Clinical trials: Diabetes Mellitus II
Hypercholesterolemia, Atherosclerosis
Ezetimibe Plus Simvastatin Versus Simvastatin in Patients With Hypercholesterolemia and Coronary Risk Factors (P03405)
The study was designed to assess whether 6 weeks of co-administration of ezetimibe and simvastatin is more effective than simvastatin monotherapy in allowing patients in the CHD risk strata of the NCEP III guidelines to achieve…
- Trial name
- NCT00651014
- Testing
- Ezetimibe
- Volunteers
- 82 people
- Sponsor
- Organon and Co
Diabetes Mellitus, Type II
A Study to Compare the Concentrations of LY2189265 After Different Methods of Administration to Healthy Volunteers.
LY2189265 is an investigational drug being developed for the treatment of type 2 diabetes mellitus. This study will compare the concentrations of LY2189265 using different methods of administration: subcutaneous (or SC- an…
- Trial name
- NCT01301092
- Testing
- LY2189265
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Diabetes Mellitus Type II
The Effect of n-3 Fatty Acid Supplementation on Serum Levels, and Gene Expression of type2 Diabetes Patient
The aim of this study is to determine the effects of supplementation with n-3 fatty acid or placebo for 10 weeks on the expression of Sirt-1, AdipoR1 \& AdipoR2 genes in the peripheral blood mononuclear cell (PBMC) and…
- Trial name
- NCT02261545
- Testing
- n-3 Fatty Acid
- Volunteers
- 88 people
- Sponsor
- Tehran University of Medical Sciences
HCC, Diabetes
p53 Gene Therapy in Treatment of Diabetes Concurrent With Hepatocellular Carcinoma
An open-labeled phase II study to investigate preliminary efficacy using p53 gene therapy in treatment of diabetes concurrent with hepatocellular carcinoma (HCC).
- Trial name
- NCT02561546
- Testing
- p53 gene therapy, Trans-catheter embolization
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Shenzhen SiBiono GeneTech Co.,Ltd
Type II Diabetes
A Study to Assess the Effect of Food on HR20033 and Pharmacokinetic After Multiple Dose in Healthy Volunteers
According to the objective, the trial is constituted by two study groups: one is food effect assessment group, and another is multiple dose pharmacokinetic assessment group.
- Trial name
- NCT05120219
- Testing
- FDC tablet
- Where
- China
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Shandong Suncadia Medicine Co., Ltd.
Choroidal Neovascularization, Diabetic Retinopathy
PF-04523655 Dose Escalation Study, and Evaluation of PF-04523655 With/Without Ranibizumab in Diabetic Macular Edema (DME)
This is a two-part study. The first part (Stratum I) is an open-label, dose escalation, safety, tolerability and pharmacokinetic study, where active study drug (PF-04523655) will be given to all patients who participate.
- Conditions
- Choroidal Neovascularization, Diabetic Retinopathy, Diabetic Macular Edema
- Trial name
- MATISSE (NCT01445899)
- Testing
- PF-04523655 (Stratum I), ranibizumab, PF-04523655 (Stratum II)
- Where
- 51 sites in United States, Belgium and 5 more
- Volunteers
- 258 people
- Sponsor
- Quark Pharmaceuticals
Diabetes Mellitus, Type II
Effectiveness & Tolerability of Novel, Initial Triple Combination Therapy vs Conventional Therapy in Type 2 Diabetes
In this study, the investigators will assess the efficacy and tolerability of a novel, initial triple combination therapy with metformin, saxaglipitin, and dapagliflozin, compared to conventional stepwise add-on therapy in…
- Trial name
- NCT02946632
- Testing
- triple combination therapy, Stepwise add-on therapy
- Where
- South Korea
- Volunteers
- 104 people
- Sponsor
- Korea University Anam Hospital
Type 2 Diabetes
Bosentan Use in Patients With Diabetic Nephropathy
There is little doubt of the necessity for further improvement in the prevention and therapy of end-stage renal disease. Despite the success of ARB in treating diabetic nephropathy, not all patients obtain satisfactory control of…
- Trial name
- NCT00638131
- Testing
- bosentan
- Where
- Canada
- Volunteers
- 1 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Diabetes Mellitus, Type 2
Eze/Simva Switch Study in Diabetics (0653A-807)
A study to assess the effectiveness and tolerability of MK0653A and MK0653A versus Atorvastatin in lowering LDL-C levels.
- Trial name
- NCT00541697
- Testing
- MK0653A, ezetimibe (+) simvastatin / Duration of Treatment: 6 Weeks, Comparator: atorvastatin / Duration of Treatment: 6 Weeks
- Volunteers
- 648 people
- Sponsor
- Organon and Co
Painful Diabetic Neuropathies
Safety and Efficacy Study for the Treatment of Painful Diabetic Neuropathy
The purpose of this study is to determine if Engensis (VM202) is safe and effective in treating painful diabetic neuropathy.
- Trial name
- NCT01475786
- Testing
- Low Dose: 16 mg Engensis (VM202), High Dose: 32 mg Engensis (VM202)
- Where
- 17 sites in United States, South Korea
- Volunteers
- 104 people
- Sponsor
- Helixmith Co., Ltd.
Obesity, Morbid, Type 2 Diabetes Mellitus
The Effects of the Laparoscopic Roux-en-Y Gastric Bypass and Laparoscopic Mini Gastric Bypass on the Remission of Type II Diabetes Mellitus
It is estimated that there will be 439-552 million people with type 2 diabetes mellitus (T2DM) globally in 2030. Type 2 Diabetes Mellitus is present in one quarter of patients at the bariatric outpatient clinic.
- Trial name
- DIABAR (NCT03330756)
- Testing
- laparoscopic Roux-en-Y gastric bypass, laparoscopic Mini gastric bypass
- Where
- Netherlands
- Volunteers
- 220 people
- Sponsor
- Slotervaart Hospital
Type 2 Diabetes Mellitus
Safety, Tolerance and Activity of HE3286 in Patients With Type 2 Diabetes Mellitus
This is a phase II, double-blind, randomized, placebo-controlled study of the safety, tolerance and activity of HE3286 in patients with type 2 diabetes mellitus.
- Trial name
- NCT00694057
- Testing
- HE3286
- Where
- 22 sites in United States
- Volunteers
- 164 people
- Sponsor
- Harbor Therapeutics
Type2 Diabetes Mellitus
Investigate the Efficacy and Safety of Low-Glu in Patients Newly Diagnosed With Type II Diabetes Mellitus
Ficus deltoidea leaves, Cinnamomum cassia and Black seed powdered extract have long been used for the treatment of type 2 diabetes mellitus.
- Trial name
- NCT05343767
- Testing
- Natural Wellness Low-Glu low dose, Natural Wellness Low-Glu high dose, Metformin
- Where
- Egypt
- Volunteers
- 198 people
- Sponsor
- Natural Wellness Egypt
Diabetes Mellitus, Type 2, Metabolic Syndrome X
A Phase IIa Proof-of-concept Study of NC-503 in Patients With Type II Diabetes
The main objectives of the current study are to establish the safety and clinical proof-of-concept of NC-503 in inadequately controlled patients with Type 2 diabetes and features of metabolic syndrome treated with either…
- Trial name
- NCT00675857
- Testing
- NC-503 (eprodisate disodium)
- Where
- 21 sites in Canada
- Volunteers
- 200 people
- Sponsor
- Bellus Health Inc. - a GSK company
Overweight, Obesity
Weight Loss in Chronic Disease Patient Population
This study will assess the effect of in-home tele-health monitoring on health outcomes for LSUHCSD chronic disease, overweight or obese patients diagnosed with type II diabetes or hypertension.
- Conditions
- Overweight, Obesity, Diabetes, Hypertension
- Trial name
- NCT01155050
- Testing
- Tele-health Home Monitoring, TrestleTree Telephone Coaching, Tele-health Home Monitoring Plus Trestle Telephone Coaching
- Where
- 3 sites in United States
- Volunteers
- 202 people
- Sponsor
- Pennington Biomedical Research Center
Congestive Heart Failure, Type II Diabetes Mellitus
Effect of Vildagliptin on Left Ventricular Function in Patients With Type 2 Diabetes and Congestive Heart Failure
This study will assess the effect of vildagliptin on left ventricular function in patients with type 2 diabetes and congestive heart failure (NYHA Class I-III).
- Trial name
- NCT00894868
- Testing
- vildagliptin
- Where
- 93 sites in Czechia, Denmark and 13 more
- Volunteers
- 798 people
- Sponsor
- Novartis Pharmaceuticals
Diabetes, Sedentary Lifestyle
Primary Care-Based Physical Activity for Diabetic Latinas
The goal of this proposal is to test the efficacy of a primary care-delivered, print-based physical activity intervention for Latinas with type II diabetes.
- Trial name
- NCT02741050
- Testing
- Tailored Physical Activity Intervention, Standard of Care
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of California, San Diego
Type 2 Diabetes
Study to Assess the Safety and Tolerability After Multiple Oral Doses of AZD1656 in Patients With Type 2 Diabetes Mellitus Treated With Metformin
The purpose of this study is to assess the 1 month safety and tolerability after multiple oral doses of AZD1656 in patients with Type 2 Diabetes Mellitus Treated with Metformin
- Trial name
- NCT00817778
- Testing
- AZD1656
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- AstraZeneca
Diabetes Mellitus, Macular Edema
Laser and Medical Treatment of Diabetic Macular Edema
This study will compare the side effects of two laser treatments for diabetic macular edema, a common condition in patients with diabetes.
- Trial name
- NCT00027287
- Testing
- Vitamin E
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- National Eye Institute (NEI)
Diabetes
Study to Determine the Efficacy, Safety, Tolerability & Pharmacokinetics of RO 205-2349 in Patients With Type 2 Diabetes Mellitus
The objective of the study is to determine the dose(s) of Ro 205-2349 which, when compared to placebo, are efficacious, safe and tolerable in improving glycemic control in patients with type 2 diabetes.
- Trial name
- NCT00057304
- Testing
- RO 205-2349
- Where
- 46 sites in United States, Bulgaria and 7 more
- Volunteers
- 190 people
- Sponsor
- Hoffmann-La Roche