-Loop Control System
- Where
- 3 sites in United States
- Volunteers
- 32 people
- Sponsor
- Sansum Diabetes Research Institute
Diabetes
Inulin Supplementation in Patients With Type 1 Diabetes
The aim of this study is to compare the glycemic and metabolic control of type 1 diabetic patients in replacement therapy with insulin, comparing those treated with a supplementation of prebiotics (inulin) and those treated with…
- Trial name
- NCT05795972
- Testing
- inulin, standard therapy
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Healthy Volunteers and Diabetes Participants
Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of PAL-119 in Healthy Volunteers and Adult Participants With Type 1 or Type 2 Diabetes
This is a Phase 1/2 randomized study of oral doses of PAL-119 in healthy volunteers and participants with diabetes.
- Trial name
- NCT07901595
- Testing
- PAL-119
- Volunteers
- 147 people, healthy volunteers welcome
- Sponsor
- Paulex Bio Inc.
Diabetes Mellitus, Type 1
Carbohydrate Content in the Diet in Type 1 Diabetes
The aim of this study is to analyse the effect of a diet with a moderate amount of carbohydrates and compare it with a traditional diabetic diet with a higher content of carbohydrates on mean glucose level, high and low glucose…
- Trial name
- NCT03400618
- Testing
- Moderate carbohydrate diet, Higher carbohydrate diet
- Where
- Sweden
- Volunteers
- 54 people
- Sponsor
- Vastra Gotaland Region
Diabetes Mellitus, Type 1
A Study for Patients With Type 1 Diabetes Mellitus
The purpose of the study is to compare the human insulin inhalation powder plus insulin glargine with injected insulin (regular human insulin or insulin lispro) plus insulin glargine on lowering the blood sugar level.
- Trial name
- NCT00447213
- Testing
- Insulin glargine, Human Insulin Inhalation Powder, Injectable Insulin
- Where
- 5 sites in Japan, Taiwan
- Volunteers
- 70 people
- Sponsor
- Eli Lilly and Company
Hypoglycemia, Diabetes Mellitus, Type 1
The Late Effects of Ethanol Intake on the Glucose Response to Subcutaneous Glucagon in Type 1 Diabetes
Objective: Because many people with type 1 diabetes drink ethanol and because glucagon is used to treat mild hypoglycaemia, it is essential to determine whether ethanol will impair the effectiveness of glucagon to increase…
- Trial name
- ALCO1 (NCT02881060)
- Testing
- Alcohol
- Where
- Denmark
- Volunteers
- 12 people
- Sponsor
- Hvidovre University Hospital
Type 1 Diabetes
Absorption of Insulin Following Subcutaneous Bolus Administration With Different Bolus Durations
To cover meal-related insulin requirements, insulin pumps allow insulin to be delivered at high rates over a short period of time (bolus delivery).
- Trial name
- NCT01792323
- Testing
- Insulin LISPRO
- Where
- Austria
- Volunteers
- 20 people
- Sponsor
- Medical University of Graz
Periodontitis, Type 2 Diabetes
Salivary C1P and PGE2 Levels in Periodontitis Patients With T2DM and Effect of Non-Surgical Periodontal Treatment
Diabetes and periodontal disease are the most common chronic multifactorial and inflammatory diseases in humans, and there is a bidirectional relationship between type 2 diabetes and periodontitis.
- Trial name
- NCT05454059
- Testing
- Non-surgical periodontal treatment, ELISA Test, Periodontal Examination
- Where
- Turkey (Türkiye)
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Ondokuz Mayıs University
Type 1 Diabetes
HCT Cash-Only INcentive to Promote Mealtime Insulin DOSE Engagement
Type 1 Diabetes (T1D) is a serious disease that happens because the body cannot control blood glucose (sugar) levels. People with T1D need insulin shots because their body does not make insulin. Insulin lowers blood sugar levels.
- Trial name
- NCT04621890
- Testing
- LOAN2DOSE and COIN2DOSE
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- Children's Mercy Hospital Kansas City
Hypertension, Type 2 Diabetes
Survey on the Treatment of Hypertension in Patients With Type 2 Diabetes
Multi-centre survey of type 2 diabetic patients who are currently on anti-hypertensive treatment. Data collection for each patient will take place at one visit.
- Trial name
- NCT00803660
- Where
- 19 sites in Vietnam
- Volunteers
- 1,060 people
- Sponsor
- AstraZeneca
Type 1 Diabetes, Nocturnal Hypoglycemia
Development and Assessment of Feasibility of Non-invasive Multiple Sensor Hypo-Sense as a Tool for Detection of Hypoglycemia
Hypo Sense is a non- invasive method for detection of hypoglycemia. The Hypo Sense combines an array of non-invasive sensors which monitors the patient's physiological parameters (heart \& respiration rate, perspiration, skin…
- Trial name
- Hypo-Sense (NCT02225379)
- Testing
- Hypo-Sense (non invasive sensor)
- Where
- Israel
- Volunteers
- 3 people
- Sponsor
- Rabin Medical Center
Type1 Diabetes
The Role of the Thymus in Type I Diabetes.
Regulatory T lymphocytes play a major role in the protection from autoimmune pathology. Defects in immunosuppression mediated by these cells is therefore suspected to contribute to these diseases.
- Trial name
- TregDiab (NCT03236558)
- Testing
- Blood collection
- Where
- France
- Volunteers
- healthy volunteers welcome
- Sponsor
- University Hospital, Toulouse
Type 1 Diabetes Mellitus
A Randomized Control Trial in People With Type 1 Diabetes Who Will Fast Ramadan: Does Insulin Timing and Dose Matter?
Fasting Ramadan is one of the five pillars of Islam and requested only from healthy adults to abstain from eating and drinking from sunrise to sunset.
- Trial name
- NCT04135248
- Where
- Kuwait
- Volunteers
- 50 people
- Sponsor
- Dasman Diabetes Institute
Diabetes, Diabetes Mellitus, Type 1
Efficacy and Safety of Insulin Aspart in Subjects With Type 1 or Type 2 Diabetes
This trial is conducted in Asia. The aim of this trial is to compare the efficacy of postprandial plasma glucose of two treatment regimens in Chinese subjects.
- Conditions
- Diabetes, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
- Trial name
- NCT00593255
- Testing
- soluble human insulin, insulin aspart, insulin NPH
- Where
- 5 sites in China
- Volunteers
- 220 people
- Sponsor
- Novo Nordisk A/S
Diabetes Mellitus, Type 1
Comparison of Insulin Degludec With Insulin Glargine U100 for Adults With Type 1 Diabetes Crossing Multiple Time Zones.
The purpose of the proposed study is to compare insulin Degludec [TRESIBA® (insulin degludec injection)] with insulin Glargine U100 [Lantus® (insulin glargine injection)] to determine the basal insulin of choice for adults with…
- Trial name
- SafrTravlT1D (NCT03668808)
- Testing
- Insulin Degludec, Insulin Glargine, TRESIBA® FLEXTOUCH®
- Where
- 2 sites in United States
- Volunteers
- 25 people
- Sponsor
- Sansum Diabetes Research Institute
Type 1 Diabetes, Pregnancy
Single Arm Intervention Trial of DEKA TWIIST TM Insulin Pump Utilizing Tidepool Loop Algorithm in Pregnant People With Pre-existing Type 1 Diabetes
Suboptimal glycemic control during pregnancy contributes to adverse maternal and fetal health outcomes and previous automated insulin delivery (AID) studies have demonstrated improvement in glucose control across all ages and…
- Trial name
- NCT07808385
- Testing
- Automated Insulin Delivery (AID)
- Where
- 4 sites in United States
- Volunteers
- 32 people
- Sponsor
- Mayo Clinic
Diabetes Mellitus, Type 1
INHALE-3: Afrezza® Combined With Insulin Degludec Versus Usual Care in Adults With Type 1 Diabetes
INHALE-3 is a Phase 4, randomized controlled trial (RCT) that will randomly assign participants ≥18 years of age with type 1 diabetes (T1D) using multiple daily injections (MDI), an automated insulin delivery (AID) system, or a…
- Trial name
- NCT05904743
- Testing
- Afrezza, insulin degludec, Rapid-acting Insulin Analog
- Where
- 19 sites in United States
- Volunteers
- 141 people
- Sponsor
- Mannkind Corporation
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