Clinical trials: Diabetes Mellitus, Type I
Type 1 Diabetes
Bromocriptine Quick Release (BCQR) as Adjunct Therapy in Type 1 Diabetes
Type 1 diabetes (T1D) continues to be a disease plagued by hyperglycemia, insulin resistance (IR), and increased cardiovascular disease (CVD) despite advances in insulin delivery and glucose monitoring.
- Trial name
- NCT02544321
- Testing
- Bromocriptine
- Where
- United States
- Volunteers
- 108 people
- Sponsor
- University of Colorado, Denver
Type 1 Diabetes Mellitus, T1D
Simultaneous Measurement and Responsive Treatment - Part 2
This research study is testing an investigational dual-port insulin patch pump that integrates a continuous glucose monitor (CGM) in adults with type 1 diabetes.
- Conditions
- Type 1 Diabetes Mellitus, T1D, Type 1 Diabetes, T1DM
- Trial name
- SMART02 (NCT07655076)
- Testing
- DPP System (Insulin Pump and Continuous Glucose Monitoring Platform)
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- ClinSurge Research
Oncology, CTLA4 Haploinsufficiency
Safety and Toxicity Study of IMM27M in Patients With Advanced Solid Tumor
This is a single arm, open label, multi-center and fist in human dose escalation study, to evaluate the safety, tolerability, pharmacokinetics and anti-tumor activity in patients with advanced and metastatic solid tumor.
- Trial name
- NCT05235438
- Testing
- IMM27M
- Where
- 6 sites in China
- Volunteers
- 16 people
- Sponsor
- ImmuneOnco Biopharmaceuticals (Shanghai) Inc.
Type 1 Diabetes
Mechanisms of Hypoglycemia Associated Autonomic Dysfunction, Q4-Atomoxetine
This study is aimed at determining if the drug Atomoxetine (Strattera-used to treat Attention Deficit Hyperactivity Disorder(ADHD) has effects on the body's ability to defend itself against low blood sugar.
- Trial name
- NCT00780650
- Testing
- Atomoxetine
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Diabetes Mellitus, Type 1
Diabetes Technology Study of Real-Time Glucose Alerts in the Team Management of Diabetes
Many people with diabetes have a desire to share blood glucose data with other members of their team. Using a unique wireless glucose meter device, real-time wireless alerts may be automatically sent to a specific team of…
- Trial name
- NCT00322478
- Testing
- Automated informatics driven education and social networking, Blood Glucose Notifications to Remote Caregivers, Frequency of Pattern Management
- Where
- United States
- Volunteers
- 432 people
- Sponsor
- Diabetech
Diabetes Mellitus, Type 1
Bone and Vascular Health in Postmenopausal Women With Type 1 Diabetes
The study is designed to evaluate the differences in bone mineral density (BMD) and Carotid Intima Media Thickness (CIMT) between postmenopausal women with type 1 diabetes (T1D) compared to postmenopausal women without diabetes.
- Trial name
- NCT02693964
- Testing
- Bone density and carotid ultrasound
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Type 1 Diabetes Mellitus
Individualizing Automated Closed Loop Glucose Control Through Pharmacokinetic Profiling in an Insulin-Only Bionic Pancreas
Subjects will participate in three weeks of the bionic pancreas in the insulin-only configuration. Each week, subjects will use a different rapid acting insulin analog -- Humalog, Novolog, or BC222 insulin lispro -- in a…
- Trial name
- NCT03262116
- Testing
- Humalog, Novolog, BC222 insulin lispro
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Massachusetts General Hospital
Type 1 Diabetes Mellitus
Feasibility Study Using Zone-MPC Controller (Zone-Model Predictive Control) and Health Monitoring System (HMS)
This clinical trial is a feasibility study to assess the performance of an Artificial Pancreas (AP) device using the Artificial Pancreas System (APS©) platform for subjects with type 1 diabetes.
- Trial name
- NCT01472406
- Testing
- Sansum Closed-Loop Artificial Pancreas, Insulin infusion pump, Continuous Glucose Monitor
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Sansum Diabetes Research Institute
Type 1 Diabetes Mellitus
Glycemic Profiles And Insulin Delivery Across The Menstrual Cycle In Women With Type 1 Diabetes
This is an observational study. Forty females with type 1 diabetes (age 18-40) using a continuous glucose monitor and an insulin pump will be enrolled for a 3-month data collection.
- Trial name
- NCT04665999
- Testing
- Continuous Glucose Monitor
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- University of Virginia
Diabete Mellitus, Autoimmune Diabetes
Differentiating Heart Disease Between Adult-onset Autoimmune and Type 2 Diabetes
Background: The study of factors associated with diabetic heart disease (DHD), the leading cause of mortality in diabetes, represents an unmet need.
- Conditions
- Diabete Mellitus, Autoimmune Diabetes, Latent Autoimmune Diabetes in Adult (LADA), Type 2 Diabetes
- Trial name
- HD DIAB (NCT07911007)
- Testing
- Cardiac Magnetic Resonance
- Where
- Italy
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Roma La Sapienza
Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
Empagliflozin and ACEi- Effects on Hyperfiltration: BETWEEN Study
This is a randomized, double-blind, double-dummy, placebo-controlled, cross over design trial with empagliflozin compared to placebo that is added to open-label ramipril.
- Conditions
- Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Obesity
- Trial name
- NCT02632747
- Testing
- Empagliflozin, ramipril
- Where
- Canada
- Volunteers
- 31 people
- Sponsor
- Boehringer Ingelheim
Diabetes, Diabetes Mellitus, Type 1
Comparison of Human Insulin Produced by the Current Process and the NN729 Process in Type 1 Diabetes
This trial is conducted in Asia and Oceania. The aim of this trial is to compare the efficacy and safety of human insulin produced by the current process and the NN729 process in type 1 diabetes.
- Trial name
- NCT00569400
- Testing
- human insulin
- Where
- 15 sites in Australia, Hong Kong and 2 more
- Volunteers
- 241 people
- Sponsor
- Novo Nordisk A/S
Type 1 Diabetes (T1D)
Clinical Study on the Treatment of Type 1 Diabetes With CNK-UT009 Cell Injection
This is a single-arm, open, investigator-initiated clinical study of CNK-UT009 cell injection in patients with type 1 diabetes. The purpose of this study is to evaluate the safety and tolerability of CNK-UT009 cell injection in…
- Trial name
- CNK-UT009 (NCT07051564)
- Testing
- CNK-UT009 cell injection
- Where
- China
- Volunteers
- 12 people
- Sponsor
- Zibo Central Hospital
Type1 Diabetes Mellitus, Diabetes Mellitus, Type 1
MEtabolic and Renal Effects of AutoMAted Insulin Delivery Systems in Youth With Type 1 Diabetes Mellitus
In type 1 diabetes (T1DM), automated insulin delivery (AID) systems such as the hybrid closed loop artificial pancreas (HCL AP) combine the use of an insulin pump, continuous blood sugar monitor, and control algorithm to adjust…
- Conditions
- Type1 Diabetes Mellitus, Diabetes Mellitus, Type 1, Autoimmune Diabetes, Juvenile Diabetes
- Trial name
- MERMAID-T1D (NCT03945747)
- Testing
- Blood draw, Urine sample collection, DXA scan
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Colorado, Denver
Diabetes Mellitus, Type 1, Periodontal Diseases
Antimicrobial Photodynamic Therapy on Periodontal Treatment and Salivary Status of Type 1 Diabetes Mellitus Patients
The aim of this study is to evaluate adjuvant effect of antimicrobial photodynamic therapy in periodontal treatment and salivary status of type 1 diabetes patients.
- Conditions
- Diabetes Mellitus, Type 1, Periodontal Diseases, Periodontal Pocket
- Trial name
- NCT03102892
- Testing
- Scaling root planing, Antimicrobial photodynamic therapy
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- University of Sao Paulo
Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2
Application of UCPCR as a Testing Tool for Identification of MODY Patients in the UAE
The study aims to investigate the validity of 2 hour post-prandial UCPCR test in paediatric and adult patients with diabetes duration greater than 2 and 5 years, respectively, for the purposes of distinguishing between patients…
- Conditions
- Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Maturity-onset Diabetes of the Young
- Trial name
- NCT03607604
- Testing
- Next generation sequencing (NGS)
- Where
- United Arab Emirates
- Volunteers
- 778 people, healthy volunteers welcome
- Sponsor
- Imperial College London Diabetes Centre
Diabetes Mellitus Type 1
Continuous Glucose Monitoring During Intecorse in Young Adults With Type 1 Diabetes
Determine the incidence of hypoglycemia during / after sexual intercourse among young adults with type 1 diabetes using continuous -type sugar meter IPRO for a week.
- Trial name
- NCT02750111
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- Dr. Orit Hamiel
type1diabetes
Feasibility Trial of a Mindfulness Based Intervention in Youth With Type 1 Diabetes
Type 1 diabetes (T1D) is one of the most common chronic illnesses of childhood. The involved treatment regimen, including daily insulin administration/pump management, frequent blood glucose checks, and careful track-ing of food…
- Trial name
- BREATHE-T1D (NCT05268393)
- Testing
- BREATHE-T1D
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Children's National Research Institute
Type1 Diabetes Mellitus
DiabetesFlex - Patient Involvement and Patient-reported Outcome Measures in Type 1 Diabetes
The aim of this study is to investigate the effect of the use of DiabetesFlex in diabetes care compared to standard care in relation to patient involvement and relevance for specific group of persons with T1DM.
- Trial name
- NCT03202732
- Testing
- DiabetesFlex
- Where
- Denmark
- Volunteers
- 344 people
- Sponsor
- Annesofie Lunde Jensen
Diabetes, Type I
Childhood Diabetes
Purpose of the study: To compare three different regimes for children newly diagnosed with type 1 diabetes: (1) traditional hospital based care, (2) intensive psychological support to the family, and (3) home based family…
- Trial name
- NCT00804232
- Testing
- childhood diabetes
- Where
- 2 sites in Sweden
- Volunteers
- 210 people
- Sponsor
- Vardalinstitutet The Swedish Institute for Health Sciences
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