Clinical trials: Diabetes Mellitus, Type I
Type 2 Diabetes
Pharmacokinetic Similarity, Safety, and Immunogenicity of Semaglutide Injection and Ozempic ® Injection in Healthy Subjects.
This study is a randomized, open-label, single-dose, parallel-controlled biosimilar comparison study comparing the pharmacokinetics, safety and immunogenicity of the investigational drug and the active comparator in healthy adult…
- Trial name
- NCT06634927
- Testing
- Ozempic®, HDG1901
- Where
- China
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd.
Type 1 Diabetes
Dual-hormone Artificial Pancreas Versus Single-hormone Under Exercise and a Meal Challenge
The present clinical trial aims to examine alternative strategies for preventing/mitigating hypoglycemic events among adults with type 1 diabetes utilizing a highly personalized control system.
- Trial name
- TAILOR/3 (NCT06082973)
- Testing
- Automated insulin delivery system algorithm with a dual-hormone configuration (insulin and glucagon) for glucose control, Automated insulin delivery system with a single-hormone configuration (insulin) with rescue carbohydrate recommendations for glucose control
- Where
- Spain
- Volunteers
- 15 people
- Sponsor
- Universitat Politècnica de València
Diabetes Mellitus, Type 1, Pregnancy
BGAT (Blood Glucose Awareness Training) for Users Who Might Become Pregnant
Ineffective management of blood glucose (BG) levels during preconception and pregnancy has been associated with severe maternal and fetal complications in women with type 1 diabetes (T1DM).
- Trial name
- Bump2Be (NCT02508779)
- Testing
- Bump2be, Routine Care
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Type 1 Diabetes
Safety and Effectiveness Study of a Closed Loop System Maintaining Patients' Glucose Levels During an Overnight Period
Currently, patients diagnosed with type 1 diabetes rely on either finger stick or sensor glucose readings when making their insulin dosage decisions.
- Trial name
- NCT01712594
- Testing
- Closed Loop Procedure (Medtronic)
- Where
- United Kingdom
- Volunteers
- 9 people
- Sponsor
- Medtronic MiniMed, Inc.
Type 1 Diabetes
Hypothalamo-pituitary Adrenal Axis Activity and Neuropsychological Consequences in Type 1 Diabetes in Childhood
The general objective is to precise the role of HPA axis activity in neuropsychological consequences of type 1 diabetes. The investigators hypothesize that hyperactivity of HPA axis is associated with higher scores of depression…
- Trial name
- CORTICODIAB (NCT02377583)
- Testing
- T1DM analyses
- Where
- 3 sites in France
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bordeaux
Fatty Liver, Nonalcoholic
The Impact Of SGLT2 -I on Metabolic Dysfunction -Associated Steatotic Liver Disease In Patients With Type 2 Diabetes Mellitus
Study question 1:Could SGLT2-I improve hepatic fibrosis, steatosis, and inflammatory markers in type 2 diabetic patients with Metabolic associated steatotic liver disease Question 2:Which drug of SGLT2-I group is more effective…
- Trial name
- NCT06117137
- Testing
- SGLT2 inhibitor
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Sohag University
Prediabetes, Type 1 Diabetes
Diabetes Prevention - Immune Tolerance
A double-blind, randomized investigator-initiated study to determine the safety and the effect of Diamyd® on the progression to type 1 diabetes in children with multiple islet cell autoantibodies Eligible children are 4 years or…
- Trial name
- DIAPREV-IT (NCT01122446)
- Testing
- Diamyd
- Where
- Sweden
- Volunteers
- 50 people
- Sponsor
- Lund University
Diabetes Mellitus, Type 1
Optimal Insulin Correction Factor in Post- High Intensity Exercise Hyperglycemia in Adults With Type 1 Diabetes (FIT)
The overall objective of this study is to investigate the glycemic response of a 0%, 50%, 100% and 150% bolus insulin correction (based on personal insulin correction factor) of post-exercise hyperglycemia in physically active…
- Trial name
- FIT (NCT03057470)
- Testing
- 50% bolus insulin correction, 100% bolus insulin correction, 150% bolus insulin correction
- Where
- Canada
- Volunteers
- 18 people
- Sponsor
- LMC Diabetes & Endocrinology Ltd.
Diabetes, Autoimmune, Diabetes Mellitus, Adult-Onset
Early Insulin Treatment in Patients With Latent Autoimmune Diabetes
Among adult patients diagnosed with type 2 diabetes, about 6% have autoantibodies directed against the insulin producing beta cells in the pancreas.
- Trial name
- NCT01109927
- Testing
- Insulin
- Volunteers
- 42 people
- Sponsor
- Lund University Hospital
Diabetes (Insulin-requiring, Type 1 or Type 2)
MiniMed Fit Payload Wear Study
The purpose of this study is to assess success/failure of the MiniMed Fit Payload adhesive components in different wear locations over a 7-day period to support development of the future commercialized patch pump.
- Trial name
- NCT07408141
- Testing
- MiniMed Fit Payload adhesive components
- Where
- 4 sites in United States
- Volunteers
- 159 people
- Sponsor
- Medtronic MiniMed, Inc.
Type 1 Diabetes
Outpatient Reduction of Nocturnal Hypoglycemia by Using Predictive Algorithms and Pump Suspension in Children
The purpose of this study is to see whether low blood sugar at night can be reduced by using a system that turns off the insulin pump automatically.
- Trial name
- PSO4 (NCT01823341)
- Testing
- Pump suspension algorithm
- Where
- 3 sites in United States, Canada
- Volunteers
- 97 people
- Sponsor
- Jaeb Center for Health Research
Diabetes Mellitus, Diabetes Mellitus, Type 1
Turkish Version of The Diabetes Quality of Life Brief Clinical Inventory Validity and Reliability
This study aims to develop Turkish version of the Diabetes Quality of Life Brief Clinical Inventory (DQL-BCI) and to perform validity and reliability evaluations.
- Conditions
- Diabetes Mellitus, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Diabetes
- Trial name
- NCT05407454
- Testing
- Questionnaire
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- İlke KARA, PT
Type 1 Diabetes Mellitus
Effect of 4 Weeks of Oral Probiotic Desulfovibrio Piger Supplementation on Immunological and Metabolic Parameters in Individuals With Longstanding Type 1 Diabetes
The goal is to establish the effect of oral probiotic Desulfovibrio piger (D. piger) supplementation on immunological and metabolic parameters in individuals with longstanding type 1 diabetes with residual beta cell function.
- Trial name
- PROSPER (NCT07585994)
- Testing
- Probiotic dietary supplement
- Where
- 2 sites in Netherlands
- Volunteers
- 20 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Type 1 Diabetes, Autoimmunity
Prospective Assessment in Newborns for Diabetes Autoimmunity
This is an observational study designed to help researchers understand the genetics and pathogenesis of type 1 diabetes, and to identify biomarkers for disease and disease complication prediction.
- Trial name
- PANDA (NCT00649246)
- Where
- 3 sites in United States
- Volunteers
- 25,055 people, healthy volunteers welcome
- Sponsor
- Augusta University
Type 1 Diabetes
Comparison of an Artificial Pancreas Versus Threshold Low Glucose Suspend in Type 1 Diabetic Children
The objective of this study is to assess the efficacy of an Artificial Pancreas system which includes a Control-To-Range algorithm, versus standard Insulin Pump Therapy with Threshold Low glucose Suspend feature.
- Trial name
- SHAN (NCT02509429)
- Testing
- Insulin therapy (aspart, lispro ou glulisine) with Control-to-Range algorithm, Insulin therapy ((aspart, lispro ou glulisine) withThreshold Low Glucose Suspend
- Where
- 4 sites in France
- Volunteers
- 24 people
- Sponsor
- University Hospital, Montpellier
Type 1 Diabetes Mellitus, Diabetic Ketoacidosis
Diabetic Kidney Alarm (DKA) Study
The overarching goals of this study are to determine whether tubular dysfunction (elevated urine sodium, bicarbonate and amino acids) and injury (elevated kidney injury molecule 1 [KIM-1], neutrophil gelatinase-associated…
- Trial name
- DKA (NCT03128229)
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- University of Colorado, Denver
Diabetes Mellitus
Efficacy of Pioglitazone Compared to Glyburide in Treating Subjects With Type 2 Diabetes Mellitus and Mild Cardiac Disease
The purpose of this study is to evaluate the cardiovascular effects of pioglitazone, once daily (QD), versus glyburide when administered to patients with type 2 diabetes mellitus and mild cardiac disease.
- Trial name
- NCT00521742
- Testing
- Pioglitazone, Glyburide
- Volunteers
- 300 people
- Sponsor
- Takeda
Diabetes Mellitus Type 2, Diabetes Mellitus, Type 1
Diabetes Telemedicine Consultation: A Systems Improvement Intervention
This study seeks to evaluate and document the processes of outreach consultation through joint-clinics via teleconferencing as an intervention for system improvement in care delivery and management of diabetes mellitus (DM) at a…
- Conditions
- Diabetes Mellitus Type 2, Diabetes Mellitus, Type 1, Primary Care Provider
- Trial name
- NCT00119041
- Testing
- The Diabetes Treatment Satisfaction Questionnaire, Diabetes Empowerment Scale, CBOC's undergo half-day joint-clinics via teleconference
- Where
- 2 sites in United States
- Volunteers
- 304 people
- Sponsor
- US Department of Veterans Affairs
Type 1 Diabetes
Device-Less Technique in Islet Transplantation
Islet transplantation is an effective modality for treating type 1 diabetes. Despite marked progress in clinical islet transplantation with the achievement and maintenance of insulin independence in over half of recipients up to…
- Trial name
- NCT05073302
- Testing
- Implantation of Nylon catheter (Device-less sentinel unit)
- Where
- Canada
- Volunteers
- 5 people
- Sponsor
- University of Alberta
Diabetes
Genetically Informed Screening for Early-Stage Type 1 Diabetes
This study is a test to find out if genetic information can be used to help healthcare providers identify diseases. Specifically, the investigators want to find out how genetic information can help healthcare providers identify…
- Trial name
- PATHS-T1D (NCT07802496)
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
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